Tears of Love

https://digitalcommons.library.umaine.edu/mmb-vp/6411/thumbnail.jp

Identifying as in, out, or sexually inexperienced: Perception of sex-related personal disclosures

The current research explored perceptions of disclosing the information of "I am gay", "I am heterosexual", and "I am a virgin" to a variety of audiences. Participants were 842 undergraduate students who evaluated the valence of each disclosure, listed the associated feelings, and rated the comfort of disclosing such information to various audiences (e.g., a family member, online community). Participants rated the statement consistent with their own sexual orientation as being significantly more positive. No significant difference was found between gay and heterosexual participants’ ratings about disclosing virginity, and disclosure of virginity status was ranked as the most uncomfortable of the three disclosures. Both heterosexual and gay respondents indicated it would be more comfortable to disclose a heterosexual orientation than a gay one, despite gay participants rating a gay orientation as more positive. The audience ranked most to least comfortable to disclose varied with sexual orientation and disclosure content. Perceived closeness of audience was correlated with comfort of disclosure for known (family, partner, friend, colleague) audiences, but not professional (counsellor) or unknown (stranger, online) audiences. These findings are discussed with reference to the literature on “coming out”, addressing important differences in the perceptions of in-group and out-group disclosure of sexual orientation, and sex-related personal information

Soft X-ray emission from the inner disk of M33

We present a study, based on archival XMM-Newton observations, of the extended X-ray emission associated with the inner disk of M33. After the exclusion of point sources with L_X > 2 x 10^{35} erg/s (0.3-6 keV), we investigate the morphology and spectrum of the residual X-ray emission. This residual emission has a soft X-ray spectrum which can be fitted with a two-temperature thermal model, with kT = 0.2 keV and 0.6 keV. The soft X-ray surface brightness distribution shows a strong correlation with FUV emission, indicative of a close connection between recent star-formation activity and the production of soft X-rays. Within 3.5 kpc of the nucleus of M33, the soft X-ray and FUV surface brightness distributions exhibit similar radial profiles. This implies that the ratio of the soft X-ray luminosity (0.3-2.0 keV) to the star formation rate (SFR) per unit disk area remains fairly constant within this inner disk region. We derive a value for this ratio of 1-1.5 x 10^{39} (erg/s)/(M_sun/yr), consistent with previous studies. In the same region, the ratio of soft X-ray luminosity to stellar mass (derived from K-band photometry) is 4 x 10^{28} erg/s/M_sun, a factor of 5-10 higher than is typical of dwarf elliptical galaxies, suggesting that 10-20% of the unresolved emission seen in M33 may originate in its old stellar population. The remainder of the soft X-ray emission is equally split between two spatial components, one which closely traces the spiral arms of the galaxy and the other more smoothly distributed across the inner disk of M33. The former must represent a highly clumped low-filling factor component linked to sites of recent or ongoing star formation, whereas the distribution of the latter gives few clues as to its exact origin.Comment: 13 pages, 4 figures, 5 tables. Accepted for publication in MNRA

Quantification and Predictors of OCT-Based Macular Curvature and Dome-Shaped Configuration: Results From the UK Biobank

PURPOSE. To investigate macular curvature, including the evaluation of potential associations and the dome-shaped macular configuration, given the increasing myopia prevalence and expected associated macular malformations. METHODS. The study included a total of 65, 440 subjects with a mean age (± SD) of 57.3 ± 8.11 years with spectral-domain optical coherence tomography (OCT) data from a unique contemporary resource for the study of health and disease that recruited more than half a million people in the United Kingdom (UK Biobank). A deep learning model was used to segment the retinal pigment epithelium. The macular curvature of the OCT scans was calculated by polynomial fit and evaluated. Further, associations with demographic, functional, ocular, and infancy factors were examined. RESULTS. The overall macular curvature values followed a Gaussian distribution with high inter-eye agreement. Although all of the investigated parameters, except maternal smoking, were associated with the curvature in a multilinear analysis, ethnicity and refractive error consistently revealed the most significant effect. The prevalence of a macular dome-shaped configuration was 4.8% overall, most commonly in Chinese subjects as well as hypermetropic eyes. An increasing frequency up to 22.0% was found toward high refractive error. Subretinal fluid was rarely found in these eyes. CONCLUSIONS. Macular curvature revealed associations with demographic, functional, ocular, and infancy factors, as well as increasing prevalence of a dome-shaped macular configuration in high refractive error including high myopia and hypermetropia. These findings imply different pathophysiologic processes that lead to macular development and might open new fields to future myopia and macula research

Foveal Curvature and Its Associations in UK Biobank Participants

PURPOSE. To examine whether sociodemographic, and ocular factors relate to optical coherence tomography (OCT)-derived foveal curvature (FC) in healthy individuals. METHODS. We developed a deep learning model to quantify OCT-derived FC from 63, 939 participants (age range, 39-70 years). Associations of FC with sociodemographic, and ocular factors were obtained using multilevel regression analysis (to allow for right and left eyes) adjusting for age, sex, ethnicity, height (model 1), visual acuity, spherical equivalent, corneal astigmatism, center point retinal thickness (CPRT), intraocular pressure (model 2), deprivation (Townsend index), higher education, annual income, and birth order (model 3). Fovea curvature was modeled as a z-score. RESULTS. Males had on average steeper FC (0.077; 95% confidence interval [CI] 0.077-0.078) than females (0.068; 95% CI 0.068-0.069). Compared with whites, non-white individuals showed flatter FC, particularly those of black ethnicity. In black males, -0.80 standard deviation (SD) change when compared with whites (95% CI -0.89, -0.71; P 5.2e10-68). In black females, -0.70 SD change when compared with whites (95% CI -0.77, -0.63; p 2.3e10-93). Ocular factors (visual acuity, refractive status, and CPRT) showed a graded inverse association with FC that persisted after adjustment. Macular curvature showed a positive association with FC. Income showed a linear trend increase in males (P for linear trend = 0.005). CONCLUSIONS. We demonstrate marked differences in FC with ethnicity on the largest cohort studied for this purpose to date. Ocular factors showed a graded association with FC. Implementation of FC quantification in research and on the clinical setting can enhance the understanding of clinical macular phenotypes in health and disease

The effect of aluminium on twinning in binary alpha-titanium

The deformation mechanisms of binary Ti–Al model alloys (0–13.1 at.% Aluminium) have been investigated with respect to the twinning activity using in-situ loading in combination with neutron diffraction as well as detailed post mortem electron backscatter diffraction analysis. A consistent starting grain size and texture was generated for all alloys promoting tensile twinning during compression testing. Long-wavelength neutron diffraction and selected area diffraction transmission electron microscopy analysis were carried out to detect evidence of Aluminium ordering and Ti3Al formation.It was found that raising the Aluminium content in Titanium does first slightly enhance twinning, with {10View the MathML source2} tensile twinning being by far the dominant type, while the critical residual intergranular strains for twin initiation decreases. This suggests that either the lowering of stacking fault energy by Aluminium or its solute solution strengthening effect are important factors. At around 7 at.% Aluminium a turning point in twinning activity was noticed and a further increase in Aluminium did result in a dramatic loss of twinning activity particularly when the material had been exposed to an additional low temperature age. The dramatic decrease of twinning activity is strongly correlated with increasing evidence of short range ordering and also early signs of Ti3Al-formation in case of the highest Aluminium content. In addition, electron backscatter diffraction analysis revealed that the formation of Aluminium ordered zones do severely hinder growth of twin boundaries

The Milky Way in X-rays for an outside observer: Log(N)-Log(S) and Luminosity Function of X-ray binaries from RXTE/ASM data

We study the Log(N)-Log(S) and X-ray luminosity function in the 2-10 keV energy band, and the spatial (3-D) distribution of bright, log(L_X) > 34-35 erg/s, X-ray binaries in the Milky Way. In agreement with theoretical expectations and earlier results we found significant differences between the spatial distributions of low (LMXB) and high (HMXB) mass X-ray binaries. The volume density of LMXB sources peaks strongly at the Galactic Bulge. HMXBs tend to avoid the inner 3-4 kpc of the Galaxy, HMXBs are more concentrated towards the Galactic Plane and show clear signatures of the spiral structure in their spatial distribution. LMXB sources have a flatter Log(N)-Log(S) distribution and luminosity function than HMXBs. The integrated 2-10 keV luminosities of X-ray binaries, averaged over 1996--2000, are 2-3 * 10^39 (LMXB) and 2-3 * 10^38 (HMXB) erg/s. Normalised to the stellar mass and the star formation rate, respectively, these correspond to 5 * 10^28 erg/s/M_sol for LMXBs and 5 * 10^37 erg/s/(M_sol/yr) for HMXBs. Due to the shallow slopes of the luminosity functions the integrated emission of X-ray binaries is dominated by the 5-10 most luminous sources which determine the appearance of the Milky Way in the standard X-ray band for an outside observer. In particular variability of individual sources or an outburst of a bright transient source can increase the integrated luminosity of the Milky Way by as much as a factor of ~2. Although the average LMXB luminosity function shows a break near the Eddington luminosity for a 1.4 M_sol neutron star, at least 11 sources showed episodes of super-Eddington luminosity during ASM observations. We provide the maps of distribution of X-ray binaries in the Milky Way in various projections, which can be compared to images of nearby galaxies taken by CHANDRA and XMM-Newton.Comment: 23 pages, 19 figures, accepted by A&

Circulating protein biomarkers in systemic sclerosis related pulmonary arterial hypertension: a review of published data

Pulmonary arterial hypertension (PAH) develops in 7-12% of patients with systemic sclerosis (SSc) and is associated with a 3 year survival of 52%. Early detection by screening is therefore recommended for all patients with SSc. Historically, screening has been performed using echocardiography and measurement of gas transfer. More recently the DETECT protocol, using a combination of biomarkers (including N-terminal pro-brain natriuretic peptide) and clinical parameters, has been developed. The optimal method of screening for PAH with high sensitivity and specificity is, however, not clear. Protein expression differences between different SSc disease phenotypes have been reported, and include alterations in concentration of NT-proBNP, endoglin, soluble vascular endothelial growth factor receptor 1, placenta growth factor, growth differentiation factor-15, vascular endothelial growth factor alpha, resistin-like molecule beta, and soluble thrombomodulin. This review summarizes the current knowledge of these protein changes in patients with SSc and PAH