Apolipoprotein M

Apolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL). Human apoM gene is located in p21.31 on chromosome 6 (chromosome 17, in mouse). Human apoM cDNA (734 base pairs) encodes 188-amino acid residue-long protein. It belongs to lipocalin protein superfamily. Human tissue expression array study indicates that apoM is only expressed in liver and in kidney and small amounts are found in fetal liver and kidney. In situ apoM mRNA hybridization demonstrates that apoM is exclusively expressed in the hepatocytes and in the tubule epithelial cells in kidney. Expression of apoM could be regulated by platelet activating factor (PAF), transforming growth factors (TGF), insulin-like growth factor (IGF) and leptin in vivo and/or in vitro. It has been demonstrated that apoM expression is dramatically decreased in apoA-I deficient mouse. Hepatocyte nuclear factor-1α (HNF-1α) is an activator of apoM gene promoter. Deficiency of HNF-1α mouse shows lack of apoM expression. Mutations in HNF-1α (MODY3) have reduced serum apoM levels. Expression of apoM is significantly decreased in leptin deficient (ob/ob) mouse or leptin receptor deficient (db/db) mouse. ApoM concentration in plasma is positively correlated to leptin level in obese subjects. These may suggest that apoM is related to the initiation and progression of MODY3 and/or obesity

An advocacy coalition approach to a study of the politics of education in Tennessee

This was an instrumental case study that examined the extent to which the politics of education in Tennessee that resulted in the passage of the Education Improvement Act of 1992 and related tax increases conformed to the assumptions of the Advocacy Coalition Framework as articulated by Sabatier. The framework viewed education policy change as the result of the interaction of (a) competing advocacy coalitions within a policy subsystem over a decade or more, (b) changes that are external to the policy subsystem, and the (c) effects of stable system parameters. The researcher used a snowballing technique to identify 12 key education and political leaders in Tennessee, who were interviewed using a protocol developed specifically for this study. Data about the policy subsystem over the previous two decades were collected using formal research studies. Interview and document data were aggregated by predetermined categories and analyzed systematically. Findings were presented chronologically and according to research question. The study found two competing advocacy coalitions that had interacted in the education policy subsystem throughout the past two decades. The coalition of education groups valued quality and advocated increased spending for education to improve the quality of education and, in turn, their quality of life. Coalition members advocated measures such as, teacher pay increases, statewide kindergarten programs, improved curriculum materials, a career ladder and reduced class sizes for teachers, and equitable funding to improve education for all students. Over time, coalition members disagreed on specific strategies but consistently agreed on the policy core of quality. The other coalition, whose members were primarily business and tax payer groups valued efficient delivery of government services. They opposed tax increases and advocated centralized control, regulation, and scientific management to increase efficiency of the delivery of education. Members of both coalitions published studies and held conferences to bolster their arguments, but the studies did not lead to policy change. Consistent with the Advocacy Coalition Framework, the skillful exploitation of dynamic external events appeared to have been the impetus of policy change in 1972, 1984, and 1992

A Chandra Observation of the Diffuse Emission in the Face-on Spiral NGC 6946

This paper describes the {\it Chandra} observation of the diffuse emission in the face-on spiral NGC 6946. Overlaid on optical and H${\alpha}$ images, the diffuse emission follows the spiral structure of the galaxy. An overlay on a 6 cm polarized radio intensity map confirms the phase offset of the polarized emission. We then extract and fit the spectrum of the unresolved emission with several spectral models. All model fits show a consistent continuum thermal temperature with a mean value of 0.25$\pm$0.03 keV. Additional degrees of freedom are required to obtain a good fit and any of several models satisfy that need; one model uses a second continuum component with a temperature of 0.70$\pm$0.10 keV. An abundance measure of 3$^{+1.95}_{-1.90}$ for Si differs from the solar value at the 90% confidence level; the net diffuse spectrum shows the line lies above the instrumental Si feature. For Fe, the abundance measure of 0.67$\pm$0.13 is significant at 99%. Multiple gaussians also provide a good fit. Two of the fitted gaussians capture the O VII and O VIII emission; the fitted emission is consistent with an {\it XMM-Newton} RGS spectrum of diffuse gas in M81. The ratio of the two lines is $<$0.6-0.7 and suggests the possibility of non-equilibrium ionization conditions exist in the ISM of NGC 6946. An extrapolation of the point source luminosity distribution shows the diffuse component is not the sum of unresolved point sources; their contribution is at most 25%.Comment: accepted for ApJ; 16 pages; 12 figs; to meet Archive size limits, most converted to jpe

Descriptive Phenomenological Analysis of Influences to Death Anxiety

There are two certainties in life: we are born, and we will die. Everything in between birth and death is our life. This truth leads many individuals to existential questions: What is the meaning of life? How do we become satisfied with life, knowing that death is impending? Does awareness of death motivate how we live? Death anxiety is a well-studied subject; well over 500 studies provide information on who is the most fearful of death among a variety of groups (women versus men, religious verses secular, youth verses elderly, et cetera). These studies also use presuppositions to explain fear of death, such as, elder individuals have less fear of death due to life experience, a practical reason that makes sense and is likely true. My study looks beyond practical reasoning. I used descriptive phenomenological research to explore the subjective experiences of six individuals, to look beyond presuppositions and examine personal reasoning, and explore whether there were commonalities among their experiences. This study found ten (10) commonalities within the subjective experience of each participant that influenced each person’s fear of death. In the whole these commonalities describe the structure of a phenomenon, experiences that alter the fear of death and influences actions taken in life. The commonalities are loss, selfishness, worry about the process of dying, helplessness over what cannot be controlled, common daily fears, meaning-making that is embedded in general reasoning, reports of self-protection, pleasure-seeking drives, struggles with internal and external values, and a feeling of relief that is found in those who have lost a loved one to chronic illness. This study provides an enhanced understanding of how individuals process death anxiety. This dissertation is available in open access at AURA, http://aura.antioch.edu/ and Ohio Link ETD Center, https://etd.ohiolink.edu/etd

Dissecting the spiral galaxy M83: mid-infrared emission and comparison with other tracers of star formation

We present a detailed mid-infrared study of the nearby, face-on spiral galaxy M83 based on ISOCAM data. M83 is a unique case study, since a wide variety of MIR broad-band filters as well as spectra, covering the wavelength range of 4 to 18\mu m, were observed and are presented here. Emission maxima trace the nuclear and bulge area, star-formation regions at the end of the bar, as well as the inner spiral arms. The fainter outer spiral arms and interarm regions are also evident in the MIR map. Spectral imaging of the central 3'x3' (4 kpc x 4 kpc) field allows us to investigate five regions of different environments. The various MIR components (very small grains, polycyclic aromatic hydrocarbon (PAH) molecules, ionic lines) are analyzed for different regions throughout the galaxy. In the total 4\mu m to 18\mu m wavelength range, the PAHs dominate the luminosity, contributing between 60% in the nuclear and bulge regions and 90% in the less active, interarm regions. Throughout the galaxy, the underlying continuum emission from the small grains is always a smaller contribution in the total MIR wavelength regime, peaking in the nuclear and bulge components. The implications of using broad-band filters only to characterize the mid-infrared emission of galaxies, a commonly used ISOCAM observation mode, are discussed. We present the first quantitative analysis of new H-alpha and 6cm VLA+Effelsberg radio continuum maps of M83. The distribution of the MIR emission is compared with that of the CO, HI, R band, H-alpha and 6cm radio. A striking correlation is found between the intensities in the two mid-infrared filter bands and the 6cm radio continuum. To explain the tight mid-infrared-radio correlation we propose the anchoring of magnetic field lines in the photoionized shells of gas clouds.Comment: 22 pages, 15 figures. Accepted for publication in A&