761 research outputs found
Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis
SummaryObjectivesWe hypothesised that osteochondral and synovial angiogenesis in osteoarthritis (OA) are independent processes. We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA.DesignSynovium and medial tibial plateaux were obtained from 62 patients undergoing total knee joint replacement for OA (18 [29%] had chondrocalcinosis) and from 31 recently deceased people with no evidence of joint pathology post-mortem (PM). Vascular endothelium, proliferating endothelial cells (ECs) and macrophages were quantified by immunohistochemistry for CD34, CD31/Ki67 and CD14, respectively. Grades were assigned for radiographic and histological OA disease severity, clinical disease activity and histological synovitis (based on cellular content of the synovium).ResultsBlood vessels breached the tidemark in 60% of patients with OA and 20% of PM controls. Osteochondral vascular density increased with increasing cartilage severity and clinical disease activity scores, but not with synovitis. Synovial EC proliferation, inflammation and macrophage infiltration were higher in OA than in PM controls. Synovial angiogenesis indices increased with increasing histological synovitis, but were not related to osteochondral vascular density or other indices of OA disease severity. OA changes were more severe in patients with concurrent chondrocalcinosis. Chondrocalcinosis was not associated with increased angiogenesis or histological synovitis beyond that seen in OA alone.ConclusionOsteochondral and synovial angiogenesis appear to be independent processes. Osteochondral vascularity is associated with the severity of OA cartilage changes and clinical disease activity, whereas synovial angiogenesis is associated with histological synovitis. Modulation of osteochondral and synovial angiogenesis may differentially affect OA disease
Gravitationally lensed QSOs in the ISSIS/WSO-UV era
Gravitationally lensed QSOs (GLQs) at redshift z = 1-2 play a key role in
understanding the cosmic evolution of the innermost parts of active galaxies
(black holes, accretion disks, coronas and internal jets), as well as the
structure of galaxies at intermediate redshifts. With respect to studies of
normal QSOs, GLQ programmes have several advantages. For example, a monitoring
of GLQs may lead to unambiguous detections of intrinsic and extrinsic
variations. Both kinds of variations can be used to discuss central engines in
distant QSOs, and mass distributions and compositions of lensing galaxies. In
this context, UV data are of particular interest, since they correspond to
emissions from the immediate surroundings of the supermassive black hole. We
describe some observation strategies to analyse optically bright GLQs at z of
about 1.5, using ISSIS (CfS) on board World Space Observatory-Ultraviolet.Comment: 7 pages, 4 figures, Accepted for publication in Astrophysics & Space
Scienc
The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles
Cosmological distance indicators
We review three distance measurement techniques beyond the local universe:
(1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and
(3) HI intensity mapping. We describe the principles and theory behind each
method, the ingredients needed for measuring such distances, the current
observational results, and future prospects. Time delays from strongly lensed
quasars currently provide constraints on with < 4% uncertainty, and with
1% within reach from ongoing surveys and efforts. Recent exciting discoveries
of strongly lensed supernovae hold great promise for time-delay cosmography.
BAO features have been detected in redshift surveys up to z <~ 0.8 with
galaxies and z ~ 2 with Ly- forest, providing precise distance
measurements and with < 2% uncertainty in flat CDM. Future BAO
surveys will probe the distance scale with percent-level precision. HI
intensity mapping has great potential to map BAO distances at z ~ 0.8 and
beyond with precisions of a few percent. The next years ahead will be exciting
as various cosmological probes reach 1% uncertainty in determining , to
assess the current tension in measurements that could indicate new
physics.Comment: Review article accepted for publication in Space Science Reviews
(Springer), 45 pages, 10 figures. Chapter of a special collection resulting
from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in
the Space Ag
Congruency within rural social networks as an indicator of interpersonal influence on risk judgments: the great stir caused by BSE in a village in northern Germany
Cosmological Applications of Gravitational Lensing
The last decade has seen an enormous increase of activity in the field of
gravitational lensing, mainly driven by improvements of observational
capabilities. I will review the basics of gravitational lens theory, just
enough to understand the rest of this contribution, and will then concentrate
on several of the main applications in cosmology. Cluster lensing, and weak
lensing, will constitute the main part of this review.Comment: 26 pages, including 2 figures (a third figure can be obtained from
the author by request) gziped and uuencoded postscript file; to be published
in Proceedings of the Laredo Advanced Summer School, Sept. 9
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
Measurement of the top pair production cross section in 8 TeV proton-proton collisions using kinematic information in the lepton plus jets final state with ATLAS
A measurement is presented of the inclusive production
cross-section in collisions at a center-of-mass energy of TeV
using data collected by the ATLAS detector at the CERN Large Hadron Collider.
The measurement was performed in the lepton+jets final state using a data set
corresponding to an integrated luminosity of 20.3 fb. The cross-section
was obtained using a likelihood discriminant fit and -jet identification was
used to improve the signal-to-background ratio. The inclusive
production cross-section was measured to be
pb assuming a top-quark mass of 172.5 GeV, in good agreement with the
theoretical prediction of pb. The production cross-section in the fiducial region
determined by the detector acceptance is also reported.Comment: Published version, 19 pages plus author list (35 pages total), 3
figures, 2 tables, all figures including auxiliary figures are available at
http://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/TOPQ-2013-06
The semiology of changing brand image
This article considers the attempted change to the image of an established brand by studying the semiotics within the brand’s historical advertising campaigns. The use of semiotics to study the interpretation of messages is discussed, and the link between interpretation of messages and advertising effectiveness in changing brand image is explored. The authors deconstruct advertisements of a brand to provide a model containing opposing dialectics that may aid managers by highlighting alternative symbolic messages contained in advertisements. Oncwe identified, these alternative symbolic messages may be used to help change brand image and influence advertising effectiveness. Although the study focuses upon a major brand of beer, this is an industry in which there are numerous small firms, and many of those have constrained marketing budgets, and thus need to make sure that their advertising is effective. Equally, entrepreneurial marketing is not to found only in the small firm, and the case study discusses a radical and imaginative brand repositioning of a well established product
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