Diffuse inference system for valuation of companies

The objective of this research is to propose a tool based on diffuse logic that would allow its implementation in the valuation of companies, accepting the inclusion of non-quantitative variables and criteria that have not been included in said process. Initially, some of the main company valuation methodologies are explored, identifying the factors that have an impact on them. Then, they are established as supply for the tool proposed in this research work. Subsequently, the diffuse logic theoretical framework is presented, which is the basis of the mentioned tool. Then, the characteristics are established in diffuse terms of its own components, and several results are disclosed. The presented tool, apart from including qualitative variables and supporting the investment decision-making process, allows the follow-up of the management as it facilitates the measurement of the variations that some organizational decisions generate in the value of the company.El objetivo de esta investigación es proponer una herramienta basada en lógica difusa que permita implementarse en la valoración de empresas, admitiendo la inclusión de variables y criterios no cuantitativos en dicho proceso. Inicialmente, se exploran algunas de las principales metodologías de valoración de empresas, se identifican los factores que las impactan, y se establecen como insumo para la herramienta que propone esta investigación. Posteriormente, se presenta el marco teórico de lógica difusa y sobre el cual se sustenta la herramienta. Luego, se establecen las características en términos difusos de los componentes de la misma y se comparten algunos resultados. La herramienta presentada, además de incluir variables cualitativas y apoyar la toma de decisiones de inversión, permite el seguimiento a la gestión, ya que facilita medir las variaciones que algunas decisiones organizacionales generan en el valor de la empres

Lean construction - LC under lean thinking

Lean Construction es una filosofía que cambia el pensamiento tradicional de trabajo en el sector construcción por medio de sistemas de gestión innovadores fundamentados en análisis de pérdidas, planificando las actividades con el objetivo de mejorar la productividad en la construcción, eliminando actividades que no aportan para el resultado de la obra.El pensamiento LEAN está constituido por técnicas implementadas en la empresa Toyota para minimizar los desperdicios en la cadena productiva y aumentar el valor de los productos.Este artículo de revisión propone la aplicación del pensamiento LEAN en procesos del sector construcción y se ilustra con un ejemplo tomado de un proceso real que puede ser parte de la interventoría. Lean Construction is a philosophy that changes the traditionalist thoughtin the construction area through innovative management systems based on the analysis of waste, planning activities in order to improve productivity at construction, eliminating activities that do not contribute to the result of the work. Lean Thinking techniques are implemented in Toyota enterprise to minimize waste in the supply chain and increase the value of the products. This review article shows the application of lean thinking processes at the construction area, illustrated with an example taken from a real process that may be part of supervision

Sistema de inferencia difuso para la valoración de empresas

The objective of this research is to propose a tool based on diffuse logic that would allow its implementation in the valuation of companies, accepting the inclusion of non-quantitative variables and criteria that have not been included in said process. Initially, some of the main company valuation methodologies are explored, identifying the factors that have an impact on them. Then, they are established as supply for the tool proposed in this research work. Subsequently, the diffuse logic theoretical framework is presented, which is the basis of the mentioned tool. Then, the characteristics are established in diffuse terms of its own components, and several results are disclosed. The presented tool, apart from includingqualitative variables and supporting the investment decision-makingprocess, allows the follow-up of the management as it facilitates the measurement of the variations that some organizational decisions generate in the value of the company.El objetivo de esta investigación es proponer una herramienta basada en lógica difusa que permita implementarse en la valoración de empresas, admitiendo la inclusión de variables y criterios no cuantitativos en dicho proceso. Inicialmente, se exploran algunas de las principales metodologías de valoración de empresas, se identifican los factores que las impactan, y se establecen como insumo para la herramienta que propone esta investigación. Posteriormente, se presenta el marco teórico de lógica difusa y sobre el cual se sustenta la herramienta. Luego, se establecen lascaracterísticas en términos difusos de los componentes de la misma y se comparten algunos resultados. La herramienta presentada, además de incluir variables cualitativas y apoyar la toma de decisiones de inversión, permite el seguimiento a la gestión, ya que facilita medir las variaciones que algunas decisiones organizacionales generan en el valor de la empres

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV

The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe