74 research outputs found
Deep-sea coral evidence for lower Southern Ocean surface nitrate concentrations during the last ice age
The Southern Ocean regulates the oceanâs biological sequestration of CO_2 and is widely suspected to underpin much of the ice age decline in atmospheric CO_2 concentration, but the specific changes in the region are debated. Although more complete drawdown of surface nutrients by phytoplankton during the ice ages is supported by some sediment core-based measurements, the use of different proxies in different regions has precluded a unified view of Southern Ocean biogeochemical change. Here, we report measurements of the ^(15)N/^(14)N of fossil-bound organic matter in the stony deep-sea coral Desmophyllum dianthus, a tool for reconstructing surface ocean nutrient conditions. The central robust observation is of higher ^(15)N/^(14)N across the Southern Ocean during the Last Glacial Maximum (LGM), 18â25 thousand years ago. These data suggest a reduced summer surface nitrate concentration in both the Antarctic and Subantarctic Zones during the LGM, with little surface nitrate transport between them. After the ice age, the increase in Antarctic surface nitrate occurred through the deglaciation and continued in the Holocene. The rise in Subantarctic surface nitrate appears to have had both early deglacial and late deglacial/Holocene components, preliminarily attributed to the end of Subantarctic iron fertilization and increasing nitrate input from the surface Antarctic Zone, respectively
Is hepatitis C virus elimination possible among people living with HIV and what will it take to achieve it?
Introduction
The World Health Organization targets for hepatitis C virus (HCV) elimination include a 90% reduction in new infections by 2030. Our objective is to review the modelling evidence and cost data surrounding feasibility of HCV elimination among people living with HIV (PLWH), and identify likely components for elimination. We also discuss the realâworld experience of HCV direct acting antiviral (DAA) scaleâup and elimination efforts in the Netherlands.
Methods
We review modelling evidence of what intervention scaleâup is required to achieve WHO HCV elimination targets among HIVâinfected (HIV+) people who inject drugs (PWID) and men who have sex with men (MSM), review costâeffectiveness of HCV therapy among PLWH and discuss economic implications of elimination. We additionally use the realâworld experience of DAA scaleâup in the Netherlands to illustrate the promise and potential challenges of HCV elimination strategies in MSM. Finally, we summarize key components of the HCV elimination response among PWLH.
Results and discussion
Modelling indicates HCV elimination among HIV+ MSM and PWID is potentially achievable but requires combination treatment and either harm reduction or behavioural risk reductions. Preliminary modelling indicates elimination among HIV+ PWID will require elimination efforts among PWID more broadly. Treatment for PLWH and highârisk populations (PWID and MSM) is costâeffective in highâincome countries, but costs of DAAs remain a barrier to scaleâup worldwide despite the potential low production price ($50 per 12 week course). In the Netherlands, universal DAA availability led to rapid uptake among HIV+ MSM in 2015/16, and a 50% reduction in acute HCV incidence among HIV+ MSM from 2014 to 2016 was observed. In addition to HCV treatment, elimination among PLWH globally also likely requires regular HCV testing, development of lowâcost accurate HCV diagnostics, reduced costs of DAA therapy, broad treatment access without restrictions, close monitoring for HCV reinfection and retreatment, and harm reduction and/or behavioural interventions.
Conclusions
Achieving WHO HCV Elimination targets is potentially achievable among HIVâinfected populations. Among HIV+ PWID, it likely requires HCV treatment scaleâup combined with harm reduction for both HIV+ and HIVâ populations. Among HIV+ MSM, elimination likely requires both HCV treatment and behaviour risk reduction among the HIV+ MSM pop
The isotope effect of nitrate assimilation in the Antarctic Zone: Improved estimates and paleoceanographic implications
Both the nitrogen (N) isotopic composition (ÎŽ^(15)N) of the nitrate source and the magnitude of isotope discrimination associated with nitrate assimilation are required to estimate the degree of past nitrate consumption from the ÎŽ^(15)N of organic matter in Southern Ocean sediments (e.g., preserved within diatom microfossils). It has been suggested that the amplitude of isotope discrimination (i.e. the isotope effect) correlates with mixed layer depth, driven by a physiological response of phytoplankton to light availability, which introduces complexity to the interpretation of sedimentary records. However, most of the isotope effectestimates that underpin this hypothesis derive from acid-preserved water samples, from which nitrite would have been volatilized and lost during storage. Nitrite ÎŽ^(15)N in Antarctic Zone surface waters is extremely low (â61âŻÂ±âŻ20â°), consistent with the expression of an equilibrium isotope effect associated with nitrateânitrite interconversion. Its loss from the combined nitrateâŻ+âŻnitrite pool would act to raise the ÎŽ^(15)N of nitrate, potentially yielding overestimation of the isotope effect. Here, we revisit the nitrate assimilation isotope effect in the Antarctic Zone with measurements of the ÎŽ^(15)N and concentration of nitrate with and without nitrite, using frozen sea water samples from 5 different cruises that collectively cover all sectors of the Southern Ocean. The N isotope effect estimated using nitrateâŻ+âŻnitrite ÎŽ^(15)N is relatively constant (5.5âŻÂ±âŻ0.6â°) across the Antarctic Zone, shows no relationship with mixed layer depth, and is in agreement with sediment trap ÎŽ^(15)N measurements. Estimates of the N isotope effect derived from nitrate-only ÎŽ^(15)N are higher and more variable (7.9âŻÂ±âŻ1.5â°), consistent with an artifact from nitrate-nitrite isotope exchange. In the case of the Southern Ocean, we conclude that the ÎŽ^(15)N of nitrateâŻ+âŻnitrite better reflects the isotope effect of nitrate assimilation. The stability of this isotope effect across the Antarctic Zone simplifies the effort to reconstruct the past degree of nitrate consumption
A review of nitrogen isotopic alteration in marine sediments
Key Points: Use of sedimentary nitrogen isotopes is examined; On average, sediment 15N/14N increases approx. 2 per mil during early burial; Isotopic alteration scales with water depth
Abstract:
Nitrogen isotopes are an important tool for evaluating past biogeochemical cycling from the paleoceanographic record. However, bulk sedimentary nitrogen isotope ratios, which can be determined routinely and at minimal cost, may be altered during burial and early sedimentary diagenesis, particularly outside of continental margin settings. The causes and detailed mechanisms of isotopic alteration are still under investigation. Case studies of the Mediterranean and South China Seas underscore the complexities of investigating isotopic alteration. In an effort to evaluate the evidence for alteration of the sedimentary N isotopic signal and try to quantify the net effect, we have compiled and compared data demonstrating alteration from the published literature. A >100 point comparison of sediment trap and surface sedimentary nitrogen isotope values demonstrates that, at sites located off of the continental margins, an increase in sediment 15N/14N occurs during early burial, likely at the seafloor. The extent of isotopic alteration appears to be a function of water depth. Depth-related differences in oxygen exposure time at the seafloor are likely the dominant control on the extent of N isotopic alteration. Moreover, the compiled data suggest that the degree of alteration is likely to be uniform through time at most sites so that bulk sedimentary isotope records likely provide a good means for evaluating relative changes in the global N cycle
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Glacial-to-interglacial changes in nitrate supply and consumption in the subarctic North Pacific from microfossil-bound N isotopes at two trophic levels
Reduced nitrate supply to the subarctic North Pacific (SNP) surface during the last ice age has been inferred from coupled changes in diatom-bound delta N-15 (DB-delta N-15), bulk sedimentary delta N-15, and biogenic fluxes. However, the reliability of bulk sedimentary and DB-delta N-15 has been questioned, and a previously reported delta N-15 minimum during Heinrich Stadial 1 (HS1) has proven difficult to explain. In a core from the western SNP, we report the foraminifera-bound delta N-15 (FB-delta N-15) in Neogloboquadrina pachyderma and Globigerina bulloides, comparing them with DB-delta N-15 in the same core over the past 25 kyr. The delta N-15 of all recorders is higher during the Last Glacial Maximum (LGM) than in the Holocene, indicating more complete nitrate consumption. N. pachyderma FB-delta N-15 is similar to DB-delta N-15 in the Holocene but 2.2% higher during the LGM. This difference suggests a greater sensitivity of FB-delta(15)NZ to changes in summertime nitrate drawdown and delta N-15 rise, consistent with a lag of the foraminifera relative to diatoms in reaching their summertime production peak in this highly seasonal environment. Unlike DB-delta N-15, FB-delta N-15 does not decrease from the LGM into HS1, which supports a previous suggestion that the HS1 DB-delta N-15 minimum is due to contamination by sponge spicules. FB-delta N-15 drops in the latter half of the Bolling/Allerod warm period and rises briefly in the Younger Dryas cold period, followed by a decline into the mid-Holocene. The FB-delta N-15 records suggest that the coupling among cold climate, reduced nitrate supply, and more complete nitrate consumption that characterized the LGM also applied to the deglacial cold events
Increased nutrient supply to the Southern Ocean during the Holocene and its implications for the pre-industrial atmospheric CO<sub>2</sub> rise
A rise in the atmospheric CO2 concentration of ~20 parts per million over the course of the Holocene has long been recognized as exceptional among interglacials and is in need of explanation. Previous hypotheses involved natural or anthropogenic changes in terrestrial biomass, carbonate compensation in response to deglacial outgassing of oceanic CO2, and enhanced shallow water carbonate deposition. Here, we compile new and previously published fossil-bound nitrogen isotope records from the Southern Ocean that indicate a rise in surface nitrate concentration through the Holocene. When coupled with increasing or constant export production, these data suggest an acceleration of nitrate supply to the Southern Ocean surface from underlying deep water. This change would have weakened the oceanâs biological pump that stores CO2 in the ocean interior, possibly explaining the Holocene atmospheric CO2 rise. Over the Holocene, the circum-North Atlantic region cooled, and the formation of North Atlantic Deep Water appears to have slowed. Thus, the âseesawâ in deep ocean ventilation between the North Atlantic and the Southern Ocean that has been invoked for millennial-scale events, deglaciations and the last interglacial period may have also operated, albeit in a more gradual form, over the Holocene
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Proceedings of the 13th annual conference of INEBRIA
CITATION: Watson, R., et al. 2016. Proceedings of the 13th annual conference of INEBRIA. Addiction Science & Clinical Practice, 11:13, doi:10.1186/s13722-016-0062-9.The original publication is available at https://ascpjournal.biomedcentral.comENGLISH SUMMARY : Meeting abstracts.https://ascpjournal.biomedcentral.com/articles/10.1186/s13722-016-0062-9Publisher's versio
Size-specific opal-bound nitrogen isotope measurements in North Pacific sediments
The nitrogen isotope composition of diatom opal (delta N-15(db)) is a valuable recorder of nitrate utilization in the polar surface oceans and a measure of the efficiency of the biological pump. Past down-core records of delta N-15(db) involved the measurement of the biogenic opal fraction up to 150 mu m in size, which should represent the bulk of the preserved diatoms but may also include non-diatom opal such as radiolaria and sponge spicules. In this study, the opal from subarctic Pacific and Bering Sea sediments from the Holocene back to the last glacial was separated into different size fractions to measure their individual delta N-15. We found a general trend of decreasing delta N-15 with increasing size at all sites and through time. Microscopic investigation of smear slides and image area analysis of microphotographs of the analyzed opal revealed that the larger size fractions contained greater proportions of sponge spicules and radiolaria. Manual isolation and measurement of the sponge spicules showed that they have a very low delta N-15 (similar to -11 parts per thousand). Ultrasonication during sample preparation caused greater spicule and radiolaria contamination due to fragmentation of these relatively large fossils, leading to a dramatic delta N-15(db) decrease with increasing size and lower delta N-15(db) across all size fractions in sonicated versus non-sonicated samples. Nevertheless, these contaminants were also present albeit less abundant in the various size fractions of samples separated without sonication, and these samples also showed a delta N-15(db) decrease with increasing size. Simple isotope mass-balance calculations of Holocene Bering Sea sediments indicate that most of the delta N-15(db) variations among the larger size fractions can be explained by the relative abundance of low-delta N-15 sponge spicules in each fraction. However, some of the size fraction delta N-15 differences in the downcore records require a different explanation. Both diatom inter-or intra-species effects are evident and indicate lower delta N-15(db) among the larger (centric) versus smaller (pennate) diatom species and a delta N-15(db) decrease with increasing size of centric diatom frustules.Contamination of N by non-diatomaceous opal should not normally compromise total-diatom-bound delta N-15 (0-150 mu m) because the non-diatom opal typically contributes less than similar to 5% to the total opal. However, the early deglacial (Heinrich Stadial 1-correlative) period in the subarctic North Pacific is an important possible exception: a substantial fraction of its low concentration of opal appears to be sponge spicules and radiolaria, such that the reconstructed total-diatom delta N-15(db) decrease at this time may be an artifact. While the glacial-age sediments are also vulnerable to non-diatom contamination, this should work to lower delta N-15(db), such that the observed high glacial delta N-15(db) in North Pacific sediments cannot be explained by contamination. Thus, the previous interpretation of enhanced nutrient consumption in the North Pacific regions during the last ice age remains valid
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