Malay Mathematics Based on Terengganu Inscription

We exhibit the Malay Mathematics in the 14th century Terengganu Inscription dated 702H, that is 1303. There are several mathematical elements that we classify as Malay numbers (cardinal and ordinal), units of measurement, position (location and position in a family), elements of logic, and time (day, month and year). We also give an equivalent amount of fine imposed to convicts as listed in the inscription

Effect of Surface Hardness on Joint Contact Forces during Barefoot Running: A Pilot Study

This paper presents an experimental pilot study on the effect of different surface hardness to the joint contact force during barefoot running. Peak joint contact forces during the stance phase of a male subject that running barefoot on three types of surface with different hardness level (concrete, artificial grass and rubber) were investigated experimentally. Differences in peak joint contact force at the ankle, medial tibiofemoral, lateral tibiofemoral, hip and patellofemoral due to surface effects were analysed using Freebody (Version2.1) software. The result showed that the pattern of peak joint contact force was similar for ankle with medial tibiofemoral and hip with lateral patellofemoral. The joint contact force was varied in the varying of the surface hardness. The correlation between various surface hardness and joint contact force was found at the ankle and medial tibiofemoral joint. However, the findings of this pilot study provide the insight into the method and approach selected for the experiment be suitable for an actual experiment for more subjects

Ergogenic, anti-diabetic and antioxidant attributes of selected Malaysian herbs: characterisation of flavonoids and correlation of functional activities

In the present work, aqueous ethanolic (60% ethanol) extracts from selected Malaysian herbs including Murraya koenigii L. Spreng, Lawsonia inermis L., Cosmos caudatus Kunth, Piper betle L., and P. sarmentosum Roxb. were evaluated for their ergogenic, anti-diabetic and antioxidant potentials. Results showed that the analysed herbs had ergogenic property and were able to activate 5'AMP-activated protein kinase (AMPK) in a concentration dependant manner. The highest AMPK activation was exhibited by M. koenigii extract which showed no significant (p > 0.05) difference with green tea (positive control). For anti-diabetic potential, the highest α-glucosidase inhibition was exhibited by M. koenigii extract with IC50 of 43.35 ± 7.5 μg/mL, which was higher than acarbose (positive control). The determinations of free radical scavenging activity and total phenolics content (TPC) indicated that the analysed herbs had good antioxidant activity. However, C. caudatus extract showed superior antioxidant activity with IC50 against free radical and TPC of 21.12 ± 3.20 μg/mL and 221.61 ± 7.49 mg GAE/g, respectively. RP-HPLC analysis established the presence of flavonoids in the herbs wherein L. inermis contained the highest flavonoid (catechin, epicatechin, naringin and rutin) content (668.87 mg/kg of extract). Correlations between the analyses were conducted, and revealed incoherent trends. Overall, M. koenigii was noted to be the most potent herb for enhancement of AMPK activity and α-glucosidase inhibition but exhibited moderate antioxidant activity. These results revealed that the selected herbs could be potential sources of natural ergogenic and anti-diabetic/antioxidant agents due to their rich profile of phenolics. Further analysis in vivo should be carried out to further elucidate the mechanism of actions of these herbs as ergogenic aids and anti-diabetic/antioxidant agents

ASSIMILATING GEOSPATIAL METAMODEL AND INVENTORY MAPPING FOR NON-STRUCTURAL MITIGATION OF LANDSLIDE

In Malaysia, issues related to disaster management are always given attention in society and by the responsible parties. However, in general, citizen do not think of the consequential impact of disaster due to less of knowledge regarding the early phase in disaster management. Therefore, citizen in those areas will be more vulnerable to landslide as the citizen face difficulties in identifying specific areas with the tendency of landslides. This paper presents a geospatial metamodel approach for non-structural mitigation of landslide using data from airborne LiDAR and aerial photograph. Disaster management metamodel with geospatial element combines activity for managing disaster along with geospatial database that makes it handy for appreciating the metamodel. On the other hand, the digital terrain model (DTM) from LiDAR and aerial photograph is required to produce landslide inventory mapping. The case study area is located in Kundasang, Sabah, where landslides occur frequently. In order to get better visual in identifying landslides in the study area, three types of data are required to carry out image interpretation. The three types of data are hillshade, topographic openness and colour composite. The result of the landslide inventory map shows that there are five types of landslide, which is debris flow, debris fall, mud flow, deep-seated landslide and shallow landslide. Finally, the result of landslide inventory map will be integrated into the developed metamodel for presentation to the users. This landslide inventory map is used as a non-structural mitigation step in one of disaster management phases that is suitable to prepare and use in mitigating the landslide hazard impact

GEOSPATIAL APPROACH FOR LANDSLIDE ACTIVITY ASSESSMENT AND MAPPING BASED ON VEGETATION ANOMALIES

Remote sensing has been widely used for landslide inventory mapping and monitoring. Landslide activity is one of the important parameters for landslide inventory and it can be strongly related to vegetation anomalies. Previous studies have shown that remotely sensed data can be used to obtain detailed vegetation characteristics at various scales and condition. However, only few studies of utilizing vegetation characteristics anomalies as a bio-indicator for landslide activity in tropical area. This study introduces a method that utilizes vegetation anomalies extracted using remote sensing data as a bio-indicator for landslide activity analysis and mapping. A high-density airborne LiDAR, aerial photo and satellite imagery were captured over the landslide prone area along Mesilau River in Kundasang, Sabah. Remote sensing data used in characterizing vegetation into several classes of height, density, types and structure in a tectonically active region along with vegetation indices. About 13 vegetation anomalies were derived from remotely sensed data. There were about 14 scenarios were modeled by focusing in 2 landslide depth, 3 main landslide types with 3 landslide activities by using statistical approach. All scenarios show that more than 65% of the landslides are captured within 70% of the probability model indicating high model efficiency. The predictive model rate curve also shows that more than 45% of the independent landslides can be predicted within 30% of the probability model. This study provides a better understanding of remote sensing data in extracting and characterizing vegetation anomalies induced by hillslope geomorphology processes in a tectonically active region in Malaysia

MAPPING POTENTIAL HABITATS FOR ARTHROPOD VECTORS OF TRYPANOSOMIASIS INFECTION IN NORTHERN NIGERIA: AN INTRODUCTORY SYNTHESIS

This paper presents an introductory synthesis for mapping potential habitats of arthropod vectors responsible for animal trypanosomiasis diseases in Northern Nigeria, where there is high production of livestock. Animal trypanosomiasis is considered an arthropod-borne viral disease which is endemic in 36 countries of sub-Saharan Africa and particularly in northern Nigeria. The disease which is transmitted by the vector tsetse fly remains a threat to both humans and livestock in many rural communities of Nigeria. The outbreak of the disease is known to occur as a result of the changing climate which relates to changes in sea surface temperatures otherwise known as “El Niño Southern Oscillations” (ENSO). Trypanosomiasis is mainly experienced whenever there are changes in global precipitation as a result of the changing climate. Monthly Satellite data of Normalized Difference Vegetation Index (NDVI) at 2.5° spatial resolution was sourced from NASA-MODIS/CMD and subjected to principal component analysis using standardized principal components of GIS with a digital elevation model (DEM) supplemented in the analysis. Results revealed pockets of probable habitats of arthropod vectors to be around forest islands characterized by dry woodland and savanna, and in other cases around gallery forests and few lowland and riverine areas. This study demonstrates that geospatial technology is a cost effective tool in mapping of the arthropod vector habitats for Northern Nigeria

Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

<p>Abstract</p> <p>Background</p> <p>Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA. Protein arginine deiminase type 4 (PAD4) is the enzyme responsible for catalyzing the conversion of peptidylarginine into peptidylcitrulline. PAD4 is a new therapeutic target for RA treatment. In order to search for inhibitors of PAD4, structure-based virtual screening was performed using LIDAEUS (Ligand discovery at Edinburgh university). Potential inhibitors were screened experimentally by inhibition assays.</p> <p>Results</p> <p>Twenty two of the top-ranked water-soluble compounds were selected for inhibitory screening against PAD4. Three compounds showed significant inhibition of PAD4 and their IC₅₀values were investigated. The structures of the three compounds show no resemblance with previously discovered PAD4 inhibitors, nor with existing drugs for RA treatment.</p> <p>Conclusion</p> <p>Three compounds were discovered as potential inhibitors of PAD4 by virtual screening. The compounds are commercially available and can be used as scaffolds to design more potent inhibitors against PAD4.</p

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially