164 research outputs found
A probabilistic model of insolation for the Mojave Desert area
A discussion of mathematical models of insolation characteristics suitable for use in analysis of solar energy systems is presented and shows why such models are essential for solar energy system design. A model of solar radiation for the Mojave Desert area is presented with probabilistic and deterministic components which reflect the occurrence and density of clouds and haze, and mimic their effects on both direct and indirect radiation. Multiple comparisons were made between measured total energy received per day and the corresponding simulated totals. The simulated totals were all within 11 percent of the measured total. The conclusion is that a useful probabilistic model of solar radiation for the Goldstone, California, area of the Mojave Desert has been constructed
âWhat matters to someone who matters to meâ: using media campaigns with young people to prevent interpersonal violence and abuse
Background:
While media campaigns are increasingly advocated as a strategy for preventing interpersonal violence and abuse, there is little evidence available regarding their effectiveness.
Setting and design:
Consultation with experts and young people was used as part of a UK scoping review to capture current thinking and practice on the use of media campaigns to address interpersonal violence and abuse among young people. Three focus groups and 16 interviews were undertaken with UK and international experts, and three focus groups were held with young people.
Main results:
Participants argued that, although campaigns initially needed to target whole populations of young people, subsequently, messages should be âgranulatedâ for subgroups including young people already exposed to interpersonal violence and lesbian, gay, bisexual and transgender young people. It was suggested that boys, as the most likely perpetrators of interpersonal violence and abuse, should be the primary target for campaigns. Young people and experts emphasized that drama and narrative could be used to evoke an emotional response that assisted learning. Authenticity emerged as important for young people and could be achieved by delivering messages through familiar characters and relevant stories. Involving young people themselves in creating and delivering campaigns strengthened authenticity.
Conclusions:
Practice is developing rapidly, and robust research is required to identify the key conditions for effective campaigns in this field. The emotional impact of campaigns in this field appears to be as important as the transmission of learning
COVID-19 infection and vaccination uptake in men and gender-diverse people who have sex with men in the UK: analyses of a large, online community cross-sectional survey (RiiSH-COVID) undertaken NovemberâDecember 2021
BACKGROUND: Men and gender-diverse people who have sex with men are disproportionately affected by health conditions associated with increased risk of severe illness due to COVID-19 infection. METHODS: An online cross-sectional survey of men and gender-diverse people who have sex with men in the UK recruited via social networking and dating applications from 22 November-12 December 2021. Eligible participants included self-identifying men, transgender women, or gender-diverse individuals assigned male at birth (AMAB), agedââ„â16, who were UK residents, and self-reported having had sex with an individual AMAB in the last year. We calculated self-reported COVID-19 test-positivity, proportion reporting long COVID, and COVID-19 vaccination uptake anytime from pandemic start to survey completion (November/December 2021). Logistic regression was used to assess sociodemographic, clinical, and behavioural characteristics associated with SARS-CoV-2 (COVID-19) test positivity and complete vaccination (â„â2 vaccine doses). RESULTS: Among 1,039 participants (88.1% white, median age 41Â years [interquartile range: 31-51]), 18.6% (95% CI: 16.3%-21.1%) reported COVID-19 test positivity, 8.3% (95% CI: 6.7%-10.1%) long COVID, and 94.5% (95% CI: 93.3%-96.1%) complete COVID-19 vaccination through late 2021. In multivariable models, COVID-19 test positivity was associated with UK country of residence (aOR: 2.22 [95% CI: 1.26-3.92], England vs outside England) and employment (aOR: 1.55 [95% CI: 1.01-2.38], current employment vs not employed). Complete COVID-19 vaccination was associated with age (aOR: 1.04 [95% CI: 1.01-1.06], per increasing year), gender (aOR: 0.26 [95% CI: 0.09-0.72], gender minority vs cisgender), education (aOR: 2.11 [95% CI: 1.12-3.98], degree-level or higher vs below degree-level), employment (aOR: 2.07 [95% CI: 1.08-3.94], current employment vs not employed), relationship status (aOR: 0.50 [95% CI: 0.25-1.00], single vs in a relationship), COVID-19 infection history (aOR: 0.47 [95% CI: 0.25-0.88], test positivity or self-perceived infection vs no history), known HPV vaccination (aOR: 3.32 [95% CI: 1.43-7.75]), and low self-worth (aOR: 0.29 [95% CI: 0.15-0.54]). CONCLUSIONS: In this community sample, COVID-19 vaccine uptake was high overall, though lower among younger age-groups, gender minorities, and those with poorer well-being. Efforts are needed to limit COVID-19 related exacerbation of health inequalities in groups who already experience a greater burden of poor health relative to other men who have sex with men
RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006.
Background: Serratia sp. ATCC 39006 (S39006) is a Gram-negative enterobacterium that is virulent in plant and animal models. It produces a red-pigmented trypyrrole secondary metabolite, prodigiosin (Pig), and a carbapenem antibiotic (Car), as well as the exoenzymes, pectate lyase and cellulase. Secondary metabolite production in this strain is controlled by a complex regulatory network involving quorum sensing (QS). Hfq and RsmA (two RNA binding proteins and major post-transcriptional regulators of gene expression) play opposing roles in the regulation of several key phenotypes within S39006. Prodigiosin and carbapenem production was abolished, and virulence attenuated, in an S39006 âhfq mutant, while the converse was observed in an S39006 rsmA transposon insertion mutant.Results: In order to define the complete regulon of Hfq and RsmA, deep sequencing of cDNA libraries (RNA-seq) was used to analyse the whole transcriptome of S39006 âhfq and rsmA::Tn mutants. Moreover, we investigated global changes in the proteome using an LC-MS/MS approach. Analysis of differential gene expression showed that Hfq and RsmA directly or indirectly regulate (at the level of RNA) 4% and 19% of the genome, respectively, with some correlation between RNA and protein expression. Pathways affected include those involved in antibiotic regulation, virulence, flagella synthesis, and surfactant production. Although Hfq and RsmA are reported to activate flagellum production in E. coli and an adherent-invasive E. coli hfq mutant was shown to have no flagella by electron microscopy, we found that flagellar production was increased in the S39006 rsmA and hfq mutants. Additionally, deletion of rsmA resulted in greater genomic flux with increased activity of two mobile genetic elements. This was confirmed by qPCR and analysis of rsmA culture supernatant revealed the presence of prophage DNA and phage particles. Finally, expression of a hypothetical protein containing DUF364 increased prodigiosin production and was controlled by a putative 5âČ cis-acting regulatory RNA element. Conclusion: Using a combination of transcriptomics and proteomics this study provides a systems-level understanding of Hfq and RsmA regulation and identifies similarities and differences in the regulons of two major regulators. Additionally our study indicates that RsmA regulates both core and variable genome regions and contributes to genome stability
Brown dwarfs and very low mass stars in the Praesepe open cluster: a dynamically unevolved mass function?
[Abridged] In this paper, we present the results of a photometric survey to
identify low mass and brown dwarf members of the old open cluster Praesepe (age
of 590[+150][-120]Myr and distance of 190[+6.0][-5.8]pc) and use this to infer
its mass function which we compare with that of other clusters. We have
performed an optical (Ic-band) and near-infrared (J and Ks-band) photometric
survey of Praesepe with a spatial coverage of 3.1deg^2. With 5sigma detection
limits of Ic=23.4 and J=20.0, our survey is sensitive to objects with masses
from about 0.6 to 0.05Msol. The mass function of Praesepe rises from 0.6Msol
down to 0.1Msol and then turns-over at ~0.1Msol. The rise observed is in
agreement with the mass function derived by previous studies, including a
survey based on proper motion and photometry. Comparing our mass function with
that for another open cluster with a similar age, the Hyades (age ~ 600Myr), we
see a significant difference. Possible reasons are that dynamical evaporation
has not influenced the Hyades and Praesepe in the same way, or that the
clusters did not have the same initial mass function, or that dynamical
interactions have modified the evolution of one or both clusters. Although a
difference in the binary fractions of the clusters could cause the observed
(i.e. system) mass functions to differ, measurements in the literature give no
evidence for a significant difference in the binary fractions of the two
clusters. Of our cluster candidates, six have masses predicted to be equal to
or below the stellar/substellar boundary at 0.072Msol.Comment: 11 pages, 11 figures, accepted for publication in A&A. Higher
resolution of Figures 2-3-4-5 in A&A published version. Revised version
corrected for Englis
Magnetoluminescence
Pulsar Wind Nebulae, Blazars, Gamma Ray Bursts and Magnetars all contain
regions where the electromagnetic energy density greatly exceeds the plasma
energy density. These sources exhibit dramatic flaring activity where the
electromagnetic energy distributed over large volumes, appears to be converted
efficiently into high energy particles and gamma-rays. We call this general
process magnetoluminescence. Global requirements on the underlying, extreme
particle acceleration processes are described and the likely importance of
relativistic beaming in enhancing the observed radiation from a flare is
emphasized. Recent research on fluid descriptions of unstable electromagnetic
configurations are summarized and progress on the associated kinetic
simulations that are needed to account for the acceleration and radiation is
discussed. Future observational, simulation and experimental opportunities are
briefly summarized.Comment: To appear in "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts
and Blazars: Physics of Extreme Energy Release" of the Space Science Reviews
serie
Unravelling the Difference Between Men and Women in Post-CABG Survival
OBJECTIVES: Women have a worse prognosis after coronary artery bypass grafting (CABG) surgery compared to men. We sought to quantify to what extent this difference in post-CABG survival could be attributed to sex itself, or whether this was mediated by difference between men and women at the time of intervention. Additionally, we explored to what extent these effects were homogenous across patient subgroups. METHODS: Time to all-cause mortality was available for 102,263 CABG patients, including 20,988 (21%) women, sourced through an individual participant data meta-analysis of five cohort studies. Difference between men and women in survival duration was assessed using KaplanâMeier estimates, and Coxâs proportional hazards model. RESULTS: During a median follow-up of 5 years, 13,598 (13%) patients died, with women more likely to die than men: female HR 1.20 (95%CI 1.16; 1.25). We found that differences in patient characteristics at the time of CABG procedure mediated this sex effect, and accounting for these resulted in a neutral female HR 0.98 (95%CI 0.94; 1.02). Next we performed a priori defined subgroup analyses of the five most prominent mediators: age, creatinine, peripheral vascular disease, type 2 diabetes, and heart failure. We found that women without peripheral vascular disease (PVD) or women aged 70+, survived longer than men (interaction p-values 0.04 and 6 Ă 10â5, respectively), with an effect reversal in younger women. CONCLUSIONS: Sex differences in post-CABG survival were readily explained by difference in patient characteristics and comorbidities. Pre-planned analyses revealed patient subgroups (aged 70+, or without PVD) of women that survived longer than men, and a subgroup of younger women with comparatively poorer survival
Unravelling the Difference Between Men and Women in Post-CABG Survival
OBJECTIVES: Women have a worse prognosis after coronary artery bypass grafting (CABG) surgery compared to men. We sought to quantify to what extent this difference in post-CABG survival could be attributed to sex itself, or whether this was mediated by difference between men and women at the time of intervention. Additionally, we explored to what extent these effects were homogenous across patient subgroups. METHODS: Time to all-cause mortality was available for 102,263 CABG patients, including 20,988 (21%) women, sourced through an individual participant data meta-analysis of five cohort studies. Difference between men and women in survival duration was assessed using KaplanâMeier estimates, and Coxâs proportional hazards model. RESULTS: During a median follow-up of 5 years, 13,598 (13%) patients died, with women more likely to die than men: female HR 1.20 (95%CI 1.16; 1.25). We found that differences in patient characteristics at the time of CABG procedure mediated this sex effect, and accounting for these resulted in a neutral female HR 0.98 (95%CI 0.94; 1.02). Next we performed a priori defined subgroup analyses of the five most prominent mediators: age, creatinine, peripheral vascular disease, type 2 diabetes, and heart failure. We found that women without peripheral vascular disease (PVD) or women aged 70+, survived longer than men (interaction p-values 0.04 and 6 Ă 10(â5), respectively), with an effect reversal in younger women. CONCLUSION: Sex differences in post-CABG survival were readily explained by difference in patient characteristics and comorbidities. Pre-planned analyses revealed patient subgroups (aged 70+, or without PVD) of women that survived longer than men, and a subgroup of younger women with comparatively poorer survival
Infall Times for Milky Way Satellites From Their Present-Day Kinematics
We analyze subhalos in the Via Lactea II (VL2) cosmological simulation to
look for correlations among their infall times and z = 0 dynamical properties.
We find that the present day orbital energy is tightly correlated with the time
at which subhalos last crossed into the virial radius. This energy-infall
correlation provides a means to infer infall times for Milky Way satellite
galaxies. Assuming that the Milky Way's assembly can be modeled by VL2, we show
that the infall times of some satellites are well constrained given only their
Galactocentric positions and line-of-sight velocities. The constraints sharpen
for satellites with proper motion measurements. We find that Carina, Ursa
Minor, and Sculptor were all accreted early, more than 8 Gyr ago. Five other
dwarfs, including Sextans and Segue 1, are also probable early accreters,
though with larger uncertainties. On the other extreme, Leo T is just falling
into the Milky Way for the first time while Leo I fell in \sim 2 Gyr ago and is
now climbing out of the Milky Way's potential after its first perigalacticon.
The energies of several other dwarfs, including Fornax and Hercules, point to
intermediate infall times, 2 - 8 Gyr ago. We compare our infall time estimates
to published star formation histories and find hints of a dichotomy between
ultrafaint and classical dwarfs. The classical dwarfs appear to have quenched
star formation after infall but the ultrafaint dwarfs tend to be quenched long
before infall, at least for the cases in which our uncertainties allow us to
discern differences. Our analysis suggests that the Large Magellanic Cloud
crossed inside the Milky Way virial radius recently, within the last \sim 4
billion years.Comment: 15 pages, 7 figures, all figures include colors, submitted for
publication in MNRA
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