Iatrogenic Hypoglycemia Induced by Valproic Acid in an Adult Patient

Literature on antiepileptic induced iatrogenic hypoglycemia is scanty. Due to its broad spectrum of activity and mechanisms of action, valproic acid (VPA), a fatty acid, is the most widely prescribed epilepsy treatment worldwide.Herein, we describe an adult epileptic patient, where persistent, otherwise unexplained hypoglycemia, was most likely induced by VPA, as suggested by the VPA time course and glucose blood levels. Indeed, no further hypoglycemic episodes occurred after VPA discontinuation and the diagnostic work-up ruled out other possible causes of hypoglycemia.This case supports the hypothesis that VPA may induce hypoglycemia, due to still not well-defined metabolic mechanisms of action. Moreover, it emphasizes the fact that an iatrogenic pathogenesis should be considered if an apparently unexplained hypoglycemia occurs in a patient on chronic therapy with antiepileptics, even at a therapeutical dosage

Design Consideration on a Polarized Gas Target for the LHC

Since 2017, the LHCSpin study group is investigating the installation of a HERMES-type polarized gas target (PGT) in front of the LHCb detector in order to perform Single-Spin Transverse Asymmetry (SSTA) measurements. In cooperation with LHC experts, the conditions for applying a PGT are being studied. As a viable option, a cold openable storage cell is considered. A key role for avoiding instabilities of the 7 TeV proton beam is the choice of a proper coating and the suppression of wake fields. A first warm (300 K) test storage cell is planned for installation in 2019 inside the VELO vessel, subject to final approval. It will improve the ongoing SMOG program of LHCb fixed target measurements, and will provide valuable experience of running a storage cell in the harsh LHC environment. The status of the design considerations on a PGT in the LHC beam and of the discussion of critical machine issues is presented.Comment: 8 pages, 7 figures, 11 reference

Sobre el uso del radar meteorológico para el diagnóstico de granizo

Fil: Vidal, Luciano. Servicio Meteorológico Nacional. Dirección Nacional de Ciencia e Innovación en Productos y Servicios. Dirección de Productos de Modelación Ambiental y de Sensores Remotos; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y Los Océanos; Argentina.Fil: Ishikame, Gabriela. Servicio Meteorológico Nacional. Dirección Nacional de Pronósticos y Servicios para la Sociedad. Dirección de Pronósticos del Tiempo y Avisos. Coordinación de Pronósticos Inmediatos; Argentina.Fil: Pappalardo, Laura. Servicio Meteorológico Nacional. Dirección Nacional de Pronósticos y Servicios para la Sociedad. Dirección de Pronósticos del Tiempo y Avisos. Coordinación de Pronósticos Inmediatos; Argentina.Fil: Rugna, Martín Ezequiel. Servicio Meteorológico Nacional. Dirección Nacional de Ciencia e Innovación en Productos y Servicios. Dirección de Productos de Modelación Ambiental y de Sensores Remotos; Argentina.El granizo es uno de los fenómenos meteorológicos más frecuentes asociados a la ocurrencia de convección húmeda profunda. El diagnóstico y pronóstico de la ocurrencia de granizo requiere que el pronosticador analice desde variables medioambientales que le permitan identificar entornos favorables para el desarrollo de tormentas de granizo hasta el análisis cualitativo y cuantitativo en tiempo cuasi real de información provista por los radares meteorológicos. Luego, el objetivo de la presente Nota Técnica es realizar un repaso de las técnicas y algoritmos más relevantes para el diagnóstico de granizo tanto con radares de polarización simple como doble.Hail is one of the most frequent meteorological phenomena associated with the occurrence of moist and deep convection. The diagnosis and forecast of the occurrence of hail requires the forecaster to analyze not only environmental variables that allow him to identify favorable environments for the development of hail storms but also the qualitative and quantitative analysis in quasi real time of information provided by weather radars. Thus, the goal of this Technical Note is to review the most relevant techniques and algorithms for hail diagnosis with both single and dual polarization radar

Reporte de disponibilidad de datos de radares pre-RMA durante el año 2015

Lohigorry, Pedro Miguel. Servicio Meteorológico Nacional. Gerencia de Servicios a la Comunidad. División de Vigilancia Meteorológica por Sensoramiento Remoto; Argentina.Fil: Pappalardo, Laura. Servicio Meteorológico Nacional. Gerencia de Servicios a la Comunidad. División de Vigilancia Meteorológica por Sensoramiento Remoto; Argentina.Fil: Vidal, Luciano. Servicio Meteorológico Nacional. Gerencia de Investigación, Desarrollo y Capacitación. Departamento de Investigación y Desarrollo; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y Los Océanos; Argentina.Fil: De Elía, Ramón. Servicio Meteorológico Nacional. Gerencia de Investigación, Desarrollo y Capacitación; Argentina.Fil: Mezher, Romina. Instituto Nacional de Tecnología Agropecuaria. Instituto del Clima y del Agua; Argentina.La red de radares meteorológicos de Argentina tiene pocos años de vida pero ya juega un rol indispensable en la vigilancia de fenómenos meteorológicos severos que afectan distintos sectores del país. Es por ello que interrupciones en el servicio de cualquiera de estos radares pueden tener importantes consecuencias. Este reporte es el primer estudio sobre la robustez de la red de radares y se llevó a cabo con datos recopilados por la División Vigilancia Meteorológica por Sensores Remotos (DVMSR) del Servicio Meteorológico Nacional durante 2015. La descripción estadística de estos casos es presentada, así como también la información completa de los acontecimientos durante 2015. De los cuatro radares analizados --aquellos ubicados en Anguil (La Pampa), Ezeiza (Buenos Aires), Paraná (Entre Ríos) y Pergamino (Buenos Aires)-- solo Pergamino y Paraná presentaron durante 2015 una tasa de operatividad comparable con estándares internacionales.Argentina´s weather radar network in available since a few years ago and plays now a central role in the vigilance of severe weather events. It is for this reason that interruptions in the service in any of the radars may have a negative impact on the population. This technical report presents the first study of the network’s robustness and was carried out with information compiled during 2015 by the division Vigilancia Meteorológica por Sensores Remotos (VMSR) of the SMN. This information is presented along with a statistical description of the events that took place during the year. Four radars of the network were studied: Anguil (La Pampa), Ezeiza (Buenos Aires), Paraná (Entre Ríos) y Pergamino (Buenos Aires). From these, only Pergamino and Paraná displayed during 2015 a robustness comparable to those expected in other weather services around the world

Human VDAC pseudogenes: an emerging role for VDAC1P8 pseudogene in acute myeloid leukemia

Background Voltage-dependent anion selective channels (VDACs) are the most abundant mitochondrial outer membrane proteins, encoded in mammals by three genes, VDAC1, 2 and 3, mostly ubiquitously expressed. As ’mitochondrial gatekeepers’, VDACs control organelle and cell metabolism and are involved in many diseases. Despite the presence of numerous VDAC pseudogenes in the human genome, their significance and possible role in VDAC protein expression has not yet been considered. Results We investigated the relevance of processed pseudogenes of human VDAC genes, both in physiological and in pathological contexts. Using high-throughput tools and querying many genomic and transcriptomic databases, we show that some VDAC pseudogenes are transcribed in specific tissues and pathological contexts. The obtained experimental data confirm an association of the VDAC1P8 pseudogene with acute myeloid leukemia (AML). Conclusions Our in-silico comparative analysis between the VDAC1 gene and its VDAC1P8 pseudogene, together with experimental data produced in AML cellular models, indicate a specific over-expression of the VDAC1P8 pseudogene in AML, correlated with a downregulation of the parental VDAC1 gene. Keywords Pseudogene, Voltage-dependent anion selective channels (VDAC

Evaluación de un visualizador de imágenes de radar para su uso operacional

Fil: Pappalardo, Laura. Servicio Meteorológico Nacional. Gerencia de Servicios a la Comunidad. División de Vigilancia Meteorológica por Sensoramiento Remoto; Argentina.Fil: Lohigorry, Pedro Miguel. Servicio Meteorológico Nacional. Gerencia de Servicios a la Comunidad. División de Vigilancia Meteorológica por Sensoramiento Remoto; Argentina.Fil: Vidal, Luciano. Servicio Meteorológico Nacional. Gerencia de Investigación, Desarrollo y Capacitación. Departamento de Investigación y Desarrollo; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias de la Atmósfera y Los Océanos; Argentina.Fil: De Elía, Ramón. Servicio Meteorológico Nacional. Gerencia de Investigación, Desarrollo y Capacitación; Argentina.Fil: Sánchez Marino, Manuela. Servicio Meteorológico Nacional. Gerencia de Servicios a la Comunidad. División de Vigilancia Meteorológica por Sensoramiento Remoto; Argentina.Fil: Irurzun, Pablo. Servicio Meteorológico Nacional. Gerencia de Servicios a la Comunidad. División de Vigilancia Meteorológica por Sensoramiento Remoto; Argentina.La información que brindan los radares es de gran importancia para la detección y monitoreo de tormentas severas. Sin embargo, para poder visualizar toda la información disponible de forma ágil y simple, es necesario un software adecuado. Cada oficina meteorológica necesita que el software permita llevar a cabo tareas específicas. El presente trabajo detalla cuales son las características que debería tener un software, para que se puedan realizar las distintas tareas en la división de Vigilancia Meteorológica por Sensores Remotos (DVMSR), y describe el análisis de un software en particular.Weather radars provide key information for monitoring and detecting the evolution of severe storms. In order to take advantage of this information in a simple, fast and comfortable way, a sophisticated display software is generally used. Each weather office has its own particular structure and specific needs. This technical note describes the technical characteristics that a software displaying radar information should have to satisfy the needs of the responsible division, the Vigilancia Meteorológica por Sensores Remotos (DVMSR). In addition, the evaluation of a specific software is presented as an example

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe