349 research outputs found
The Role of the Side Chain on the Performance of N-type Conjugated Polymers in Aqueous Electrolytes.
- Author
- Publication venue
- Chem Mater
- Publication date
- 10/04/2018
- Field of study
We report a design strategy that allows the preparation of solution processable n-type materials from low boiling point solvents for organic electrochemical transistors (OECTs). The polymer backbone is based on NDI-T2 copolymers where a branched alkyl side chain is gradually exchanged for a linear ethylene glycol-based side chain. A series of random copolymers was prepared with glycol side chain percentages of 0, 10, 25, 50, 75, 90, and 100 with respect to the alkyl side chains. These were characterized to study the influence of the polar side chains on interaction with aqueous electrolytes, their electrochemical redox reactions, and performance in OECTs when operated in aqueous electrolytes. We observed that glycol side chain percentages of >50% are required to achieve volumetric charging, while lower glycol chain percentages show a mixed operation with high required voltages to allow for bulk charging of the organic semiconductor. A strong dependence of the electron mobility on the fraction of glycol chains was found for copolymers based on NDI-T2, with a significant drop as alkyl side chains are replaced by glycol side chains
The time course of changes induced by resistance training and detraining on muscular and physical function in older adults
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
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- Apollinari G
- Apresyan A
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- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
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- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
A new look at an old virus: patterns of mutation accumulation in the human H1N1 influenza virus since 1918
- Author
- A Grande-Perez
- A Kedwaii
- A Steel
- AH Reid
- AL Greninger
- AM Presanis
- AP Kendal
- B Olsen
- CSMEC
- D Anhlan
- DA Buonagurio
- E Domingo
- E Duarte
- E Yuste
- E Yuste
- ETW Bowen
- F Iglesia
- G Martin
- G-W LI
- J Dushoff
- J Zhang
- JE Stajich
- JK Taubenberger
- John C Sanford
- JR Coleman
- JW Drake
- K Holmes-Maybank
- K Ito
- K Nakajima
- L Simonsen
- LA Loeb
- LJ Donaldson
- M De La Pena
- M Levine
- M Nei
- MC Christman
- MI Nelson
- MMC Lai
- MR Barber
- NM Ferguson
- OG Pybus
- OT Gorman
- P Palese
- R Carter
- R Sanjuan
- R Sanjuan
- RA Smith
- RG Webster
- RM Bush
- RM Bush
- Robert W Carter
- S Bhatt
- S Crotty
- S Crotty
- S Crotty
- SF Elena
- T Bedford
- T LI
- TA Hall
- TG Fanning
- W Chen
- WM Fitch
- X Xia
- X Xu
- Y Qu
- Y Suzuki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Space Charge at Nanoscale: Probing Injection and Dynamic Phenomena Under Dark/Light Configurations by Using KPFM and C-AFM
- Author
- A Boularas
- A Galembeck
- A Kerber
- A Liscio
- A. Witvrouw
- Abraham. Savitzky
- Albert K. Henning
- B Bhushan
- B Martin
- BJ Leever
- C A Rezende
- C Barth
- C Riedel
- C Schonenberger
- C Villeneuve-Faure
- C Villeneuve-Faure
- C Villeneuve-Faure
- C Zhao
- C. Villeneuve-Faure
- C. Villeneuve-Faure
- D Moerman
- D Ziegler
- Daniel A. Kamkar
- DC Coffey
- DC Coffey
- DE Sviridov
- DJ Fonseca
- DJ Lacks
- Dominik Ziegler
- DSH Charrier
- E Palleau
- E Strassburg
- EJ Spadafora
- F Marchi
- G Bersuker
- G Cohen
- G Li
- G Lubarsky
- G Teyssedre
- HO Jacobs
- I Alhossen
- I Beinik
- I. D. Baikie
- J Nishitani
- J Rouzo Le
- JE Stern
- Jie Xu
- Justin L. Luria
- K Faliya
- K Makasheva
- K Makasheva
- K Maturova
- K Sridhara
- L Borowik
- L Ressier
- M Bieletzki
- M Labardi
- M Lee
- M Nonnenmacher
- M. Saint Jean
- Marco Chiesa
- Mark Dante
- MC Scharber
- MY Li
- N Balke
- NB Bercu
- O Kryvchenkova
- O. Douhéret
- OG Reid
- P Eyben
- P Girard
- P Normand
- P Rysselberghe Van
- R Arinero
- R Diaz
- R Eisenberg
- R Shikler
- R Williams
- Rajiv Giridharagopal
- S Diaham
- S Morita
- S Morita
- S Sadewasser
- S-Y Park
- T Okamoto
- T Shinbrot
- T Takada
- Todd G. Ruskell
- U Celano
- U Zaghloul
- U Zaghloul
- V Palermo
- V. Yanev
- W Meliz
- W Zhou
- Y Han
- Y Rosenwaks
- Y Shen
- Yu Sheng Zhou
- ZZ Lwin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/08/2019
- Field of study
International audienc
Refinement and Pattern Formation in Neural Circuits by the Interaction of Traveling Waves with Spike-Timing Dependent Plasticity
- Author
- A Kohn
- A Maccione
- AB Saul
- AD Huberman
- AJ Bell
- AJ Watt
- AL Kolodkin
- AM Turing
- AR Chandrasekaran
- BA Olshausen
- BA Olshausen
- BK Stafford
- BO Braastad
- Brent Doiron
- C Blakemore
- C Blakemore
- C Blakemore
- C Clopath
- C Enroth-Cugell
- C Enroth-Cugell
- C Savin
- C Sun
- C von der Malsburg
- CJ Akerman
- CJ Akerman
- D Cai
- DA Butts
- DA Butts
- DA Butts
- DC Sterratt
- DE Feldman
- DE Feldman
- DH Hubel
- DH Hubel
- DH Hubel
- DH Hubel
- DK Warland
- DN Mastronarde
- DO Hebb
- E Pastalkova
- E Sernagor
- E Sernagor
- EH Adelson
- ES Frechette
- F Thorn
- GC DeAngelis
- GG Turrigiano
- GJ Goodhill
- GM Wittenberg
- H Honda
- H Markram
- H Meinhardt
- H Sherk
- HZ Shouval
- IR Fiete
- J Conhaim
- J Fiser
- J Gjorgjieva
- J Wolfe
- J Zylberberg
- JA Movshon
- JA Movshon
- JA Movshon
- James E. M. Bennett
- JH van Hateren
- JM Alonso
- K Kobayashi
- KD Miller
- KD Miller
- KD Miller
- KI Blum
- KJ Ford
- L Bodenstein
- LC Katz
- LE White
- LF Abbott
- LI Zhang
- LI Zhang
- M Gilson
- M Graupner
- M Meister
- M Nishiyama
- MB Feller
- MB Feller
- MM Syed
- MP Stryker
- MR Mehta
- N Caporale
- N Caporale
- NJ Buchs
- NV Swindale
- O Garaschuk
- OA Shipton
- OG Wenisch
- R Gütig
- R Kempter
- RC Froemke
- RC Reid
- RHR Hahnloser
- RL De Valois
- RPN Rao
- S Kondo
- S Song
- S Song
- S Wimbauer
- SB Nelson
- SD van Hooser
- SH Tavazoie
- T McLaughlin
- T Nevian
- T Ohshiro
- W Bair
- W Gerstner
- W Mooney
- W Senn
- Wyeth Bair
- X Leinekugel
- XB Liu
- Y Guo
- Y Ikegaya
- Y Li
- Z Henderson
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/08/2015
- Field of study
Traveling waves in the developing brain are a prominent source of highly correlated spiking activity that may instruct the refinement of neural circuits. A candidate mechanism for mediating such refinement is spike-timing dependent plasticity (STDP), which translates correlated activity patterns into changes in synaptic strength. To assess the potential of these phenomena to build useful structure in developing neural circuits, we examined the interaction of wave activity with STDP rules in simple, biologically plausible models of spiking neurons. We derive an expression for the synaptic strength dynamics showing that, by mapping the time dependence of STDP into spatial interactions, traveling waves can build periodic synaptic connectivity patterns into feedforward circuits with a broad class of experimentally observed STDP rules. The spatial scale of the connectivity patterns increases with wave speed and STDP time constants. We verify these results with simulations and demonstrate their robustness to likely sources of noise. We show how this pattern formation ability, which is analogous to solutions of reaction-diffusion systems that have been widely applied to biological pattern formation, can be harnessed to instruct the refinement of postsynaptic receptive fields. Our results hold for rich, complex wave patterns in two dimensions and over several orders of magnitude in wave speeds and STDP time constants, and they provide predictions that can be tested under existing experimental paradigms. Our model generalizes across brain areas and STDP rules, allowing broad application to the ubiquitous occurrence of traveling waves and to wave-like activity patterns induced by moving stimuli
Web-based tool for dynamic functional outcome after acute ischemic stroke and comparison with existing models
- Author
- A Muscari
- AA Kramer
- AE Baird
- AS Go
- C Counsell
- C Counsell
- C Weimar
- C Weimar
- CD Bushnell
- CD Bushnell
- CD Gillespie
- EC Jauch
- EE Smith
- ER DeLong
- FB Young
- G Ntaios
- G Saposnik
- Gaifen Liu
- Haipeng Shen
- Hao Li
- IR Konig
- J Bamford
- JM Reid
- JV Tu
- KC Johnston
- KR Lees
- MD Birkner
- MJ O’Donnell
- NR Cook
- OG Solberg
- PA Ringleb
- Penglian Wang
- R Ji
- Ruijun Ji
- SE Kasner
- Wanliang Du
- Xingquan Zhao
- Y Wang
- Y Wang
- Yilong Wang
- Yongjun Wang
- Yuesong Pan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
BACKGROUND: Acute ischemic stroke (AIS) is one of the leading causes of death and adult disability worldwide. In the present study, we aimed to develop a web-based risk model for predicting dynamic functional status at discharge, 3-month, 6-month, and 1-year after acute ischemic stroke (Dynamic Functional Status after Acute Ischemic Stroke, DFS-AIS). METHODS: The DFS-AIS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Good functional outcome was defined as modified Rankin Scale (mRS) score ≤ 2 at discharge, 3-month, 6-month, and 1-year after AIS, respectively. Independent predictors of each outcome measure were obtained using multivariable logistic regression. The area under the receiver operating characteristic curve (AUROC) and plot of observed and predicted risk were used to assess model discrimination and calibration. RESULTS: A total of 12,026 patients were included and the median age was 67 (interquartile range: 57–75). The proportion of patients with good functional outcome at discharge, 3-month, 6-month, and 1-year after AIS was 67.9%, 66.5%, 66.9% and 66.9%, respectively. Age, gender, medical history of diabetes mellitus, stroke or transient ischemic attack, current smoking and atrial fibrillation, pre-stroke dependence, pre-stroke statins using, admission National Institutes of Health Stroke Scale score, admission blood glucose were identified as independent predictors of functional outcome at different time points after AIS. The DFS-AIS was developed from sets of predictors of mRS ≤ 2 at different time points following AIS. The DFS-AIS demonstrated good discrimination in the derivation and validation cohorts (AUROC range: 0.837-0.845). Plots of observed versus predicted likelihood showed excellent calibration in the derivation and validation cohorts (all r = 0.99, P < 0.001). When compared to 8 existing models, the DFS-AIS showed significantly better discrimination for good functional outcome and mortality at discharge, 3-month, 6-month, and 1-year after AIS (all P < 0.0001). CONCLUSION: The DFS-AIS is a valid risk model to predict functional outcome at discharge, 3-month, 6-month, and 1-year after AIS. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12883-014-0214-z) contains supplementary material, which is available to authorized users
CMS Data Processing Workflows during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anisimov A
- Antillon E
- Antipov P
- Antonelli L
- Anttila E
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
- Arora S
- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
- Avetisyan A
- Avila C
- Awan MIM
- Ayan AS
- Ayhan A
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babb J
- Babucci E
- Baccaro S
- Bacchetta N
- Bacchi W
- Bachtis M
- Baden D
- Badgett W
- Baechler J
- Baer H
- Baesso P
- Baffioni S
- Bagby L
- Bagliesi G
- Bahk SY
- Bailleux D
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Baldin B
- Ball AH
- Ball G
- Ballin J
- Bally SL
- Ban Y
- Bandurin D
- Banerjee S
- Banerjee S
- Banicz K
- Bansal S
- Banzuzi K
- Barashko V
- Barbagli G
- Barberis E
- Barbone L
- Barcala JM
- Barcellan L
- Bard R
- Bargassa P
- Baringer P
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Bartalini P
- Bartoloni A
- Bartz E
- Basegmez S
- Battilana C
- Baty C
- Baud A
- Bauer G
- Bauer J
- Bauerdick LAT
- Baur U
- Bawa HS
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaumont W
- Bechtel F
- Bedjidian M
- Bedoya CF
- Beetz CP
- Behrens U
- Bejar JC
- Belforte S
- Beliy N
- Bell KW
- Bellan P
- Bellan R
- Bellato M
- Bellinger JN
- Belotelov I
- Benaglia A
- Bencze G
- Bendavid J
- Bender W
- Benedetti D
- Benelli G
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- Beni N
- Benucci L
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- Benvenuti AC
- Berengueres JOL
- Beretvas A
- Bergauer H
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- Bernardini J
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- Berry D
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- Berryhill J
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- Bertoldi M
- Berzano U
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- Besson A
- Betchart B
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- Beuselinck R
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- Blumenfeld B
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
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- Anttila E
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- Antunovic Z
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- Apollinari G
- Apresyan A
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- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arnold B
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- Artamonov A
- Asaadi J
- Asghar MI
- Ashby S
- Askew A
- Atac M
- Atramentov O
- Auffray E
- Aurisano A
- Autermann C
- Avery P
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- Ayan AS
- Ayhan A
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- Yoo HD
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- Zachariadou A
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Impact of clinical phenotypes on management and outcomes in European atrial fibrillation patients: a report from the ESC-EHRA EURObservational Research Programme in AF (EORP-AF) General Long-Term Registry
- Author
- ?liwi?ski A.
- ?zin B.
- Aalborg University
- Aalborg University Hospital
- Aarup A.
- Abalea J.
- Abela E.
- Acimovic T.
- Adamczewski J.
- Adams C.
- Adams L.
- Adams M.
- Adrag?o P.
- Ahadi N.
- Ahmad S.
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- Alam I.
- Alcalde O.
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- Allison J.
- Almeida S.
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- Austin R.
- Axthelm C.
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- Azhari A.
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- Berger M.
- Bernardo R.
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- Bertomeu Gonzalez Gonzalez V.
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- Carol Davila University of Medicine and Pharmacy
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- Department of Anaesthesiology and Intensive Care
- Department of Cardiology
- Department of Clinical Medicine
- Department of Gastroenterology and Hepatology
- Desai H.
- Desteghe L.
- Di Chiara Chiara A.
- Dickinson C.
- Diemberger I.
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- Hvilsted Rasmussen Rasmussen L.
- Hôpital Trousseau CHU de Tours
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- Investigators on behalf of the ESC-EHRA EORP-AF Long-Term General Registry
- Ionac A.
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- IRCCS Istituti Clinici Scientifici Maugeri S.p.A. SB - Pavia
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- Vettus R.
- Vijgen J.
- Vinereanu D.
- Vintila M.
- Vintila V.
- Vitolo Marco
- Vold A.
- Vonderhagen E.
- Vujisic-Tesic B.
- Vukmirovic M.
- Vuleta M.
- Wadams B.
- Waggett L.
- Waintraub X.
- Walker E.
- Walter S.
- Wancerz A.
- Warwicker S.
- Watts J.
- Wcislo T.
- Wegink D.
- Wenzel I.
- Wester A.
- Westermeier D.
- Whiteside C.
- Widjaja W.
- Wiggers P.
- Wilde A.
- Wilhelm K.
- Willard E.
- Willems S.
- Willems S.
- William F.
- Williams L.
- Wilson A.
- Wilson T.
- Winiarska-Filipek A.
- Winkler J.
- Winstanley L.
- Winter K.
- Winum P.
- Wo?niak P.
- Wood A.
- Wood D.
- Wozakowska-Kaplon B.
- Wrigley B.
- Wrigley M.
- Xhaet O.
- Xuereb R.
- Yakova D.
- Yilmaz K.
- Yilmaz M.B.
- Yncheva T.
- Yotov Y.
- Young E.
- Yuksel S.
- Yuksel Y.
- Z?ra E.
- Zajac P.
- Zakrzewski M.
- Zaman J.
- Zavyalova O.
- Zdravkovic M.
- Zhigalov S.
- Ziacchi M.
- Zieli?ski L.
- Ziemi?ska-?u? M.
- Zink M.
- Zlatanovik N.
- Zlatar M.
- Zoccali C.
- Zubova T.
- Zuzans R.
- Zycinski P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background: Epidemiological studies in atrial fibrillation (AF) illustrate that clinical complexity increase the risk of major adverse outcomes. We aimed to describe European AF patients\u2019 clinical phenotypes and analyse the differential clinical course. Methods: We performed a hierarchical cluster analysis based on Ward\u2019s Method and Squared Euclidean Distance using 22 clinical binary variables, identifying the optimal number of clusters. We investigated differences in clinical management, use of healthcare resources and outcomes in a cohort of European AF patients from a Europe-wide observational registry. Results: A total of 9363 were available for this analysis. We identified three clusters: Cluster 1 (n = 3634; 38.8%) characterized by older patients and prevalent non-cardiac comorbidities; Cluster 2 (n = 2774; 29.6%) characterized by younger patients with low prevalence of comorbidities; Cluster 3 (n = 2955;31.6%) characterized by patients\u2019 prevalent cardiovascular risk factors/comorbidities. Over a mean follow-up of 22.5 months, Cluster 3 had the highest rate of cardiovascular events, all-cause death, and the composite outcome (combining the previous two) compared to Cluster 1 and Cluster 2 (all P <.001). An adjusted Cox regression showed that compared to Cluster 2, Cluster 3 (hazard ratio (HR) 2.87, 95% confidence interval (CI) 2.27\u20133.62; HR 3.42, 95%CI 2.72\u20134.31; HR 2.79, 95%CI 2.32\u20133.35), and Cluster 1 (HR 1.88, 95%CI 1.48\u20132.38; HR 2.50, 95%CI 1.98\u20133.15; HR 2.09, 95%CI 1.74\u20132.51) reported a higher risk for the three outcomes respectively. Conclusions: In European AF patients, three main clusters were identified, differentiated by differential presence of comorbidities. Both non-cardiac and cardiac comorbidities clusters were found to be associated with an increased risk of major adverse outcomes
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