A Formal Approach to P3P Privacy Policies Evaluation

Colloque avec actes et comité de lecture. internationale.International audienceWriting and evaluating policies is a recurrent problem over the Internet. These policies, which deal with fields like privacy (P3P), security (P3P) and provisioning (COPS-PR) are often made of many ordered rules. In this paper, we present our work related to P3P rules formalization and validation in an evaluation environnement based on rewriting process. We also develop an environnement which returns the right behavior regarding Internet ressources, P3P policies and APPEL user's preferences

CubeSpec, A Mission Overview

CubeSpec is an in-orbit demonstration CubeSat mission in the ESA technology programme, developed and funded in Belgium. The goal of the mission is to demonstrate high-spectral-resolution astronomical spectroscopy from a 6-unit CubeSat. The prime science demonstration case for the in-orbit demonstration mission is to unravel the interior of massive stars using asteroseismology by high-cadance monitoring of the variations in spectral line profiles during a few months. The technological challenges are numerous. The 10x20cm aperture telescope and echelle spectrometer have been designed to fit in a 10x10x20cm volume. Under low-Earth orbit thermal variations, maintaining the fast telescope focus and spectrometer alignment is achieved via an athermal design. Straylight rejection and thermal shielding from the Sun and Earth infrared flux is achieved via deploying Earth and Sunshades. The narrow spectrometer slit requires arcsecond-level pointing stability using a performant 3-axis wheel stabilised attitude control system with star tracker augmented with a fine beam steering mechanism controlled in closed loop with a guiding sensor. The high cadence, long-term monitoring requirement of the mission poses specific requirements on the orbit and operational scenarios to enable the required sky visibility. CubeSpec is starting the implementation phase, with a planned launch early 2024

Staphylococcus aureus infective endocarditis versus bacteremia strains: Subtle genetic differences at stake

AbstractInfective endocarditis (IE)(1) is a severe condition complicating 10–25% of Staphylococcus aureus bacteremia. Although host-related IE risk factors have been identified, the involvement of bacterial features in IE complication is still unclear. We characterized strictly defined IE and bacteremia isolates and searched for discriminant features. S. aureus isolates causing community-acquired, definite native-valve IE (n=72) and bacteremia (n=54) were collected prospectively as part of a French multicenter cohort. Phenotypic traits previously reported or hypothesized to be involved in staphylococcal IE pathogenesis were tested. In parallel, the genotypic profiles of all isolates, obtained by microarray, were analyzed by discriminant analysis of principal components (DAPC)(2). No significant difference was observed between IE and bacteremia strains, regarding either phenotypic or genotypic univariate analyses. However, the multivariate statistical tool DAPC, applied on microarray data, segregated IE and bacteremia isolates: IE isolates were correctly reassigned as such in 80.6% of the cases (C-statistic 0.83, P<0.001). The performance of this model was confirmed with an independent French collection IE and bacteremia isolates (78.8% reassignment, C-statistic 0.65, P<0.01). Finally, a simple linear discriminant function based on a subset of 8 genetic markers retained valuable performance both in study collection (86.1%, P<0.001) and in the independent validation collection (81.8%, P<0.01). We here show that community-acquired IE and bacteremia S. aureus isolates are genetically distinct based on subtle combinations of genetic markers. This finding provides the proof of concept that bacterial characteristics may contribute to the occurrence of IE in patients with S. aureus bacteremia

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

[Excerpt] Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS) [1], and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM [2]. The somatic mutational landscape of sporadic MM has been increasingly investigated, aiming to identify recurrent genetic events involved in myelomagenesis. Whole exome and whole genome sequencing studies have shown that MM is a genetically heterogeneous disease that evolves through accumulation of both clonal and subclonal driver mutations [3] and identified recurrently somatically mutated genes, including KRAS, NRAS, FAM46C, TP53, DIS3, BRAF, TRAF3, CYLD, RB1 and PRDM1 [3,4,5]. Despite the fact that family-based studies have provided data consistent with an inherited genetic susceptibility to MM compatible with Mendelian transmission [6], the molecular basis of inherited MM predisposition is only partly understood. Genome-Wide Association (GWAS) studies have identified and validated 23 loci significantly associated with an increased risk of developing MM that explain ~16% of heritability [7] and only a subset of familial cases are thought to have a polygenic background [8]. Recent studies have identified rare germline variants predisposing to MM in KDM1A [9], ARID1A and USP45 [10], and the implementation of next-generation sequencing technology will allow the characterization of more such rare variants. [...]French National Cancer Institute (INCA) and the Fondation Française pour la Recherche contre le Myélome et les Gammapathies (FFMRG), the Intergroupe Francophone du Myélome (IFM), NCI R01 NCI CA167824 and a generous donation from Matthew Bell. This work was supported in part through the computational resources and staff expertise provided by Scientific Computing at the Icahn School of Medicine at Mount Sinai. Research reported in this paper was supported by the Office of Research Infrastructure of the National Institutes of Health under award number S10OD018522. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors thank the Association des Malades du Myélome Multiple (AF3M) for their continued support and participation. Where authors are identified as personnel of the International Agency for Research on Cancer / World Health Organization, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer / World Health Organizatio

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Demande d'un projet de décret sur l'affaire Toulouse-Lautrec et conclusion de la séance du 25 juin 1790

Moreau Etienne-Vincent. Demande d'un projet de décret sur l'affaire Toulouse-Lautrec et conclusion de la séance du 25 juin 1790. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XVI - Du 31 mai au 8 juillet 1790. Paris : Librairie Administrative P. Dupont, 1883. p. 464

Dénonciation par M. Moreau d'un numéro de M. Marat, lors de la séance du 30 septembre 1790

Moreau Etienne-Vincent. Dénonciation par M. Moreau d'un numéro de M. Marat, lors de la séance du 30 septembre 1790. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XIX - Du 16 septembre au 23 octobre 1790. Paris : Librairie Administrative P. Dupont, 1884. p. 322

Amendement de M. Moreau à l'article 4 du titre IV du décret sur les biens nationaux à vendre ou à conserver, lors de la séance du 12 octobre 1790

Moreau Etienne Vincent. Amendement de M. Moreau à l'article 4 du titre IV du décret sur les biens nationaux à vendre ou à conserver, lors de la séance du 12 octobre 1790. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XIX - Du 16 septembre au 23 octobre 1790. Paris : Librairie Administrative P. Dupont, 1884. p. 581

Intervention de M. Moreau sur l'article 7 du projet de décret du comité de Constitution sur les contestations pendantes à l'ancien conseil du roi, lors de la séance du 27 avril 1791

Moreau Etienne-Vincent. Intervention de M. Moreau sur l'article 7 du projet de décret du comité de Constitution sur les contestations pendantes à l'ancien conseil du roi, lors de la séance du 27 avril 1791. In: Archives Parlementaires de 1787 à 1860 - Première série (1787-1799) Tome XXV - Du 13 avril 1791 au 11 mai 1791. Paris : Librairie Administrative P. Dupont, 1886. p. 362