Evidence for Colour-Octet Mechanism from CERN LEP2 gamma gamma -> J/psi + X Data

We present theoretical predictions for the transverse-momentum distribution of J/psi mesons promptly produced in gamma gamma collisions within the factorization formalism of nonrelativistic quantum chromodynamics, including the contributions from both direct and resolved photons, and we perform a conservative error analysis. The fraction of J/psi mesons from decays of bottom-flavoured hadrons is estimated to be negligibly small. New data taken by the DELPHI Collaboration at LEP2 nicely confirm these predictions, while they disfavour those obtained within the traditional colour-singlet model.Comment: 11 pages (Latex), 3 figures (Postscript); updated experimental data included, references added, accepted for publication in Phys. Rev. Let

Charmonium Production via Fragmentation at DESY HERA

The cross section for the photoproduction of large-p_T J/psi mesons at HERA is calculated at next-to-leading order, adopting a perturbative approach to describe the fragmentation of charm quarks and gluons into J/psi mesons. We treat the charm quark according to the massless factorization scheme, where it is assumed to be one of the active flavours inside the proton and the resolved photon. We present inclusive distributions in transverse momentum and rapidity, including the contributions due to direct and resolved photons. The importance of the colour-octet components of the J/psi wave function, which contribute to the fragmentation process, is emphasized. In addition to prompt J/psi production, we consider also the production of chi_{cJ} states followed by radiative decays to J/psi mesons, both in the colour-singlet and colour-octet channels.Comment: 32 pages (Latex), 12 figures (Postscript

J/psi plus prompt-photon associated production in two-photon collisions at next-to-leading order

We calculate the cross section of J/psi plus prompt-photon inclusive production in gamma gamma collisions at next-to-leading order within the factorization formalism of nonrelativistic quantum chromodynamics (NRQCD) focusing on direct photoproduction. Apart from direct J/psi production, we also include the feed-down from directly-produced chi_{cJ} and psi' mesons. We discuss the analytical calculation, in particular the treatment of the various types of singularities and the NRQCD operator renormalization, in some detail. We present theoretical predictions for the future e^+e^- linear collider TESLA, taking into account both brems- and beamstrahlung.Comment: 31 pages, 9 figure

Associated Production of Bottomonia and Higgs Bosons at Hadron Colliders

We study the associated production of bottomonia and Higgs bosons at hadron colliders within the factorization formalism of nonrelativistic quantum chromodynamics providing all contributing partonic cross sections in analytic form. While such processes tend to be suppressed in the standard model, they may have interesting cross sections in its minimal supersymmetric extension, especially at large values of tan(beta), where the bottom Yukawa couplings are enhanced. We present numerical results for the processes involving the lighter CP-even h^0 boson and the CP-odd A^0 boson appropriate for the Fermilab Tevatron and the CERN LHC.Comment: 33 pages, 7 figures, Latex, to appear in Phys. Rev.

In vivo hippocampal subfield volumes in bipolar disorder—A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group

The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta‐Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1‐weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed‐effects models and mega‐analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = −0.20), cornu ammonis (CA)1 (d = −0.18), CA2/3 (d = −0.11), CA4 (d = −0.19), molecular layer (d = −0.21), granule cell layer of dentate gyrus (d = −0.21), hippocampal tail (d = −0.10), subiculum (d = −0.15), presubiculum (d = −0.18), and hippocampal amygdala transition area (d = −0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non‐users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD

X-chromosome and kidney function:evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements

X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.</p

Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

Left-right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case-control study of structural brain asymmetries in schizophrenia, using MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets in the ENIGMA consortium, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case-control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case-control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case-control status. Subtle case-control differences of brain macro-structural asymmetry may reflect differences at the molecular, cytoarchitectonic or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder