10 research outputs found
Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis
- Author
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: Familial hemophagocytosis (FHL) is a rare disease associated with defects in proteins involved in CD8+ T-cell cytotoxicity. Hyperactivation of immune cells results in a perilous, Th1-driven cytokine storm. We set out to explore the regulation of cytokines in an FHL patient who was clinically stable on low-dose immunosuppressive therapy after bone marrow transplantation over a six-month period. During this period, chimerism analyses showed that the fraction of host cells was between 1 and 10%. Both parents of the patient as well as healthy volunteers were studied for comparison. Methods/Principal Findings: Using ELISA, quantitative real-time PCR, and clinical laboratory methods, we investigated constitutive and inducible cytokines, polymorphisms, and clinical parameters in whole blood and whole blood cultures. Although routine laboratory tests were within the normal range, the chemokines IP-10 and IL-8 as well as the cytokine IL-27p28 were increased up to 10-fold under constitutive and stimulated conditions compared to healthy controls. Moreover, high levels of IFNgamma and TNFalpha were produced upon stimulation. Unexpectedly, IFNgamma induction of IL-18 binding protein (IL-18BP) was markedly reduced (1.6-fold vs 5-fold in controls). The patient's mother featured intermediately increased cytokine levels, whereas levels in the father were similar to those in the controls. Conclusions/Significance: Since IL-18 plays a major role in perpetuating hemophagocytosis, the failure of IFNgamma to induce IL-18BP may constitute a fundamental pathogenetic mechanism. Furthermore, increased production of IL-8 and IL-27 appears to be associated with this disease. Such dysregulation of cytokines was also found in the heterozygous parents, providing a novel insight into genotype-phenotype correlation of FHL which may encourage future research of this rare disease
IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells
- Author
- A Companjen
- A Iannello
- A Kaser
- A Takeda
- AH Bani-Hani
- AP Lotito
- AR Companjen
- B Moller
- C Antonopoulos
- C Johansen
- CA Dinarello
- CD Sadik
- D Boraschi
- D Hu
- D Novick
- D Novick
- D Wang
- DJ Esteban
- DR Murray
- E Corsini
- E Ziesche
- F Favilli
- GD Kalliolias
- H Kampfer
- H Muhl
- H Muhl
- Heiko Mühl
- HJ Park
- IB McInnes
- J Paulukat
- Josef Pfeilschifter
- JS Stumhofer
- K Takeda
- L Hibbert
- M Bachmann
- M Batten
- M Wittmann
- M Wittmann
- M Wittmann
- Malte Bachmann
- MF Nold
- Miriam Wittmann
- N Calvani
- N Hayashi
- N Kanda
- N Sugiyama
- O Ludwiczek
- PC Reading
- Pierre Bobé
- PP Tak
- Q Yu
- R Gutzmer
- Rosella Doble
- S Akira
- S Gangemi
- S Lucas
- S Pflanz
- S Pflanz
- S Shibata
- S Yamagata
- SH Kim
- SJ Lee
- SM Naik
- SS Xing
- T Yoshimura
- Thomas Werfel
- V Hurgin
- WP Arend
- Y Ohta
- Y Xiang
- Y Xiang
- Z Mallat
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
IL-18 is an important mediator involved in chronic inflammatory conditions such as cutaneous lupus erythematosus, psoriasis and chronic eczema. An imbalance between IL-18 and its endogenous antagonist IL-18 binding protein (BP) may account for increased IL-18 activity. IL-27 is a cytokine with dual function displaying pro- and anti-inflammatory properties. Here we provide evidence for a yet not described anti-inflammatory mode of action on skin resident cells. Human keratinocytes and surprisingly also fibroblasts (which do not produce any IL-18) show a robust, dose-dependent and highly inducible mRNA expression and secretion of IL-18BP upon IL-27 stimulation. Other IL-12 family members failed to induce IL-18BP. The production of IL-18BP peaked between 48–72 h after stimulation and was sustained for up to 96 h. Investigation of the signalling pathway showed that IL-27 activates STAT1 in human keratinocytes and that a proximal GAS site at the IL-18BP promoter is of importance for the functional activity of IL-27. The data are in support of a significant anti-inflammatory effect of IL-27 on skin resident cells. An important novel property of IL-27 in skin pathobiology may be to counter-regulate IL-18 activities by acting on keratinocytes and importantly also on dermal fibroblasts
Alignment of the CMS tracker with LHC and cosmic ray data
- Author
- Abbaneo D.
- Abbiendi G.
- Abbrescia M.
- Abdelalim A. A.
- Abdullin S.
- Abdulsalam A.
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- Adiguzel A.
- Adler V.
- Adzic P.
- Afer C. Sch
- Agram J.-L.
- Aguilar-Benitez M.
- Ahmad M.
- Ahmed I.
- Ahuja S.
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- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
© CERN 2014 for the benefit of the CMS collaboration, published under the terms of the Creative Commons Attribution 3.0 License by IOP Publishing Ltd and Sissa Medialab srl. Any further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation and DOI.The central component of the CMS detector is the largest silicon tracker ever built. The precise alignment of this complex device is a formidable challenge, and only achievable with a significant extension of the technologies routinely used for tracking detectors in the past. This article describes the full-scale alignment procedure as it is used during LHC operations. Among the specific features of the method are the simultaneous determination of up to 200 000 alignment parameters with tracks, the measurement of individual sensor curvature parameters, the control of systematic misalignment effects, and the implementation of the whole procedure in a multi-processor environment for high execution speed. Overall, the achieved statistical accuracy on the module alignment is found to be significantly better than 10μm
Excessive cytokine production in WB cultures from the FHL patient.
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- Publication venue
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- Field of study
<p>WB culture were incubated for 20 h; thereafter, ELISA was performed on lysates (IL-8) or supernatants (others). Data are shown as cytokine protein in pg normalized to 1 million white blood cells ± SEM, n = 4 time points for IP-10 and IL-8 and n = 3 for IFNγ and TNFα spanning 6 months for all subjects; the same three healthy donors were tested on each time point. *, p<0.05 and **, p<0.01 for healthy controls vs patient, mother, and father; #, p<0.05 and ##, p<0.01 for patient vs mother and father.</p
Regulation of IL-18BP and IL-27p28.
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- Publication venue
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- Field of study
<p>RNA was isolated from WB culture after a 20 h incubation with or without 50 ng/ml IFNγ. <b>A,</b> Data are shown as absolute copy numbers of IL-18BP normalized to GAPDH×10<sup>3</sup>± SEM, n = 4 time points for all subjects; three control individuals were assayed on each time point. <b>B,</b> IFNγ-induced fold-changes in normalized IL-18BP mRNA copy numbers are shown. <b>A</b> and <b>B,</b> *, p<0.05 and **, p<0.01 for healthy donors vs patient, mother, and father; #, p<0.05 for patient vs mother and father. <b>C,</b> IL-27p28 PCR from the same samples. Differences in GAPDH copy numbers were negligible. One representative of 3 different gels showing similar results is depicted. Healthy donor C exhibited no expression of IL-27p28 (not shown).</p
Cytokine levels in WB cultures stimulated with LPS.
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- Publication venue
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- Field of study
<p>WB cultures were incubated in the presence of 100 ng/ml LPS for 20 h. In panel <b>D</b>, IL-12 (20 ng/ml) was also added. IL-8 was measured in cell lysates, IP-10, TNFα, and IFNγ were determined in the supernatants. Data are depicted as cytokine protein in pg normalized to 1 million white blood cells ± SEM, n = 4 time points for IP-10 and IL-8 and n = 3 for IFNγ and TNFα over a period of 6 months for all subjects; the identical healthy volunteers were tested on each time point. *, p<0.05 and **, p<0.01 for healthy controls vs patient, mother, and father; #, p<0.05 and ##, p<0.01 for patient vs mother and father.</p
Inhaled IL-10 reduces biotrauma and mortality in a model of ventilator-induced lung injury
- Author
- Andrea Dolfen
- Asadullah
- Bernard
- Bernhard Zwissler
- Bradford
- Brain
- Calfee
- Chen
- Chernoff
- Chiumello
- Christian Hofstetter
- Corbel
- Ding
- Dreyfuss
- Dreyfuss
- Eberhardt
- Ferring
- Foda
- Frank
- Frank
- Haitsma
- Halbertsma
- Heiko Muhl
- Hoegl
- Hofstetter
- Hofstetter
- Holger Czerwonka
- Huhn
- Huhn
- Imai
- Keystone
- Kim
- Kim A. Boost
- Lacraz
- Lee
- Li
- Lim
- Mallat
- Moore
- Mosser
- Narimanbekov
- Ohbayashi
- Patrick Scheiermann
- Ranieri
- Ribeiro
- Sandra Hoegl
- Slutsky
- Stuber
- Tremblay
- Vlahakis
- Vreugdenhil
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Molecular signature of interleukin-22 in colon carcinoma cells and organoid models
- Author
- Ahmed
- Alam
- Alanen
- Aujla
- Aujla
- Bachmann
- Bard
- Berg
- Berner
- Blaschitz
- Boniface
- Brand
- Bromberg
- Cascio
- Cupedo
- Duffy
- Dumoutier
- Dumoutier
- Edelstein
- Elizabeth Richards
- Erez
- Eyerich
- Fatehullah
- Fichera
- Fickenscher
- Fukui
- Geboes
- Genevieve Kerr
- Geng
- Gorzelak-Pabis
- Grada
- Heiko Mühl
- Helen E. Abud
- Hoegl
- Holmer
- Horvay
- Ikeuchi
- Ilantzis
- Ina Rudloff
- Jarde
- Jarde
- Jiang
- Jiang
- Karen Oliva
- Kirchberger
- Kirstin D. Elgass
- Kitamura
- Kotenko
- Koyasu
- Kryczek
- Ksiazek
- Lehto
- Liang
- Lindemans
- Liu
- Liu
- Luci
- Maeda
- Malte Bachmann
- Marcel F. Nold
- Martinez-Carreres
- Muhl
- Muhl
- Nagalakshmi
- Nefzger
- Parsons
- Paul J. McMurrick
- Peng
- Pennino
- Pfaffl
- Pickert
- Preibisch
- Radaeva
- Rama
- Rebekah Engel
- Roessler
- Rudloff
- Sadik
- Sato
- Sato
- Savan
- Schindelin
- Sekhejane
- Sekikawa
- Simon Wilkins
- Sonnenberg
- Sugimoto
- Takatori
- Tang
- Thierry Jardé
- Tomida
- Trivella
- Urban
- van de Wetering
- Voigt
- Walker
- Wirth
- Wolk
- Wolk
- Wolk
- Wu
- Xie
- Xie
- Xie
- Yamada
- Yang
- Zenewicz
- Zheng
- Zheng
- Zhou
- Ziesche
- Ziprin
- Zwarycz
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Description and performance of track and primary-vertex reconstruction with the CMS tracker
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Imtiaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albert Eric
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Ian
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arezzini Silvia
- Arfaei Hessamaddin
- Argiro Stefano
- Arndt Kirk
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Bartz Ed
- Barvich Tobias
- Basegmez Suzan
- Basti Andrea
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baulieu Guillaume
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaumont Willem
- Beaupere Nicolas
- Becker Robert
- Beernaert Kelly
- Behnamian Hadi
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Riccardo
- Bellato Marco
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F.
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Berger Lutz Olaf
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berruti Gaia Maria
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C.
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
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- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bisello Dario
- Biskop Heike
- Bissi Lucia
- Bitioukov Sergei
- Blanchot Georges
- Blekman Freya
- Blobel Volker
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- Bloch Philippe
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- Bluj Michal
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- Bodek Arie
- Boegelspacher Felix
- Boimska Bożena
- Bolla Gino
- Bolognesi Sara
- Bonacorsi Daniele
- Bonato Alessio
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- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bosi Filippo
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Boutle Sarah
- Bradmiller-Feld John
- Braibant-Giacomelli Sylvie
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- Branson James G.
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- Brochero Cifuentes Javier Andres
- Brochet Sébastien
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- Brona Grzegorz
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- Bubna Mayur
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- Buchmuller Oliver
- Bucinskaite Inga
- Buhmann Peter
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H.
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
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- Bösiger Kurt
- Cabrillo Iban Jose
- Caebergs Thierry
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calamba Aristotle
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- Zito Giuseppe
- Zoccarato Yannick
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zuber Adam
- Zucca Stefano
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zwalinski Lukasz
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Description and performance of track and primary-vertex reconstruction with the CMS tracker
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Imtiaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albert Eric
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Ian
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arezzini Silvia
- Arfaei Hessamaddin
- Argiro Stefano
- Arndt Kirk
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Bartz Ed
- Barvich Tobias
- Basegmez Suzan
- Basti Andrea
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar AT
- Baulieu Guillaume
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaumont Willem
- Beaupere Nicolas
- Becker Robert
- Beernaert Kelly
- Behnamian Hadi
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W
- Bellan Riccardo
- Bellato Marco
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Berger Lutz Olaf
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berruti Gaia Maria
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bisello Dario
- Biskop Heike
- Bissi Lucia
- Bitioukov Sergei
- Blanchot Georges
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Boegelspacher Felix
- Boimska Bożena
- Bolla Gino
- Bolognesi Sara
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bonnin Christian
- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bosi Filippo
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Boutle Sarah
- Bradmiller-Feld John
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brianzi Mirko
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Brown Robert M
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Bubna Mayur
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bucinskaite Inga
- Buhmann Peter
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Böser Christian
- Bösiger Kurt
- Cabrillo Iban Jose
- Caebergs Thierry
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calamba Aristotle
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Calpas Betty
- Calvert Brian
- Calvo Enrique
- Calzolari Federico
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Cappello Gigi
- Cardaci Marco
- Cariola Pasquale
- Carlin Roberto
- Carlsmith Duncan
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Casimiro Linares Edgar
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Caudron Adrien
- Caudron Julien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Ceresa Davide
- Cerminara Gianluca
- Cerrada Marcos
- Cervantes Mayra
- Chabert Eric Christian
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charles Laurent
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
- Checchia Paolo
- Checcucci Bruno
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Po-Hsun
- Chen Yi
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chramowicz John
- Christiansen Jorgen
- Christiansen Tim
- Christopher Grant
- Chwalek Thorsten
- Chávez Niemelä Aleksis Osku
- Ciampa Alberto
- Ciangottini Diego
- Ciaranfi Roberto
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David JA
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
- Contardo Didier
- Conte Eric
- Conti Elia
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooper William
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Costanza Francesco
- Couderc Fabrice
- Coughlan John A
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Crucy Shannon
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cussans David
- Custódio Analu
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Angelo Pasqualino
- D'Auria Andrea
- D'Enterria David
- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Silva Di Calafiori Diogo Raphael
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Daguin Jerome
- Dahmes Bryan
- Dahms Torsten
- Dalchenko Mykhailo
- Dall'Osso Martino
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Danielson Thomas
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- Dauncey Paul
- David Tinoco Mendes Andre
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Callatay Bernard
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Robertis Giuseppe
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wolf Eddi A
- Degano Alessandro
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delgado Peris Antonio
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demiragli Zeynep
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Deptuch Grzegorz
- Dermenev Alexander
- Derylo Greg
- Descroix Alexis
- Detraz Stephane
- Devroede Olivier
- Deyrail Dominique
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
- Di Marco Emanuele
- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dishaw Adam
- Dissertori Günther
- Dittmann Jay
- Dittmar Michael
- Djambazov Lubomir
- Dobrzynski Ludwik
- Dobson Marc
- Dobur Didar
- Doesburg Robert
- Dolen James
- Dolinska Ganna
- Dominguez Aaron
- Dominik Wojciech
- Domínguez Vázquez Daniel
- Donato Silvio
- Donegà Mauro
- Dooling Samantha
- Dordevic Milos
- Dorigo Tommaso
- Dorland Tyler
- Dorney Brian
- Doroba Krzysztof
- Dos Reis Martins Thiago
- Dozen Candan
- Dragicevic Marko
- Dragoiu Cosmin
- Drell Brian Robert
- Dremin Igor
- Drouhin Frédéric
- Drozdetskiy Alexey
- Du Pree Tristan
- Du Ran
- Duarte Campderros Jordi
- Duarte Javier
- Dubinin Mikhail
- Duchardt Deborah
- Dudero Phillip Russell
- Dudko Lev
- Dugad Shashikant
- Duggan Daniel
- Dumanoglu Isa
- Dupont-Sagorin Niels
- Duric Senka
- Durkin Lloyd Stanley
- Duru Firdevs
- Dutta Dipanwita
- Dutta Suchandra
- Dutta Valentina
- Dünser Marc
- Eber Robert
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
- Edelhoff Matthias
- Eerola Paula
- Eggert Nicholas
- Eichhorn Thomas
- Ekmedzic Marko
- El Mamouni Houmani
- Elgammal Sherif
- Eller Philipp
- Elliott-Peisert Anna
- Ellison John Anthony
- Ellithi Kamel Ali
- Elmer Peter
- Elvira Victor Daniel
- Enderle Holger
- Eno Sarah Catherine
- Epshteyn Vladimir
- Erbacher Robin
- Erdmann Martin
- Erdmann Wolfram
- Erdogan Yusuf
- Erfle Joachim
- Erhan Samim
- Ershov Alexander
- Erö Janos
- Eshaq Yossof
- Eskut Eda
- Esser Hans
- Etesami Seyed Mohsen
- Eugster Jürg
- Eusebi Ricardo
- Evangelou Ioannis
- Evans David
- Evdokimov Olga
- Everaerts Pieter
- Everett Adam
- Fabbri Fabrizio
- Fabbri Franco
- Fabbricatore Pasquale
- Fabbro Bernard
- Fabjan Christian
- Fabozzi Francesco
- Faccio Federico
- Faccioli Pietro
- Fahim Ali
- Fan Jiawei
- Fanfani Alessandra
- Fangmeier Caleb
- Fantasia Cory
- Fanò Livio
- Farrell Chris
- Fasanella Daniele
- Faulkner James
- Faure Jean-Louis
- Favaro Carlotta
- Favart Denis
- Favart Laurent
- Fay Jean
- Fedi Giacomo
- Fehling David
- Feindt Michael
- Felcini Marta
- Feld Lutz
- Felici Daniele
- Ferapontov Alexey
- Ferbel Thomas
- Ferencek Dinko
- Ferguson Thomas
- Ferguson William
- Fernandez Bedoya Cristina
- Fernandez Menendez Javier
- Fernandez Marcos
- Fernández Ramos Juan Pablo
- Ferrando Antonio
- Ferreira Parracho Pedro Guilherme
- Ferretti Roberta
- Ferri Federico
- Ferro Cristina
- Ferro Fabrizio
- Field Richard D
- Finger Jr Michael
- Finger Miroslav
- Fiore Luigi
- Fiorendi Sara
- Fiori Francesco
- Fischer Robert
- Fisher Matthew
- Fisk Ian
- Flacher Henning
- Flanagan Will
- Flix Jose
- Florent Alice
- Flores Chad
- Florez Carlos
- Flouris Giannis
- Flowers Kristen
- Flowers Sean
- Flucke Gero
- Flügge Günter
- Focardi Ettore
- Folgueras Santiago
- Fonseca De Souza Sandro
- Fontaine Jean-Charles
- Ford William T
- Forthomme Laurent
- Foudas Costas
- Fouz Maria Cruz
- Foà Lorenzo
- Francis Brian
- Franco Sevilla Manuel
- Franco Michele
- Frank Norbert
- Franzoni Giovanni
- Frazier Robert
- Freeman Jim
- Frensche Benno
- Friedl Markus
- Friis Evan
- Frueboes Tomasz
- Fruehwirth Rudolf
- Fu Yu
- Fulcher Jonathan
- Funk Wolfgang
- Furic Ivan-Kresimir
- Futyan David
- Gabusi Michele
- Gadrat Sébastien
- Gaioni Luigi
- Galanti Mario
- Gallinaro Michele
- Gallo Elisabetta
- Gamsizkan Halil
- Ganguly Sanmay
- Ganjour Serguei
- Gao Yanyan
- Garabedian Alex
- Garcia Guillaume
- Garcia-Abia Pablo
- Garcia-Bellido Aran
- Gardner Michael
- Garutti Erika
- Gary J William
- Gascon Susan
- Gasparini Fabrizio
- Gasparini Ugo
- Gaultney Vanessa
- Gauthier Lucie
- Gavrilenko Mikhail
- Gavrilov Vladimir
- Gay Arnaud
- Gaz Alessandro
- Geenen Heiko
- Geffert Paul
- Geiser Achim
- Geisler Matthias
- Gelé Denis
- Genchev Vladimir
- Gennai Simone
- George Christopher
- George Jimin
- Geralis Theodoros
- Gerber Cecilia Elena
- Gerosa Raffaele
- Gershtein Yuri
- Geurts Frank JM
- Ghete Vasile Mihai
- Ghezzi Alessio
- Ghosh Saranya
- Giacomelli Paolo
- Giammanco Andrea
- Giassi Alessandro
- Gibbons Lawrence Kent
- Giffels Manuel
- Gigi Dominique
- Gilbert Andrew
- Gill Karl
- Gilmore Jason
- Gingu V Cristinel
- Giordano Domenico
- Giordano Ferdinando
- Girgis Semiray
- Girone Maria
- Giubilato Piero
- Giunta Marina
- Givernaud Alain
- Glege Frank
- Glushkov Ivan
- Gninenko Sergei
- Gobbo Benigno
- Godinovic Nikola
- Godshalk Andrew
- Goebel Kristin
- Goerlach Ulrich
- Goetzmann Christophe
- Goh Junghwan
- Gokbulut Gul
- Goldenzweig Pablo
- Goldstein Joel
- Golf Frank
- Gollapinni Sowjanya
- Golovtsov Victor
- Golubev Nikolai
- Golutvin Igor
- Gomber Bhawna
- Gomez Ceballos Guillelmo
- Gomez Moreno Bernardo
- Gomez Gervasio
- Gomez Jaime
- Gomez Juan Pablo
- Gomez-Reino Garrido Robert
- Goncharov Maxim
- Gonzalez Caballero Isidro
- Gonzalez Lopez Oscar
- Gonzalez Sanchez Javier
- Gonzalez Suarez Rebeca
- Gonzi Sandro
- Goodell Joseph
- Gorbunov Ilya
- Gori Valentina
- Gosselink Martijn
- Gottschalk Erik
- Goulianos Konstantin
- Gouskos Loukas
- Gouzevitch Maxime
- Govoni Pietro
- Gowdy Stephen
- Goy Lopez Silvia
- Gozzelino Andrea
- Grab Christoph
- Grandi Claudio
- Granier de Cassagnac Raphael
- Gras Philippe
- Grassi Marco
- Gray Julia
- Gray Lindsey
- Gray Richard
- Graziano Alberto
- Grebenyuk Anastasia
- Green Dan
- Greene Senta
- Gribushin Andrey
- Grimes Mark
- Grippo Maria Teresa
- Gritsan Andrei
- Gronberg Jeffrey
- Gross Laurent
- Grothe Monika
- Grundler Ulysses
- Grunewald Martin
- Grünendahl Stefan
- Guchait Monoranjan
- Gude Alexander
- Guida Roberto
- Guiducci Luigi
- Guler Ali Murat
- Gulhan Doga
- Guneratne Bryer Arlo
- Gunnellini Paolo
- Guo Yifei
- Gupta Ruchi
- Gurpinar Emine
- Gurrola Alfredo
- Gurtu Atul
- Guthoff Moritz
- Gutsche Oliver
- Gyun Dooyeon
- Górski Maciej
- Görner Martin
- Gülmez Erhan
- Günaydin Yusuf Oguzhan
- Güth Andreas
- Haas Jeff
- Habib Shiraz
- Hadjiiska Roumyana
- Hadley Nicholas John
- Hagopian Sharon
- Hagopian Vasken
- Hahn Kristan Allan
- Haj Ahmad Wael
- Hajdu Csaba
- Haley Joseph
- Halkiadakis Eva
- Hall Geoffrey
- Hall-Wilton Richard
- Haller Johannes
- Halyo Valerie
- Hamel de Monchenault Gautier
- Hammad Gregory Habib
- Hammer Josef
- Hampe Jan
- Han Jiyeon
- Hansen Karsten
- Hansen Magnus
- Hanson Gail
- Harder Kristian
- Hare Daryl
- Harel Amnon
- Harper Sam
- Harr Robert
- Harris Philip
- Harris Robert M
- Hartl Christian
- Hartmann Frank
- Hassan Qamar
- Hatakeyama Kenichi
- Hatherell Zoe
- Hauk Johannes
- Hauser Jay
- Hauth Thomas
- Hays Jonathan
- Haytmyradov Maksat
- Heath Greg P
- Heath Helen F
- Hebbeker Thomas
- Hebda Philip
- Hegeman Jeroen
- Heidemann Carsten
- Heilman Jesse
- Heindl Stefan Michael
- Heintz Ulrich
- Heister Arno
- Held Hauke
- Hellwig Gregor
- Hempel Maria
- Henderson Conor
- Henrique Gomes E Souza Moacyr
- Heracleous Natalie
- Heredia-de La Cruz Ivan
- Hernandez Jose M
- Herndon Matthew
- Hervé Alain
- Hewamanage Samantha
- Hidas Dean
- Hidas Pàl
- Hildreth Michael
- Hill Christopher
- Hindrichs Otto
- Hinzmann Andreas
- Hirosky Robert
- Hirschauer James
- Hits Dmitry
- Hobson Peter R
- Hoehle Felix
- Hoepfner Kerstin
- Hoff Jim R
- Hoffmann Karl-Heinz
- Hoffmann Malte
- Hofman David Jonathan
- Hohlmann Marcus
- Hollar Jonathan
- Holzner André
- Hong Byung-Sik
- Honma Alan
- Hooberman Benjamin
- Hoorani Hafeez R
- Hopkins Walter
- Horisberger Roland
- Horisberger Urs
- Horton Dean
- Horvath Dezso
- Hos Ilknur
- Hoss Jan
- Hou George Wei-Shu
- Howell Joseph
- Hreus Tomas
- Hrubec Josef
- Hrycyk Michael
- Hsiung Yee
- Hu Zhen
- Hughes Richard
- Hugon Justin
- Hunt Adam
- Husemann Ulrich
- Härkönen Jaakko
- Höing Rebekka Sophie
- Hörmann Natascha
- Iaselli Giuseppe
- Iashvili Ia
- Iaydjiev Plamen
- Ignatenko Mikhail
- Iiyama Yutaro
- Iles Gregory
- Ilic Jelena
- Ille Bernard
- Incandela Joe
- Ingram Quentin
- Innocente Vincenzo
- Iorio Alberto Orso Maria
- Isildak Bora
- Ivanov Andrew
- Ivanov Yury
- Ivova Rikova Mirena
- Jabeen Shabnam
- Jacob Jeson
- Jafari Abideh
- Jain Sandhya
- Jain Shilpi
- Jain Supriya
- Jandir Pawandeep
- Jang Dong Wook
- Janot Patrick
- Janssen Xavier
- Jaramillo Echeverria Richard William
- Jarry Patrick
- Jarvis Chad
- Jarvis Martyn
- Jeitler Manfred
- Jessop Colin
- Jez Pavel
- Jha Manoj
- Jiang Chun-Hua
- Jindal Pratima
- Jindariani Sergo
- Jo Mihee
- Johns Willard
- Johnson Kurtis F
- Johnson Marvin
- Jones John
- Jones Matthew
- Jorda Clara
- Josa Maria Isabel
- Joshi Umesh
- Juillot Pierre
- Jung Hannes
- Jung Kurt
- Junkes Alexandra
- Juodagalvis Andrius
- Justus Christopher
- Kaadze Ketino
- Kachanov Vassili
- Kadastik Mario
- Kadija Kreso
- Kaestli Hans-Christian
- Kailas Swaminathan
- Kaisen Josh
- Kalakhety Himali
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- Smith John
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- von Gunten Hans Peter
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- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xiao Meng
- Xie Si
- Xie Wei
- Xu Lingshan
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zoccarato Yannick
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zuber Adam
- Zucca Stefano
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zwalinski Lukasz
- Publication venue
- Publication date
- 01/01/2014
- Field of study
A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tbar t events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p(T) > 0.9GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p(T) = 100GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in p(T), and respectively, 10μm and 30μm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10–12μm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung