79 research outputs found
Influence of solar radiation on the production of secondary metabolites in three rice (Oryza sativa) cultivars
Rice (Oryza sativa L.) is one of the most produced and consumed cereals worldwide and has its importance highlighted mainly in developing countries, where it plays a strategic economic and social role. Due to the importance of rice in the diet, its composition and nutritional characteristics are directly related to the health of the population. In the rice production systems, some climatic factors are determinants for the good performance of the crop, inducing the biosynthesis of primary and secondary metabolites. The present study determined the metabolic profiles through UV-visible spectrophotometry of leaf samples of three rice cultivars (Marques -- white, \\^Onix -- black, and Rubi -- red pericarp) throughout the rice's vegetative stages in two experimental times, from September to December 2015 and from January to April 2016. Solar radiation was recorded along the experimental period. To the organosolvent extracts of leaf samples, UV-vis spectrophotometric techniques were applied and the quantitative results of certain metabolites, e.g., chlorophylls, carotenoids, phenolics, flavonoids, and sugars, as well the antioxidant activity, which were analyzed by chemometrics tools. The results showed that biochemical parameters carotenoids, chlorophylls and sugars are more affected by the intensity of the radiation do que as vari\\'\a\veis phenolics, flavonoids and these alterations may be detected through statistical analysis of biochemical concentrations and UV-vis spectra.CAPES -Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior(407323/2013-9)info:eu-repo/semantics/publishedVersio
O Efeito da Complexidade Estrutural da Fonte de Carbono e NitrogĂȘnio no Desempenho Fermentativo de Leveduras iIdustrias
Saccharomyces cerevisiae tem evoluĂdo para utilizar melhor os nutrientes acessĂveis e se adaptar as deficiĂȘncias nutricionais de forma a maximizar sua sobrevivĂȘncia. O presente trabalho avaliou o efeito das fontes de carbono e nitrogĂȘnio no desempenho fermentativo de leveduras industriais (Catanduva-1 e Pedra-2). As anĂĄlises dos parĂąmetros fermentativos mostraram que o tipo da fonte de carbono e a complexidade estrutural da fonte nitrogenada causam efeitos diferentes sobre o metabolismo das linhagens industriais. As fontes de carbono contendo glicose e sacarose suplementadas com a fonte nitrogenada (peptona) apresentaram melhor desempenho fermentativo para as linhagens estudadas. Este estudo mostrou que a complexidade estrutural da fonte de nitrogĂȘnio, em correlação com o tipo de açĂșcar, tem um efeito importante no desempenho fermentativo de leveduras industriais
Collaborating Center on Food and School Nutrition (CECANE/UFT) in state of Tocantins
The Collaborating Center on Food and School Nutrition (CECANE) are partnerships between the National Fund for the Development of Education (FNDE) and Federal Institutions for Higher Education, which intend to provide technical and operational support to the implementation of the National School Feeding Program (PNAE), in order to guarantee the supply of adequate and healthy food to the students of public and philanthropic schools. Among the activities implemented by CECANE of the Federal University of Tocantins (UFT), it is worth noting the advising and monitoring of 36 municipalities in the years 2016 to 2017, contributing to the training of human resources responsible for PNAE and data collection on execution. It is concluded that there is a need for the continuation of CECANE / UFT actions, in order to continuously serve the largest number of municipalities and social actors of the PNAE, in order to promote the effective execution of the PNAE
Rastreamento de uso de ĂĄlcool por gestantes de serviços pĂșblicos de saĂșde do Rio de Janeiro
OBJECTIVE: To assess the prevalence of suspected cases of alcohol use during pregnancy in women seeking care in public health services. METHODS: Cross-sectional study comprising 537 women randomly selected in public maternity hospitals in Rio de Janeiro, Southeastern Brazil, from March to October 2000. A well-trained team of female interviewers used the instruments Cut-down, Annoyed, Guilty, Eye-opener (CAGE), Tolerance Cut-down, Annoyed, Eye-opener (T-ACE) and Tolerance Worry Eye-opener Annoyed Cut-down (TWEAK) to assess suspect cases of alcohol misuse. The Chi-square test was used in the analysis according to socioeconomic and demographic variables. RESULTS: About 40% of women informed having used any type of alcoholic beverage during pregnancy. Beer was the most frequently used drink (83.9%). Depending on the measurement instrument used, estimates of alcohol misuse varied from 7.3% to 26.1%. Suspected cases of alcohol abuse were more common among non-white, older and less educated women; those not living with a partner; those reporting use of tobacco and illicit drugs either by one or both partners in a couple; and those with little social support. CONCLUSIONS: High prevalence of suspected alcohol misuse and its overlapping with several risk factors for adverse pregnancy outcomes indicate this is an important issue of public health concern requiring continuous screening during prenatal care.OBJETIVO: Avaliar a prevalĂȘncia de casos suspeitos de uso inadequado de ĂĄlcool durante a gestação entre mulheres atendidas na rede pĂșblica de saĂșde. MĂTODOS: Estudo transversal com 537 parturientes selecionadas aleatoriamente em maternidades pĂșblicas do Rio de Janeiro entre março e outubro de 2000. Entrevistadoras adequadamente treinadas identificaram os casos suspeitos de uso inadequado de ĂĄlcool utilizando os instrumentos Cut-down, Annoyed, Guilty e Eye-opener (CAGE), Tolerance Cut-down, Annoyed e Eye-opener (T-ACE) e Tolerance Worry Eye-opener Annoyed Cut-down (TWEAK). Na anĂĄlise segundo variĂĄveis socioeconĂŽmicas e demogrĂĄficas utilizou-se o teste qui-quadrado. RESULTADOS: Cerca de 40% das mulheres relataram fazer uso de algum tipo de bebida alcoĂłlica durante a gestação, sendo a cerveja a bebida mais consumida (83,9%). Dependendo do instrumento de identificação, estimou-se que entre 7,3% e 26,1% das mulheres eram casos suspeitos de uso inadequado de ĂĄlcool. A suspeição de utilização inadequada foi mais comum entre as mulheres de idade mais avançada; de baixa escolaridade; que nĂŁo se declararam brancas; que nĂŁo viviam com companheiro; que relataram tabagismo e uso de drogas ilĂcitas por um dos membros do casal; e com pouco apoio social. CONCLUSĂES: A alta prevalĂȘncia de suspeição de uso inadequado de ĂĄlcool e sua superposição com diferentes fatores de risco para desfechos deletĂ©rios na gestação indicam um importante problema de saĂșde pĂșblica, merecendo ser rotineiramente rastreada durante o acompanhamento pĂ©-natal
prĂĄticas artĂsticas no ensino bĂĄsico e secundĂĄrio
info:eu-repo/semantics/publishedVersio
PatrimĂŽnio e desenvolvimento: as polĂticas de patrimĂŽnio cultural nos anos 1960
This article aims at analyzing aspects of 1960s Brazilian cultural heritage policies, highlighting changes related to the articulation of concepts such as development, culture and heritage within the Directory of National Historical and Artistic Heritage - DPHAN, today Institute of National Historical and Artistic Heritage (IPHAN). It discusses the effects of industrialization, urban growth and development improvement measures on heritage concepts and policies, analyzing initiatives that focus on preserving cultural assets acknowledged as national historical and artistic heritage and enhancing their economical potential. The discussion emphasizes notions and understandings on heritage and preservation that had substantial bearing on preservation measures carried on by DPHAN from the 1960s on regarding the identification, valorization and protection of cultural heritage, as well as the disciplinary and institutional debates this Directory proposed.O objetivo deste artigo Ă© analisar especificidades dos anos 1960 no que diz respeito Ă s polĂticas de patrimĂŽnio, destacando algumas mudanças de entendimentos, noçÔes e propostas, notadamente referentes Ă s relaçÔes entre desenvolvimento, cultura e patrimĂŽnio trabalhadas pelo Instituto do PatrimĂŽnio HistĂłrico e ArtĂstico Nacional, entĂŁo Diretoria do PatrimĂŽnio HistĂłrico e ArtĂstico Nacional (DPHAN). Para tanto, vai-se partir das discussĂ”es e debates desse momento acerca dos efeitos da industrialização, do crescimento urbano e das polĂticas desenvolvimentistas sobre as polĂticas de patrimĂŽnio a partir dessa dĂ©cada, analisando as iniciativas voltadas Ă patrimonialização de bens culturais, Ă preservação do acervo que compunha o patrimĂŽnio histĂłrico e artĂstico nacional e ao fomento de suas potencialidades econĂŽmicas. Na discussĂŁo proposta neste artigo, priorizar-se-ĂŁo os entendimentos e açÔes de preservação da DPHAN relacionados a identificação, valoração e proteção dos bens culturais, assim como os diĂĄlogos disciplinares e institucionais que a diretoria procurou estabelecer
Taking the pulse of Earth's tropical forests using networks of highly distributed plots
Tropical forests are the most diverse and productive ecosystems on Earth. While better understanding of these forests is critical for our collective future, until quite recently efforts to measure and monitor them have been largely disconnected. Networking is essential to discover the answers to questions that transcend borders and the horizons of funding agencies. Here we show how a global community is responding to the challenges of tropical ecosystem research with diverse teams measuring forests tree-by-tree in thousands of long-term plots. We review the major scientific discoveries of this work and show how this process is changing tropical forest science. Our core approach involves linking long-term grassroots initiatives with standardized protocols and data management to generate robust scaled-up results. By connecting tropical researchers and elevating their status, our Social Research Network model recognises the key role of the data originator in scientific discovery. Conceived in 1999 with RAINFOR (South America), our permanent plot networks have been adapted to Africa (AfriTRON) and Southeast Asia (T-FORCES) and widely emulated worldwide. Now these multiple initiatives are integrated via ForestPlots.net cyber-infrastructure, linking colleagues from 54 countries across 24 plot networks. Collectively these are transforming understanding of tropical forests and their biospheric role. Together we have discovered how, where and why forest carbon and biodiversity are responding to climate change, and how they feedback on it. This long-term pan-tropical collaboration has revealed a large long-term carbon sink and its trends, as well as making clear which drivers are most important, which forest processes are affected, where they are changing, what the lags are, and the likely future responses of tropical forests as the climate continues to change. By leveraging a remarkably old technology, plot networks are sparking a very modern revolution in tropical forest science. In the future, humanity can benefit greatly by nurturing the grassroots communities now collectively capable of generating unique, long-term understanding of Earth's most precious forests.Additional co-authors: Susan Laurance, William Laurance, Francoise Yoko Ishida, Andrew Marshall, Catherine Waite, Hannsjoerg Woell, Jean-Francois Bastin, Marijn Bauters, Hans Beeckman, Pfascal Boeckx, Jan Bogaert, Charles De Canniere, Thales de Haulleville, Jean-Louis Doucet, Olivier Hardy, Wannes Hubau, Elizabeth Kearsley, Hans Verbeeck, Jason Vleminckx, Steven W. Brewer, Alfredo AlarcĂłn, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Ezequiel Chavez, Todd Fredericksen, RenĂ© GuillĂ©n Villaroel, Gloria Gutierrez Sibauty, Timothy Killeen, Juan Carlos Licona, John Lleigue, Casimiro Mendoza, Samaria Murakami, Alexander Parada Gutierrez, Guido Pardo, Marielos Peña-Claros, Lourens Poorter, Marisol Toledo, Jeanneth Villalobos Cayo, Laura Jessica Viscarra, Vincent Vos, Jorge Ahumada, Everton Almeida, Jarcilene Almeida, Edmar Almeida de Oliveira, Wesley Alves da Cruz, Atila Alves de Oliveira, FabrĂcio Alvim Carvalho, FlĂĄvio Amorim Obermuller, Ana Andrade, Fernanda Antunes Carvalho, Simone Aparecida Vieira, Ana Carla Aquino, Luiz AragĂŁo, Ana Claudia AraĂșjo, Marco Antonio Assis, Jose Ataliba Mantelli Aboin Gomes, FabrĂcio Baccaro, PlĂnio Barbosa de Camargo, Paulo Barni, Jorcely Barroso, Luis Carlos Bernacci, Kauane Bordin, Marcelo Brilhante de Medeiros, Igor Broggio, JosĂ© LuĂs Camargo, Domingos Cardoso, Maria Antonia Carniello, Andre Luis Casarin Rochelle, Carolina Castilho, Antonio Alberto Jorge Farias Castro, Wendeson Castro, Sabina Cerruto Ribeiro, FlĂĄvia Costa, Rodrigo Costa de Oliveira, Italo Coutinho, John Cunha, Lola da Costa, Lucia da Costa Ferreira, Richarlly da Costa Silva, Marta da Graça Zacarias Simbine, Vitor de Andrade Kamimura, Haroldo Cavalcante de Lima, Lia de Oliveira Melo, Luciano de Queiroz, JosĂ© Romualdo de Sousa Lima, MĂĄrio do EspĂrito Santo, Tomas Domingues, Nayane Cristina dos Santos Prestes, Steffan Eduardo Silva Carneiro, Fernando Elias, Gabriel Eliseu, Thaise Emilio, Camila LaĂs Farrapo, LetĂcia Fernandes, Gustavo Ferreira, Joice Ferreira, Leandro Ferreira, Socorro Ferreira, Marcelo Fragomeni Simon, Maria Aparecida Freitas, Queila S. GarcĂa, Angelo Gilberto Manzatto, Paulo Graça, Frederico Guilherme, Eduardo Hase, Niro Higuchi, Mariana Iguatemy, Reinaldo Imbrozio Barbosa, Margarita Jaramillo, Carlos Joly, Joice Klipel, IĂȘda LeĂŁo do Amaral, Carolina Levis, Antonio S. Lima, MaurĂcio Lima Dan, Aline Lopes, Herison Madeiros, William E. Magnusson, Rubens Manoel dos Santos, Beatriz Marimon, Ben Hur Marimon Junior, Roberta Marotti Martelletti Grillo, Luiz Martinelli, Simone Matias Reis, SalomĂŁo Medeiros, Milton Meira-Junior, Thiago Metzker, Paulo Morandi, Natanael Moreira do Nascimento, Magna Moura, Sandra Cristina MĂŒller, Laszlo Nagy, Henrique Nascimento, Marcelo Nascimento, Adriano Nogueira Lima, Raimunda Oliveira de AraĂșjo, Jhonathan Oliveira Silva, Marcelo Pansonato, Gabriel Pavan Sabino, Karla Maria Pedra de Abreu, Pablo JosĂ© Francisco Pena Rodrigues, Maria Piedade, Domingos Rodrigues, JosĂ© Roberto Rodrigues Pinto, Carlos Quesada, Eliana Ramos, Rafael Ramos, Priscyla Rodrigues, Thaiane Rodrigues de Sousa, Rafael SalomĂŁo, FlĂĄvia Santana, Marcos Scaranello, Rodrigo Scarton Bergamin, Juliana Schietti, Jochen Schöngart, Gustavo Schwartz, Natalino Silva, Marcos Silveira, Cristiana SimĂŁo Seixas, Marta Simbine, Ana Claudia Souza, Priscila Souza, Rodolfo Souza, Tereza Sposito, Edson Stefani Junior, Julio Daniel do Vale, Ima CĂ©lia GuimarĂŁes Vieira, Dora Villela, Marcos Vital, Haron Xaud, Katia Zanini, Charles Eugene Zartman, Nur Khalish Hafizhah Ideris, Faizah binti Hj Metali, Kamariah Abu Salim, Muhd Shahruney Saparudin, Rafizah Mat Serudin, Rahayu Sukmaria Sukri, Serge Begne, George Chuyong, Marie Noel Djuikouo, Christelle Gonmadje, Murielle Simo-Droissart, Bonaventure SonkĂ©, Hermann Taedoumg, Lise Zemagho, Sean Thomas, FidĂšle Baya, Gustavo Saiz, Javier Silva Espejo, Dexiang Chen, Alan Hamilton, Yide Li, Tushou Luo, Shukui Niu, Han Xu, Zhang Zhou, Esteban Ălvarez-DĂĄvila, Juan Carlos AndrĂ©s Escobar, Henry Arellano-Peña, Jaime Cabezas Duarte, Jhon CalderĂłn, Lina Maria Corrales Bravo, Borish Cuadrado, Hermes Cuadros, Alvaro Duque, Luisa Fernanda Duque, Sandra Milena Espinosa, Rebeca Franke-Ante, Hernando GarcĂa, Alejandro GĂłmez, Roy GonzĂĄlez-M., Ălvaro IdĂĄrraga-PiedrahĂta, Eliana Jimenez, RubĂ©n Jurado, Wilmar LĂłpez Oviedo, RenĂ© LĂłpez-Camacho, Omar Aurelio Melo Cruz, Irina Mendoza Polo, Edwin Paky, Karen PĂ©rez, Angel Pijachi, Camila Pizano, Adriana Prieto, Laura Ramos, Zorayda Restrepo Correa, James Richardson, Elkin RodrĂguez, Gina M. Rodriguez M., AgustĂn Rudas, Pablo Stevenson, MarkĂ©ta ChudomelovĂĄ, Martin Dancak, Radim HĂ©dl, Stanislav Lhota, Martin Svatek, Jacques Mukinzi, Corneille Ewango, Terese Hart, Emmanuel Kasongo Yakusu, Janvier Lisingo, Jean-Remy Makana, Faustin Mbayu, Benjamin Toirambe, John Tshibamba Mukendi, Lars Kvist, Gustav Nebel, Selene BĂĄez, Carlos CĂ©ron, Daniel M. Griffith, Juan Ernesto Guevara Andino, David Neill, Walter Palacios, Maria Cristina Peñuela-Mora, Gonzalo Rivas-Torres, Gorky Villa, Sheleme Demissie, Tadesse Gole, Techane Gonfa, Kalle Ruokolainen, Michel Baisie, Fabrice BĂ©nĂ©det, Wemo Betian, Vincent Bezard, Damien Bonal, JerĂŽme Chave, Vincent Droissart, Sylvie Gourlet-Fleury, Annette Hladik, Nicolas LabriĂšre, PĂ©trus Naisso, Maxime RĂ©jou-MĂ©chain, Plinio Sist, Lilian Blanc, Benoit Burban, GĂ©raldine Derroire, AurĂ©lie Dourdain, Clement Stahl, Natacha Nssi Bengone, Eric Chezeaux, FidĂšle Evouna Ondo, Vincent Medjibe, Vianet Mihindou, Lee White, Heike Culmsee, Cristabel DurĂĄn Rangel, Viviana Horna, Florian Wittmann, Stephen Adu-Bredu, Kofi Affum-Baffoe, Ernest Foli, Michael Balinga, Anand Roopsind, James Singh, Raquel Thomas, Roderick Zagt, Indu K. Murthy, Kuswata Kartawinata, Edi Mirmanto, Hari Priyadi, Ismayadi Samsoedin, Terry Sunderland, Ishak Yassir, Francesco Rovero, Barbara Vinceti, Bruno HĂ©rault, Shin-Ichiro Aiba, Kanehiro Kitayama, Armandu Daniels, Darlington Tuagben, John T. Woods, Muhammad Fitriadi, Alexander Karolus, Kho Lip Khoon, Noreen Majalap, Colin Maycock, Reuben Nilus, Sylvester Tan, Almeida Sitoe, Indiana Coronado G., Lucas Ojo, Rafael de Assis, Axel Dalberg Poulsen, Douglas Sheil, Karen ArĂ©valo Pezo, Hans Buttgenbach Verde, Victor Chama Moscoso, Jimmy Cesar Cordova Oroche, Fernando Cornejo Valverde, Massiel Corrales Medina, Nallaret Davila Cardozo, Jano de Rutte Corzo, Jhon del Aguila Pasquel, Gerardo Flores Llampazo, Luis Freitas, Darcy Galiano Cabrera, Roosevelt GarcĂa Villacorta, Karina Garcia Cabrera, Diego GarcĂa Soria, Leticia Gatica Saboya, Julio Miguel Grandez Rios, Gabriel Hidalgo Pizango, EurĂdice Honorio Coronado, Isau Huamantupa-Chuquimaco, Walter Huaraca Huasco, Yuri Tomas Huillca Aedo, Jose Luis Marcelo Peña, Abel Monteagudo Mendoza, Vanesa Moreano Rodriguez, Percy NĂșñez Vargas, Sonia Cesarina Palacios Ramos, Nadir Pallqui Camacho, Antonio Peña Cruz, Freddy Ramirez Arevalo, JosĂ© Reyna Huaymacari, Carlos Reynel Rodriguez, Marcos Antonio RĂos Paredes, Lily Rodriguez Bayona, Rocio del Pilar Rojas Gonzales, Maria Elena Rojas Peña, Norma Salinas Revilla, Yahn Carlos Soto Shareva, Raul Tupayachi Trujillo, Luis Valenzuela Gamarra, Rodolfo Vasquez Martinez, Jim Vega Arenas, Christian Amani, Suspense Averti Ifo, Yannick Bocko, Patrick Boundja, Romeo Ekoungoulou, Mireille Hockemba, Donatien Nzala, Alusine Fofanah, David Taylor, Guillermo Bañares-de Dios, Luis Cayuela, Ăñigo Granzow-de la Cerda, Manuel MacĂa, Juliana Stropp, Maureen Playfair, Verginia Wortel, Toby Gardner, Robert Muscarella, Hari Priyadi, Ervan Rutishauser, Kuo-Jung Chao, Pantaleo Munishi, Olaf BĂĄnki, Frans Bongers, Rene Boot, Gabriella Fredriksson, Jan Reitsma, Hans ter Steege, Tinde van Andel, Peter van de Meer, Peter van der Hout, Mark van Nieuwstadt, Bert van Ulft, Elmar Veenendaal, Ronald Vernimmen, Pieter Zuidema, Joeri Zwerts, Perpetra Akite, Robert Bitariho, Colin Chapman, Eilu Gerald, Miguel Leal, Patrick Mucunguzi, Miguel Alexiades, Timothy R. Baker, Karina Banda, Lindsay Banin, Jos Barlow, Amy Bennett, Erika Berenguer, Nicholas Berry, Neil M. Bird, George A. Blackburn, Francis Brearley, Roel Brienen, David Burslem, Lidiany Carvalho, Percival Cho, Fernanda Coelho, Murray Collins, David Coomes, Aida Cuni-Sanchez, Greta Dargie, Kyle Dexter, Mat Disney, Freddie Draper, Muying Duan, Adriane Esquivel-Muelbert, Robert Ewers, Belen Fadrique, Sophie Fauset, Ted R. Feldpausch, Filipe França, David Galbraith, Martin Gilpin, Emanuel Gloor, John Grace, Keith Hamer, David Harris, Tommaso Jucker, Michelle Kalamandeen, Bente Klitgaard, Aurora Levesley, Simon L. Lewis, Jeremy Lindsell, Gabriela Lopez-Gonzalez, Jon Lovett, Yadvinder Malhi, Toby Marthews, Emma McIntosh, Karina Melgaço, William Milliken, Edward Mitchard, Peter Moonlight, Sam Moore, Alexandra Morel, Julie Peacock, Kelvin Peh, Colin Pendry, R. Toby Pennington, Luciana de Oliveira Pereira, Carlos Peres, Oliver L. Phillips, Georgia Pickavance, Thomas Pugh, Lan Qie, Terhi Riutta, Katherine Roucoux, Casey Ryan, Tiina Sarkinen, Camila Silva Valeria, Dominick Spracklen, Suzanne Stas, Martin Sullivan, Michael Swaine, Joey Talbot, James Taplin, Geertje van der Heijden, Laura Vedovato, Simon Willcock, Mathew Williams, Luciana Alves, Patricia Alvarez Loayza, Gabriel Arellano, Cheryl Asa, Peter Ashton, Gregory Asner, Terry Brncic, Foster Brown, Robyn Burnham, Connie Clark, James Comiskey, Gabriel Damasco, Stuart Davies, Tony Di Fiore, Terry Erwin, William Farfan-Rios, Jefferson Hall, David Kenfack, Thomas Lovejoy, Roberta Martin, Olga Martha Montiel, John Pipoly, Nigel Pitman, John Poulsen, Richard Primack, Miles Silman, Marc Steininger, Varun Swamy, John Terborgh, Duncan Thomas, Peter Umunay, Maria Uriarte, Emilio Vilanova Torre, Ophelia Wang, Kenneth Young, Gerardo A. Aymard C., Lionel HernĂĄndez, Rafael Herrera FernĂĄndez, Hirma RamĂrez-Angulo, Pedro Salcedo, Elio Sanoja, Julio Serrano, Armando Torres-Lezama, Tinh Cong Le, Trai Trong Le, Hieu Dang Tra
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
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