Reestructuración de procesos en la cadena de suministros de Agrosuper para la entrega de productos envasados de cerdos.

83 p.El presente proyecto se realizó en la empresa de alimentos Agrosuper, más específicamente sobre la gerencia de cadena de suministro; esto, con la finalidad de implementar una reestructuración en los procesos de abastecimiento en productos envasados frescos de cerdo en las zonas centro norte, centro y centro sur de Chile para así solucionar los problemas de rentabilidad que se presentan al abastecer a sus clientes objetivos bajo una estimación basada en una demanda con alta variabilidad. La primera etapa del desarrollo de este proyecto, luego de la descripción de objetivos, el respaldo teórico del proyecto y la metodología a utilizar, contempla la inserción y levantamiento de actividades en los procesos de negocio que esta gerencia tiene, es decir, formaliza las tareas del equipo de planificación comercial, el equipo de planificación industrial, la producción en planta y la distribución desde plantas productivas hasta los centros de abastecimiento a clientes para los productos cuyas características presentan como principal complejidad la vida útil al ser de origen orgánicos y llegar al cliente sin pasar por un proceso de congelado. Al tener consolidada la situación actual se realiza el análisis de la información, los tiempos asociados a los procesos involucrados en el abastecimiento del cliente, oportunidades, procesos, y tiempos en la entrega para, luego de esto, elaborar el diagnostico con el cual se identifica la principal causa y foco para diseñar la propuesta a implementar. La siguiente etapa consiste en el diseño de la nueva manera en la que se realizaran los procesos de negocio en la cadena de suministro, esto poniendo foco en las necesidades del cliente. Teniendo la propuesta diseñada se procede a planificar la implementación del proyecto teniendo en cuenta sus riesgos y definiendo etapas con sus debidas definiciones, se crean además herramientas de control para el seguimiento de la implementación y, durante la marcha, se rediseñan los procesos bajo metodologías agiles de implementación. El proyecto finaliza mostrando como evoluciono el proyecto con cada etapa de implementación, mostrando cual fue su impacto a nivel nacional en cuando a participación, que problemas se presentaron y que resultados entregaba, ya para concluir, muestra una evaluación del antes y después del proyecto, analizando los indicadores de negocio que se plantearon en la problemática y situación inicial para así poder cuantificar el impacto de esta implementación que, como se vera en este informe, entrego resultados positivos para el negocio. /ABSTRACT: This project was implemented in Agrosuper S.A., specifically in the Supply Chain Department, with the intention to restructure the supply processes of the fresh pig’s packing products, which are carried out in the central-north and central-south zone of Chile, in order to resolve profitability problems that are present when the customers must be provided, using the estimation based on a high variability demand. The first stage is the develop of the project, then the description of the goals, the theoretical support and the methodology, followed by the gathering of information about the activities on the business processes of this department: businesses, industrial and production planning works, in addition to the distribution activities for the products, which must be delivered to the customers without a freezing process, from the production plant to the supply centers and customers. After knowing the actual situation, an information analysis about the times associated with the processes involved in customer supply, and delivery schedule, is carried out in order to identify the main problems causes, to design an improvement proposal processes needed by it. The next stage, is the design of a new way to perform business processes by the supply chain, based on the customer needs. With the new proposal designed, it is proceed with the planning of the project implementation, considering their risk and defining their stages, in addition to design control tools to the monitoring of the implementation, and during the develop of it, there can be a redesign of the processes based on agile methods of implementation. Finally, the project demonstrate his evolution in every implementation stage, showing the project implementation impact in the company, the problems and the results obtained, concluding with the analysis of the business indicators, in order to quantify the implementation impact, which gives a positive result in the business context

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Observation of tW production in the single-lepton channel in pp collisions at root s=13 TeV

A measurement of the cross section of the associated production of a single top quark and a W boson in final states with a muon or electron and jets in proton-proton collisions at root s = 13 TeV is presented. The data correspond to an integrated luminosity of 36 fb(-1) collected with the CMS detector at the CERN LHC in 2016. A boosted decision tree is used to separate the tW signal from the dominant t (t) over bar background, whilst the subleading W+jets and multijet backgrounds are constrained using data-based estimates. This result is the first observation of the tW process in final states containing a muon or electron and jets, with a significance exceeding 5 standard deviations. The cross section is determined to be 89 +/- 4 (stat) +/- 12 (syst) pb, consistent with the standard model.Peer reviewe

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| &lt; 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of B-c(2S)(+) and B-c*(2S)(+) cross section ratios in proton-proton collisions at root s=13 TeV

Peer reviewe

Reconstruction of signal amplitudes in the CMS electromagnetic calorimeter in the presence of overlapping proton-proton interactions

A template fitting technique for reconstructing the amplitude of signals produced by the lead tungstate crystals of the CMS electromagnetic calorimeter is described. This novel approach is designed to suppress the contribution to the signal of the increased number of out-of-time interactions per beam crossing following the reduction of the accelerator bunch spacing from 50 to 25 ns at the start of Run 2 of the LHC. Execution of the algorithm is sufficiently fast for it to be employed in the CMS high-level trigger. It is also used in the offline event reconstruction. Results obtained from simulations and from Run 2 collision data (2015-2018) demonstrate a substantial improvement in the energy resolution of the calorimeter over a range of energies extending from a few GeV to several tens of GeV.Peer reviewe

Observation of the Production of Three Massive Gauge Bosons at root s=13 TeV

The first observation is reported of the combined production of three massive gauge bosons (VVV with V = W, Z) in proton-proton collisions at a center-of-mass energy of 13 TeV. The analysis is based on a data sample recorded by the CMS experiment at the CERN LHC corresponding to an integrated luminosity of 137 fb(-1). The searches for individualWWW, WWZ, WZZ, and ZZZ production are performed in final states with three, four, five, and six leptons (electrons or muons), or with two same-sign leptons plus one or two jets. The observed (expected) significance of the combinedVVV production signal is 5.7 (5.9) standard deviations and the corresponding measured cross section relative to the standard model prediction is 1.02(-0.23)(+0.26). The significances of the individual WWW and WWZ production are 3.3 and 3.4 standard deviations, respectively. Measured production cross sections for the individual triboson processes are also reported