Dynamics and numerical simulations to predict empirical antibiotic treatment of multi-resistant Pseudomonas aeruginosa infection

This work discloses an epidemiological mathematical model to predict an empirical treatment for dogs infected by Pseudomonas aeruginosa. This dangerous pathogen is one of the leading causes of multi-resistant infections and can be transmitted from dogs to humans. Numerical simulations and appropriated codes were developed using Matlab software to gather information concerning long-time dynamics of the susceptible, infected and recovered individuals. All data compiled from the mathematical model was used to provide an appropriated antibiotic sensitivity panel for this specific infection. In this study, several variables have been included in this model to predict which treatment should be prescribed in emergency cases, when there is no time to perform an antibiogram or the cost of it could not be assumed. In particular, we highlight the use of this model aiming to become part of the convenient toolbox of Public Health research and decision-making in the design of the mitigation strategy of bacterial pathogens

Tunable magnetocaloric effect around room temperature by Fe doping in Mn0.98Cr(0.02-x)FexAs compound

In this work, we present an investigation of the magnetic and magnetocaloric properties of Mn0.98Cr(0.02-x)FexAs compounds with x = 0.002, 0.005 and 0.010. Our findings show that as Fe content increases the unit cell volume decreases, which indicates that Fe doping emulates the pressure effect on the crystalline structure. The transition temperature TC decreases as x increases and it can be set at approximate value of room temperature by changing the doping level. In addition, the magnetic entropy change ΔSM was determined using a discontinuous measurement protocol, and realistic values from the magnetocaloric effect presented by MnAs-type compounds under pressure (emulated pressure) could be obtained. The values of ΔSMMAX are very large, around −11 Jkg−1K−1 with ΔH = 15 kOe, which is higher than that observed for most compounds with TC around room temperature. However, ΔSM is confined to a narrow temperature range of 11 K. To overcome this drawback, the composition of a theoretical composite formed by our samples was calculated in order to obtain a table-shaped ΔSM curve. The simulated composite showed a high value of full width at half maximum δTFWHM of 33 K, which is much higher than that of single sample.Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ E-26/110.393/2014, E-16/210.263/2014Coordenação de aperfeiçoamento de pessoal de nivel superior - CAPES 485200/2013-9Fundación de Apoyo a la Investigación del Estado de São Paulo - FAPESP 2012/03480-0Ministerio de Economía y Competitividad MAT2013-45165-

Effects of Ga substitution on the structural and magnetic properties of half metallic Fe2MnSi Heusler compound

FAPERJ - FUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIROFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOThe so-called half-metallic magnets have been proposed as good candidates for spintronic applications due to the feature of exhibiting a hundred percent spin polarization at the Fermi level. Such materials follow the Slater-Pauling rule, which relates the magnetic moment with the valence electrons in the system. In this paper, we study the bulk polycrystalline half-metallic Fe2MnSi Heusler compound replacing Si by Ga to determine how the Ga addition changes the magnetic, the structural, and the half-metal properties of this compound. The material does not follow the Slater-Pauling rule, probably due to a minor structural disorder degree in the system, but a linear dependence on the magnetic transition temperature with the valence electron number points to the half-metallic behavior of this compound.The so-called half-metallic magnets have been proposed as good candidates for spintronic applications due to the feature of exhibiting a hundred percent spin polarization at the Fermi level. Such materials follow the Slater-Pauling rule, which relates the magnetic moment with the valence electrons in the system. In this paper, we study the bulk polycrystalline half-metallic Fe2MnSi Heusler compound replacing Si by Ga to determine how the Ga addition changes the magnetic, the structural, and the half-metal properties of this compound. The material does not follow the Slater-Pauling rule, probably due to a minor structural disorder degree in the system, but a linear dependence on the magnetic transition temperature with the valence electron number points to the half-metallic behavior of this compound.117115FAPERJ - FUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIROFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOFAPERJ - FUNDAÇÃO CARLOS CHAGAS FILHO DE AMPARO À PESQUISA DO ESTADO DO RIO DE JANEIROFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOCAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOSem informaçãoSem informaçãoSem informaçãoSem informaçãoGraf, T., Felser, C., Parkin, S.S.P., (2011) Prog. Solid State Chem., 39, p. 1Hiroi, M., Yano, I., Sezaki, K., Shigeta, I., Ito, M., Manaka, H., Terada, N., (2012) J. Phys.: Conf. Ser., 400Hamad, B., Hu, Q.-M., (2011) Phys. Status Solidi B, 248, p. 2893Wurmehl, S., Fecher, G.H., Kandpal, H.C., Ksenofontov, V., Felser, C., Lin, H.-J., Morais, J., (2005) Phys. Rev. B, 72Galanakis, I., Dederichs, P.H., (2002) Phys. Rev. B, 66Kawakami, M., (1993) Physica B, 186-188, p. 1037Ersez, T., Etheridge, G.T., Hicks, T.J., (1998) J. Magn. Magn. Mater., 177-181, p. 1351Kudryavtsev, Y.V., Uvarov, N.V., Iermolenko, V.N., Glavatskyy, I.N., Dubowik, J., (2012) Acta Mater., 60, p. 4780Zhang, L., Brück, E., Tegus, O., Buschow, K.H.J., De Boer, F.R., (2003) Physica B, 328, p. 295Vegard, L., (1921) Z. Phys., 5, p. 17Du, Y., Xu, G.Z., Zhang, X.M., Liu, Z.Y., Yu, S.Y., Liu, E.K., Wang, W.H., Wu, G.H., (2013) Europhys. Lett., 103, p. 37011Hongzhi, L., Zhiyong, Z., Li, M., Shifeng, X., Heyan, L., Jingping, Q., Yangxian, L., Guangheng, W., (2007) J. Phys. D: Appl. Phys., 40, p. 7121Umetsu, R.Y., Okubo, A., Xu, X., Kainuma, R., (2014) J. Alloys Compd., 588, p. 153Fecher, G.H., Kandpal, H.C., Wurmehl, S., Felser, C., Schönhense, G., (2006) J. Appl. Phys., 99Du, Y., Xu, G.Z., Liu, E.K., Li, G.J., Zhang, H.G., Yu, S.Y., Wang, W.H., Wu, G.H., (2013) J. Magn. Magn. Mater., 335, p. 101Hamad, B., Charifi, Z., Baaziz, H., Soyalp, F., (2012) J. Magn. Magn. Mater., 324, p. 3345Graf, T.S., Parkin, S.S.P., Felser, C., (2011) IEEE Trans. Magn., 47, p. 367Nakatani, T.M., Rajanikanth, A., Gercsi, Z., Takahashi, Y.K., Inomata, K., Hono, K., (2007) J. Appl. Phys., 102Access to Laboratório de Caracterização de Materiais at IF-Sudeste MG (Juiz de Fora, Brazil), Laboratório de Difração de Raios-X at IF - UFF (Niterói, Brazil), and Laboratório de Baixas Temperaturas at UNICAMP (Campinas, Brazil) is gratefully acknowledged by all authors. The authors also acknowledge FAPERJ, FAPESP, CAPES, CNPq, and PROPPI-UFF for financial support

Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio

ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.Peer reviewe