665 research outputs found
Selenotriapine â An isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors
Triapine, the most studied α-N-heterocyclic thiosemicarbazone, revealed potent activity against advanced leukemia, but was ineffective against a variety of solid tumors. Moreover, methemoglobinemia, which is a side effect of triapine administration, may limits all clinical application. To enhance anticancer activity and reduce side effects, we applied an isosteric replacement of sulfur to selenium atom was performed by synthesis and characterization of selenium triapine analog, 3-aminopyridine-2-carboxaldehyde selenosemicarbazone (selenotriapine). Compared to triapine, selenotriapine revealed superior pro-apoptotic activity with activation of intrinsic apoptotic pathway in both human monocytic leukemia (THP-1) and mammary adenocarcinoma (MCF-7) cell lines. For MCF-7 2-D cultures, selenotriapine induced notable increase in mitochondrial superoxide radical generation and dissipation of mitochondrial transmembrane potential. A significant delay in growth of MCF-7 spheroids (3-D culture) was accompanied by phenotypic stem cell reprogramming (Oct-4 expression). Additionally, selenotriapine demonstrated a very low toxicity profile as compared to triapine, confirmed over alleviated extent of methemoglobin formation and higher IC50 value in brine shrimp cytotoxicity assay
Ageing and cognition in men with fragile X syndrome
Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing-related cognitive changes in men with FXS. Method A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years. Results At follow-up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p <.001). Conclusion Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.Peer reviewe
Measurement of pion, kaon and proton production in proton-proton collisions at TeV
The measurement of primary , K, p and
production at mid-rapidity ( 0.5) in proton-proton collisions at
TeV performed with ALICE (A Large Ion Collider Experiment) at
the Large Hadron Collider (LHC) is reported. Particle identification is
performed using the specific ionization energy loss and time-of-flight
information, the ring-imaging Cherenkov technique and the kink-topology
identification of weak decays of charged kaons. Transverse momentum spectra are
measured from 0.1 up to 3 GeV/ for pions, from 0.2 up to 6 GeV/ for kaons
and from 0.3 up to 6 GeV/ for protons. The measured spectra and particle
ratios are compared with QCD-inspired models, tuned to reproduce also the
earlier measurements performed at the LHC. Furthermore, the integrated particle
yields and ratios as well as the average transverse momenta are compared with
results at lower collision energies.Comment: 33 pages, 19 captioned figures, 3 tables, authors from page 28,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/156
Measurement of an excess in the yield of J/ at very low in Pb-Pb collisions at = 2.76 TeV
We report on the first measurement of an excess in the yield of J/ at
very low transverse momentum ( GeV/) in peripheral hadronic
Pb-Pb collisions at = 2.76 TeV, performed by ALICE at the
CERN LHC. Remarkably, the measured nuclear modification factor of J/ in
the rapidity range reaches about 7 (2) in the range 0-0.3
GeV/ in the 70-90% (50-70%) centrality class. The J/ production cross
section associated with the observed excess is obtained under the hypothesis
that coherent photoproduction of J/ is the underlying physics mechanism.
If confirmed, the observation of J/ coherent photoproduction in Pb-Pb
collisions at impact parameters smaller than twice the nuclear radius opens new
theoretical and experimental challenges and opportunities. In particular,
coherent photoproduction accompanying hadronic collisions may provide insight
into the dynamics of photoproduction and nuclear reactions, as well as become a
novel probe of the Quark-Gluon Plasma.Comment: 18 pages, 3 captioned figures, 1 table, authors from page 13,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/191
Đ ĐŸĐ·ĐČĐžŃĐŸĐș ŃĐŽĐ”Ń ŃĐČŃĐŸĐżĐ”ĐčŃŃĐșĐŸŃ ŃĐœŃДгŃĐ°ŃŃŃ ŃĐ° ŃŃ Đ·ĐœĐ°ŃĐ”ĐœĐœŃ ĐŽĐ»Ń ĐŁĐșŃĐ°ŃĐœĐž
ĐŁ ŃŃĐ°ŃŃŃ Đ°ĐœĐ°Đ»ŃĐ·ŃŃŃŃŃŃ ŃŃŃĐœŃŃŃŃ ŃĐŽĐ”Ń ŃĐČŃĐŸĐżĐ”ĐčŃŃĐșĐŸŃ ŃĐœŃДгŃĐ°ŃŃŃ,
ŃŃ Đ”ĐČĐŸĐ»ŃŃŃŃ ĐżŃĐŸŃŃĐłĐŸĐŒ ŃŃĐŸĐ»ŃŃŃ. ĐĐŸŃĐ»ŃЎжŃŃŃŃŃŃ ŃĐ”ĐŸŃĐ”ŃĐžŃĐœŃ ĐŸŃĐœĐŸĐČĐž
ŃĐŸŃĐŒŃĐČĐ°ĐœĐœŃ ŃĐ° ŃĐŸĐ·ĐČĐžŃĐșŃ ĐĐČŃĐŸĐżĐ”ĐčŃŃĐșĐŸĐłĐŸ ĐĄĐŸŃĐ·Ń, ĐŸĐ±ÒŃŃĐœŃĐŸĐČŃŃŃŃŃŃ
ĐœĐ”ĐŸĐ±Ń
ŃĐŽĐœŃŃŃŃ ŃĐČŃĐŸŃĐœŃДгŃĐ°ŃŃĐčĐœĐŸŃ ŃŃŃĐ°ŃДгŃŃ ĐŁĐșŃĐ°ŃĐœĐž ŃĐș ĐșĐ»ŃŃĐŸĐČĐŸĐłĐŸ
ĐżŃŃĐŸŃĐžŃĐ”ŃŃ Đ·ĐŸĐČĐœŃŃĐœŃĐŸŃ ŃĐ° ĐČĐœŃŃŃŃŃĐœŃĐŸŃ ĐżĐŸĐ»ŃŃĐžĐșĐž ĐœĐ°ŃĐŸŃ ĐŽĐ”ŃжаĐČĐž.The article analyses the essence of the idea of European integration,
its evolution during the centuries and researches the theoretical
foundations of the formation and development of the European Union,
proves the need for European integration strategy of Ukraine as a key
priority of foreign and internal policy
Đ€ŃĐœĐșŃĐžĐŸĐœĐ°Đ»ŃĐœŃĐ” ĐŸŃĐŸĐ±Đ”ĐœĐœĐŸŃŃĐž ŃĐ»ĐŸĐČĐŸĐŸĐ±ŃĐ°Đ·ĐŸĐČĐ°ŃДлŃĐœŃŃ ŃĐžĐœĐŸĐœĐžĐŒĐŸĐČ ŃĐŸĐČŃĐ”ĐŒĐ”ĐœĐœĐŸĐłĐŸ ĐœĐ”ĐŒĐ”ŃĐșĐŸĐłĐŸ ŃĐ·ŃĐșĐ°
ĐĄŃĐ°ŃŃŃ ĐžĐ· ŃпДŃОалОзОŃĐŸĐČĐ°ĐœĐœĐŸĐłĐŸ ĐČŃĐżŃŃĐșĐ° ĐœĐ°ŃŃĐœĐŸĐłĐŸ жŃŃĐœĐ°Đ»Đ° "ĐŃĐ»ŃŃŃŃĐ° ĐœĐ°ŃĐŸĐŽĐŸĐČ ĐŃĐžŃĐ”ŃĐœĐŸĐŒĐŸŃŃŃ", ĐŒĐ°ŃĐ”ŃĐžĐ°Đ»Ń ĐșĐŸŃĐŸŃĐŸĐłĐŸ ĐŸĐ±ŃĐ”ĐŽĐžĐœĐ”ĐœŃ ĐŸĐ±ŃĐ”Đč ŃĐ”ĐŒĐŸĐč "ĐŻĐ·ŃĐș Đž ĐĐžŃ" Đž ĐżĐŸŃĐČŃŃĐ”ĐœŃ ĐŸĐ±ŃĐžĐŒ ĐČĐŸĐżŃĐŸŃĐ°ĐŒ ĐŻĐ·ŃĐșĐŸĐ·ĐœĐ°ĐœĐžŃ Đž ĐżŃĐžŃŃĐŸŃĐ”ĐœŃ Đș 80-лДŃĐžŃ ŃĐŸ ĐŽĐœŃ ŃĐŸĐ¶ĐŽĐ”ĐœĐžŃ ĐĐžĐșĐŸĐ»Đ°Ń ĐлДĐșŃĐ°ĐœĐŽŃĐŸĐČĐžŃĐ° Đ ŃĐŽŃĐșĐŸĐČĐ°.ĐĄŃĐ°ŃŃŃ ŃĐ· ŃпДŃŃĐ°Đ»ŃĐ·ĐŸĐČĐ°ĐœĐŸĐłĐŸ ĐČОпŃŃĐșŃ ĐœĐ°ŃĐșĐŸĐČĐŸĐłĐŸ жŃŃĐœĐ°Đ»Ń "ĐŃĐ»ŃŃŃŃĐ° ĐœĐ°ŃĐŸĐŽĐŸĐČ ĐŃĐžŃĐ”ŃĐœĐŸĐŒĐŸŃŃŃ", ĐŒĐ°ŃĐ”ŃŃалО ŃĐșĐŸĐłĐŸ ĐżĐŸŃĐŽĐœĐ°ĐœŃ Đ·Đ°ĐłĐ°Đ»ŃĐœĐŸŃ ŃĐ”ĐŒĐŸŃ "ĐĐŸĐČĐ° Ń ĐĄĐČŃŃ" Ń ĐżŃĐžŃĐČŃŃĐ”ĐœŃ Đ·Đ°ĐłĐ°Đ»ŃĐœĐžĐŒ пОŃĐ°ĐœĐœŃĐŒ ĐŒĐŸĐČĐŸĐ·ĐœĐ°ĐČŃŃĐČĐ° Ń ĐżŃĐžŃŃĐŸŃĐ”ĐœŃ ĐŽĐŸ 80-ŃŃŃŃŃ Đ· ĐŽĐœŃ ĐœĐ°ŃĐŸĐŽĐ¶Đ”ĐœĐœŃ ĐĐžĐșĐŸĐ»Đž ĐлДĐșŃĐ°ĐœĐŽŃĐŸĐČĐžŃĐ° Đ ŃĐŽŃĐșĐŸĐČĐ°
ĐĄŃĐ°ĐČĐœĐžŃДлŃĐœŃĐ” ŃДзŃĐ»ŃŃĐ°ŃŃ Ń ĐžŃŃŃгОŃĐ”ŃĐșĐŸĐłĐŸ Đž ĐșĐŸĐŒĐ±ĐžĐœĐžŃĐŸĐČĐ°ĐœĐœĐŸĐłĐŸ лДŃĐ”ĐœĐžŃ Đ±ĐŸĐ»ŃĐœŃŃ ŃĐ°ĐșĐŸĐŒ пОŃĐ”ĐČĐŸĐŽĐ°
РДзŃĐŒĐ”. ĐŃДЎŃŃĐ°ĐČĐ»Đ”ĐœŃ ĐœĐ”ĐżĐŸŃŃДЎŃŃĐČĐ”ĐœĐœŃĐ” Đž ĐŸŃĐŽĐ°Đ»Đ”ĐœĐœŃĐ” ŃДзŃĐ»ŃŃĐ°ŃŃ Đ»Đ”ŃĐ”ĐœĐžŃ 167 Đ±ĐŸĐ»ŃĐœŃŃ
ŃĐ°ĐșĐŸĐŒ пОŃĐ”ĐČĐŸĐŽĐ°. ĐĐŸĐŒĐ±ĐžĐœĐžŃĐŸĐČĐ°ĐœĐœĐŸĐ” лДŃĐ”ĐœĐžĐ” Ń ĐžŃĐżĐŸĐ»ŃĐ·ĐŸĐČĐ°ĐœĐžĐ”ĐŒ ĐżŃĐ”ĐŽĐŸĐżĐ”ŃĐ°ŃĐžĐŸĐœĐœĐŸĐč ĐłĐ°ĐŒĐŒĐ°-ŃĐ”ŃапОО ĐșŃŃĐżĐœŃĐŒĐž ŃŃĐ°ĐșŃĐžŃĐŒĐž бŃĐ»ĐŸ ĐżŃĐŸĐČĐ”ĐŽĐ”ĐœĐŸ 95 паŃĐžĐ”ĐœŃĐ°ĐŒ, Ń
ĐžŃŃŃгОŃĐ”ŃĐșĐŸĐ” â 72. ĐŃĐŒĐ”ŃĐ”ĐœĐŸ, ŃŃĐŸ ĐżŃĐ”ĐŽĐŸĐżĐ”ŃĐ°ŃĐžĐŸĐœĐœĐŸĐ” ĐŸĐ±Đ»ŃŃĐ”ĐœĐžĐ” ĐœĐ” ŃĐŸĐżŃĐŸĐČĐŸĐ¶ĐŽĐ°Đ»ĐŸŃŃ ŃĐČДлОŃĐ”ĐœĐžĐ”ĐŒ ŃĐ°ŃŃĐŸŃŃ ĐżĐŸŃĐ»Đ”ĐŸĐżĐ”ŃĐ°ŃĐžĐŸĐœĐœŃŃ
ĐŸŃĐ»ĐŸĐ¶ĐœĐ”ĐœĐžĐč, ĐœĐŸ Đž ĐœĐ” ŃĐżĐŸŃĐŸĐ±ŃŃĐČĐŸĐČĐ°Đ»ĐŸ ŃĐ»ŃŃŃĐ”ĐœĐžŃ ĐŸŃĐŽĐ°Đ»Đ”ĐœĐœŃŃ
ŃДзŃĐ»ŃŃĐ°ŃĐŸĐČ ĐŸĐżĐ”ŃĐ°ŃĐžĐč.
ĐĐ»ŃŃĐ”ĐČŃĐ” ŃĐ»ĐŸĐČĐ°: ŃĐ°Đș пОŃĐ”ĐČĐŸĐŽĐ°, ĐșĐŸĐŒĐ±ĐžĐœĐžŃĐŸĐČĐ°ĐœĐœĐŸĐ” лДŃĐ”ĐœĐžĐ”, Ń
ĐžŃŃŃгОŃĐ”ŃĐșĐŸĐ” лДŃĐ”ĐœĐžĐ”.Summary. Immediate and remote results of the treatment of 167 patients with esophagus cancer are reported. Combined treatment with pre-surgery large-fraction gamma-therapy was applied in 95 patients; 72 patients were operated without pre-surgery radiation treatment. Pre-surgery irradiation is shown to cause no increase in the frequency of post-operation complications. At the same time, it failed to improve the remote results of surgery.
Key Words: esophagus cancer, combined treatment, surgery
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider
Measurements of multi-particle azimuthal correlations (cumulants) for charged
particles in p-Pb and Pb-Pb collisions are presented. They help address the
question of whether there is evidence for global, flow-like, azimuthal
correlations in the p-Pb system. Comparisons are made to measurements from the
larger Pb-Pb system, where such evidence is established. In particular, the
second harmonic two-particle cumulants are found to decrease with multiplicity,
characteristic of a dominance of few-particle correlations in p-Pb collisions.
However, when a gap is placed to suppress such correlations,
the two-particle cumulants begin to rise at high-multiplicity, indicating the
presence of global azimuthal correlations. The Pb-Pb values are higher than the
p-Pb values at similar multiplicities. In both systems, the second harmonic
four-particle cumulants exhibit a transition from positive to negative values
when the multiplicity increases. The negative values allow for a measurement of
to be made, which is found to be higher in Pb-Pb collisions at
similar multiplicities. The second harmonic six-particle cumulants are also
found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find
which is indicative of a Bessel-Gaussian
function for the distribution. For very high-multiplicity Pb-Pb
collisions, we observe that the four- and six-particle cumulants become
consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and
Pb-Pb are measured. These are found to be similar for overlapping
multiplicities, when a gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20,
published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87
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