33 research outputs found
LesĂľes histolĂłgicas no sistema nervoso central de cĂŁes com encefalite e diagnĂłstico molecular da infecção pelo vĂrus da cinomose canina
Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach
The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multi-center collaborative consortium established to develop a translational research infrastructure for Nephrotic Syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary studies program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis and membranous nephropathy for detailed clinical, histopathologic, and molecular phenotyping at the time of clinically-indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and bi-annually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histologic data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for Nephrotic Syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies
Studies of jet quenching using isolated-photon + jet correlations in PbPb and pp collisions at sqrt(s[NN]) = 2.76 TeV
Results from the first study of isolated-photon + jet correlations in
relativistic heavy ion collisions are reported. The analysis uses data from
PbPb collisions at a centre-of-mass energy of 2.76 TeV per nucleon pair
corresponding to an integrated luminosity of 150 inverse microbarns recorded by
the CMS experiment at the LHC. For events containing an isolated photon with
transverse momentum pt(gamma) > 60 GeV and an associated jet with pt(Jet) > 30
GeV, the photon + jet pt imbalance is studied as a function of collision
centrality and compared to pp data and PYTHIA calculations at the same
collision energy. Using the pt(gamma) of the isolated photon as an estimate of
the momentum of the associated parton at production, this measurement allows an
unbiased characterisation of the in-medium parton energy loss. For more central
PbPb collisions, a significant decrease in the ratio pt(Jet)/pt(gamma) relative
to that in the PYTHIA reference is observed. Furthermore, significantly more
pt(gamma) > 60 GeV photons in PbPb are observed not to have an associated
pt(Jet) > 30 GeV jet, compared to the reference. However, no significant
broadening of the photon + jet azimuthal correlation is observed.Comment: Submitted to Physics Letters