Validación del Cuestionario de Salud General de Goldberg (versión 28 ítems) en consultas de Atención Primaria.

Se realiza un estudio para medir la validez del cuestionario GHQ-28 de Goldberg, comparándolo con la entrevista psiquiátrica estructurada PSE-ID, 9ª edición. Se expone el método utilizado en la selección de 150 pacientes de ambos sexos, todos provenientes de consultas de Atención Primaria, para la entrevista psiquiátrica de validación. Se analiza el cuestionario en tres órdenes: como test de "screening", como detector de morbilidad psiquiátrica real y como indicador de severidad clínica. Tras comparar los resultados con otros trabajos similares, se concluye con algunas recomendaciones para el uso del GHQ-28

Validación del Cuestionario de Salud General de Goldberg (versión 28 ítems) en consultas de Atención Primaria.

Se realiza un estudio para medir la validez del cuestionario GHQ-28 de Goldberg, comparándolo con la entrevista psiquiátrica estructurada PSE-ID, 9ª edición. Se expone el método utilizado en la selección de 150 pacientes de ambos sexos, todos provenientes de consultas de Atención Primaria, para la entrevista psiquiátrica de validación. Se analiza el cuestionario en tres órdenes: como test de "screening", como detector de morbilidad psiquiátrica real y como indicador de severidad clínica. Tras comparar los resultados con otros trabajos similares, se concluye con algunas recomendaciones para el uso del GHQ-28

Validación del Cuestionario de Salud General de Goldberg (versión 28 ítems) en consultas de Atención Primaria.

Se realiza un estudio para medir la validez del cuestionario GHQ-28 de Goldberg, comparándolo con la entrevista psiquiátrica estructurada PSE-ID, 9ª edición. Se expone el método utilizado en la selección de 150 pacientes de ambos sexos, todos provenientes de consultas de Atención Primaria, para la entrevista psiquiátrica de validación. Se analiza el cuestionario en tres órdenes: como test de "screening", como detector de morbilidad psiquiátrica real y como indicador de severidad clínica. Tras comparar los resultados con otros trabajos similares, se concluye con algunas recomendaciones para el uso del GHQ-28

Higher Education as modulator of gender inequalities: Evidence of the Spanish case

Raising educational levels may help to reduce inequalities between men and women in certain social and economic aspects. Using statistics for Spain, we analyse labour market behaviours such as the rates of activity and unemployment by sex according to the educational level. The results reveal that the differences between men and women decrease as the educational level increases. In particular, the modulator effect of education is very important at the higher level, where differences in labour market behaviour between men and women with an university education almost disappear, except in terms of salaries. Nevertheless, it can be seen that the current economic crisis has reduced the modulator role of education in gender differences in Spain

The decisions of Spanish youth : a cross-section study

The original publication is available at www.springerlink.comThis paper presents a simultaneous model for the joint decisions of working, studying and leaving the parental household by young people in Spain. Using cross-section data from the 1990–1991 Encuesta de Presupuestos Familiares, the model is estimated by a two stage estimation method. Endogeneity of the three decisions proves to be important in order to understand the dynamics of household formation. Our results also confirm a number of plausible intuitions about the effect of individual characteristics and economic variables on these decisions, and provide some new insights into the reasons for young people in Spain remaining in large numbers in the parental home. Most of the results are gender independent.Publicad

Nano-enabled bioanalytical approaches to ultrasensitive detection of low abundance single nucleotide polymorphisms

Single nucleotide polymorphisms (SNPs) constitute the most common types of genetic variations in the human genome. A number of SNPs have been linked to the development of life threatening diseases including cancer, cardiovascular diseases and neurodegenerative diseases. The ability for ultrasensitive and accurate detection of low abundant disease-related SNPs in bodily fluids (e.g. blood, serum, etc.) holds a significant value in the development of non-invasive future biodiagnostic tools. Over the past two decades, nanomaterials have been utilized in a myriad of biosensing applications due to their ability of detecting extremely low quantities of biologically important biomarkers with high sensitivity and accuracy. Of particular interest is the application of such technologies in the detection of SNPs. The use of various nanomaterials, coupled with different powerful signal amplification strategies, has paved the way for a new generation of ultrasensitive SNP biodiagnostic assays. Over the past few years, several ultrasensitive SNP biosensors capable of detecting specific targets down to the ultra-low regimes (ca. aM and below) and therefore holding great promises for early clinical diagnosis of diseases have been developed. This mini review will highlight some of the most recent, significant advances in nanomaterial-based ultrasensitive SNP sensing technologies capable of detecting specific targets on the attomolar (10-18 M) regime or below. In particular, the design of novel, powerful signal amplification strategies that hold the key to the ultrasensitivity is highlighted

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

Pharmaceuticals, and more recently biopharmaceuticals, have become the mainstay for antineoplastic treatments in combination with surgical interventions and radiation therapy. In recent years, advances have been made in the development of nano-technological interventions for the treatment of cancer alone or in combination with existing therapeutic modalities. Nanotechnology used for therapeutic drug delivery and sensitization of photodynamic, sonodynamic and radiotherapy are now being tested in preclinical and clinical trials for the treatment of cancer. This article will review the current state of the art for nanotechnology therapies with an emphasis on targeted drug delivery and the observed and likely benefits when used in combination with existing therapeutic approaches

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis

The authors would like to thank members of OBD Reference Facility Benjamin Foulkes, Chloe Bird, Emily Corfeld and Matthew Salter for expedient processing of clinical samples on the EpiSwitch™ platform and Magdalena Jeznach and Willem Westra for help with preparation of the manuscript. The study employed samples from the SERA Biobank used with permission and approval of the SERA Approval Group. We gratefully acknowledge the invaluable contribution of the clinicians and operating team in SERA. We would also like to thank Prof. Raju Kucherlapati (Harvard Medical School), and Prof. Jane Mellor (Oxford Univ.), Prof. John O’Shea (National Institute of Health) and Prof. John Isaacs (New Castle Univ.) for their independent and critical review of our study. A list of Scottish Early Rheumatoid Arthritis (SERA) inception cohort investigators is provided in Additional fle 1: Additional Note. Funding This work was funded by Oxford BioDynamics.Peer reviewedPublisher PD