A preval?ncia do negociado sobre o legislado: uma altera??o trazida pela reforma trabalhista (lei n? 13.467, de 13 de julho de 2017)

O presente artigo visa demonstrar o impacto da lei n? 13.467, de 13 de julho de 2017, a qual ficou popularmente conhecida como reforma trabalhista, mais especificadamente no tocante a preval?ncia do negociado sobre o legislado, utilizando-se de m?todo dial?tico para se analisar posi??es doutrinarias a respeito do estudo delimitado, e ainda, o m?todo sistem?tico e indutivo, com o estudo do panorama nacional brasileiro, buscando a compreens?o de textos legais, doutrinas, jurisprud?ncias e demais legisla??es, para se propor uma solu??o/recomenda??o para a aplicabilidade do instituto ora estudado. O desenvolvimento foi com a inten??o de evidenciar o hist?rico de transforma??o do direito do trabalho, o qual ao longo do tempo vem sofrendo flexibiliza??o em sua aplica??o. Demonstrando que o negociado prevalecendo sobre o legislado, ? uma consequ?ncia necess?ria para o direito do trabalho, uma vez que as rela??es do trabalho se encontram fragilizadas, e um dos prim?rdios do direito do trabalho ? proteger exatamente a rela??o de trabalho, e n?o uma determinada classe. A pesquisa constatou que o novo artigo 611-A da consolida??o das leis do trabalho, buscou flexibilizar e ao mesmo tempo regulamentar as condi??es do trabalho, com a devida observ?ncia dos limites impostos pela pr?pria lei, permitindo que a rela??o de trabalho se torne o mais pr?ximo da realidade vivenciada. Concluindo que nos casos em que uma parte buscar uma vantagem excessiva em detrimento da outra, caber? ao judici?rio proteger o direito observando sempre a analogia, os costumes e os princ?pios gerais do direito

The influence of (central) auditory processing disorder on the severity of speech-sound disorders in children

OBJECTIVE: To identify a cutoff value based on the Percentage of Consonants Correct-Revised index that could indicate the likelihood of a child with a speech-sound disorder also having a (central) auditory processing disorder . METHODS: Language, audiological and (central) auditory processing evaluations were administered. The participants were 27 subjects with speech-sound disorders aged 7 to 10 years and 11 months who were divided into two different groups according to their (central) auditory processing evaluation results. RESULTS: When a (central) auditory processing disorder was present in association with a speech disorder, the children tended to have lower scores on phonological assessments. A greater severity of speech disorder was related to a greater probability of the child having a (central) auditory processing disorder. The use of a cutoff value for the Percentage of Consonants Correct-Revised index successfully distinguished between children with and without a (central) auditory processing disorder. CONCLUSIONS: The severity of speech-sound disorder in children was influenced by the presence of (central) auditory processing disorder. The attempt to identify a cutoff value based on a severity index was successful

Mielite granulomatosa associada à síndrome hemorrágica devido ao consumo de Vicia villosa em um bovino

An unusual case of spontaneous Vicia villosa poisoning affected a 6-year-old Holstein cow. Although the most striking findings included a generalized hemorrhagic condition associated with granulomatous myelitis, histological lesions typically seen with the vetch-associated systemic granulomatous syndrome were also present. Prominent gross findings were bloody nasal and oral discharges, disseminated hemorrhages, and bloody feces. Generalized hemorrhages associated with infiltration of numerous organs by lymphocytes, plasma cells, macrophages, multinucleated giants cells, and eosinophils were the main microscopic findings. Anti-CD68 immunostaining confirmed the presence of moderate histiocytic infiltrate and multinucleated giant cells in the bone marrow. These changes in the bone marrow probably caused the generalized hemorrhagic changes described here. __________________________________________________________________________________________ ABSTRACTUm bovino Holandês de seis anos naturalmente intoxicado pela Vicia villosa apresentou lesões não comumente encontradas nessa intoxicação. Embora a lesão mais evidente fosse hemorragia generalizada associada à mielite granulomatosa, as lesões granulomatosas típicas da intoxicação pela ervilhaca também estavam presentes histologicamente. Os principais achados macroscópicos foram hemorragias nasal e oral, hemorragias generalizadas e fezes com sangue. Lesões hemorrágicas generalizadas associadas com infiltrado inflamatório de linfócitos, plasmócitos, macrófagos, células gigantes multinucleadas e eosinófilos foram os principais achados microscópicos encontrados. O teste imuno-histoquímico anti-CD68 confirmou a presença de infiltrado moderado de macrófagos e de células gigantes multinucleadas na medula óssea. As alterações na medula óssea provavelmente constituem a causa da hemorragia generalizada descrita nesse caso

Co-infecção por circovírus suíno tipo 2 e parvovírus suíno em fetos abortados e natimortos suínos no Sul do Brasil

Estudou-se retrospectivamente (2005-2007) a associação de casos de abortos e natimortos suínos com infecções por circovírus suíno (PCV) tipos 1 e 2 e parvovírus suíno (PPV). Outros agentes patogênicos foram pesquisados em amostras de fetos com lesões. O estudo incluiu natimortos e fetos mumificados de tamanhos variados. Dilatação ventricular, áreas pálidas miocárdicas e edema de mesocólon foram as lesões macroscópicas observadas. Escherichia coli coinfectou com PCV2 as amostras dos casos com edema de mesocólon. Lesões microscópicas incluíram miocardite não supurativa, necrose e fibrose miocárdicas, focos de mineralização e corpúsculos de inclusão em cardiomiócitos e pneumonia intersticial mononuclear. Entre os 121 fetos suínos abortados ou natimortos analisados, sete (5,78%) tinham lesões compatíveis com origem viral e foram positivos pelas técnicas de imunoistoquímica e PCR para PCV2. Além disso, três (2.47%) desses sete casos também foram confirmados como co-infectados com PPV através da PCR. Antígenos de PCV2 foram observados principalmente em macrógafos e no interior de miócitos dos fetos suínos abortados e natimortos. PCV2 e PPV foram detectados em diferentes estágios de gestação. PCV1 não foi associado isoladamente com feto ou natimorto afetado, mas estava presente em associação com PCV2 e/ou PPV em alguns desses produtos. Esses achados indicam que a infecção por PCV2, isoladamente ou em associação com PPV, deve ser considerada no diagnóstico de aborto infeccioso suíno no Brasil. __________________________________________________________________________________________ ABSTRACTPorcine circovirus types 1 and 2 (PCV1, PCV2) and porcine parvovirus (PPV) are widespread in pig populations around the world. Nevertheless, only PCV2 has been associated with different clinical syndromes, thus representing a major problem to the pig industry. The association of cases of swine abortions and stillborns with PCV1 and PCV2 and PPV was studied retrospectively (2005-2007). Additional pathogens were also investigated in lesioned fetuses. The studied litters included stillborn piglets and several mummified fetuses of varied sizes. Ventricular dilatation, myocardial pale areas, and mesocolic edema were the gross lesions. Escherichia coli was detected as co-infecting with PCV2 the cases in which mesocolic edema was seen. Microscopic lesions included non-suppurative myocarditis, myocardial necrosis and fibrosis, mineralization foci and intranuclear inclusion bodies in cardiomyocytes, and interstitial mononuclear pneumonia. Samples from 7 (5.78 per cent) of 121 aborted fetuses and stillborn piglets had lesions consistent with a viral cause and showed both positive anti-PCV2 immunostaining as well as PCV2-PCR. In samples from 3 (2.47 per cent) of these 7 fetuses, coinfection with PPV was confirmed by Nested-PCR. Both viruses were detected in fetuses at different stages of gestation. Viral antigens of PCV2 were detected by immunohistochemistry mainly in macrophages and myocytes. PCV1 individually was not detected in any of these affected fetuses, but it was associated with PCV2 and/or PPV in some of them. These findings indicate that PCV2 alone or in association with PPV should be kept in mind when investigating causes of infectious abortion in pigs in Brazil

MENOPAUSA E CÂNCER DE MAMA: RISCOS E PREVENÇÃO

The menopause is a natural period in women's lives, marked by the cessation of menstruation and significant hormonal changes. However, this stage is also associated with an increased risk of breast cancer. This study aims to analyze the risk factors for breast cancer during the menopause and propose effective prevention measures. To achieve this objective, a systematic review of the literature was carried out, including epidemiological studies, clinical trials and recent reviews. Data related to age at menopause, hormone therapy, family history and lifestyle habits were analyzed. In addition, prevention strategies were identified, such as weight control, regular physical activity, healthy eating and mammography screening. The menopause is a critical period for women's health, with increased risks of breast cancer due to hormonal changes. However, awareness and the adoption of preventive measures can significantly reduce this risk. Weight control, physical activity and a balanced diet play essential roles in prevention. In addition, regular mammographic screening in women in the appropriate age group is essential for the early detection of breast cancer.A menopausa é um período natural na vida das mulheres, marcado pela cessação da menstruação e mudanças hormonais significativas. No entanto, esse estágio também está associado a um aumento do risco de câncer de mama. Este estudo tem como objetivo analisar os fatores de risco do câncer de mama durante a menopausa e propor medidas de prevenção eficazes. Para alcançar esse objetivo, realizou-se uma revisão sistemática da literatura, incluindo estudos epidemiológicos, ensaios clínicos e revisões recentes. Foram analisados dados relacionados à idade da menopausa, terapia hormonal, histórico familiar e hábitos de vida. Além disso, foram identificadas estratégias de prevenção, como o controle de peso, atividade física regular, alimentação saudável e rastreamento mamográfico. A menopausa é um período crítico para a saúde da mulher, com riscos aumentados de câncer de mama devido às mudanças hormonais. No entanto, a conscientização e a adoção de medidas preventivas podem reduzir significativamente esse risco. O controle do peso, a prática de atividades físicas e uma dieta equilibrada desempenham papéis essenciais na prevenção. Além disso, o rastreamento mamográfico regular em mulheres na faixa etária apropriada é fundamental para a detecção precoce do câncer de mama

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Measurement of the W gamma Production Cross Section in Proton-Proton Collisions at root s=13 TeV and Constraints on Effective Field Theory Coefficients

A fiducial cross section for W gamma production in proton-proton collisions is measured at a center-of-mass energy of 13 TeV in 137 fb(-1) of data collected using the CMS detector at the LHC. The W -> e nu and mu nu decay modes are used in a maximum-likelihood fit to the lepton-photon invariant mass distribution to extract the combined cross section. The measured cross section is compared with theoretical expectations at next-to-leading order in quantum chromodynamics. In addition, 95% confidence level intervals are reported for anomalous triple-gauge couplings within the framework of effective field theory.Peer reviewe