Numerical modelling and in-situ experiment for self-sealing of the induced fracture network of drift into the Callovo-Oxfordian claystone during a hydration process

The excavation damage zone surrounding an underground tunnel/gallery, and in particular its evolution, is being studied for the performance assessment of a radioactive waste underground repository. This paper focuses on numerical analysis of the self-sealing of the damaged zone based on an in-situ CDZ experiment for exploring the self-sealing of excavation damage zone during a hydration process. A plastic damage model is employed to describe the mechanical behaviour of Callovo-Oxfordian claystone (COx), and an added deformation model coupled with the standard Biot's model to simulate the significant deformation of COx claystone during the change of water content. Crack estimation and permeability evaluation of unsaturated fractured COx claystone are carried out through a post-processing method based on the fracture energy regularization and the cubic law, respectively. The validation of the proposed model is performed by numerical simulation of: (1) COx claystone swelling and triaxial compression tests, (2) self-sealing of fractured COx claystone samples during hydration process, (3) self-sealing of the damaged zone during a hydration process. Comparisons between the numerical and experimental results demonstrate the reliability of the proposed model to accurately describe the self-sealing of the fractured COx claystone, and the global water permeability reduction in hydration illustrates the accomplishment of the self-sealing of damaged zone

QCD and QED Corrections to Higgs Boson Production in Charged Current epep Scattering

First order QCD and leading QED corrections to Higgs boson production in the channel $e^-p \to \nu H^0 X; H^0 \to b\bar{b}$ are calculated for the kinematical conditions at LEP $\otimes$ LHC (\sqrt{s} = 1360 \GeV) and the interesting mass range 80 < M_H < 150 \GeV. In the DIS scheme the QCD corrections (not including the corrections to the branching ratio, which are well-known) are found to be about 1\% for the total cross section and $-13\%$ to $-10\%$ for the observable cross section as defined by appropriate cuts. The latter results depend on the definition of these cuts. The QED corrections amount to about $-5\%$. Also obtainable with anonymous ftp from gluon.hep.physik.uni-muenchen.de.Comment: latex, 16 pages + 9 pages figures in PostScript (included

An SU(3) model for octet baryon and meson fragmentation

The production of the octet of baryons and mesons in e^+ e^- collisions is analysed, based on considerations of SU(3) symmetry and a simple model for SU(3) symmetry breaking in fragmentation functions. All fragmentation functions, D_q^h(x, Q^2), describing the fragmentation of quarks into a member of the baryon octet (and similarly for fragmentation into members of the meson octet) are expressed in terms of three SU(3) symmetric functions, \alpha(x, Q^2), \beta(x, Q^2), and \gamma(x, Q^2). With the introduction of an SU(3) breaking parameter, \lambda, the model is successful in describing hadroproduction data at the Z pole. The fragmentation functions are then evolved using leading order evolution equations and good fits to currently available data at 34 GeV and at 161 GeV are obtained.Comment: 24 pages LaTeX file including 11 postscript figure file

Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events

The $B^0$-$\bar B^0$ oscillation frequency has been measured with a sample of 23 million \B\bar B pairs collected with the BABAR detector at the PEP-II asymmetric B Factory at SLAC. In this sample, we select events in which both B mesons decay semileptonically and use the charge of the leptons to identify the flavor of each B meson. A simultaneous fit to the decay time difference distributions for opposite- and same-sign dilepton events gives $\Delta m_d = 0.493 \pm 0.012{(stat)}\pm 0.009{(syst)}$ ps$^{-1}$.Comment: 7 pages, 1 figure, submitted to Physical Review Letter

Search for rare quark-annihilation decays, B --> Ds(*) Phi

We report on searches for B- --> Ds- Phi and B- --> Ds*- Phi. In the context of the Standard Model, these decays are expected to be highly suppressed since they proceed through annihilation of the b and u-bar quarks in the B- meson. Our results are based on 234 million Upsilon(4S) --> B Bbar decays collected with the BABAR detector at SLAC. We find no evidence for these decays, and we set Bayesian 90% confidence level upper limits on the branching fractions BF(B- --> Ds- Phi) Ds*- Phi)<1.2x10^(-5). These results are consistent with Standard Model expectations.Comment: 8 pages, 3 postscript figues, submitted to Phys. Rev. D (Rapid Communications

Divergent Genomic and Epigenomic Landscapes of Lung Cancer Subtypes Underscore the Selection of Different Oncogenic Pathways during Tumor Development

For therapeutic purposes, non-small cell lung cancer (NSCLC) has traditionally been regarded as a single disease. However, recent evidence suggest that the two major subtypes of NSCLC, adenocarcinoma (AC) and squamous cell carcinoma (SqCC) respond differently to both molecular targeted and new generation chemotherapies. Therefore, identifying the molecular differences between these tumor types may impact novel treatment strategy. We performed the first large-scale analysis of 261 primary NSCLC tumors (169 AC and 92 SqCC), integrating genome-wide DNA copy number, methylation and gene expression profiles to identify subtype-specific molecular alterations relevant to new agent design and choice of therapy. Comparison of AC and SqCC genomic and epigenomic landscapes revealed 778 altered genes with corresponding expression changes that are selected during tumor development in a subtype-specific manner. Analysis of >200 additional NSCLCs confirmed that these genes are responsible for driving the differential development and resulting phenotypes of AC and SqCC. Importantly, we identified key oncogenic pathways disrupted in each subtype that likely serve as the basis for their differential tumor biology and clinical outcomes. Downregulation of HNF4α target genes was the most common pathway specific to AC, while SqCC demonstrated disruption of numerous histone modifying enzymes as well as the transcription factor E2F1. In silico screening of candidate therapeutic compounds using subtype-specific pathway components identified HDAC and PI3K inhibitors as potential treatments tailored to lung SqCC. Together, our findings suggest that AC and SqCC develop through distinct pathogenetic pathways that have significant implication in our approach to the clinical management of NSCLC

Observation of B0→χc0K*0 and evidence for B+→χc0K*+

We present the observation of the decay B 0 → χ c 0 K * 0 as well as evidence of B + → χ c 0 K * + , with an 8.9 and a 3.6 standard deviation significance, respectively, using a data sample of 454 × 10 6 Υ ( 4 S ) → B ¯¯¯ B decays collected with the BABAR detector at the PEP-II B meson factory located at the Stanford Linear Accelerator Center (SLAC). The measured branching fractions are B ( B 0 → χ c 0 K * 0 ) = ( 1.7 ± 0.3 ± 0.2 ) × 10 − 4 and B ( B + → χ c 0 K * + ) = ( 1.4 ± 0.5 ± 0.2 ) × 10 − 4 , where the first quoted errors are statistical and the second are systematic. We obtain a branching fraction upper limit of B ( B + → χ c 0 K * + ) < 2.1 × 10 − 4 at the 90% confidence level

Measurement of Trilinear Gauge Couplings in e+e−e^+ e^- Collisions at 161 GeV and 172 GeV

Trilinear gauge boson couplings are measured using data taken by DELPHI at 161~GeV and 172~GeV. Values for $WWV$ couplings ($V=Z, \gamma$) are determined from a study of the reactions \eeWW\ and \eeWev, using differential distributions from the $WW$ final state in which one $W$ decays hadronically and the other leptonically, and total cross-section data from other channels. Limits are also derived on neutral $ZV\gamma$ couplings from an analysis of the reaction \eegi

Search for neutral heavy leptons produced in ZZ decays

Weak isosinglet Neutral Heavy Leptons (νm) have been searched for using data collected by the DELPHI detector corresponding to 3.3 × 106 hadronic Z0 decays at LEP1. Four separate searches have been performed, for short-lived νm production giving monojet or acollinear jet topologies, and for long-lived νm giving detectable secondary vertices or calorimeter clusters. No indication of the existence of these particles has been found, leading to an upper limit for the branching ratio BR(Z0 → νmν̄) of about 1.3 × 10-6 at 95% confidence level for νm masses between 3.5 and 50 GeV/c2. Outside this range the limit weakens rapidly with the νm mass. The results are also interpreted in terms of limits for the single production of excited neutrinos. © Springer-Verlag 1997

Observation of a significant excess of π0π0\pi^{0}\pi^{0} events in B meson decays

We present an observation of the decay $B^{0} \to \pi^{0} \pi^{0}$ based on a sample of 124 million $B\bar{B}$ pairs recorded by the BABAR detector at the PEP-II asymmetric-energy $B$ Factory at SLAC. We observe $46 \pm 13 \pm 3$ events, where the first error is statistical and the second is systematic, corresponding to a significance of 4.2 standard deviations including systematic uncertainties. We measure the branching fraction \BR(B^{0} \to \pi^{0} \pi^{0}) = (2.1 \pm 0.6 \pm 0.3) \times 10^{-6}, averaged over $B^{0}$ and $\bar{B}^{0}$ decays