Structure and temporal dynamics of a seaweed assemblage dominated by the invasive lineage 2 of Asparagopsis taxiformis (Bonnemaisoniaceae, Rhodophyta) in the Alboran Sea

Asparagopsis taxiformis is a rhodophycean species composed of six genetic lineages, one of which is considered a relevant invasive component of Mediterranean flora. This study describes seasonal changes in the structure and biomass of the native community associated with A. taxiformis on the coast of Granada (southern Spain). The native community was represented by 18 Rhodophyta, 3 Chlorophyta, and 4 Ochrophyta species. Biomass was dominated by A. taxiformis and Halopteris filicina. In January, A. taxiformis represented only 16% of the whole community biomass, but 2 months later, more than 90% of the community biomass was formed by the invasive species. During the study period, species richness, the Shannon diversity index, and species evenness showed low and generally stable values. Given that A. taxiformis gametophytes are present throughout the year, they likely pose a constant stress to the development of the native community. This survey provides baseline information on the macroalgal community structure, which may be useful to further studies on the actual impact of the invasive lineage of A. taxiformisThis work was funded by the projects CGL2008/01549/ BOS (Ministerio de Ciencia e Innovación, Spain), P09- RNM-5187 (Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía, Spain), 806/5.03.3553 and 806/5.03.3673 (Instituto de Estudios Ceutíes, Spain). It was developed in the framework of the Research Collaboration Agreement between Consejería de Medio Ambiente y Ordenación del Territorio de la Junta de Andalucía and the University of Málaga

Estudio de diversas especies de los géneros Trachelomonas y Strombomonas (Euglenophyta)

Seven species of Euglenophyceae with lorica (2 Strombomonas and 5 Trachelomonas) haven been studied. We analyzed their lorica microarchitecture by means of ligh microscopy and scanning electron microscopy, enumerating their different ornamental elements. We stand out the study of three population of Trachelomonas, two of them are provisionally included in T. nigra and T. similis respectively. The third one: Trachelomonas sp. show a large morphological variability with only one common ornamental character within of the population: a ring of perforations around the flagellum pore.Se estudian siete especies de Euglenofíceas loricadas, 2 pertenecientes al género Strombomonas y5 de Trachelomonas. Se analiza la microarquitectura de la lórica a microscopio óptico y electrónico de barrido, describiendo los elementos ornamentales de cada especie. Destacamos el estudio de tres poblaciones de Trachelomonas, dos de ellas incluidas provisionalmente en T. nigra y T. similis respectivamente, mientras que en la tercera: Trachelomonas sp., con una gran variabilidad morfológica de la lórica, destaca la existencia de un anillo de perforaciones que se disponen alrededor del poro flagelar

The invasive species Asparagopsis taxiformis (Bonnemaisoniales, Rhodophyta) on Andalusian coast (Southern Spain): reproductive stages, new records and invaded communities

The invasive species Asparagopsis taxiformis (Bonnemaisoniales, Rhodophyta) on Andalusian coasts (Southern Spain): reproductive stages, new records and invaded communities.The present study provides new records from Andalusian coasts of the exotic invasive seaweed Asparagopsis taxiformis (Delile) Trevisan. These records demonstrate that A. taxiformis has rapidly and widely expanded its distribution range in this region, from Almería to Cádiz (Strait of Gibraltar).The latter locality may represent the western geographical limit of the species in the Mediterranean Sea. Spermatangial heads and cystocarps were observed in the collected gametophytes. Additionally, we report the first record of the tetrasporophytic stage, Falkenbergia hillebrandii (Bornet) Falkenberg from the Andalusian coast, although tetraspores were not encountered in these samples. Consequently, information on the affected communities and arguments for considering A. taxiformis as an invasive species in the Andalusian coast are provided.La especie invasora Asparagopsis taxiformis (Bonnemaisoniales, Rhodophyta) en las costas andaluzas (Sur de España): fases reproductivas, nuevas citas y comunidades invadidas. El presente trabajo aporta nuevas citas para las costas andaluzas de la especie exótica invasora de macroalga Asparagopsis taxiformis (Delile) Trevisan. Estas citas muestran que la especie ha aumentado ampliamente su área de distribución de manera rápida en esta región, desde Almería hasta Cádiz (Estrecho de Gibraltar). Esta última localidad representaría el límite occidental de la especie en el mar Mediterráneo. En las muestras recogidas de gametofitos se pudieron observar ramas espermatangiales y cistocarpos. Se aporta la primera cita del estadio tetrasporofítico, Falkenbergia hillebrandii (Bornet) Falkenberg en las costas andaluzas, aunque no se observaron tetrásporas en estas muestras. Se informa sobre las comunidades afectadas y se dan argumentos para considerar a A.taxiformis invasora en las costas andaluzas

Antimicrobianos e periodonto: manejo médico pelo dentista geral

Abstract: Odontogenic infections (OI) are related to dental pulp and periodontal involvement, they are polymicrobial but strict anaerobes predominate. In addition to drainage or surgical management, antimicrobials are used that shorten the resolution time and favor outcome, predominantly in terms of probing depth (PD) reduction and attachment-level gain. The most commonly used antimicrobials are beta-lactams combined with betlalactamase inhibitor, nitroimidazole metronidazole, azithromycin among macrolides, lincosamine mainly clindamycin and quinolone with greater success with moxifloxacin. Different regimens of these antimicrobials have been used to determine noninferiority in the majority, but specific advantages have been found with the use of some as the shortest time of therapy, the greatest effectiveness in the case of the emergence of bacterial resistance and fewer side effects.Resumen: las infecciones odontogénicas (IO) están relacionadas con compromiso de la pulpa dental y afección del periodonto, son polimicrobianas pero predominan los anaerobios estrictos.  Además del drenaje o manejo quirúrgico, se utilizan antimicrobianos que acortan el tiempo de resolución y favorecen desenlaces predominantemente en términos de reducción de la profundidad de sondaje (PD) y ganancia de nivel de inserción. Los antimicrobianos más usados son los betalactámicos combinados con inhibidor de betalactamasa, el nitroimidazol, metronidazol, la azitromicina, entre los macrólidos, la lincosaminas, principalmente la clindamicina y las quinolonas con mayor éxito la moxifloxacina. Se han utilizado diversos regímenes de estos antimicrobianos para determinar  la no inferioridad en la mayoría, pero se han encontrado ventajas específicas con el uso de algunos como el menor tiempo de terapia, la mayor efectividad en el caso de la aparición de resistencia bacteriana y menores efectos secundarios.Resumo: as infecções odontogênicas (OI) estão relacionadas ao envolvimento da polpa dentária e à doença periodontal, são polimicrobianas, mas predominam os anaeróbios estritos. Além da drenagem ou do tratamento cirúrgico, são utilizados antimicrobianos que diminuem o tempo de resolução e favorecem os resultados predominantemente em termos de redução na profundidade da sondagem (DP) e ganho no nível de inserção. Os antimicrobianos mais comumente usados ​​são beta-lactâmicos combinados com inibidor de betalactamase, nitroimidazol, metronidazol, azitromicina, entre macrolídeos, lincosaminas, principalmente clindamicina e quinolonas com maior sucesso moxifloxacino. Vários regimes desses antimicrobianos foram usados ​​para determinar a não inferioridade na maioria, mas foram encontradas vantagens específicas com o uso de alguns como o menor tempo de terapia, a maior eficácia no caso do aparecimento de resistência bacteriana e efeitos mais baixos secundário

Funciones cognitivas en la descendencia de pacientes con trastorno bipolar I

Objective: To describe the neuropsychological characteristics of offspring children and adolescents of patients with bipolar disorder type 1 diagnosis through the application of a standardized intelligence test. Materials and methods: In this descriptive cross-sectional observational study, the authors investigated aspects such as Intelligence Quotient, Verbal Comprehension Index, Perceptual Reasoning Index, Working Memory Index, and Processing Speed Index. Here, 30 descendants were evaluated by applying several subtests of the Wechsler Intelligence Scale for Children (WISC-IV). Results: The Total  Intelligence Quotient of 63.3% of the participants is below the average of the Normal Distribution curve according to the standardization of the intelligence test applied which classifies the tendency of the sample as a low normal average. The working memory and verbal comprehension indexes were the cognitive functions with the lowest scores in the sample. Discussion: Our findings suggest a risk in children of patients with Bipolar Disorder type I, which may contribute to a quantitative increase of cognitive disorders, especially in terms of working memory and verbal comprehension indexes. These findings may indicate a possible endophenotype of Bipolar Disorder type I patients and their offspring in regards to the early manifestation of cognitive disorders in this risk group. These children could be a target for studies that determine prediction and thus perform an early treatment.Objetivo: Describir las características neuropsicológicas de niños y adolescentes descendientes de padres con antecedentes de TB I,  respecto a la aplicación de una prueba estandarizada de inteligencia. Materiales y métodos: Estudio observacional descriptivo de corte transversal, en donde los autores investigaron  el Coeficiente Intelectual Total; Índice de compresión verbal; Índice de Razonamiento Perceptual; Índice de Memoria de trabajo; Índice de Velocidad de Procesamiento. Se evaluaron  (n=30) descendientes al aplicar varias subpruebas de la Escala de inteligencia de Weschler para niños, (WISC –IV). Resultados: El Coeficiente Intelectual Total de los participantes con un  63,3% está por debajo del promedio de la curva de distribución normal, según la estandarización del test de inteligencia aplicado. Clasificando la tendencia de la muestra como un promedio normal bajo, en cuanto a la muestra evaluada. Los índices de memoria de trabajo y compresión verbal fueron las funciones cognitivas con puntuaciones más bajas en la muestra. Discusión: Nuestros hallazgos sugieren un riesgo en hijos de pacientes con TBI, que puede contribuir a un incremento cuantitativo de las alteraciones cognitivas, especialmente el índice de memoria de trabajo y compresión verbal. Estos hallazgos pueden sugerir un posible endofenotipo del TB I y su descendencia, en relación a la presentación temprana de alteraciones cognitivas en este grupo de riesgo. Dichos hijos podrían ser un punto de partida para realizar estudios que determinen predicción y realizar así un abordaje temprano

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.<p></p> Methods: Sixty-six non-HLA SNPs showing a P value <10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.<p></p> Conclusion: Our results suggest a role of PPARG gene in the development of SSc

Influence of the Cumulative Incidence of COVID-19 Cases on the Mental Health of the Spanish Out-of-Hospital Professionals

This study aimed to analyze the psychological affectation of health professionals (HPs) of Spanish Emergency Medical Services (EMSs) according to the cumulative incidence (CI) of COVID19 cases in the regions in which they worked. A cross-sectional descriptive study was designed, including all HPs working in any EMS of the Spanish geography between 1 February 2021 and 30 April 2021. Their level of stress, anxiety and depression (DASS-21) and the perception of self-efficacy (GSES) were the study’s main results. A 2-factor analysis of covariance was used to determine if the CI regions of COVID-19 cases determined the psychological impact on each of the studied variables. A total of 1710 HPs were included. A third presented psychological impairment classified as severe. The interaction of CI regions with the studied variables did not influence their levels of stress, anxiety, depression or self-efficacy. Women, younger HPs or those with less EMS work experience, emergency medical technicians (EMT), workers who had to modify their working conditions or those who lived with minors or dependents suffered a greater impact from the COVID-19 pandemic in certain regions. These HPs have shown high levels of stress, anxiety, depression and medium levels of self-efficacy, with similar data in the different geographical areas. Psychological support is essential to mitigate their suffering and teach them to react to adverse events.This research was funded by Fundación ASISA and Sociedad Española de Urgencias y Emergencias (SEMES)

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P <.05) and less refractoriness (4.5% vs 14.1%; P <.05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P <.05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P <.001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX

Memorias del 4o. coloquio de estudios sobre juegos de rol

Aquí se recopilan las ponencias recibidas para ser publicadas en el 4o. Coloquio de estudios sobre juegos de rol (2019), realizado en el Tec de Monterrey campus Puebla el 4 y 5 de julio de 2019. Únicamente se publican las ponencias cuyos autores dieron permiso explícito para ello y que facilitaron copia de su trabajo. Los resúmenes de las ponencias pasaron por un proceso de revisión doble ciego para ser admitidas en el coloquio. Editor: Mauricio Rangel Jiménezhttps://digitalcommons.njit.edu/stemresources/1021/thumbnail.jp

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX