Le dimanche à Paris en 2030: Enquête sur les rythmes urbains

Economic, social and technical development have transformed the urban rhythms during the last 30 years and determining a new horizon for the cities. Among those rhythms, Sundays'one occupy a special symbolic place. This research program aims at questioning the transformation of Parisian rhythms. Specifically: How does socio-economical evolution change Sunday activities? What makes it still different from the other days of the week? Is it becoming normal to offer a city without interruption, constantly opened, on a 24/7? How will our Sundays look like in 2030? Confronting territorial changes with the customs and representations of the populations and with placed-bases projects will help to understand urban rhythms, as well as Sunday evolution trends on the 2030 horizon.Les évolutions économiques, sociales, religieuses et techniques bouleversent l’ensemble des rythmes urbains depuis une trentaine d'années et interrogent le devenir des villes. Parmi ceux-ci le dimanche occupe une place singulière. Cette recherche vise à interroger les transformations des rythmes urbains parisiens. De quelles manières les évolutions socio-économiques en cours transforment-elles le dimanche ? En quoi celui-ci reste-il différent des autres jours de la semaine ? Tend-t-il à se banaliser pour offrir une ville sans interruption, vivant 24 heures sur 24, 7 jours sur 7 ? Quel(s) dimanche(s) se profilent à l’horizon 2030

Jellyfish biodiversity and abundance patterns in northern Patagonia (Valdés Biosphere Reserve, UNESCO 2014)

Understanding how key components of plankton food webs, such as jellyfish communities, are structured by local hydrography has important management implications for fisheries and higher trophic predators within the ecosystem. Here, we report for the first time on the jellyfish abundance, richness, and diversity distribution across the Nuevo Gulf (42° 42′S, 64° 30′W), a World Heritage Site in Argentine Patagonia and part of the Valdés Biosphere Reserve, during spring (2019 and 2020) and summer (2020 and 2021) at two depths. We found that the most abundant species was the hydromedusae Eucheilota ventricularis, followed by other Leptothecata species, representing more than 50% of the total community's abundance. Abundance and diversity were significantly higher in spring than in summer, with seasonality playing a crucial role in modulating the jellyfish community dynamics and also being related to environmental variables and other mesozooplankton groups. Variability in the abundances across the Gulf and between depths was significantly and positively associated with chlorophyll a and ammonium, but negatively correlated with temperature, agreeing with previous results for the region. Jellyfish were more abundant near the mouth of the Gulf and during spring, possibly due to the connection and exchange of colder and nutrient-enriched water masses with those coming from the continental shelf. Significant correlations were found between jellyfish species and other mesozooplankton groups in spring. Our results highlight the importance of intensifying sampling in the vertical and horizontal dimensions along an annual cycle to begin to elucidate and increase the current scarce knowledge about the jellyfish's distribution and abundance patterns in northern Patagonian gulfs.Fil: Nocera, Ariadna Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco"; ArgentinaFil: Dutto, María Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto Argentino de Oceanografía. Universidad Nacional del Sur. Instituto Argentino de Oceanografía; ArgentinaFil: D'agostino, Valeria Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Schloss, Irene Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina. Ministerio de Relaciones Exteriores, Comercio Interno y Culto. Dirección Nacional del Antártico. Instituto Antártico Argentino; Argentina. Universidad Nacional de Tierra del Fuego; ArgentinaFil: Gonçalves, Rodrigo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco"; Argentin

La salud mental de los profesionales médicos: una experiencia extensionista en el hospital público

En las siguientes líneas se presenta una lectura posible de una intervención institucional realizada por integrantes de la cátedra de Psicología Institucional (UNLP), en un hospital público. La actividad se realizó durante el año 2014, a partir del pedido del equipo a cargo de la residencia de uno de los servicios, por las dificultades, afectaciones y malestares presentes en sus prácticas médicas. El trabajo emprendido se enmarcó en la teoría del Análisis Institucional y la Intervención socio-analítica, este abordaje constituye la forma privilegiada del trabajo con grupos en instituciones, ya que apunta a conmover prácticas y discursos instituidos, en pos de propiciar que los mismos puedan pensarse y posicionarse como actores responsables de las realidades institucionales y generadores de cambio. En un sentido amplio, el análisis institucional designa un método de análisis social, a base de observación y análisis de documentos, centrado en el concepto de institución; en un sentido estricto es un método de intervención en la práctica social de los grupos, las organizaciones y las instituciones (Lourau, 1975).Facultad de Psicologí

La salud mental de los profesionales médicos: una experiencia extensionista en el hospital público

En las siguientes líneas se presenta una lectura posible de una intervención institucional realizada por integrantes de la cátedra de Psicología Institucional (UNLP), en un hospital público. La actividad se realizó durante el año 2014, a partir del pedido del equipo a cargo de la residencia de uno de los servicios, por las dificultades, afectaciones y malestares presentes en sus prácticas médicas. El trabajo emprendido se enmarcó en la teoría del Análisis Institucional y la Intervención socio-analítica, este abordaje constituye la forma privilegiada del trabajo con grupos en instituciones, ya que apunta a conmover prácticas y discursos instituidos, en pos de propiciar que los mismos puedan pensarse y posicionarse como actores responsables de las realidades institucionales y generadores de cambio. En un sentido amplio, el análisis institucional designa un método de análisis social, a base de observación y análisis de documentos, centrado en el concepto de institución; en un sentido estricto es un método de intervención en la práctica social de los grupos, las organizaciones y las instituciones (Lourau, 1975).Facultad de Psicologí

La salud mental de los profesionales médicos: una experiencia extensionista en el hospital público

En las siguientes líneas se presenta una lectura posible de una intervención institucional realizada por integrantes de la cátedra de Psicología Institucional (UNLP), en un hospital público. La actividad se realizó durante el año 2014, a partir del pedido del equipo a cargo de la residencia de uno de los servicios, por las dificultades, afectaciones y malestares presentes en sus prácticas médicas. El trabajo emprendido se enmarcó en la teoría del Análisis Institucional y la Intervención socio-analítica, este abordaje constituye la forma privilegiada del trabajo con grupos en instituciones, ya que apunta a conmover prácticas y discursos instituidos, en pos de propiciar que los mismos puedan pensarse y posicionarse como actores responsables de las realidades institucionales y generadores de cambio. En un sentido amplio, el análisis institucional designa un método de análisis social, a base de observación y análisis de documentos, centrado en el concepto de institución; en un sentido estricto es un método de intervención en la práctica social de los grupos, las organizaciones y las instituciones (Lourau, 1975).Facultad de Psicologí

2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice

Objective: To formulate evidence-based recommendations and overarching principles on the use of imaging in the clinical management of crystal-induced arthropathies (CiAs). Methods: An international task force of 25 rheumatologists, radiologists, methodologists, healthcare professionals and patient research partners from 11 countries was formed according to the EULAR standard operating procedures. Fourteen key questions on the role of imaging in the most common forms of CiA were generated. The CiA assessed included gout, calcium pyrophosphate deposition disease and basic calcium phosphate deposition disease. Imaging modalities included conventional radiography, ultrasound, CT and MRI. Experts applied research evidence obtained from four systematic literature reviews using MEDLINE, EMBASE and CENTRAL. Task force members provided level of agreement (LoA) anonymously by using a Numerical Rating Scale from 0 to 10. Results: Five overarching principles and 10 recommendations were developed encompassing the role of imaging in various aspects of patient management: making a diagnosis of CiA, monitoring inflammation and damage, predicting outcome, response to treatment, guided interventions and patient education. Overall, the LoA for the recommendations was high (8.46-9.92). Conclusions: These are the first recommendations that encompass the major forms of CiA and guide the use of common imaging modalities in this disease group in clinical practice

Recent results on heavy-ion induced reactions of interest for neutrinoless double beta decay at INFN-LNS

Abstract. The possibility to use a special class of heavy-ion induced direct reactions, such as double charge exchange reactions, is discussed in view of their application to extract information that may be helpful to determinate the nuclear matrix elements entering in the expression of neutrinoless double beta decay halflife. The methodology of the experimental campaign presently running at INFN - Laboratori Nazionali del Sud is reported and the experimental challenges characterizing such activity are describe

OP0319 DIAGNOSTIC ACCURACY OF ULTRASOUND IN CALCIUM PYROPHOSPHATE DEPOSITION DISEASE: PRELIMINARY RESULTS OF THE OMERACT US IN CPPD SUB-GROUP

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Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder