Héroes de la Conquista del Desierto : Muerte del jefe del Regimiento Nº 5 de Caballería de Linea Gral. Güemes, don Estanislao Heredia

Este valeroso oficial, cuya brillante foja de servicios en su largo y duro batallar no tuvo pausa, nació en Catamarca en 1834. Incorporado al Ejército, en mayo de 1857 ocupa su plaza con el grado de alférez en el Regimiento de Granaderos a Caballo, en el campo de Marte (Azul). En 1858, ascendido a Teniente Graduado, se lo destaca al Sur de la provincia de Buenos Aires para repeler a los salvajes del Desierto. Desde entonces su ardua lucha no tuvo tregua. Se le vio constantemente recorrer la dilatada frontera que se extendía desde Bahía Blanca hasta el Sur de Santa Fe, combatir contra el Paraguay, participar en la campaña contra López Jordán y volver nuevamente a la azarosa vida de fronteras.Universidad Nacional de La Plat

Héroes de la Conquista del Desierto : Muerte del jefe del Regimiento Nº 5 de Caballería de Linea Gral. Güemes, don Estanislao Heredia

Este valeroso oficial, cuya brillante foja de servicios en su largo y duro batallar no tuvo pausa, nació en Catamarca en 1834. Incorporado al Ejército, en mayo de 1857 ocupa su plaza con el grado de alférez en el Regimiento de Granaderos a Caballo, en el campo de Marte (Azul). En 1858, ascendido a Teniente Graduado, se lo destaca al Sur de la provincia de Buenos Aires para repeler a los salvajes del Desierto. Desde entonces su ardua lucha no tuvo tregua. Se le vio constantemente recorrer la dilatada frontera que se extendía desde Bahía Blanca hasta el Sur de Santa Fe, combatir contra el Paraguay, participar en la campaña contra López Jordán y volver nuevamente a la azarosa vida de fronteras.Universidad Nacional de La Plat

Interstitial pneumonitis following intrapleural chemotherapy

<p>Abstract</p> <p>Background</p> <p>Mucinous neoplasms within the abdomen may disseminate by direct extension through the diaphragm to involve the pleural space. Treatment of this condition is by parietal and visceral pleurectomy followed by hyperthermic intrapleural chemotherapy.</p> <p>Case presentation</p> <p>In this case report a patient developed persistent right upper lobe interstitial pneumonitis and progressive parenchymal fibrosis following intrapleural chemotherapy treatment with mitomycin C and doxrubicin. The condition persisted until death 28 months later. Death was from progressive intraabdominal disease with intestinal obstruction and sepsis associated with progressive pulmonary parenchymal disease. The right pleural space disease did not recur.</p> <p>Conclusion</p> <p>This manuscript is the first case report describing interstitial pneumonitis and lung fibrosis following intrapleural chemotherapy. Since pulmonary toxicity from chemotherapy is a dose-dependent phenomenon, dose reduction of intrapleural as compared to intraperitoneal hyperthermic chemotherapy may be necessary.</p

Impact of moment-based, energy integrated neutrino transport on microphysics and ejecta in binary neutron star mergers

We present an extensive study of the effects of neutrino transport in 3-dimensional general relativistic radiation hydrodynamics (GRHD) simulations of binary neutron star (BNS) mergers using our moment-based, energy-integrated neutrino radiation transport (M1) scheme. We consider a total of 8 BNS configurations, while varying equation of state models, mass ratios and grid resolutions, for a total of 16 simulations. We find that M1 neutrino transport is crucial in modeling the local absorption of neutrinos and the deposition of lepton number throughout the medium. We provide an in-depth look at the effects of neutrinos on the fluid dynamics and luminosity during the late inspiral and post-merger phases, the properties of ejecta and outflow, and the post-merger nucleosynthesis. The simulations presented in this work comprise an extensive study of the combined effect of the equation of state and M1 neutrino transport in GRHD simulations of BNS mergers, and establish that the solution provided by our M1 scheme is robust across system properties and provides insight into the effects of neutrino trapping in BNS mergers

Improving supermartensitic stainless steel weld metal toughness: eliminating ferrite, maximizing austenite, and softening martensite through PWHT markedly improved toughness with respect to the as-welded condition

Welding of supermartensitic stainless steel plays a crucial role in fabricated components, influencing their toughness, weldability and resistance to sulphide stress cracking. Post weld heat treatment adjusts the final properties of the weldments, bearing on microstructural evolution. The objective of this work was to maximize all weld metal toughness by microstructural modifications achieved by means of post-weld heat treatments (PWHTs). Two all-weld metal test coupons were prepared according to standard ANSI/AWS A5.22-95, using a 1.2 mm diameter tubular metal-cored wire under Ar-5%He and Ar-18%CO2 gas shielding mixtures in the flat position, with a nominal heat input of 1.6 kJ mm-1. Single tempering, solution annealing, solution annealing plus single tempering and solution annealing plus double tempering treatments were carried out at different times and temperatures. All-weld metal chemical composition analysis, metallurgical characterization, hardness and tensile property measurements and Charpy-V tests were carried out. It was found that eliminating ferrite, maximizing austenite and softening martensite through PWHT, improved toughness up to almost three times with respect of the as-welded condition, for both shielding gases used.  When welding under Ar-18%CO2 shielding gas, it was detected a) higher all-weld metal contents of C, O and N and slightly lower contents of Mn, Si, Cr, Ni, Mo, Cu; this fact produced slightly lower both ferrite and austenite contents in as-welded condition and b) lower toughness and ductility, and higher strength and hardness, regarding the samples welded under Ar-5%He mixture.Fil: Zappa Maidana, Norberto Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Lomas de Zamora. Facultad de Ingeniería; ArgentinaFil: Svoboda, Hernán Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; ArgentinaFil: Ramini, Mabel. Universidad Tecnológica Nacional; ArgentinaFil: Surian, Estela Silvia. No especifíca;Fil: de Vedia, Luis Alberto. Universidad de Buenos Aires. Facultad de Ingeniería; Argentin

Improving supermartensitic stainless steel weld metal toughness: eliminating ferrite, maximizing austenite, and softening martensite through PWHT markedly improved toughness with respect to the as-welded condition

Welding of supermartensitic stainless steel plays a crucial role in fabricated components, influencing their toughness, weldability and resistance to sulphide stress cracking. Post weld heat treatment adjusts the final properties of the weldments, bearing on microstructural evolution. The objective of this work was to maximize all weld metal toughness by microstructural modifications achieved by means of post-weld heat treatments (PWHTs). Two all-weld metal test coupons were prepared according to standard ANSI/AWS A5.22-95, using a 1.2 mm diameter tubular metal-cored wire under Ar-5%He and Ar-18%CO2 gas shielding mixtures in the flat position, with a nominal heat input of 1.6 kJ mm-1. Single tempering, solution annealing, solution annealing plus single tempering and solution annealing plus double tempering treatments were carried out at different times and temperatures. All-weld metal chemical composition analysis, metallurgical characterization, hardness and tensile property measurements and Charpy-V tests were carried out. It was found that eliminating ferrite, maximizing austenite and softening martensite through PWHT, improved toughness up to almost three times with respect of the as-welded condition, for both shielding gases used.  When welding under Ar-18%CO2 shielding gas, it was detected a) higher all-weld metal contents of C, O and N and slightly lower contents of Mn, Si, Cr, Ni, Mo, Cu; this fact produced slightly lower both ferrite and austenite contents in as-welded condition and b) lower toughness and ductility, and higher strength and hardness, regarding the samples welded under Ar-5%He mixture.Fil: Zappa Maidana, Norberto Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Lomas de Zamora. Facultad de Ingeniería; ArgentinaFil: Svoboda, Hernán Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ingeniería; ArgentinaFil: Ramini, Mabel. Universidad Tecnológica Nacional; ArgentinaFil: Surian, Estela Silvia. No especifíca;Fil: de Vedia, Luis Alberto. Universidad de Buenos Aires. Facultad de Ingeniería; Argentin

Association between pre-biologic T2-biomaker combinations and response to biologics in patients with severe asthma

Funding This study was conducted by the Observational and Pragmatic Research Institute (OPRI) Pte Ltd and was partially funded by Optimum Patient Care Global (OPCG) and AstraZeneca Ltd. No funding was received by the OPRI for its contribution. The International Severe Asthma Registry (ISAR) is operated by OPCG and co-funded by OPCG and AstraZenecaPeer reviewe

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Thin-walled cysts as a pathognomonic CT finding in cystic mesothelioma

Aim. Cystic mesothelioma is a rare disease that results in abdominal distention and poorly defined abdominal pain. Diagnosis has always been made by tissue biopsy rather than by radiologic studies. Materials and methods. Our experience with 7 patients with cystic mesothelioma includes 4 patients who had not had prior surgery before the performance of a high resolution CT scan. A special review of the radiology of these cases was performed in order to identify any pathognomonic signs of this disease. Results. In all patients who did not have a distortion of the radiologic images (as a result of surgical interventions) prior to the performance of a high resolution CT scan at our institution, a pathognomonic thin-wall cystic structure located within the gelatinous appearing mass was observed. These thin-walled cysts were of variable size and preferentially located within the greater omentum, pelvis and beneath the right hemidiaphragm. Conclusion. Cystic mesothelioma can be diagnosed preoperatively by a high resolution abdominal and pelvic CT. The thin-walled cysts with great variation in size are located beneath the right hemidiaphragm, within the greater omentum and in the pelvis. No other disease with these radiologic findings has been identified.5 page(s

Mesenchymal stem cell therapy improves spatial memory and hippocampal structure in aging rats

There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of intracerebroventricular (icv) administration of human bone marrow-derived MSCs (hBM-MSCs) on spatial memory and hippocampal morphology of senile (27 months) female rats, using 3-months-old counterparts as young controls. Half of the animals were injected in the lateral ventricles (LV) with a suspension containing 5 × 105hBM-MSCs in 8 μl per side. The other half received no treatment (senile controls). Spatial memory performance was assessed with a modified version of the Barnes maze test. We employed one probe trial, one day after training in order to evaluate learning ability as well as spatial memory retention. Neuroblast (DCX) and microglial (Iba-1 immunoreactive) markers were also immunohistochemically quantitated in the animals by means of an unbiased stereological approach. In addition, hippocampal presynaptic protein expression was assessed by immunoblotting analysis. After treatment, the senile MSC-treated group showed a significant improvement in spatial memory accuracy and extended permanence in a one- and 3-hole goal sectors as compared with senile controls. The MSC treatment increased the number of neuroblasts in the hippocampal dentate gyrus, reduced the number of reactive microglial cells, and restored presynaptic protein levels as compared to senile controls. We conclude that icv injected hBM-MSCs are effective in improving spatial memory in senile rats and that the strategy improves some functional and morphologic brain features typically altered in aging rats.Fil: Zappa Villar, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Lehmann, Marianne. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: García, Mariana Gabriela. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Mazzolini Rizzo, Guillermo Daniel. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; ArgentinaFil: Morel, Gustavo Ramón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Cónsole, Gloria M.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Podhajcer, Osvaldo Luis. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reggiani, Paula Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentin