30 research outputs found
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
- Beckham Jean C.
- Beekman Aartjan T. F.
- Beins Eva C.
- Bellivier Frank
- Bellivier Frank
- Bencko Vladimir
- Bengesser Susanne
- Bergen Andrew W.
- Bergen Andrew W.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Berrettini Wade H.
- Bhushan Sujata
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Birgegård Andreas
- Birner Armin
- Blackwood Douglas H. R.
- Boden Joseph M.
- Boehm Ilka
- Boehnke Michael
- Boehnke Michael
- Bohus Martin
- Bohus Martin
- Boks Marco P.
- Boks Marco P.
- Boni Claudette
- Boomsma Dorret I.
- Bosch Rosa
- Bosch Rosa
- Boyko Edward
- Braff David L.
- Brandt Harry
- Brandt Harry
- Breeling James
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brewer Jessica V.
- Brophy Mary T.
- Brum Murielle
- Brumpton Ben M.
- Brunkhorst-Kanaan Nathalie
- Bryant Richard
- Bryois Julien
- Bryois Julien
- Bryois Julien
- Budde Monika
- Budde Monika
- Buehren Katharina
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børte Sigrid
- Cahn Wiepke
- Cai Na
- Cairns Murray
- Campos Adrian I.
- Carlberg Laura
- Carr Vaughan J.
- Carter Bruce W.
- Casas Miguel
- Casas Miquel
- Cassina Matteo
- Castelao Enrique
- Castelao Enrique
- Catts Stanley
- Cervantes Pablo
- Cervilla Jorge A.
- Chang Kyong-Mi
- Chang Xiao
- Charney Alexander W.
- Chaumette Boris
- Chen Hsi-Chung
- Chen Wei J.
- Cho Kelly
- Cho Kelly
- Christensen Jane Hvarregaard
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Clementi Maurizio
- Cohen David
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Colodro-Conde Lucía
- Cone Roger D.
- Connor Todd
- Constans Joseph
- Coombes Brandon
- Coon Hilary
- Corvin Aiden
- Corvin Aiden
- Courtet Philippe
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craddock Nick
- Craig David
- Crawford Gregory E.
- Crawford Steven
- Crawford Steven
- Crivelli Silvia
- Crow Scott
- Crow Scott
- Crowley James J.
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo
- Cunningham Julie
- Curtis David
- Czerski Piotr M.
- Dahmen Norbert
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- Dalkner Nina
- Danner Unna N.
- Dannlowski Udo
- Dannlowski Udo
- David Friederike S.
- Davies Gail
- Davis Oliver S. P.
- de Geus E. J. C.
- de Zwaan Martina
- Dedoussis George
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degortes Daniela
- Dellitalia Louis
- Demontis Ditte
- Dennis Michelle F.
- Depaulo J. Raymond
- DePaulo J. Raymond
- der Auwera Sandra Van
- Derks Eske M.
- DeSocio Janiece E.
- Di Florio Arianna
- DiBlasi Emily
- Dick Danielle M.
- Dietl Lydie
- Dikeos Dimitris
- Dikeos Dimitris
- Dina Christian
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Dmitrzak-Weglarz Monika
- Do Nhan
- Dobbyn Amanda L.
- Docherty Anna R.
- Dolan Conor V.
- Domenici Enrico
- Domschke Katharina
- Douzenis Athanassios
- Drange Ole Kristian
- Duncan Laramie E.
- Dunn Erin C.
- Duriez Philibert
- Edenberg Howard J.
- Edenberg Howard J.
- Edwards Alexis C.
- Egberts Karin
- Ehrlich Stefan
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erlangsen Annette
- Escaramís Geòrgia
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Espeseth Thomas
- Estivill Xavier
- Etain Bruno
- Fanous Ayman H.
- Farmer Anne
- Favaro Angela
- Fayad Joseph
- Ferentinos Panagiotis
- Fernández-Aranda Fernando
- Fernández-Aranda Fernando
- Ferrier I. Nicol
- Fichter Manfred M.
- Fichter Manfred M.
- Finucane Hilary K.
- Fiorentino Alessia
- Fischer Krista
- Florez Hermes
- Floyd James A. B.
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- Foretova Lenka
- Foroud Tatiana M.
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- Forzan Monica
- Frank Josef
- Frank Josef
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- Franklin Christopher S.
- Frei Oleksandr
- Freimer Nelson B.
- Frisén Louise
- Frye Mark
- Frye Mark
- Fullerton Janice M.
- Fullerton Janice M.
- Föcker Manuel
- Gaddy Melinda
- Gade Katrin
- Galfalvy Hanga
- Gallinger Steven
- Gallinger Steven
- Gambaro Giovanni
- Gandal Michael
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- Gappy Saib
- Garnham Julie
- Gaspar Héléna A.
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- Gatt Justine M.
- Gawlik Micha
- Gaziano J. Michael
- Gaziano J. Michael
- Gejman Pablo V.
- Gelernter Joel
- Gelernter Joel
- Gershon Elliot S.
- Gibson Gretchen
- Giegling Ina
- Giegling Ina
- Gill Michael
- Giuranna Johanna
- Giusti-Rodríquez Paola
- Gizer Ian R.
- Glatt Stephen J.
- Godschalk Michael
- Goes Fernando S.
- Goes Fernando S.
- Gonidakis Fragiskos
- Gordon Scott
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Gorwood Philip
- Gorwood Philip
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- Grabe Hans J.
- Greco Jennifer
- Green Melissa J.
- Green Melissa J.
- Greenwood Tiffany A.
- Grevet Eugenio H.
- Grigoroiu-Serbanescu Maria
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guillaume Sébastien
- Guo Yiran
- Guo Yiran
- Gupta Samir
- Gutierrez Blanca
- Gutierrez Salvador
- Guzman-Parra Jose
- Guzman-Parra José
- Ha Kyooseob
- Hafferty Jonathan D.
- Hagenaars Saskia P.
- Hakonarson Hakon
- Hakonarson Hakon
- Hall Lynsey S.
- Halmi Katherine A.
- Halmi Katherine A.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Kimberly
- Hamner Mark
- Hamshere Marian L.
- Hanscombe Ken B.
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F.
- Haraldsson Magnus
- Harley John
- Hartmann Annette
- Harvey Phillip D.
- Hassan Kiadeh Farnush Farhadi
- Hatzikotoulas Konstantinos
- Hauser Elizabeth
- Hauser Elizabeth R.
- Hauser Joanna
- Hauser Joanna
- Hauser Joanna
- Hauser Michael A.
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Hebebrand Johannes
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Helder Sietske G.
- Hellgren Dennis
- Henders Anjali K.
- Henskens Frans
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Herpertz-Dahlmann Beate
- Herzog Wolfgang
- Hickie Ian B.
- Hillert Jan
- Hinney Anke
- Hishimoto Akitoyo
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holmans Peter A.
- Homuth Georg
- Hong Kyung Sue
- Horn Carsten
- Horwood L. John
- Hottenga Jouke-Jan
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- Hougaard David M.
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- Huckins Laura
- Huckins Laura M.
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- Hung Adriana
- HUNT All-In Psychiatry
- Huq Mostaqul
- Hurley Robin
- Hveem Kristian
- Hwu Hai-Gwo
- Hübel Christopher
- Ikeda Masashi
- Imgart Hartmut
- Inoko Hidetoshi
- Iruvanti Pran
- Ising Marcus
- Ising Marcus
- Ivins Douglas
- Iwata Nakao
- Jablensky Assen V.
- Jacobson Daniel
- Jacono Frank
- Jain Sonia
- Jamain Stéphane
- Jamain Stéphane
- Janout Vladimir
- Jansen Rick
- Jhala Darshana
- Jiménez-Murcia Susana
- Jiménez-Murcia Susana
- Johnson Craig
- Johnson Craig
- Johnson Jessica S.
- Jones Ian
- Jones Ian
- Jones Ian
- Jones Lisa A.
- Jones Lisa A.
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- Jordan Jennifer
- Jorgenson Eric
- Julià Antonio
- Jungkunz Martin
- Kahn René S.
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- Kalman Janos L.
- Kalsi Gursharan
- Kamatani Yoichiro
- Kaminsky Laurence
- Kaminská Deborah
- Kamitaki Nolan
- Kang JooEun
- Kaplan Allan S.
- Kaplan Allan S.
- Kaprio Jaakko
- Karhunen Leila
- Karwautz Andreas
- Kas Martien J. H.
- Kay Yang Jessica Mei
- Kaye Walter H.
- Kaye Walter H.
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- Kelsoe John R.
- Kendler Kenneth S.
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- Kennedy James L.
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- Kessler Ronald C.
- Kiezebrink Kirsty
- Kim Minsoo
- Kim Minsoo
- Kim Youl-Ri
- Kimbrel Nathan A.
- Kinlay Scott
- Kirk Katherine M.
- Kirov George
- Kittel-Schneider Sarah
- Klareskog Lars
- Klein Jon
- Kloiber Stefan
- Kloiber Stefan
- Klump Kelly L.
- Klump Kelly L.
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- Traylor Matthew
- Treasure Janet
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- Trubetskoy Vassily
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- Trzaskowski Maciej
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- Wu Yang
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- Zeggini Eleftheria
- Zerwas Stephanie
- Zhang Futao
- Zhao Hongyu
- Zhou Hang
- Zillich Lea
- Zillich Lea
- Zipfel Stephan
- Zwart John-Anker
- Świątkowska Beata
- Świątkowska Beata
- Świątkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
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- Yokozawa T.
- Yoo Jooheon
- Yu Hang
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- Zadrożny A.
- Zahoor Jan Aasim
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
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- KARATHANASIS CHRISTOS.
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- Massaro L.
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- MORALES ESTER. RUIZ.
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- Moraru D.
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- More Anupreeta
- More Surhud
- Moreno Claudia
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- Yaala M. Ben
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- Yamamoto Hiroaki
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- Yamazaki Ryo
- Yan S.
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- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
- Baiotti Luca
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
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- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
- Bartoletti A. M.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bates D. E.
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Baynard II. P. A.
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Belardinelli Daniele
- Bell Angus
- Benedetto V.
- Benoit William
- Bentley Joe
- Bera Sayantani
- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhardwaj Uddipta
- Bhatt R.
- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bhowmick S.
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- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Bisht A.
- Bitossi Massimiliano
- Blackburn Kent
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- Bobba F.
- Bode Nina
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- Boldrini Mattia
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- Bossilkov V.
- Boudart Vincent
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- BRANCHESI Marica
- Brandt J.
- Braun I.
- Breschi Matteo
- Briant Tristan
- Brillet A.
- Brinkmann M.
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- Brockmüller Eike
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- Cabras Giuseppe
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- Cadonati Laura
- Cagnoli Gianpietro
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- Carapella G.
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- Carolina Silva Oliveira Ana
- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini Claudio
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chakraborty Pratik
- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
- Charlton E. L.
- Charlton Philip
- Chassande-Mottin Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chattopadhyay Debatri
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
- Chen Y.
- Chen Yanbei
- Chen Yitian
- Cheng H. P.
- Chessa Piero
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- Chiadini Francesco
- Chiarini G.
- Chierici R.
- Chincarini Andrea
- Chiofalo Maria Luisa
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chugh P.
- Chun Lung Chan Juno
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi Maria
- Ciolfi Riccardo
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- Wuchner E.
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- Xu Victoria
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- Yamamura S.
- Yamazaki Ryo
- Yan S.
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- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
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- Zeeshan M.
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- Zerrad M.
- Zevin Michael
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- Zhang Rui
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
The genetics of the mood disorder spectrum:genome-wide association analyses of over 185,000 cases and 439,000 controls
- Author
- Abbott Liam
- Abbott Liam
- Abdellaoui Abdel
- Abdellaoui Abdel
- Adams Mark J.
- Adams Mark J.
- Adolfsson Annelie Nordin
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Akil Huda
- Akil Huda
- Albani Diego
- Albani Diego
- Alda Martin
- Alda Martin
- Alliey-Rodriguez Ney
- Alliey-Rodriguez Ney
- Als Thomas D.
- Als Thomas D.
- Andlauer Till F.M.
- Andlauer Till F.M.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antilla Verneri
- Arolt Volker
- Arolt Volker
- Awasthi Swapnil
- Awasthi Swapnil
- Bacanu Silviu-Alin
- Bacanu Silviu-Alin
- Backlund Lena
- Backlund Lena
- Badner Judith A.
- Badner Judith A.
- Barchas Jack D.
- Barchas Jack D.
- Bass Nicholas
- Bass Nicholas
- Bauer Michael
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Beekman Aartjan T.F.
- Beekman Aartjan T.F.
- Belliveau Richard
- Belliveau Richard
- Bellivier Frank
- Bellivier Frank
- Bergen Sarah E.
- Bergen Sarah E.
- Berger Klaus
- Berger Klaus
- Berrettini Wade H.
- Berrettini Wade H.
- Biernacka Joanna M.
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Binder Elisabeth B.
- Blackwood Douglas H.R.
- Blackwood Douglas H.R.
- Boehnke Michael
- Boehnke Michael
- Boks Marco
- Boks Marco
- Boocock James
- Boocock James
- Boomsma Dorret I.
- Boomsma Dorret I.
- Breen Gerome
- Bryois Julien
- Budde Monika
- Budde Monika
- Bunney William
- Bunney William
- Burmeister Margit
- Burmeister Margit
- Buttenschøn Henriette N.
- Buttenschøn Henriette N.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Cai Na
- Cai Na
- Casas Miquel
- Casas Miquel
- Castelao Enrique
- Castelao Enrique
- Cerrato Felecia
- Cerrato Felecia
- Cervantes Pablo
- Cervantes Pablo
- Chambert Kimberly
- Chambert Kimberly
- Charney Alexander W.
- Charney Alexander W.
- Chen Danfeng
- Chen Danfeng
- Christensen Jane Hvarregaard
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Churchhouse Claire
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Coleman Jonathan R.I.
- Colodro-Conde Lucía
- Colodro-Conde Lucía
- Corvin Aiden
- Corvin Aiden
- Coryell William
- Coryell William
- Couvy-Duchesne Baptiste
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nicholas
- Craig David W.
- Craig David W.
- Crawford Gregory E.
- Crawford Gregory E.
- Cruceanu Cristiana
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- Czerski Piotr M.
- Czerski Piotr M.
- Dale Anders M.
- Dale Anders M.
- Daly Mark J.
- Daly Mark J.
- Dannlowski Udo
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- Derks Eske M.
- Derks Eske M.
- Di Florio Arianna
- Di Florio Arianna
- Direk Nese
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
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- Fan Chun Chieh
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- Fischer Sascha B.
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- Foo Jerome C.
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- Foroud Tatiana M.
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- Forty Liz
- Frank Josef
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- Frye Mark
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- Gade Katrin
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- Garnham Julie
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- Gaspar Héléna A.
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- Giambartolomei Claudia
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- Gill Michael
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- Grigoroiu-Serbanescu Maria
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- Grove Jakob
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- Guan Weihua
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- Hall Lynsey S.
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- Hamilton Steven P.
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- Hansen Christine Søholm
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- Hauser Joanna
- Hauser Joanna
- Hautzinger Martin
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- Heilbronner Urs
- Herms Stefan
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- Holland Dominic
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- Horn Carsten
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- Huckins Laura
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- Hultman Christina M.
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- Jamain Stéphane
- Jamain Stéphane
- Jansen Rick
- Jansen Rick
- Johnson Jessica S.
- Johnson Jessica S.
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- Jones Lisa A.
- Jorgenson Eric
- Jorgenson Eric
- Juréus Anders
- Juréus Anders
- Kahn René S.
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- Kandaswamy Radhika
- Karlsson Robert
- Karlsson Robert
- Kelsoe John
- Kelsoe John
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Kirov George
- Kirov George
- Kittel-Schneider Sarah
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- Kloiber Stefan
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- Kogevinas Manolis
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- Kohane Isaac S.
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- Kraft Julia
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- Kretzschmar Warren W.
- Kretzschmar Warren W.
- Krogh Jesper
- Krogh Jesper
- Kupka Ralph
- Kupka Ralph
- Kutalik Zoltán
- Kutalik Zoltán
- Landén Mikael
- Landén Mikael
- Lavebratt Catharina
- Lavebratt Catharina
- Lawrence Jacob
- Lawrence Jacob
- Lawson William B.
- Lawson William B.
- Leber Markus
- Leber Markus
- Leboyer Marion
- Leboyer Marion
- Lee Phil H.
- Lee Phil H.
- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Levy Shawn E.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Glyn
- Lewis Glyn
- Li Jun Z.
- Li Jun Z.
- Li Qingqin S.
- Li Qingqin S.
- Li Yihan
- Li Yihan
- Lind Penelope A.
- Lind Penelope A.
- Lissowska Jolanta
- Lissowska Jolanta
- Liu Chunyu
- Liu Chunyu
- Lucae Susanne
- Lucae Susanne
- Maaser Anna
- Maaser Anna
- MacIntyre Donald J.
- MacIntyre Donald J.
- MacKinnon Dean F.
- MacKinnon Dean F.
- Madden Pamela A.F.
- Madden Pamela A.F.
- Magnusson Patrik K.
- Magnusson Patrik K.
- Mahon Pamela B.
- Mahon Pamela B.
- Maier Robert M.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Marchini Jonathan
- Marchini Jonathan
- Martin Nicholas G.
- Martin Nicholas G.
- Martinsson Lina
- Martinsson Lina
- Mattheisen Manuel
- Mattheisen Manuel
- Mayoral Fermin
- Mayoral Fermin
- Mbarek Hamdi
- Mbarek Hamdi
- McCarroll Steve
- McCarroll Steve
- McElroy Susan L.
- McElroy Susan L.
- McGrath Patrick
- McGrath Patrick
- McGuffin Peter
- McGuffin Peter
- McInnis Melvin G.
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- McIntosh Andrew M.
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- McKay James D.
- McKay James D.
- McMahon Francis J.
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- McQuillin Andrew
- McQuillin Andrew
- Medeiros Helena
- Medeiros Helena
- Medland Sarah E.
- Medland Sarah E.
- Mehta Divya
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- Melle Ingrid
- Melle Ingrid
- Meng Fan
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- Metspalu Andres
- Metspalu Andres
- Middeldorp Christel M.
- Middeldorp Christel M.
- Mihailov Evelin
- Mihailov Evelin
- Milaneschi Yuri
- Milaneschi Yuri
- Milani Lili
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- Mirza Saira Saeed
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- Mitchell Philip B.
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- Mondimore Francis M.
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- Montgomery Grant W.
- Montgomery Grant W.
- Morken Gunnar
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- Morris Derek W.
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- Mors Ole
- Mors Ole
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mostafavi Sara
- Mostafavi Sara
- Mullins Niamh
- Mullins Niamh
- Myers Richard M.
- Myers Richard M.
- Mühleisen Thomas W.
- Mühleisen Thomas W.
- Müller-Myhsok Bertram
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- Nauck Matthias
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- Neale Benjamin M.
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- Ng Bernard
- Ng Bernard
- Nguyen Hoang
- Nguyen Hoang
- Nievergelt Caroline M.
- Nievergelt Caroline M.
- Nimgaonkar Vishwajit
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- Nivard Michel G.
- Nivard Michel G.
- Nordentoft Merete
- Nordentoft Merete
- Nurnberger John I.
- Nurnberger John I.
- Nwulia Evaristus A.
- Nwulia Evaristus A.
- Nyholt Dale R.
- Nyholt Dale R.
- Nöthen Markus M.
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- O'Donovan Claire
- O'Donovan Claire
- O'Donovan Michael C.
- O'Donovan Michael C.
- O'Reilly Paul F.
- O'Reilly Paul F.
- Oedegaard Ketil J.
- Oedegaard Ketil J.
- Olde Loohuis Loes M.
- Olde Loohuis Loes M.
- Ophoff Roel A.
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- Ori Anil P.S.
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- Oruc Lilijana
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- Oskarsson Hogni
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- Owen Michael J.
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- Paciga Sara A.
- Paciga Sara A.
- Painter Jodie N.
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- Weickert Thomas W.
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- Weinsheimer Shantel Marie
- Weinsheimer Shantel Marie
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Wellmann Jürgen
- Werge Thomas
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- Whitehead Pavlides Jennifer M.
- Whitehead Pavlides Jennifer M.
- Willemsen Gonneke
- Willemsen Gonneke
- Witt Stephanie H.
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- Wray Naomi R.
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- Wu Yang
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- Xi Hualin S.
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- Xu Wei
- Xu Wei
- Yang Jian
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- Young Allan H.
- Young Allan H.
- Zandi Peter
- Zandi Peter
- Zhang Futao
- Zhang Futao
- Zhang Peng
- Zhang Peng
- Zollner Sebastian
- Zollner Sebastian
- Ösby Urban
- Ösby Urban
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/11/2019
- Field of study
Background
Mood disorders (including major depressive disorder and bipolar disorder) affect 10-20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Despite their diagnostic distinction, multiple approaches have shown considerable sharing of risk factors across the mood disorders.
Methods
To clarify their shared molecular genetic basis, and to highlight disorder-specific associations, we meta-analysed data from the latest Psychiatric Genomics Consortium (PGC) genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; non-overlapping N = 609,424).
Results
Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More genome-wide significant loci from the PGC analysis of major depression than bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell-types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment – positive in bipolar disorder but negative in major depressive disorder.
Conclusions
The mood disorders share several genetic associations, and can be combined effectively to increase variant discovery. However, we demonstrate several differences between these disorders. Analysing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Air Tracy M
- Akil Huda
- Albani Diego
- Alda Martin
- Alliey-Rodriguez Ney
- Als Thomas D
- Andlauer Till F M
- Andlauer Till F M
- Andreassen Ole A
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Auburger Georg
- Awasthi Swapnil
- Bacanu Silviu-Alin
- Backlund Lena
- Badner Judith A
- Barchas Jack D
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Baune Bernhard T
- Beekman Aartjan T F
- Belliveau Richard
- Bellivier Frank
- Bergen Sarah E
- Berger Klaus
- Berrettini Wade H
- Biernacka Joanna M
- Bigdeli Tim B
- Binder Elisabeth B
- Blackwood Douglas H R
- Boehnke Michael
- Boks Marco
- Boocock James
- Boomsma Dorret I
- Breen Gerome
- Breen Gerome
- Bryois Julien
- Budde Monika
- Bunney William
- Burmeister Margit
- Buttenschøn Henriette N
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byrne Enda M
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D
- Børglum Anders D
- Cabaleiro Fabeiro Francisco J
- Cai Na
- Casas Miquel
- Castelao Enrique
- Cerrato Felecia
- Cervantes Pablo
- Chambert Kimberly
- Charney Alexander W
- Chen Danfeng
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clair David St
- Clarke Toni-Kim
- Clarke Toni-Kim
- Coleman Jonathan R I
- Coleman Jonathan R I
- Colodro-Conde Lucía
- Corvin Aiden
- Coryell William
- Couvy-Duchesne Baptiste
- Craddock Nicholas
- Craddock Nick
- Craig David W
- Crawford Gregory E
- Cruceanu Cristiana
- Czerski Piotr M
- Dale Anders M
- Daly Mark J
- Dannlowski Udo
- Dannlowski Udo
- Davies Gail
- de Diego-Otero Yolanda
- de Geus E. J. C.
- de Jong Simone
- de Leeuw Christiaan A
- Deary Ian J
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Del Río Noriega Francisco
- Del-Favero Jurgen
- DePaulo J Raymond
- DePaulo J Raymond
- Derks Eske M
- Direk Nese
- Djurovic Srdjan
- Dobbyn Amanda L
- Dolan Conor V
- Domenici Enrico
- Domschke Katharina
- Dumont Ashley
- Dunn Erin C
- Edenberg Howard J
- Eley Thalia C
- Elvsåshagen Torbjørn
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Etain Bruno
- EThorgeirsson Thorgeir
- Fan Chun Chieh
- Finucane Hilary K
- Fischer Sascha B
- Flickinger Matthew
- Florio Arianna Di
- Foo Jerome C
- Foo Jerome C
- Foroud Tatiana M
- Forstner Andreas J
- Forstner Andreas J
- Forstner Andreas J
- Forty Liz
- Frank Josef
- Frank Josef
- Frank Josef
- Fraser Christine
- Freimer Nelson B
- Frisén Louise
- Frye Mark
- Fullerton Janice M
- Gade Katrin
- Gage Diane
- Garnham Julie
- Gaspar Héléna A
- Gaspar Héléna A
- Gershon Elliot S
- Giambartolomei Claudia
- Gil Flores Susana
- Gill Michael
- Gill Michael
- Goes Fernando
- Goes Fernando S
- Goldstein Jaqueline
- González Maria José
- Gordon Scott D
- Gordon Scott D
- Gordon-Smith Katherine
- Grabe Hans J
- Green Elaine K
- Green Melissa J
- Greenwood Tiffany A
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Guan Weihua
- Guzman-Parra Jose
- Hall Lynsey S
- Hamilton Steven P
- Hamshere Marian L
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Thomas F
- Haro González Jesus
- Hauser Joanna
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C
- Heilbronner Urs
- Heilmann-Heimbach Stefanie
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Hickie Ian B
- Hipolito Maria
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Holland Dominic
- Holmans Peter A
- Homuth Georg
- Horn Carsten
- Hottenga Jouke-Jan
- Hougaard David M
- Hougaard David M
- Howard David M
- Huckins Laura
- Hultman Christina M
- Ising Marcus
- Jamain Stéphane
- Jansen Rick
- Johnson Jessica S
- Jones Ian
- Jones Ian
- Jones Lisa A
- Jones Lisa A
- Jorgenson Eric
- Juréus Anders
- Kahn René S
- Kandaswamy Radhika
- Karlsson Robert
- Kelsoe John
- Kendler Kenneth S
- Kennedy James L
- Kiadeh Farnush Farhadi Hassan
- Kirov George
- Kittel-Schneider Sarah
- Kloiber Stefan
- Knowles James A
- Knowles James A
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S
- Koller Anna C
- Kraft Julia
- Kretzschmar Warren W
- Kupka Ralph
- Kutalik Zoltán
- Landén Mikael
- Lavebratt Catharina
- Lawrence Jacob
- Lawson William B
- Leber Markus
- Leboyer Marion
- Lee Phil H
- Levinson Douglas F
- Levy Shawn E
- Lewis Cathryn M
- Lewis Cathryn M
- Lewis Glyn
- Li Jun Z
- Li Qingqin S
- Li Qingqin S
- Li Yihan
- Lind Penelope A
- Lissowska Jolanta
- Liu Chunyu
- Loohuis Loes M Olde
- Lucae Susanne
- Lucae Susanne
- Maaser Anna
- MacIntyre Donald J
- MacIntyre Donald J
- MacKinnon Dean F
- Madden Pamela A F
- Magnusson Patrik K
- Mahon Pamela B
- Maier Robert M
- Maier Wolfgang
- Maier Wolfgang
- Marchini Jonathan
- Martin Nicholas G
- Martin Nicholas G
- Martinsson Lina
- Mattheisen Manuel
- Mattheisen Manuel
- Mayoral Fermin
- Mayoral Fermín
- Mbarek Hamdi
- McCarroll Steve
- McElroy Susan L
- McGrath Patrick
- McGuffin Peter
- McGuffin Peter
- McInnis Melvin G
- McIntosh Andrew M
- McIntosh Andrew M
- McKay James D
- McMahon Francis J
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E
- Medland Sarah E
- Mehta Divya
- Melle Ingrid
- Meng Fan
- Metspalu Andres
- Metspalu Andres
- Middeldorp Christel M
- Mihailov Evelin
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Mirza Saira Saeed
- Mitchell Philip B
- Mondimore Francis M
- Montgomery Grant W
- Montgomery Grant W
- Moreno-Küstner Berta
- Morken Gunnar
- Morris Derek W
- Mors Ole
- Mors Ole
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mostafavi Sara
- Mullins Niamh
- Mullins Niamh
- Myers Richard M
- Mühleisen Thomas W
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Nauck Matthias
- Neale Benjamin M
- Ng Bernard
- Nguyen Hoang
- Nievergelt Caroline M
- Nimgaonkar Vishwajit
- Nivard Michel G
- Nordentoft Merete
- Nordentoft Merete
- Nurnberger John I
- Nwulia Evaristus A
- Nyholt Dale R
- Nöthen Markus M
- Nöthen Markus M
- Nöthen Markus M
- O'Donovan Claire
- O'Donovan Michael C
- O'Donovan Michael C
- O'Reilly Paul F
- Oedegaard Ketil J
- Ophoff Roel A
- Ori Anil P S
- Orozco Diaz Guillermo
- Oruc Lilijana
- Oskarsson Hogni
- Owen Michael J
- Owen Michael J
- Paciga Sara A
- Paciga Sara A
- Painter Jodie N
- Parra José Guzman
- Pato Carlos
- Pato Michele T
- Pavlides Jennifer M Whitehead
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L
- Penninx Brenda W J H
- Perez Fermin Perez
- Perlis Roy H
- Perlis Roy H
- Perry Amy
- Pers Tune H
- Peterson Roseann E
- Pettersson Erik
- Peyrot Wouter J
- Pfennig Andrea
- Pistis Giorgio
- Porteous David J
- Posthuma Danielle
- Posthuma Danielle
- Potash James B
- Potash James B
- Preisig Martin
- Purcell Shaun M
- Quiroz Jorge A
- Qvist Per
- Ramos-Quiroga Josep Antoni
- Regeer Eline J
- Reif Andreas
- Reinbold Céline S
- Ribasés Marta
- Rice John P
- Rice John P
- Richards Alexander L
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Ripke Stephan
- Rivas Fabio
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Rouleau Guy A
- Roussos Panos
- Ruderfer Douglas M
- Ryu Euijung
- Schaefer Catherine
- Schalling Martin
- Schatzberg Alan F
- Scheftner William A
- Schoevers Robert
- Schofield Peter R
- Schork Nicholas J
- Schulte Eva C
- Schulze Thomas G
- Schulze Thomas G
- Scott Laura J
- Serretti Alessandro
- Shehktman Tatyana
- Shen Ling
- Shi Jianxin
- Shilling Paul D
- Shyn Stanley I
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sinnamon Grant C B
- Sklar Pamela
- Slaney Claire
- Smeland Olav B
- Smit Johannes H
- Smith Daniel J
- Smoller Jordan W
- Smoller Jordan W
- Sobell Janet L
- Spijker Anne T
- Stahl Eli A
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Steffens Michael
- Steinberg Stacy
- Steinberg Stacy
- Stordal Eystein
- Strauss John S
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Strohmaier Jana
- Strohmaier Jana
- Strohmaier Jana
- Sullivan Patrick F
- Sullivan Patrick F
- Szelinger Szabolcs
- Sánchez-Mora Cristina
- Tansey Katherine E
- Teismann Henning
- Teumer Alexander
- Thompson Robert C
- Thompson Wesley
- Thomson Pippa A
- Thorgeirsson Thorgeir E
- Tiemeier Henning
- Traylor Matthew
- Treutlein Jens
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Turecki Gustavo
- Uher Rudolf
- Uitterlinden André G
- Umbricht Daniel
- Vaaler Arne E
- Van der Auwera Sandra
- van Hemert Albert M
- Vedde Helmut
- Vieta Eduard
- Viktorin Alexander
- Vincent John B
- Visscher Peter M
- Völzke Henry
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J
- Webb Bradley T
- Weickert Cynthia Shannon
- Weickert Thomas W
- Weinsheimer Shantel Marie
- Weissman Myrna M
- Wellmann Jürgen
- Werge Thomas
- Werge Thomas
- Willemsen Gonneke
- Witt Stephanie H
- Witt Stephanie H
- Witt Stephanie H
- Wray Naomi R
- Wray Naomi R
- Wu Yang
- Xi Hualin S
- Xi Simon
- Xu Wei
- Yang Jian
- Young Allan H
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zollner Sebastian
- Ösby Urban
- Publication venue
- Mol Psychiatry
- Publication date
- 20/12/2018
- Field of study
Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development
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Comparative genomics of Cluster O mycobacteriophages.
- Author
- Adair Tamarah
- Anders Kirk R
- Ball Sarah
- Bollivar David
- Bowman Charles A
- Breitenberger Caroline
- Burnett Sandra H
- Butela Kristen
- Byrnes Deanna
- Carzo Sarah
- Cornely Kathleen A
- Cresawn Steven G
- Cross Trevor
- Daniels Richard L
- De Los Santos Carla
- Dedrick Rebekah M
- Dunbar David
- Ekanem Kevin
- Findley Ann M
- Gissendanner Chris R
- Golebiewska Urszula P
- Hartzog Grant A
- Hatfull Graham F
- Hatherill J Robert
- Hendrix Roger W
- Hughes Lee E
- Jacobs-Sera Deborah
- Jalloh Chernoh S
- Khambule Sphindile L
- King Rodney A
- King-Smith Christina
- Klyczek Karen
- Krukonis Greg P
- Laing Christian
- Lapin Jonathan S
- Lopez A Javier
- Mkhwanazi Sipho M
- Molloy Sally D
- Moran Deborah
- Munsamy Vanisha
- Pacey Eddie
- Plymale Ruth
- Pope Welkin H
- Poxleitner Marianne
- Reyna Nathan
- Russell Daniel A
- Schildbach Joel F
- Stukey Joseph
- Taylor Sarah E
- Ware Vassie C
- Wellmann Amanda L
- Westholm Daniel
- Wodarski Donna
- Zajko Michelle
- Zikalala Thabiso S
- Publication venue
- eScholarship, University of California
- Publication date
- 01/01/2015
- Field of study
Mycobacteriophages--viruses of mycobacterial hosts--are genetically diverse but morphologically are all classified in the Caudovirales with double-stranded DNA and tails. We describe here a group of five closely related mycobacteriophages--Corndog, Catdawg, Dylan, Firecracker, and YungJamal--designated as Cluster O with long flexible tails but with unusual prolate capsids. Proteomic analysis of phage Corndog particles, Catdawg particles, and Corndog-infected cells confirms expression of half of the predicted gene products and indicates a non-canonical mechanism for translation of the Corndog tape measure protein. Bioinformatic analysis identifies 8-9 strongly predicted SigA promoters and all five Cluster O genomes contain more than 30 copies of a 17 bp repeat sequence with dyad symmetry located throughout the genomes. Comparison of the Cluster O phages provides insights into phage genome evolution including the processes of gene flux by horizontal genetic exchange
Acute and chronic toxicity of neonicotinoid and butenolide insecticides to the freshwater amphipod, Hyalella azteca
- Author
- Adrienne J. Bartlett
- Agatz
- Amanda M. Hedges
- Anderson
- Bartlett
- Bartlett
- Beketov
- Borgmann
- Borgmann
- de Perre
- Englert
- France J. Maisonneuve
- Goulson
- Hasenbein
- HC PMRA (Health Canada Pest Management Regulatory Agency)
- HC PMRA (Health Canada Pest Management Regulatory Agency)
- HC PMRA (Health Canada Pest Management Regulatory Agency)
- Hladik
- Ingersoll
- Jeschke
- Jeschke
- Kayser
- Kayser
- Kyna D. Intini
- Lanteigne
- Lisa R. Brown
- Main
- Main
- Maloney
- Maloney
- Metcalfe
- Moore
- Morrissey
- Patricia L. Gillis
- Prosser
- Raby
- Raimondo
- Robinson
- Robinson
- Roessink
- Salerno
- Shane R. de Solla
- Soucek
- Stacey A. Robinson
- Stoughton
- Struger
- SYSTAT
- Tomizawa
- US EPA (United States Environmental Protection Agency)
- USGS (United States Geological Survey)
- Wellmann
- Whiteside
- Whiting
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study