Damping signatures in future neutrino oscillation experiments

We discuss the phenomenology of damping signatures in the neutrino oscillation probabilities, where either the oscillating terms or the probabilities can be damped. This approach is a possibility for tests of non-oscillation effects in future neutrino oscillation experiments, where we mainly focus on reactor and long-baseline experiments. We extensively motivate different damping signatures due to small corrections by neutrino decoherence, neutrino decay, oscillations into sterile neutrinos, or other mechanisms, and classify these signatures according to their energy (spectral) dependencies. We demonstrate, at the example of short baseline reactor experiments, that damping can severely alter the interpretation of results, e.g., it could fake a value of $\sin(2\theta_{13})$ smaller than the one provided by Nature. In addition, we demonstrate how a neutrino factory could constrain different damping models with emphasis on how these different models could be distinguished, i.e., how easily the actual non-oscillation effects could be identified. We find that the damping models cluster in different categories, which can be much better distinguished from each other than models within the same cluster.Comment: 33 pages, 5 figures, LaTeX. Final version published in JHE

From parameter space constraints to the precision determination of the leptonic Dirac CP phase

We discuss the precision determination of the leptonic Dirac CP phase $\delta_{CP}$ in neutrino oscillation experiments, where we apply the concept of ``CP coverage''. We demonstrate that this approach carries more information than a conventional CP violation measurement, since it also describes the exclusion of parameter regions. This will be very useful for next-generation long baseline experiments where for sizable $\sin^2 2 \theta_{13}$ first constraints on $\delta_{CP}$ can be obtained. As the most sophisticated experimental setup, we analyze neutrino factories, where we illustrate the major difficulties in their analysis. In addition, we compare their potential to the one of superbeam upgrades and next-generation experiments, which also includes a discussion of synergy effects. We find a strong dependence on the yet unknown true values of $\sin^2 2 \theta_{13}$ and $\delta_{CP}$, as well as a strong, non-Gaussian dependence on the confidence level. A systematic understanding of the complicated parameter dependence will be given. In addition, it is shown that comparisons of experiments and synergy discussions do in general not allow for an unbiased judgment if they are only performed at selected points in parameter space. Therefore, we present our results in dependence of the yet unknown true values of $\sin^2 2 \theta_{13}$ and $\delta_{CP}$. Finally we show that for $\delta_{CP}$ precision measurements there exist simple strategies including superbeams, reactor experiments, superbeam upgrades, and neutrino factories, where the crucial discriminator is $\sin^2 2 \theta_{13} \sim 10^{-2}$.Comment: 32 pages, 9 figure

Sociocultural considerations in aging men's health: implications and recommendations for the clinician

http://dx.doi.org/10.1016/j.jomh.2009.07.00

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of SARS-CoV-2 genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three available genomic nomenclature systems for SARS-CoV-2 to all sequence data from the WHO European Region available during the COVID-19 pandemic until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation. We provide a comparison of the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.Peer reviewe

Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program

Many common and rare variants associated with hematologic traits have been discovered through imputation on large-scale reference panels. However, the majority of genome-wide association studies (GWASs) have been conducted in Europeans, and determining causal variants has proved challenging. We performed a GWAS of total leukocyte, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts generated from 109,563,748 variants in the autosomes and the X chromosome in the Trans-Omics for Precision Medicine (TOPMed) program, which included data from 61,802 individuals of diverse ancestry. We discovered and replicated 7 leukocyte trait associations, including (1) the association between a chromosome X, pseudo-autosomal region (PAR), noncoding variant located between cytokine receptor genes (CSF2RA and CLRF2) and lower eosinophil count; and (2) associations between single variants found predominantly among African Americans at the S1PR3 (9q22.1) and HBB (11p15.4) loci and monocyte and lymphocyte counts, respectively. We further provide evidence indicating that the newly discovered eosinophil-lowering chromosome X PAR variant might be associated with reduced susceptibility to common allergic diseases such as atopic dermatitis and asthma. Additionally, we found a burden of very rare FLT3 (13q12.2) variants associated with monocyte counts. Together, these results emphasize the utility of whole-genome sequencing in diverse samples in identifying associations missed by European-ancestry-driven GWASs

Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium

A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be partially due to relatively small sample sizes among studies. Altered structural connectivity may be both a neurobiological vulnerability for, and a result of, PTSD. In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3047 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). Comparing regional white matter metrics across the full brain in 1426 individuals with PTSD and 1621 controls (2174 males/873 females) between ages 18-83, 92% of whom were trauma-exposed, we report associations between PTSD and disrupted white matter organization measured by lower fractional anisotropy (FA) in the tapetum region of the corpus callosum (Cohen's d = -0.11, p = 0.0055). The tapetum connects the left and right hippocampus, for which structure and function have been consistently implicated in PTSD. Results were consistent even after accounting for the effects of multiple potentially confounding variables: childhood trauma exposure, comorbid depression, history of traumatic brain injury, current alcohol abuse or dependence, and current use of psychotropic medications. Our results show that PTSD may be associated with alterations in the broader hippocampal network.New methods for child psychiatric diagnosis and treatment outcome evaluatio

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Internationale verkenning gedwongen huwelijken Een onderzoek naar wettelijke maatregelen, beleid en publieke debatten in België, Frankrijk, Duitsland, Verenigd Koninkrijk en Zwitserland

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International Exploration on Forced Marriages

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