208 research outputs found
Novel hybrid vesicles co-assembled from a cationic lipid and PAAc-g-mPEG with pH-triggered transmembrane channels for controlled drug release
This work presents an important example of novel hybrid vesicles with pH-triggered transmembrane channels prepared by co-assembly of poly(acrylic acid)-g-poly(monomethoxy ethylene glycol) (PAAc-g-mPEG) with a cationic lipid, didodecyldimethylammonium bromide (DDAB), via electrostatic interaction for effective doxorubicin (DOX) release
Cosmological parameters from large scale structure - geometric versus shape information
The matter power spectrum as derived from large scale structure (LSS) surveys
contains two important and distinct pieces of information: an overall smooth
shape and the imprint of baryon acoustic oscillations (BAO). We investigate the
separate impact of these two types of information on cosmological parameter
estimation, and show that for the simplest cosmological models, the broad-band
shape information currently contained in the SDSS DR7 halo power spectrum (HPS)
is by far superseded by geometric information derived from the baryonic
features. An immediate corollary is that contrary to popular beliefs, the upper
limit on the neutrino mass m_\nu presently derived from LSS combined with
cosmic microwave background (CMB) data does not in fact arise from the possible
small-scale power suppression due to neutrino free-streaming, if we limit the
model framework to minimal LambdaCDM+m_\nu. However, in more complicated
models, such as those extended with extra light degrees of freedom and a dark
energy equation of state parameter w differing from -1, shape information
becomes crucial for the resolution of parameter degeneracies. This conclusion
will remain true even when data from the Planck surveyor become available. In
the course of our analysis, we introduce a new dewiggling procedure that allows
us to extend consistently the use of the SDSS HPS to models with an arbitrary
sound horizon at decoupling. All the cases considered here are compatible with
the conservative 95%-bounds \sum m_\nu < 1.16 eV, N_eff = 4.8 \pm 2.0.Comment: 18 pages, 4 figures; v2: references added, matches published versio
Constraints on the Local Sources of Ultra High-Energy Cosmic Rays
Ultra high-energy cosmic rays (UHECRs) are believed to be protons accelerated
in magnetized plasma outflows of extra-Galactic sources. The acceleration of
protons to ~10^{20} eV requires a source power L>10^{47} erg/s. The absence of
steady sources of sufficient power within the GZK horizon of 100 Mpc, implies
that UHECR sources are transient. We show that UHECR "flares" should be
accompanied by strong X-ray and gamma-ray emission, and that X-ray and
gamma-ray surveys constrain flares which last less than a decade to satisfy at
least one of the following conditions: (i) L>10^{50} erg/s; (ii) the power
carried by accelerated electrons is lower by a factor >10^2 than the power
carried by magnetic fields or by >10^3 than the power in accelerated protons;
or (iii) the sources exist only at low redshifts, z<<1. The implausibility of
requirements (ii) and (iii) argue in favor of transient sources with L>10^{50}
erg/s.Comment: 7 pages, 1 figure, submitted to JCA
Segregated tunneling-percolation model for transport nonuniversality
We propose a theory of the origin of transport nonuniversality in disordered
insulating-conducting compounds based on the interplay between microstructure
and tunneling processes between metallic grains dispersed in the insulating
host. We show that if the metallic phase is arranged in quasi-one dimensional
chains of conducting grains, then the distribution function of the chain
conductivities g has a power-law divergence for g -> 0 leading to nonuniversal
values of the transport critical exponent t. We evaluate the critical exponent
t by Monte Carlo calculations on a cubic lattice and show that our model can
describe universal as well nonuniversal behavior of transport depending on the
value of few microstructural parameters. Such segregated tunneling-percolation
model can describe the microstructure of a quite vast class of materials known
as thick-film resistors which display universal or nonuniversal values of t
depending on the composition.Comment: 8 pages, 5 figures (Phys. Rev. B - 1 August 2003)(fig1 replaced
Probing the Local Velocity Distribution of WIMP Dark Matter with Directional Detectors
We explore the ability of directional nuclear-recoil detectors to constrain
the local velocity distribution of weakly interacting massive particle (WIMP)
dark matter by performing Bayesian parameter estimation on simulated
recoil-event data sets. We discuss in detail how directional information, when
combined with measurements of the recoil-energy spectrum, helps break
degeneracies in the velocity-distribution parameters. We also consider the
possibility that velocity structures such as cold tidal streams or a dark disk
may also be present in addition to the Galactic halo. Assuming a
carbon-tetrafluoride detector with a 30-kg-yr exposure, a 50-GeV WIMP mass, and
a WIMP-nucleon spin-dependent cross-section of 0.001 pb, we show that the
properties of a cold tidal stream may be well constrained. However, measurement
of the parameters of a dark-disk component with a low lag speed of ~50 km/s may
be challenging unless energy thresholds are improved.Comment: 38 pages, 15 figure
Atomic X-ray Spectroscopy of Accreting Black Holes
Current astrophysical research suggests that the most persistently luminous
objects in the Universe are powered by the flow of matter through accretion
disks onto black holes. Accretion disk systems are observed to emit copious
radiation across the electromagnetic spectrum, each energy band providing
access to rather distinct regimes of physical conditions and geometric scale.
X-ray emission probes the innermost regions of the accretion disk, where
relativistic effects prevail. While this has been known for decades, it also
has been acknowledged that inferring physical conditions in the relativistic
regime from the behavior of the X-ray continuum is problematic and not
satisfactorily constraining. With the discovery in the 1990s of iron X-ray
lines bearing signatures of relativistic distortion came the hope that such
emission would more firmly constrain models of disk accretion near black holes,
as well as provide observational criteria by which to test general relativity
in the strong field limit. Here we provide an introduction to this phenomenon.
While the presentation is intended to be primarily tutorial in nature, we aim
also to acquaint the reader with trends in current research. To achieve these
ends, we present the basic applications of general relativity that pertain to
X-ray spectroscopic observations of black hole accretion disk systems, focusing
on the Schwarzschild and Kerr solutions to the Einstein field equations. To
this we add treatments of the fundamental concepts associated with the
theoretical and modeling aspects of accretion disks, as well as relevant topics
from observational and theoretical X-ray spectroscopy.Comment: 63 pages, 21 figures, Einstein Centennial Review Article, Canadian
Journal of Physics, in pres
Search for resonances in the mass distribution of jet pairs with one or two jets identified as b-jets in proton–proton collisions at √s=13TeV with the ATLAS detector
Searches for high-mass resonances in the dijet invariant mass spectrum with one or two jets identi-fied as b-jets are performed using an integrated luminosity of 3.2fb−1of proton–proton collisions with a centre-of-mass energy of √s=13TeVrecorded by the ATLAS detector at the Large Hadron Collider. Noevidence of anomalous phenomena is observed in the data, which are used to exclude, at 95%credibility level, excited b∗quarks with masses from 1.1TeVto 2.1TeVand leptophobic Z bosons with masses from 1.1TeVto 1.5TeV. Contributions of a Gaussian signal shape with effective cross sections ranging from approximately 0.4 to 0.001pb are also excluded in the mass range 1.5–5.0TeV
Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society
Narrowband Searches for Continuous and Long-duration Transient Gravitational Waves from Known Pulsars in the LIGO-Virgo Third Observing Run
Isolated neutron stars that are asymmetric with respect to their spin axis are possible sources of detectable continuous gravitational waves. This paper presents a fully coherent search for such signals from eighteen pulsars in data from LIGO and Virgo's third observing run (O3). For known pulsars, efficient and sensitive matched-filter searches can be carried out if one assumes the gravitational radiation is phase-locked to the electromagnetic emission. In the search presented here, we relax this assumption and allow both the frequency and the time derivative of the frequency of the gravitational waves to vary in a small range around those inferred from electromagnetic observations. We find no evidence for continuous gravitational waves, and set upper limits on the strain amplitude for each target. These limits are more constraining for seven of the targets than the spin-down limit defined by ascribing all rotational energy loss to gravitational radiation. In an additional search, we look in O3 data for long-duration (hours-months) transient gravitational waves in the aftermath of pulsar glitches for six targets with a total of nine glitches. We report two marginal outliers from this search, but find no clear evidence for such emission either. The resulting duration-dependent strain upper limits do not surpass indirect energy constraints for any of these targets. © 2022. The Author(s). Published by the American Astronomical Society
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