15 research outputs found
Syrian Hamster as an Animal Model for the Study on Infectious Diseases
Infectious diseases still remain one of the biggest challenges for human health. In
order to gain a better understanding of the pathogenesis of infectious diseases and
develop effective diagnostic tools, therapeutic agents, and preventive vaccines, a suitable
animal model which can represent the characteristics of infectious is required. The
Syrian hamster immune responses to infectious pathogens are similar to humans and
as such, this model is advantageous for studying pathogenesis of infection including
post-bacterial, viral and parasitic pathogens, along with assessing the efficacy and
interactions of medications and vaccines for those pathogens. This review summarizes
the current status of Syrian hamster models and their use for understanding the
underlying mechanisms of pathogen infection, in addition to their use as a drug discovery
platform and provides a strong rationale for the selection of Syrian hamster as animal
models in biomedical research. The challenges of using Syrian hamster as an alternative
animal model for the research of infectious diseases are also addressed.
Keywords: infectious diseases, Syrian hamster, drug discovery, infection mechanism, biomedical researc
IdentificaciĂłn de los cambios morfolĂłgicos y bioquĂmicos en entamoeba histolytica durante la muerte celular programada
Tesis (Doctorado en Ciencias en Biomedicina Molecular), Instituto Politécnico Nacional, SEPI, ENMH, 2007, 1 archivo PDF, (175 påginas). tesis.ipn.m
Prevalence of Human Papillomavirus in Women from Mexico City
Introduction. Cervical cancer is the most common cancer among Mexican women. The goal of the present study was to determine the prevalence and distribution of HPV types in women from Mexico City. Methods. Our study was conducted in the Clinica de Especialidades de la Mujer de la SecretarĂa de la Defensa Nacional, Mexico. Random samples were taken from 929 healthy women requesting a cervical Papanicolaou examination. Detection and genotyping of HPV were performed by multiplex PCR, with the HPV4A ACE Screening kit (Seegene). Results. 85 of nine hundred twenty-nine women (9.1%) were infected with HPV. Of HPV-positive women, 99% and 1% had high- and low-risk HPV genotypes, respectively. The prevalence of the 16 high-risk (HR) HPV types that were screened was 43%â:â42% (18) were HPV positive and 14% (16) were HPV positive, which includes coinfection. Multiple infections with different viral genotypes were detected in 10% of the positive cases. Abnormal cervical cytological results were found in only 15.3% of HPV-positive women, while 84.7% had normal cytological results. Conclusions. We found a similar prevalence of HPV to previous studies in Mexico. The heterogeneity of the HPV genotype distribution in Mexico is evident in this study, which found a high frequency of HPV HR genotypes, the majority of which were HPV 18