Efficient Quantum Algorithms for State Measurement and Linear Algebra Applications

We present an algorithm for measurement of $k$-local operators in a quantum state, which scales logarithmically both in the system size and the output accuracy. The key ingredients of the algorithm are a digital representation of the quantum state, and a decomposition of the measurement operator in a basis of operators with known discrete spectra. We then show how this algorithm can be combined with (a) Hamiltonian evolution to make quantum simulations efficient, (b) the Newton-Raphson method based solution of matrix inverse to efficiently solve linear simultaneous equations, and (c) Chebyshev expansion of matrix exponentials to efficiently evaluate thermal expectation values. The general strategy may be useful in solving many other linear algebra problems efficiently.Comment: 17 pages, 3 figures (v2) Sections reorganised, several clarifications added, results unchange

MYC-Micro RNA-Transcript Regulatory Crosstalks in STS Oncogenesis

MicroRNAs (miRNA) are a family of small non-coding RNAs (ncRNAs) having capability of regulating gene expression at the post-transcriptional level. MicroRNAs are reported to have role in various biological processes like development of embryo, cell proliferation, differentiation of cells into other forms, cell death, developmental timing, etc. The role of miRNAs as tumor suppressors/oncomiR has already been reported in many cancers. These ncRNAs can alter cellular metabolism by directly interacting with target gene transcripts. Therefore, miRNA profiling is used for detection and progression of cancer in various field of cancer biology such as proliferation, programmed cell death, cancer cell migration and angiogenesis. Our study is mainly based on identification of novel differentially expressed targets of MYC regulated miRNAs that are suspected to play role in fibrosarcoma from microarray data analysis followed by qRT-PCR for experimental validation of selected pair of mRNA (COL1A2 and RRM2). From qRT-PCR study in HT-1080 cell lines, we found that COL1A2 and RRM2 are over-expressed in cancer system and their targeting miRNAs are down-regulated. The altered expression of COL1A2 and RRM2 might be due to down regulation of hsa-let-7g and hsa-let-7b as these miRNAs have target sites within 3/UTR of COL1A2 and RRM2. We can assume that these target genes and their miRNAs might be playing a role in metastatic in STS by altering the expression of the corresponding mRNA through RNA interference mechanism, which can be a probable therapeutic target in fibrosarcoma

Developement of Low Cost Water purification Technique

About one-fifth of people on earth lack access to safe drinking water, a condition that led to the death of 2.2 million people in 2004, according to the United Nations. Many communities in developing countries lack clean water. In these countries contaminated water has a significant impact on numerous lives. Fortunately, efficient and cheap water purification systems can make easy access to clean water a reality. In the following project we try to develop a “Low Cost Water Purification Technique” using the basic ideas of Slow Sand Filter, some locally available filter material like charcoal, Bone char and try to improve the methodology using the UV Filter, RO Filter, Activated Carbon Filter mechanism with the National Institute of Technology Rourkela Copy right

LigEvolver: A Tool for ligand formulation using genetic algorithm

Human Immunodeficiency Virus type 1 (HIV - 1) has been found to be the cause of Acquired Immune Deficiency Syndrome (AIDS). This virus caused uproar during the 1980\u27s and started a major drug discovery race among the pharmaceutical companies. It also proved to be a milestone in the establishment of the use of computers in rational drug design. Evolutionary computation is a commonly used computational approach that has been successfully applied to a variety of fields ranging from engineering to life science. The main reason for its effectiveness is that it is driven by the principles of evolution. A genetic algorithm is an approach to evolutionary computation that allows random combination of data to occur in a series of generations and enables the identification of novel systems that might otherwise have gone undetected. This work explores the use of genetic algorithms to generate new ligand structures that may be effective in inhibiting HIV - 1 Protease, one of the major drug targets in HIV. One of the computational challenges associated with drug discovery is the conversion of chemical and biological entities into formats that the computer can use. Chemical structures can be represented by linear character strings called SMILES strings. SMILES (Simplified Molecular Input Line Entry Specification) strings are taken as the genetic representation for our approach to drug discovery, and a genetic algorithm has been developed to generate appropriate ligands for HIV-1 protease. Based on a fitness function, the ligands are evaluated and either kept or removed from the gene pool following the survival of the fittest pattern found in nature

One-size-fits-all housing : an exploration of 6-star requirements in the volume builder sector

Energy consumption attributed to the residential sector makes up around 8% of the total consumption in Australia. Roughly a third of all houses built in Victoria are done so by the largest 20 builders. These volume builders keep costs down by offering a selection of ‘clone’ designs from which the client can choose, however they lose the site-specific customisation which is required for effective passive design in favour of a one-size-fits-all approach where designs are developed to a point where they can satisfy just the minimum requirements in a range of orientations and site locations. The Australian government has implemented regulations regarding the minimum efficiency standards for housing and these initiatives to limit the carbon emissions have brought the question of energy use to the table, yet are they enough? This paper will explore the concept of cloned house designs in terms of energy efficiency and optimal siting and through computer simulation, evaluate how a cloned house design performs under different site conditions in Victoria

Institutional quality and foreign direct investment inflows : evidence from cross-country data with policy implication

Purpose: The study examines the impact of institutional quality on Foreign Direct Investment (FDI) inflows for emerging economies from South Asiain the period 2002-2016. Other economic factors such as globalisation, financial development, and GDP are also considered. Design/Methodology/Approach: The study uses Im-Pesaran-Shin (IPS) panel unit root test to check stationarity property. It uses cross dependency (CD) and cross-sectional augments IPS tests to check cross-sectional dependency and heterogeneity across the group countries. Next, it uses panel ARDL-PMG tests to check the existence of long-relationship among variables. Then, we apply the panel Granger causality test to check the direction of causality. Finally, for the robustness of results, we use the Pedroni co-integration technique. Findings: The study finds the existence of a long-run relationship between institutional quality and FDI inflows. Other economic factors such as globalization and financial development show long-run and strong causality with FDI inflows. However, the short-run unidirectional causality from institutional quality to FDI inflows is not found for all the countries. Finally, institutional quality strongly causes FDI inflows provided paired with either globalisation or financial development. Practical Implications: Institutional quality increases the FDI inflows. Therefore, policymakers should focus on institutional quality along with globalization and financial development for higher inflows of FDI in emerging countries. Originality/Value: The study considers institutional quality as one of the inputs for FDI inflows in selected emerging economies from South Asia. Further, it creates an institutional quality index for the emerging countries to examine the impact on FDI inflows.peer-reviewe

Application of ethernet over powerline communication

Powerline communication (PLC) has seen notable demand due to its efficiency and the wide range of applications. It is a system for carrying data on a conductor that is also used for electric power transmission. In this thesis, this technique is used to implement a web server using the FPGA development board (DE 2). The information is sent through Ethernet over powerline. Using DE2 Altera kit, a webserver is created. The implementation of web server is done by first instantiating a Nios II system on the board. Nios II system is built around the Altera’s Nios II processor using the SOPC builder tool of the quartus II CAD tool. The SOPC builder tool generates the VHDL code of the defined system. The developed code is, then, configured in the FPGA board to instantiate the system. After implementing the Nios II system, an application program is run in the system to implement the web server. Ethernet packets are sent through the LAN cable over powerline. The output is taken from the Ethernet port and the fed into the Homeplug adapter. The packets are captured using wireshark packet sniffer and detailed analysis is done. This idea can be used for transmitting Ethernet packets over powerline using Homplug adapters

Occupant satisfaction of Star Rated Houses in Victoria, Australia

The Victorian government implemented legislation for all new houses to achieve a 6 star rating since May 2011. It is found that having a higher star rating would provide financial and environmental benefits, however the question remains- is this sufficient to satisfy the occupants living in such houses? Are the occupants actually satisfied with the amount of money they have invested in their home? This study investigates the level of satisfaction of occupants living in different star rated houses, and explores if there is a link between the star rating of the house and the satisfaction of the occupants living in such houses