Progressive cavitating leukoencephalopathy: Case report of a rare childhood onset neurodegenerative disease

The leukoencephalopathies with cystic changes form a distinct subtype of childhood onset neurodegenerativedisorders. This group has heterogeneous etiological differentials that primarily include mitochondrial disorders, someleukodystrophies and central nervous system infections. We report this case of a 17-month old girl who presented withseizures, episodic encephalopathy, elevated blood lactate level and lactate peak on magnetic resonance spectroscopy,a typical imaging picture noted on cranial magnetic resonance imaging and absence of deletions or duplications ofmitochondrial deoxyribonucleic acid. Progressive cavitating leukoencephalopathy (PCL) is a recently described entitywith only a few cases reported so far. We report the first case of PCL from India. Accurate diagnosis can be made, notonly, by the presence of typical clinicoradiological findings of PCL, but also by the awareness of, and, ruling out of,the various other differential diagnoses that are discussed in detail below

Relativistic spin precession in the binary PSR J1141−-6545

PSR J1141$-$6545 is a precessing binary pulsar that has the rare potential to reveal the two-dimensional structure of a non-recycled pulsar emission cone. It has undergone $\sim 25 \deg$ of relativistic spin precession in the $\sim18$ years since its discovery. In this paper, we present a detailed Bayesian analysis of the precessional evolution of the width of the total intensity profile, to understand the changes to the line-of-sight impact angle ($\beta$) of the pulsar using four different physically motivated prior distribution models. Although we cannot statistically differentiate between the models with confidence, the temporal evolution of the linear and circular polarisations strongly argue that our line-of-sight crossed the magnetic pole around MJD 54000 and that only two models remain viable. For both these models, it appears likely that the pulsar will precess out of our line-of-sight in the next $3-5$ years, assuming a simple beam geometry. Marginalising over $\beta$ suggests that the pulsar is a near-orthogonal rotator and provides the first polarization-independent estimate of the scale factor ($\mathbb{A}$) that relates the pulsar beam opening angle ($\rho$) to its rotational period ($P$) as $\rho = \mathbb{A}P^{-0.5}$ : we find it to be $> 6 \rm~deg~s^{0.5}$ at 1.4 GHz with 99\% confidence. If all pulsars emit from opposite poles of a dipolar magnetic field with comparable brightness, we might expect to see evidence of an interpulse arising in PSR J1141$-$6545, unless the emission is patchy.Comment: Accepted for publication in Astrophysical Journal Letter

Modelling annual and orbital variations in the scintillation of the relativistic binary PSR J1141−-6545

We have observed the relativistic binary pulsar PSR J1141$-$6545 over a period of $\sim$6 years using the Parkes 64 m radio telescope, with a focus on modelling the diffractive intensity scintillations to improve the accuracy of the astrometric timing model. The long-term scintillation, which shows orbital and annual variations, allows us to measure parameters that are difficult to measure with pulsar timing alone. These include: the orbital inclination $i$; the longitude of the ascending node $\Omega$; and the pulsar system transverse velocity. We use the annual variations to resolve the previous ambiguity in the sense of the inclination angle. Using the correct sense, and a prior probability distribution given by a constraint from pulsar timing ($i=73\pm3^\circ$), we find $\Omega=24.8\pm1.8^\circ$ and we estimate the pulsar distance to be $D=10^{+4}_{-3}$ kpc. This then gives us an estimate of this pulsar's proper motion of $\mu_{\alpha}\cos{\delta}=2.9\pm1.0$ mas yr$^{-1}$ in right ascension and $\mu_{\delta}=1.8\pm0.6$ mas yr$^{-1}$ in declination. Finally, we obtain measurements of the spatial structure of the interstellar electron density fluctuations, including: the spatial scale and anisotropy of the diffraction pattern; the distribution of scattering material along the line of sight; and spatial variation in the strength of turbulence from epoch to epoch. We find that the scattering is dominated by a thin screen at a distance of $(0.724\pm0.008)D$, with an anisotropy axial ratio $A_{\rm r} = 2.14\pm0.11$.Comment: 17 pages, 8 figures, 2 tables. Accepted for publication in MNRA

Lense-Thirring frame dragging induced by a fast-rotating white dwarf in a binary pulsar system

Radio pulsars in short-period eccentric binary orbits can be used to study both gravitational dynamics and binary evolution. The binary system containing PSR J1141$-$6545 includes a massive white dwarf (WD) companion that formed before the gravitationally bound young radio pulsar. We observe a temporal evolution of the orbital inclination of this pulsar that we infer is caused by a combination of a Newtonian quadrupole moment and Lense-Thirring precession of the orbit resulting from rapid rotation of the WD. Lense-Thirring precession, an effect of relativistic frame-dragging, is a prediction of general relativity. This detection is consistent with the evolutionary scenario in which the WD accreted matter from the pulsar progenitor, spinning up the WD to a period $< 200$ seconds.Comment: Accepted for publication in Scienc

The MeerTime Pulsar Timing Array -- A Census of Emission Properties and Timing Potential

MeerTime is a five-year Large Survey Project to time pulsars with MeerKAT, the 64-dish South African precursor to the Square Kilometre Array. The science goals for the programme include timing millisecond pulsars (MSPs) to high precision (< 1 $\mu$s) to study the Galactic MSP population and to contribute to global efforts to detect nanohertz gravitational waves with the International Pulsar Timing Array (IPTA). In order to plan for the remainder of the programme and to use the allocated time most efficiently, we have conducted an initial census with the MeerKAT "L-band" receiver of 189 MSPs visible to MeerKAT and here present their dispersion measures, polarization profiles, polarization fractions, rotation measures, flux density measurements, spectral indices, and timing potential. As all of these observations are taken with the same instrument (which uses coherent dedispersion, interferometric polarization calibration techniques, and a uniform flux scale), they present an excellent resource for population studies. We used wideband pulse portraits as timing standards for each MSP and demonstrated that the MeerTime Pulsar Timing Array (MPTA) can already contribute significantly to the IPTA as it currently achieves better than 1 $\mu$s timing accuracy on 89 MSPs (observed with fortnightly cadence). By the conclusion of the initial five-year MeerTime programme in July 2024, the MPTA will be extremely significant in global efforts to detect the gravitational wave background with a contribution to the detection statistic comparable to other long-standing timing programmes.Comment: Accepted to PASA. 27 figures. Data to be made available under the DOI 10.5281/zenodo.5347875 at the time of publicatio

The SUrvey for Pulsars and Extragalactic Radio Bursts - III. Polarization properties of FRBs 160102 and 151230

We report on the polarization properties of two fast radio bursts (FRBs): 151230 and 160102 discovered in the SUrvey for Pulsars and Extragalactic Radio Bursts (SUPERB) at the Parkes Radio Telescope. FRB 151230 is observed to be 6 ± 11 per cent circularly polarized and 35 ± 13 per cent linearly polarized with a rotation measure (RM) consistent with zero. Conversely, FRB160102 is observed to have a circular polarization fraction of 30±11 per cent, linear polarization fraction of 84 ± 15 per cent for RM = -221(6) radm-2, and the highest measured dispersion measure (2596.1±0.3 pc cm-3) for an FRB to date.We examine possible progenitor models for FRB 160102 in extragalactic, non-cosmological and cosmological scenarios. After accounting for the Galactic foreground contribution, we estimate the intrinsic RM to be -256(9) rad m-2in the low-redshift case and ~-2.4×102rad m-2in the highredshift case. We assess the relative likeliness of these scenarios and how each can be tested. We also place constraints on the scattering measure and study the impact of scattering on the signal's polarization position angle

The MeerKAT telescope as a pulsar facility: System verification and early science results from MeerTime

We describe system verification tests and early science results from the pulsar processor (PTUSE) developed for the newly commissioned 64-dish SARAO MeerKAT radio telescope in South Africa. MeerKAT is a high-gain ( ) low-system temperature ( ) radio array that currently operates at 580–1 670 MHz and can produce tied-array beams suitable for pulsar observations. This paper presents results from the MeerTime Large Survey Project and commissioning tests with PTUSE. Highlights include observations of the double pulsar , pulse profiles from 34 millisecond pulsars (MSPs) from a single 2.5-h observation of the Globular cluster Terzan 5, the rotation measure of Ter5O, a 420-sigma giant pulse from the Large Magellanic Cloud pulsar PSR , and nulling identified in the slow pulsar PSR J0633–2015. One of the key design specifications for MeerKAT was absolute timing errors of less than 5 ns using their novel precise time system. Our timing of two bright MSPs confirm that MeerKAT delivers exceptional timing. PSR exhibits a jitter limit of whilst timing of PSR over almost 11 months yields an rms residual of 66 ns with only 4 min integrations. Our results confirm that the MeerKAT is an exceptional pulsar telescope. The array can be split into four separate sub-arrays to time over 1 000 pulsars per day and the future deployment of S-band (1 750–3 500 MHz) receivers will further enhance its capabilities

The SUrvey for Pulsars and Extragalactic Radio Bursts – II. New FRB discoveries and their follow-up

We report the discovery of four Fast Radio Bursts (FRBs) in the ongoing SUrvey for Pulsars and Extragalactic Radio Bursts at the Parkes Radio Telescope: FRBs 150610, 151206, 151230 and 160102. Our real-time discoveries have enabled us to conduct extensive, rapid multimessenger follow-up at 12 major facilities sensitive to radio, optical, X-ray, gamma-ray photons and neutrinos on time-scales ranging from an hour to a few months post-burst. No counterparts to the FRBs were found and we provide upper limits on afterglow luminosities. None of the FRBs were seen to repeat. Formal fits to all FRBs show hints of scattering while their intrinsic widths are unresolved in time. FRB 151206 is at low Galactic latitude, FRB 151230 shows a sharp spectral cut-off, and FRB 160102 has the highest dispersion measure (DM = 2596.1 ± 0.3 pc cm−3) detected to date. Three of the FRBs have high dispersion measures (DM > 1500 pc cm−3), favouring a scenario where the DM is dominated by contributions from the intergalactic medium. The slope of the Parkes FRB source counts distribution with fluences >2 Jy ms is α=−2.2+0.6−1.2 and still consistent with a Euclidean distribution (α = −3/2). We also find that the all-sky rate is 1.7+1.5−0.9×103 FRBs/(4π sr)/day above ∼2Jyms and there is currently no strong evidence for a latitude-dependent FRB sky rate