The Impact of Lidar Detection Sensitivity on Assessing Aerosol Direct Radiative Effects

Spaceborne lidar observations have great potential to provide accurate global estimates of the aerosol direct radiative effect (DRE) in both clear and cloudy conditions. However, comparisons between observations from the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite (CALIPSO) and multiple years of Atmospheric Radiation Measurement (ARM) programs ground-based Raman lidars (RL) show that CALIPSO does not detect all radiatively significant aerosol, i.e. aerosol that directly modifies the Earths radiation budget. We estimated that using CALIPSO observations results in an underestimate of the magnitude of the global mean aerosol DRE by up to 54%. The ARM RL datasets along with NASA Langley airborne high spectral resolution lidar (HSRL) data from multiple field campaigns are used to compute the detection sensitivity required to accurately resolve the aerosol DRE. This shows that a lidar with a backscatter coefficient detection sensitivity of about 12x10(exp -4)km(exp -1)sr(exp -1) at 532nm would resolve all the aerosol needed to derive the DRE to within 1%

Traumatic Anterior Shoulder Dislocation With Concomitant Pectoralis Rupture and Bankart Lesion

Traumatic anterior shoulder dislocation is frequently associated with injury to the static soft tissue stabilizers of the glenohumeral joint, with the most common injury being an anterior inferior labral avulsion (Bankart lesion) in 73% of patients after a first time dislocation1. Bony injury can also occur from a single episode of instability. Glenoid rim fractures occur in 5.4%-11% of patients. Greater tuberosity fractures occur in 12%-15% in primary anterior shoulder dislocations. Hill-Sachs lesions occur in 38%-90% of primary anterior shoulder dislocations. Less commonly there can be vascular and nerve injury. Additionally, in patients over the age of 40, rotator cuff tears can occur with anterior shoulder dislocation. Pectoralis major tendon rupture commonly occurs in 20- to 40-year-old males secondary to a rapid eccentric contraction. Of 365 identified pectoralis injuries, 83% were due to indirect trauma, 48% of those occurring in weight-training activities. To our knowledge, this is the first report of a pectoralis major tendon rupture and a Bankart lesion with both lesions treated surgically, and only the second report in the literature of this combined pathology resulting from traumatic injury. In this report, a 20-year-old male patient dislocated his shoulder during an incline bench press causing pectoralis major rupture, Hill-Sachs defect, and an acute Bankart lesion. Only the pectoralis major tendon was repaired in this case. In a retrospective study looking at pectoralis major tendon rupture in the military, 53% of tears occurred during bench pressing. There have been few cases described where pec rupture occurred by another mechanism

Accurate early positions for Swift GRBS: enhancing X-ray positions with UVOT astrometry

Here we describe an autonomous way of producing more accurate prompt XRT positions for Swift-detected GRBs and their afterglows, based on UVOT astrometry and a detailed mapping between the XRT and UVOT detectors. The latter significantly reduces the dominant systematic error -- the star-tracker solution to the World Coordinate System. This technique, which is limited to times when there is significant overlap between UVOT and XRT PC-mode data, provides a factor of 2 improvement in the localisation of XRT refined positions on timescales of less than a few hours. Furthermore, the accuracy achieved is superior to astrometrically corrected XRT PC mode images at early times (for up to 24 hours), for the majority of bursts, and is comparable to the accuracy achieved by astrometrically corrected X-ray positions based on deep XRT PC-mode imaging at later times (abridged).Comment: 12 pages, 8 figures, 1 table, submitted to Astronomy and Astrophysics, August 7th 200

The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology

The cell cycle is central to understanding fundamental biology of Leishmania, a group of human-infective protozoan parasites. Leishmania have two main life cycle morphologies: the intracellular amastigote in the mammalian host and the promastigote in the fly. We have produced the first comprehensive and quantitative description of a Leishmania promastigote cell cycle taking a morphometric approach to position any cell within the cell cycle based on its length and DNA content. We describe timings of cell cycle phases and rates of morphological changes; kinetoplast and nucleus S phase, division and position, cell body growth and morphology changes, flagellum growth and basal body duplication. We have shown that Leishmania mexicana undergoes large changes in morphology through the cell cycle and that the wide range of morphologies present in cultures during exponential growth represent different cell cycle stages. We also show promastigote flagellum growth occurs over multiple cell cycles. There are clear implications for the mechanisms of flagellum length regulation, life cycle stage differentiation and trypanosomatid division in general. This data set therefore provides a platform which will be of use for post-genomic analyses of Leishmania cell biology in relation to differentiation and infection

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study

AIMS: Technological limitations have restricted in vivo assessment of intracellular pH (pH(i)) in the myocardium. The aim of this study was to evaluate the potential of hyperpolarized [1-(13)C]pyruvate, coupled with (13)C magnetic resonance spectroscopy (MRS), to measure pH(i) in the healthy and diseased heart. METHODS AND RESULTS: Hyperpolarized [1-(13)C]pyruvate was infused into isolated rat hearts before and immediately after ischaemia, and the formation of (13)CO(2) and H(13)CO(3)(-) was monitored using (13)C MRS. The HCO(3)(-)/CO(2) ratio was used in the Henderson-Hasselbalch equation to estimate pH(i). We tested the validity of this approach by comparing (13)C-based pH(i) measurements with (31)P MRS measurements of pH(i). There was good agreement between the pH(i) measured using (13)C and (31)P MRS in control hearts, being 7.12 +/- 0.10 and 7.07 +/- 0.02, respectively. In reperfused hearts, (13)C and (31)P measurements of pH(i) also agreed, although (13)C equilibration limited observation of myocardial recovery from acidosis. In hearts pre-treated with the carbonic anhydrase (CA) inhibitor, 6-ethoxyzolamide, the (13)C measurement underestimated the (31)P-measured pH(i) by 0.80 pH units. Mathematical modelling predicted that the validity of measuring pH(i) from the H(13)CO(3)(-)/(13)CO(2) ratio depended on CA activity, and may give an incorrect measure of pH(i) under conditions in which CA was inhibited, such as in acidosis. Hyperpolarized [1-(13)C]pyruvate was also infused into healthy living rats, where in vivo pH(i) from the H(13)CO(3)(-)/(13)CO(2) ratio was measured to be 7.20 +/- 0.03. CONCLUSION: Metabolically generated (13)CO(2) and H(13)CO(3)(-) can be used as a marker of cardiac pH(i) in vivo, provided that CA activity is at normal levels

2018 Scholars at Work Conference Program

Program for the 2018 Scholars at Work Conference at Minnesota State University, Mankato on March 30, 2018

An ethnographic organisational study of alongside midwifery units: a follow-on study from the Birthplace in England programme - Full Report

Background: Alongside midwifery units (AMUs) were identified as a novel hybrid organisational form in the Birthplace in England Research Programme, to which this is a follow-on study. The number of such units (also known as hospital birth centres) has increased greatly in the UK since 2007. They provide midwife-led care to low-risk women adjacent to maternity units run by obstetricians, aiming to provide a homely environment to support normal childbirth. Women are transferred to the obstetric unit (OU) if they want an epidural or if complications occur. Aims: This study aimed to investigate the ways that AMUs in England are organised, staffed and managed. It also aimed to look at the experiences of women receiving maternity care in an AMU and the views and experiences of maternity staff, including both those who work in an AMU and those in the adjacent OU. Methods: An organisational ethnography approach was used, incorporating case studies of four AMUs, selected for maximum variation on the basis of geographical context, length of establishment of an AMU, size of unit, management, leadership and physical design. Interviews were conducted between December 2011 and October 2012 with service managers and key stakeholders (n = 35), with professionals working within and in relation to AMUs (n = 54) and with postnatal women and birth partners (n = 47). Observations were conducted of key decision-making points in the service (n = 20) and relevant service documents and guidelines were collected and reviewed. Findings: Women and their families valued AMU care highly for its relaxed and comfortable environment, in which they felt cared for and valued, and for its support for normal birth. However, key points of transition for women could pose threats to equity of access and quality of their care, such as information and preparation for AMU care, and gaining admission in labour and transfer out of the unit. Midwives working in AMUs highly valued the environment, approach and the opportunity to exercise greater professional autonomy, but relations between units could also be experienced as problematic and as threats to professional autonomy as well as to quality and safety of care. We identified key themes that pose potential challenges for the quality, safety and sustainability of AMU care: boundary work and management, professional issues, staffing models and relationships, skills and confidence, and information and access for women. Conclusions: AMUs have a role to play in contributing to service quality and safety. They provide care that is satisfying for women, their partners and families and for health professionals, and they facilitate appropriate care pathways and professional roles and skills. There is a potential for AMUs to provide equitable access to midwife-led care when midwifery unit care is the default option (opt-out) for all healthy women. The Birthplace in England study indicated that AMUs provide safe and cost-effective care. However, the opportunity to plan to birth in an AMU is not yet available to all eligible women, and is often an opt-in service, which may limit access. The alignment of physical, philosophical and professional boundaries is inherent in the rationale for AMU provision, but poses challenges for managing the service to ensure key safety features of quality and safety are maintained. We discuss some key issues that may be relevant to managers in seeking to respond to such challenges, including professional education, inter- and intraprofessional communication, relationships and teamwork, integrated models of midwifery and women’s care pathways. Further work is recommended to examine approaches to scaling up of midwifery unit provision, including staffing and support models. Research is also recommended on how to support women effectively in early labour and on provision of evidence-based and supportive information for women. Funding: The National Institute for Health Research Health Services and Delivery Research programme

Moral courage in the workplace: moving to and from the desire and decision to act

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72135/1/j.1467-8608.2007.00484.x.pd