Dungeness crab fishermen perceptions of injury causation and factors in staying safe

Background: Commercial fishing is a hazardous occupation in the United States (US). Injury surveillance data relies heavily on US Coast Guard reports, which capture injuries severe enough to require reporting. The reports do not incorporate the fishermen’s perspective on contributing factors to injuries and staying safe while fishing.  Materials and methods: We conducted a pre-season survey of Dungeness crab fishermen during 2015 to 2016. Community researchers administered surveys to fishermen. Respondents reported their opinions about factors contributing to injuries and staying safe, which were grouped into similar themes by consen- sus. Descriptive statistics were calculated to explore the number of injuries, crew position, age, and years of experience. Chi-square tests compared perceptions of injury causation, staying safe, and other factors.  Results: Four hundred twenty-six surveys were completed. Injury causation perceptions were sorted into 17 categories, and staying safe perceptions were sorted into 13 categories. The most frequently cited causes of injury were heavy workload (86, 21.9%), poor mental focus (78, 19.9%), and inexperience (56, 14.3%). The most frequently cited factors in staying safe while fishing were awareness (142, 36.1%), good and well-maintained fishing gear/vessel (41, 10.4%), and best marine practices (39, 9.9%). Opinions were not significantly associated with experiencing an injury in the past while fishing, but some opinions were significantly associated with crew position, age, and years of experience.  Conclusions: The perceptions of fishermen can be evaluated further and incorporated into training or intervention development. The fishermen-led approach of this project lends itself to developing injury pre- vention strategies that are effective, realistic and suitable. The resources available at FLIPPresources.org, such as informational sheets for new fishermen, sample crew agreements, and first aid kit resources, supply workers in this fishery with real solutions for issues they identified through their survey responses.

Saving the Last Unicorns: The Genetic Rescue of Florida’s Pillar Corals

As stony coral tissue loss disease (SCTLD) swept through the Florida Reef Tract, one of the most severely impacted species was the iconic pillar coral, Dendrogyra cylindrus. As the species’ population experienced a precipitous decline, a collaborative rescue project collected colony fragments for safekeeping at onshore and offshore nursery facilities. Between 2015 and 2019, a total of 574 fragments representing 128 genotypes were collected. These are currently dispersed among five facilities where they continue to provide opportunities to (1) refine best husbandry practices for D. cylindrus, (2) develop treatment options for SCTLD that have been adapted for use on other species, (3) maximize growth and fragmentation to provide the live tissue needed for eventual restoration, and (4) provide a source of parent colonies for assisted sexual reproduction and new genetic diversity. With the wild pillar coral population in Florida at the end of 2020 at less than 6% of its known 2014 population and continuing to decline, the rescued ex situ colonies represent the entirety of the restoration potential for this species in Florida

Airway clearance techniques for the intubated adult: a scoping review

Objective The aim of this scoping review was to understand the extent and type of evidence available in relation to airway clearance techniques in the intubated adult. Introduction This review was commissioned by the Association of Chartered Physiotherapists in Respiratory Care (ACPRC) special interest group as a method of summarising the available evidence on this topic on behalf of its members. Airway clearance in the intubated adult is a key objective of respiratory physiotherapists and although evidence-based guidelines exist in this area, there is no recent summary regarding the extent of the literature which could inform future research and clinical practice. Inclusion criteria Studies which investigated adults who were intubated either via an endo-tracheal or tracheostomy tube met the criteria. All study designs, including reviews, case reports and animal studies, which reported any physiotherapy-related airway clearance techniques were included Methods The following databases were searched: SCOPUS, PubMed, PEDro, CINAHL Plus, and Clinical Trials Registry. The search was completed in December 2021 and limited to full text papers published since 2011. Following the key word search strategy, each title and abstract was screened for relevance to the scoping review aim and the study design was identified. Population, intervention, comparator and outcome (PICO) data extraction was completed for all included papers in order to identify themes. The number and type of evidence retrieved, as well as key themes and outcomes were summarised. Results The scoping review identified 138 suitable papers for inclusion. Of these, 11 were systematic reviews and 39 were randomised clinical trials, representing a moderately large evidence-base on this topic. Also included were other experimental, observational and qualitative studies, narrative reviews and animal and bench studies. Key interventions were identified including multi-modal chest physiotherapy, hyperinflation and manual chest compression techniques. Reported outcome measures were mainly short-term, such as sputum yield and oxygenation, whilst longer-term outcome measures such as ICU length of stay and ventilator-associated pneumonia (VAP) rates were reported less frequently. Outcome measures related to physiological stability were also reported by some studies. Findings of the review were that airway clearance techniques for the intubated adult appear to be safe. There is a moderate body of evidence regarding their efficacy for short-term outcomes such as sputum yield, oxygenation and respiratory mechanics. There is limited evidence regarding their efficacy for longer-term outcomes. Conclusion This scoping review summarises the extent of available evidence regarding airway clearance for intubated adults. Future research should focus on the effects of airway clearance techniques on longer-term outcome measures such as VAP rates and extubation outcom

Dietary change, noncommunicable disease and local knowledge: results of a small-scale study of the views of older Malawians.

Interviews were conducted with a small group of Malawians over the age of 60 in rural Karonga district and in Area 25 of the capital, Lilongwe. We asked their views on the changes in diet that had taken place over their lifetimes and also on the causes of 'noncommunicable' diseases, such as Type 2 diabetes and hypertension in their communities. Their answers generally confirmed research showing that dietary diversity is decreasing in Malawi, but many of our interviewees also recalled that hunger was more frequently experienced in the past. Our interviews revealed that though the essential rural diet based on either maize or cassava appears superficially largely unchanged, there have been significant changes in the varieties of crops grown, methods of production and food processing. Many of our interviewees were concerned that the application of chemical fertiliser and pesticides was harming their health

Injury Risk Perception of Commercial Dungeness Crab Fishermen

The Fishermen Led Injury Prevention Program is the first and only research focused on non-fatal injury prevention among commercial fishermen. • No fishermen reported that they had zero chance of injury, regardless of injuries sustained in career and/or in the past year. • Fishermen who have sustained an injury in their career and/or in the past year, have a higher perception of injury risk. • There is no connection between a fisherman’s history with injury and the amount they worry about sustaining an injury.• Commercial fishing is one of the most dangerous professions in the United States. • Between 2002-2014 Dungeness crab fishermen had 209 fatalities per 100,000 full-time equivalent workers. • 405 surveys were collected by community researchers before the 2015-2016 Dungeness crab season. • We examine here the association of injury and risk perception

The SAMI Galaxy Survey: a statistical approach to an optimal classification of stellar kinematics in galaxy surveys

Large galaxy samples from multi-object IFS surveys now allow for a statistical analysis of the z~0 galaxy population using resolved kinematics. However, the improvement in number statistics comes at a cost, with multi-object IFS survey more severely impacted by the effect of seeing and lower S/N. We present an analysis of ~1800 galaxies from the SAMI Galaxy Survey and investigate the spread and overlap in the kinematic distributions of the spin parameter proxy $\lambda_{Re}$ as a function of stellar mass and ellipticity. For SAMI data, the distributions of galaxies identified as regular and non-regular rotators with \textsc{kinemetry} show considerable overlap in the $\lambda_{Re}$-$\varepsilon_e$ diagram. In contrast, visually classified galaxies (obvious and non-obvious rotators) are better separated in $\lambda_{Re}$ space, with less overlap of both distributions. Then, we use a Bayesian mixture model to analyse the observed $\lambda_{Re}$-$\log(M_*/M_{\odot})$ distribution. Below $\log(M_{\star}/M_{\odot})\sim10.5$, a single beta distribution is sufficient to fit the complete $\lambda_{Re}$ distribution, whereas a second beta distribution is required above $\log(M_{\star}/M_{\odot})\sim10.5$ to account for a population of low-$\lambda_{Re}$ galaxies. While the Bayesian mixture model presents the cleanest separation of the two kinematic populations, we find the unique information provided by visual classification of kinematic maps should not be disregarded in future studies. Applied to mock-observations from different cosmological simulations, the mixture model also predicts bimodal $\lambda_{Re}$ distributions, albeit with different positions of the $\lambda_{Re}$ peaks. Our analysis validates the conclusions from previous smaller IFS surveys, but also demonstrates the importance of using kinematic selection criteria that are dictated by the quality of the observed or simulated data.Comment: 30 pages and 17 figures, accepted for publication in MNRAS. Abstract abridged for Arxiv. The key figures of the paper are: 3, 7, 8, and 1

Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study

The burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may represent an intermediate point between genetics and the illness. This paper investigates the influence of CNVs on cognition. We conducted a systematic review and meta-analysis of the literature exploring the effect of CNV burden on general intelligence. We included ten primary studies with a total of 18,847 participants and found no evidence of association. In a new psychosis family study, we investigated the effects of CNVs on specific cognitive abilities. We examined the burden of large and rare CNVs (>200 kb, <1% MAF) as well as known schizophrenia-associated CNVs in patients with psychotic disorders, their unaffected relatives and controls (N = 3428) from the Psychosis Endophenotypes International Consortium (PEIC). The carriers of specific schizophrenia-associated CNVs showed poorer performance than non-carriers in immediate (P = 0.0036) and delayed (P = 0.0115) verbal recall. We found suggestive evidence that carriers of schizophrenia-associated CNVs had poorer block design performance (P = 0.0307). We do not find any association between CNV burden and cognition. Our findings show that the known high-risk CNVs are not only associated with schizophrenia and other neurodevelopmental disorders, but are also a contributing factor to impairment in cognitive domains such as memory and perceptual reasoning, and act as intermediate biomarkers of disease risk.This work was supported by the Medical Research Council (G0901310) and the Wellcome Trust (grants 085475/B/08/Z, 085475/Z/08/Z). This study was supported by the NIHR Biomedical Research Centre at University College London Hospitals NHS Foundation Trust and University College London and by the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust at King’s College London. Further support to EB: Mental Health Research UK’s John Grace QC award, BMA Margaret Temple grants 2016 and 2006, MRC—Korean Health Industry Development Institute Partnering Award (MC_PC_16014), MRC New Investigator Award and a MRC Centenary Award (G0901310), National Institute of Health Research UK post-doctoral fellowship, the Psychiatry Research Trust, the Schizophrenia Research Fund, the Brain and Behaviour Research foundation’s NARSAD Young Investigator Awards 2005, 2008, Wellcome Trust Research Training Fellowship, the NIHR Biomedical Research Centre at UCLH, and the NIHR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry King’s College London. Further support to co-authors: The Brain and Behaviour Research foundation’s (NARSAD’s) Young Investigator Award (Grant 22604, awarded to CI). The BMA Margaret Temple grant 2016 to JT. A 2014 European Research Council Marie Curie award to A Díez-Revuelta. HI has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 747429. A Medical Research Council doctoral studentship to JH-S, IA-Z and AB. A Mental Health Research UK studentship to RM. VB is supported by a Wellcome Trust Seed Award in Science (200589/Z/16/Z). FWO Senior Clinical Fellowship to RvW. The infrastructure for the GROUP consortium is funded through the Geestkracht programme of the Dutch Health Research Council (ZON-MW, grant number 10-000-1001), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organisations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Centre and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Centre Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical centre The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGZ Eindhoven en De Kempen, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Centre Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta). The Santander cohort was supported by Instituto de Salud Carlos III (PI020499, PI050427, PI060507), SENY Fundació (CI 2005-0308007), Fundacion Ramón Areces and Fundacion Marqués de Valdecilla (API07/011, API10/13). We thank Valdecilla Biobank for providing the biological PAFIP samples and associated data included in this study and for its help in the technical execution of this work; we also thank IDIVAL Neuroimaging Unit for its help in the acquisition and processing of imaging PAFIP data

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3

By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid. Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder frequently caused by non-assembly of dynein arm motors into cilia and flagella axonemes. Before their import into cilia and flagella, multi-subunit axonemal dynein arms are thought to be stabilized and pre-assembled in the cytoplasm through a DNAAF2–DNAAF4–HSP90 complex akin to the HSP90 co-chaperone R2TP complex. Here, we demonstrate that large genomic deletions as well as point mutations involving PIH1D3 are responsible for an X-linked form of PCD causing disruption of early axonemal dynein assembly. We propose that PIH1D3, a protein that emerges as a new player of the cytoplasmic pre-assembly pathway, is part of a complementary conserved R2TP-like HSP90 co-chaperone complex, the loss of which affects assembly of a subset of inner arm dyneins

The LEGA-C and SAMI Galaxy Surveys:Quiescent Stellar Populations and the Mass-Size Plane across 6 Gyr

We investigate the change in mean stellar population age and metallicity ([Z/H]) scaling relations for quiescent galaxies from intermediate redshift ($0.60\leq z\leq0.76$) using the LEGA-C Survey, to low redshift ($0.014\leq z\leq0.10$) using the SAMI Galaxy Survey. We find that, similarly to their low-redshift counterparts, the stellar metallicity of quiescent galaxies at $0.60\leq z\leq 0.76$ closely correlates with $M_*/R_\mathrm{e}$ (a proxy for the gravitational potential or escape velocity), in that galaxies with deeper potential wells are more metal-rich. This supports the hypothesis that the relation arises due to the gravitational potential regulating the retention of metals, by determining the escape velocity required by metal-rich stellar and supernova ejecta to escape the system and avoid being recycled into later stellar generations. On the other hand, we find no correlation between stellar age and $M_*/R_\mathrm{e}^2$ (stellar mass surface density $\Sigma$) in the LEGA-C sample, despite this being a strong relation at low redshift. We consider this change in the age--$\Sigma$ relation in the context of the redshift evolution of the star-forming and quiescent populations in the mass--size plane, and find our results can be explained as a consequence of galaxies forming more compactly at higher redshifts, and remaining compact throughout their evolution. Furthermore, galaxies appear to quench at a characteristic surface density that decreases with decreasing redshift. The $z\sim 0$ age--$\Sigma$ relation is therefore a result of building up the quiescent and star-forming populations with galaxies that formed at a range of redshifts and so a range of surface densities