A model proposal for IFRS 16 IBR adjustment based on bond market pricing

The Incremental Borrowing Rate (IBR) is generally used by companies for discounting future lease payments and calculating the value of the lease assets and liabilities under IFRS 16. According to this standard, leased asset must be considered as a collateral, and therefore the yield to be used should reflect an adequate Loss-Given Default (LGD), which may vary depending on the estimated recovery rate of the asset (machinery, real estate, vehicles, etc.). There is a lack of accounting and finance literature focused on analysing how a standard IBR should be adjusted to reflect the expected underlying asset LGD in line with IFRS principles. In this context, we propose a model that uses bond quoted information as a basis for introducing an adjustment to the standard “unsecured” IBR. The model consists of replicating the change in a certain bond yield when there is a change in the LGD (usually due to a change in the seniority level). We empirically demonstrate that the model works by using data from real bond quotations (97 outstanding bonds quoted on several secondary markets such as NY, Vienna, Frankfurt and London). The empirical analysis has been performed for two different time periods: pre- COVID 19 and post-COVID 19

PP2A-Cdc55 phosphatase regulates actomyosin ring contraction and septum formation during cytokinesis

Eukaryotic cells divide and separate all their components after chromosome segregation by a process called cytokinesis to complete cell division. Cytokinesis is highly regulated by the recruitment of the components to the division site and through post-translational modifications such as phosphorylations. The budding yeast mitotic kinases Cdc28-Clb2, Cdc5, and Dbf2-Mob1 phosphorylate several cytokinetic proteins contributing to the regulation of cytokinesis. The PP2A-Cdc55 phosphatase regulates mitosis counteracting Cdk1- and Cdc5-dependent phosphorylation. This prompted us to propose that PP2A-Cdc55 could also be counteracting the mitotic kinases during cytokinesis. Here we show that in the absence of Cdc55, AMR contraction and the primary septum formation occur asymmetrically to one side of the bud neck supporting a role for PP2A-Cdc55 in cytokinesis regulation. In addition, by in vivo and in vitro assays, we show that PP2A-Cdc55 dephosphorylates the chitin synthase II (Chs2 in budding yeast) a component of the Ingression Progression Complexes (IPCs) involved in cytokinesis. Interestingly, the non-phosphorylable version of Chs2 rescues the asymmetric AMR contraction and the defective septa formation observed in cdc55 increment mutant cells. Therefore, timely dephosphorylation of the Chs2 by PP2A-Cdc55 is crucial for proper actomyosin ring contraction. These findings reveal a new mechanism of cytokinesis regulation by the PP2A-Cdc55 phosphatase and extend our knowledge of the involvement of multiple phosphatases during cytokinesis

Análisis exploratorio de la actividad física en la auto-objetificación e insatisfacción corporal de jóvenes adolescentes

The objective of the present study has been to analyze the relationships and differences produced between physical activity, self-esteem, appearance, and body dissatisfaction, regarding gender. A total of 303 adolescents, male (150) and female (152), aged between 10 and 13 years (M = 11.74) belonging to different Primary Education centers participated in the study. The PSPP questionnaire was used for the assessment of self-esteem and appearance, the Stunkard figures for body satisfaction, and the PAQ-A questionnaire for the assessment of physical activity. Bivariate correlations, multivariate analysis, and linear regression analysis were performed considering gender. The results showed a significant predictive value of physical activity in self-esteem and appearance. By way of conclusion, it highlights the importance of the role of physical activity as a precursor of self-esteem and appearance, in addition to body image as a precursor of body satisfaction or dissatisfactionEl objetivo del presente estudio ha sido analizar las relaciones y diferencias producidas entre la actividad fí-sica, la autoestima, apariencia e insatisfacción corporal respecto al género. Un total de 303 adolescentes, mas-culinos (150) y femeninos (152), con edades compren-didas entre los 10-13 años (M = 11.74) pertenecientes a diferentes centros de Educación Primaria participaron en el estudio. Se empleó el cuestionario PSPP para la valoración de la autoestima y la apariencia, las figuras de Stunkard para la satisfacción corporal y el cuestio-nario PAQ-A para la valoración de la actividad física. Se realizaron correlaciones de bivariadas, análisis multi-variante y análisis de regresión lineal considerando el género. Los resultados mostraron un valor predictivo significativo mayor de la actividad física femenina en la autoestima y la apariencia que en la masculina. A modo de conclusión, destaca la importancia que tiene el rol de la actividad física como precursor de la autoestima, apariencia e insatisfacción corporal. Del mismo modo, la práctica de la actividad física por parte del género femenino tiende a predecir la apariencia y autoestimaActividad Física y Deport

Functional Autonomy Evaluation Levels in Middle-Aged and Older Spanish Women: On Behalf of the Healthy-Age Network

Aging is associated with a progressive loss of functional capacity that affects the health and quality of life of middle-aged and older people. The purpose of this study was to report functional autonomy evaluation levels in middle-aged and older women in the Spanish context. A total of 709 middle-aged and older women, between 50 and 90 years old, were selected to participate in the study. The sample was divided by age category every five years. The functional autonomy levels were determined by the Latin American Group for Maturity (GDLAM) protocol and we developed a classification pattern for middle-aged and older women living in Spain. The GDLAM Index (GI) was then calculated to assess functional autonomy. The classification of the tests and the GI followed the percentile rank (P) Very Good (p 0.85). It was considered that the lower the value found for the percentile, the better the result. The GDLAM protocol showed strong reliability with intraclass correlation coefficient (ICC) values greater than 0.92 in all tests. It is observed that all variables of the GDLAM protocol presented a positive and significant correlation with age (p < 0.001). The Roc Curve showed that GI values higher than 26 (CI95% = 0.97-1.00; p < 0.001) and 32 (CI95% = 0.98-1.00; p < 0.001) for middle-aged and elderly women, respectively, can predict and indicate low functional autonomy. The normative values hereby provided will enable evaluation and adequate interpretation of Spanish middle-aged and older women's functional autonomy

Multidomain Healthy-Age Programme. Recomendations for Healthy Ageing: On Behalf of the Healthy-Age Network

La Red de investigación en Envejecimiento Activo, Ejercicio y Salud: HEALTHY-AGE (referencias: 06/ UPR/19 y 08/UPR/20) está respaldada por subvención del Consejo Superior de Deportes (CSD) del Ministerio de Cultura y Deporte del gobierno de España –convocatoria de 2019 y 2020 de Redes de Ciencias del Deporte–. Los autores declaran no poseer conflictos de interés.El envejecimiento es un proceso natural asociado a un declive que repercute en un mayor riesgo de padecer discapacidad física y cognitiva, y/o afección emocional y social. En consecuencia, diversos estudios muestran los múltiples beneficios de los programas de entrenamiento multicomponente. Además, las directrices actuales amplían este enfoque hacia los programas multidominio. Por ello, el objetivo de este trabajo es presentar el programa de intervención multidominio Healthy-Age que sigue las recomendaciones de las principales instituciones y literatura científica e incluye los principales dominios (físico, social, cognitivo y motivacional) en las personas mayores. Su finalidad es la de prevenir, mantener o mejorar la salud integral (física, psíquica, emocional y social) y educarles para un envejecimiento saludable. Además de incluir unas recomendaciones generales de actividad física, se muestran recomendaciones para el entrenamiento de la resistencia aeróbica, el equilibrio, la coordinación, la fuerza y resistencia muscular, la flexibilidad y el entrenamiento cognitivo; y se presentan dos modalidades; un plan de 5 días supervisado y un plan de 3 días supervisado más 2 días autónomo.Ageing is a natural process associated with a decline that results in an increased risk of physical and cognitive disability and/or emotional and sentimental impairment. Consequently, several studies show the multiple benefits of multi-component training programmes. The current guidelines extend this approach to multi-domain programmes. For this reason, the objective of this paper is to present the Healthy-Age multi-domain intervention programme that follows the recommendations of the main institutions and scientific literature and includes the main domains (physical, social, cognitive and motivational) in older people. Its purpose is to prevent, maintain or improve the overall health (physical, psychological, emotional and social level) for a healthy ageing. In addition to including general recommendations of physical activity, recommendations are shown for aerobic resistance, balance, coordination, muscular strength and resistance, flexibility and cognitive training; and two modalities are presented; a 5-day supervised plan and a 3-day supervised plan plus 2 autonomous days.Consejo Superior de Deportes (CSD) del Ministerio de Cultura y Deporte del gobierno de España (06/ UPR/19 y 08/UPR/20

Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients

Producción CientíficaBackground: Stratification of the severity of infection is currently based on the Sequential Organ Failure Assessment (SOFA) score, which is difficult to calculate outside the ICU. Biomarkers could help to stratify the severity of infection in surgical patients. Methods: Levels of ten biomarkers indicating endothelial dysfunction, 22 indicating emergency granulopoiesis, and six denoting neutrophil degranulation were compared in three groups of patients in the first 12 h after diagnosis at three Spanish hospitals. Results: There were 100 patients with infection, 95 with sepsis and 57 with septic shock. Seven biomarkers indicating endothelial dysfunction (mid-regional proadrenomedullin (MR-ProADM), syndecan 1, thrombomodulin, angiopoietin 2, endothelial cell-specific molecule 1, vascular cell adhesion molecule 1 and E-selectin) had stronger associations with sepsis than infection alone. MR-ProADM had the highest odds ratio (OR) in multivariable analysis (OR 11·53, 95 per cent c.i. 4·15 to 32·08; P = 0·006) and the best area under the curve (AUC) for detecting sepsis (0·86, 95 per cent c.i. 0·80 to 0·91; P < 0·001). In a comparison of sepsis with septic shock, two biomarkers of neutrophil degranulation, proteinase 3 (OR 8·09, 1·34 to 48·91; P = 0·028) and lipocalin 2 (OR 6·62, 2·47 to 17·77; P = 0·002), had the strongest association with septic shock, but lipocalin 2 exhibited the highest AUC (0·81, 0·73 to 0·90; P < 0·001). Conclusion: MR-ProADM and lipocalin 2 could be alternatives to the SOFA score in the detection of sepsis and septic shock respectively in surgical patients with infection.Instituto de Salud Carlos III (grants PI15/01959, PI15/01451 and PI16/01156

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus

A genome-wide association study identifies risk alleles in plasminogen and P4HA2 associated with giant cell arteritis

Giant cell arteritis (GCA) is the most common form of vasculitis in individuals older than 50 years in Western countries. To shed light onto the genetic background influencing susceptibility for GCA, we performed a genome-wide association screening in a well-powered study cohort. After imputation, 1,844,133 genetic variants were analysed in 2,134 cases and 9,125 unaffected controls from ten independent populations of European ancestry. Our data confirmed HLA class II as the strongest associated region (independent signals: rs9268905, P = 1.94E-54, per-allele OR = 1.79; and rs9275592, P = 1.14E-40, OR = 2.08). Additionally, PLG and P4HA2 were identified as GCA risk genes at the genome-wide level of significance (rs4252134, P = 1.23E-10, OR = 1.28; and rs128738, P = 4.60E-09, OR = 1.32, respectively). Interestingly, we observed that the association peaks overlapped with different regulatory elements related to cell types and tissues involved in the pathophysiology of GCA. PLG and P4HA2 are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality