Impacto psicológico en función del grado de exposición a la pandemia por COVID-19, ¿están los sanitarios más afectados?

RESUMEN : Introducción: La pandemia por COVID-19 ha tenido un gran impacto en la salud física y mental de la población. Objetivos: 1) comparar el impacto psicológico en función de la afectación de la regióny del grado de exposición a COVID-19; 2) identificar factores de riesgo y estrategias de afrontamiento adoptadas. Métodos: estudio trasversal, naturalístico. 6068 participantes cumplimentaron una encuesta online del 16 al 23 de abril. La muestra fue dividida en dos grupos: Madrid y Barcelona (regiones más afectadas) y el resto de España (regiones menos afectadas). Así mismo, se crearon subgrupos según el grado de exposición: Población No Expuesta (PNE), Trabajadores Sanitarios Expuestos (TSE) y Otros Trabajadores Expuestos (OTE). Análisis estadístico: Chi-cuadrado, t Student o ANOVA y regresión logística. Resultados: En las regiones menos afectadas, la PNE experimentó más síntomas depresivos (p<0.001) y mayor impacto psicológico (p=0.002) que el resto de participantes, así como más pensamientos suicidas (p=0.040) que OTE y más reacciones evitativas (p=0.004) que TSE. En Madrid y Barcelona, los TSE refirieron más estrés (p=0.014) que la PNE y tanto TSE como OTE refirieron más respuestas intrusivas (p=0.047; p=0.050) que la PNE. Los TSE de las zonas más afectadas aumentaron el consumo de alcohol (p=0.027) y consumieron otras sustancias como forma de afrontamiento (p=0.040). Conclusiones: En las regiones menos afectadas por COVID-19, la PNE refirió mayor impacto psicológico que el resto de participantes. En las zonas más afectadas, los TSE son más vulnerables a desarrollar problemas de salud mental durante la pandemia por COVID-19.ABSTRACT : Introduction: The COVID-19 pandemic has had a great impact on the physical and mental health of the population. Objectives: 1) to compare the psychological impact depending on the affectation of the region and the degree of exposure to COVID-19; 2) identify risk factors and coping strategies. Methods: cross-sectional, naturalistic study. 6068 participants completed an online survey between April 16 and 23, 2020. The sample was divided into two groups: Madrid and Barcelona (most affected regions) and the rest of Spain (greater control of the pandemic). Furthermore, subgroups were created according to the degree of exposure: Population Without Exposure (PWE), Exposed Healthcare Workers, (EHW) and Exposed Non-healthcare Workers (ENW). Statistical analysis: Chi-square, t Student or ANOVA and logistic regression. Results: In the least affected regions, the PWE experienced more depressive symptoms (p <0.001) and greater psychological impact (p = 0.002) tan the rest of the participants, as well as more suicidal thoughts (p = 0.040) than ENW and more avoidance reactions (p = 0.004) than EHW. In Madrid and Barcelona, EHW reported more stress (p = 0.014) than the PWE and both EHW and ENW reported more intrusive responses (p = 0.047; p = 0.050) than the PWE. The EHW of the most affected areas increased alcohol consumption (p = 0.027) and consumed other substances as coping strategies (p = 0.040). Conclusions: In the regions least affected by COVID-19, the PWE reported a greater psychological impact than the rest of the participants. In the worst affected areas, EHW are more vulnerable to developing mental health problems during the COVID-19 pandemic.Máster en Iniciación a la Investigación en Salud Menta

Seminario Permanente de Estudios LGBTIQ+

Seminario de periodicidad mensual en el que exponer y someter a discusión interdisciplinar trabajos de investigación actualmente en curso principalmente en la UCM, tanto en el marco del Máster Oficial de Estudios LGBTIQ+ como en distintos programas de doctorado

The polygenic basis of relapse after a first episode of schizophrenia

Little is known about genetic predisposition to relapse. Previous studies have linked cognitive and psychopathological (mainly schizophrenia and bipolar disorder) polygenic risk scores (PRS) with clinical manifestations of the disease. This study aims to explore the potential role of PRS from major mental disorders and cognition on schizophrenia relapse. 114 patients recruited in the 2EPs Project were included (56 patients who had not experienced relapse after 3 years of enrollment and 58 patients who relapsed during the 3-year follow-up). PRS for schizophrenia (PRS-SZ), bipolar disorder (PRS-BD), education attainment (PRS-EA) and cognitive performance (PRS-CP) were used to assess the genetic risk of schizophrenia relapse.Patients with higher PRS-EA, showed both a lower risk (OR=0.29, 95% CI [0.11–0.73]) and a later onset of relapse (30.96± 1.74 vs. 23.12± 1.14 months, p=0.007. Our study provides evidence that the genetic burden of neurocognitive function is a potentially predictors of relapse that could be incorporated into future risk prediction models. Moreover, appropriate treatments for cognitive symptoms appear to be important for improving the long-term clinical outcome of relapse

The Beaker phenomenon and the genomic transformation of northwest Europe

From around 2750 to 2500 bc, Bell Beaker pottery became widespread across western and central Europe, before it disappeared between 2200 and 1800 bc. The forces that propelled its expansion are a matter of long-standing debate, and there is support for both cultural diffusion and migration having a role in this process. Here we present genome-wide data from 400 Neolithic, Copper Age and Bronze Age Europeans, including 226 individuals associated with Beaker-complex artefacts. We detected limited genetic affinity between Beaker-complex-associated individuals from Iberia and central Europe, and thus exclude migration as an important mechanism of spread between these two regions. However, migration had a key role in the further dissemination of the Beaker complex. We document this phenomenon most clearly in Britain, where the spread of the Beaker complex introduced high levels of steppe-related ancestry and was associated with the replacement of approximately 90% of Britain’s gene pool within a few hundred years, continuing the east-to-west expansion that had brought steppe-related ancestry into central and northern Europe over the previous centuries

Controversies on treatment of unruptured intracranial aneurysms. Value of UIATS and PHASES scores in a daily practice in a Spanish population

Appropriate management of unruptured intracranial aneurysms (UIAs) is still a matter of debate. Whether to treat patients with conservative management (CM) or with interventional management (IM) has been addressed in multiple reports with controversial risk/benefit balances.Our objective is to analyze in-hospital management decision and treatment results of UIAs and to evaluate the management of these UIAs with the UIATS and PHASES scores introduced in 2015.A total of 54 patients/71 UIAs diagnosed in 2015–2016 were reviewed. IM was performed in 34 patients/47 UIAs with surgical (15) or endovascular approaches (19), with a female predominance (59%) and 51-yo median age. Median size of UIAs was 6 mm (2–26). Aneurysm obliteration reached 100% in both groups. Major complications ranged between 5%–13%, with no reoperations or mortality. Epidemiologic risk factors in our population detected >95% of patients without family history, high-risk ethnicity, drug habit, or symptoms from UIAs.Patients with CM had lower UIATS/PHASES scores than those with IM, matching the recommendation from these scores. In contrast, UIATS score in UIAs that were managed with IM showed lower punctuations than expected, showing an institutional preference for IM. In multiple UIAs, UIATS/PHASES scores of the aneurysm leading to IM (excluding other lower risk lesions treated with the same approach) showed higher punctuations, especially in the surgical group. Final decision on treatment of UIAs in our center was mostly based on high-risk profile of aneurysm and multiplicity than on scores, p < 0.001. In our experience UIATS/PHASES scores help in decision-making process, however institutional characteristics should be taken into consideration. Keywords: Unruptured aneurysms, Intracranial hemorrhage, PHASES, UIATS, Clipping, Coilin

Memoria final Seminario Permanente de Estudios LGBTIQ+

Seminario de periodicidad mensual en el que exponer y someter a discusión interdisciplinar trabajos de investigación actualmente en curso en la UCM, tanto en el marco del Máster Oficial de Estudios LGBTIQ+ como en distintos programas de doctorado. Además del enriquecimiento interdisciplinar que esto puede aportar a las investigaciones que se realizan ya de un modo efectivo en nuestra Universidad, resultará prioritario el intento de difundirlo entre grupos de investigación españoles y extranjeros centrados en el campo de estudios LGBTIQ+ y que consideran a la UCM una Universidad de referencia en este campo. Aparte de lxs estudiantes, miembros del PAS y profesorxs que lo integran directamente, el Proyecto cuenta con el apoyo de la Oficina de Diversidad Sexual e Identidad de Género de la UCM (ODSIG) y de los Grupos de Investigación GINEDIS (GI-UCM 970798), “Estética contemporánea: arte, política y sociedad” (GI-UCM 970943), CLEPO (GI-UCM 970845)Depto. de Filosofía y SociedadFac. de FilosofíaFALSEsubmitte