An empirical study on code comprehension: DCI compared to OO

Comprehension of source code affects software development, especially its maintenance where reading code is the most time consuming performed activity. A programming paradigm imposes a style of arranging the source code that is aligned with a way of thinking toward a computable solution. Then, a programming paradigm with a programming language represents an important factor for source code comprehension. Object-Oriented (OO) is the dominant paradigm today. Although, it was criticized from its beginning and recently an alternative has been proposed. In an OO source code, system functions cannot escape outside the definition of classes and their descriptions live inside multiple class declarations. This results in an obfuscated code, a lost sense the run-time, and in a lack of global knowledge that weaken the understandability of the source code at system level. A new paradigm is emerging to address these and other OO issues, this is the Data Context Interaction (DCI) paradigm. We conducted the first human subject related controlled experiment to evaluate the effects of DCI on code comprehension compared to OO. We looked for correctness, time consumption, and focus of attention during comprehension tasks. We also present a novel approach using metrics from Social Network Analysis to analyze what we call the Cognitive Network of Language Elements (CNLE) that is built by programmers while comprehending a system. We consider this approach useful to understand source code properties uncovered from code reading cognitive tasks. The results obtained are preliminary in nature but indicate that DCI-trygve approach produces more comprehensible source code and promotes a stronger focus the attention in important files when programmers are reading code during program comprehension. Regarding reading time spent on files, we were not able to indicate with statistical significance which approach allows programmers to consume less time

Land abandonment as driver of woody vegetation dynamics in Tamaulipan thornscrub at Northeastern Mexico

Background: Vegetation structure is defined as the temporal and spatial distribution of plant species in a particular site. Vegetation structure includes vertical and horizontal distribution and has been widely used as an indicator of successional changes. Ecological succession plays an essential role in the determination of the mechanisms that structure plant communities under anthropogenic disturbances. After an anthropogenic disturbance, such as grazing, forests follow changes in the original composition and vegetation structure, which eventually could restore some of their attributes to become mature forests again. To know how the time of abandonment affects woody plant communities, we ask the following questions: (1) How does the species richness, diversity, and vertical structure (A index) change concerning the time of abandonment? (2) Are species similarities among woody vegetation communities determined by land abandonment? (3) Which woody species have the highest ecological importance in each successional stage? Methods: We explored how successional stages after land abandonment mediated the species richness, species diversity (alpha and beta), and ecological importance value index on four areas of Tamaulipan thornscrub. We selected four areas that differed in time of abandonment: 10, 20, 30, and >30 years. The first three areas were used for cattle grazing, whereas the >30-year area was selected as a control since it does not have a record of disturbance by cattle grazing or agriculture. During the summer of 2012, we randomly established four square plots (40 m × 40 m) in each area, separated at least 200 m from each other. In each plot, we recorded all woody individuals per species with a basal diameter ≥1 cm at 10 cm above ground level. We estimated species richness indices, species diversity (alpha and beta), and ecological importance value index. Results: We recorded 27 woody species belonging to 23 genera and 15 families. Fabaceae accounted for 40% of the species. Acacia farnesiana was the most important and abundant species in the first three successional stages. We suggested that older successional stages of Tamaulipan thornscrub promote woody plant communities, characterized by a higher complex structure than younger communities. We observed the highest species similarity between the sites with a closer time of abandonment, while the lowest similarity was shown between the sites with extreme time of abandonment. We conclude that Tamaulipan thornscrub shows a similar trend of ecological succession to other dry forests and the time of abandonment has a high mediation on plant dynamics in the Tamaulipan thornscrub. Also, we stand out the importance of secondary forests for Tamaulipan thornscrub woody plant communities. Finally, we recommended future studies include aspects of regeneration speed, the proximity of mature vegetation, and the interactions of plants with their seed dispersers.Eduardo Alanis aquired funding from Programa de Mejoramiento al Profesorado (PROMEP/103.5/12/3585). Cristian A. Martínez-Adriano was granted from a CONACYT national postdoctoral fellowship (grants 710775 and 740202)

Field campaign on pressure on the crown wall at the outer port of Punta Langosteira breakwater

[Abstract:] Punta Langosteira port, located in A Coruña (Spain), was monitored during the winters of 2017 and 2018, measuring wave pressure in the crown wall structure. Furthermore, the metocean variables were measured on a buoy located very close to the breakwater. This paper presents the real pressures measured at the crown wall of the breakwater during different storm events. These values are compared with the results of the application of state-of-the-art equations for the calculation of pressures on crown walls. The results obtained show the behaviour of the pressures with a crown wall fully protected by the armour, as is the case of Langosteira breakwater. Finally, several conclusions are made on the methodology for measuring the pressures using physical models and the relevance of the armour roughness.Fundação para a Ciência e a Tecnologia (FCT); PTDC/ECI-EGC/31090/201

Ortega, el pasado y el presente de la escolástica universitaria

In this article we defend the value of Ortega’s perspective on the problem of anachronism in history. To do this, we present the problem in the School of Paris (Jean-Pierre Vernant, Pierre Vidal-Naquet). Next, we explain the contributions of Ortega about the problem in the 40s. Finally, we balance the contributions of Ortega and timeliness.<br><br>En este artículo defendemos el valor de la perspectiva de Ortega sobre el problema del anacronismo en historia. Para ello, exponemos dicho problema en la Escuela de París (Pierre Vidal-Naquet, Jean-Pierre Vernant). Seguidamente, explicamos las aportaciones de Ortega sobre ese problema en los años 40. Finalmente, hacemos un balance de las aportaciones de Ortega y su actualidad

Two new Liolaemus lizards from the Andean highlands of Southern Chile (Squamata, Iguania, Liolaemidae)

Indexación: Web of Science; Scopus; Scielo.Liolaemus is a diverse genus of lizards, subdivided into two subgenera: Liolaemus (sensu stricto) and Eulaemus, distributed mainly in Chile and Argentina. The L. elongatus-kriegi complex is the most diverse group within Liolaemus (sensu stricto), especially the species closely related to L. elongatus, which form a clade currently comprising nine species. Several Chilean species of this group have been recently described, mainly from volcanoes and poorly explored mountains. Here molecular and morphological evidence are provided for a new species of the L. elongatus clade, which is characterized by its small size and lack of dorsal pattern, unusual features for the species of this group of lizards. Additionally, the lack of precloacal pores in males of Liolaemus (sensu stricto) is a trait found in few species, which do not constitute a monophyletic group. A second new southern Chilean species is also described, without precloacal pores and supported by molecular phylogenetics to be related to Liolaemus villaricensis. Both new species were found in the same locality, near a lake located in a pre-Andean zone with Araucaria and Nothofagus forest. The two species are dedicated to prominent Lonkos (tribal chiefs) of the Mapuche and Pehuenche people: Janequeo and Leftraru. Additionally, the phylogenetic results suggest that L. lonquimayensis is a synonym of L. elongatus.http://zookeys.pensoft.net/articles.php?id=952

Soil indicators to assess the effectiveness of restoration strategies in dryland ecosystems

Soil indicators may be used for assessing both land suitability for restoration and the effectiveness of restoration strategies in restoring ecosystem functioning and services. In this review paper, several soil indicators, which can be used to assess the effectiveness of ecological restoration strategies in dryland ecosystems at different spatial and temporal scales, are discussed. The selected indicators represent the different viewpoints of pedology, ecology, hydrology, and land management. Two overall outcomes stem from the review. (i) The success of restoration projects relies on a proper understanding of their ecology, namely the relationships between soil, plants, hydrology, climate, and land management at different scales, which are particularly complex due to the heterogeneous pattern of ecosystems functioning in drylands. (ii) The selection of the most suitable soil indicators follows a clear identification of the different and sometimes competing ecosystem services that the project is aimed at restoring

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

This work is licensed under a Creative Commons Attribution-NonCommercialNoDerivs 3.0 Unported License.-- et al.The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease (NAFLD) are not fully understood. In this study, we aimed to assess the relationship between endoplasmic reticulum (ER) stress and autophagy in human and mouse hepatocytes during NAFLD. ER stress and autophagy markers were analyzed in livers from patients with biopsy-proven non-alcoholic steatosis (NAS) or non-alcoholic steatohepatitis (NASH) compared with livers from subjects with histologically normal liver, in livers from mice fed with chow diet (CHD) compared with mice fed with high fat diet (HFD) or methionine-choline-deficient (MCD) diet and in primary and Huh7 human hepatocytes loaded with palmitic acid (PA). In NASH patients, significant increases in hepatic messenger RNA levels of markers of ER stress (activating transcription factor 4 (ATF4), glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP)) and autophagy (BCN1) were found compared with NAS patients. Likewise, protein levels of GRP78, CHOP and p62/SQSTM1 (p62) autophagic substrate were significantly elevated in NASH compared with NAS patients. In livers from mice fed with HFD or MCD, ER stress-mediated signaling was parallel to the blockade of the autophagic flux assessed by increases in p62, microtubule-associated protein 2 light chain 3 (LC3-II)/LC3-I ratio and accumulation of autophagosomes compared with CHD fed mice. In Huh7 hepatic cells, treatment with PA for 8 h triggered activation of both unfolding protein response and the autophagic flux. Conversely, prolonged treatment with PA (24 h) induced ER stress and cell death together with a blockade of the autophagic flux. Under these conditions, cotreatment with rapamycin or CHOP silencing ameliorated these effects and decreased apoptosis. Our results demonstrated that the autophagic flux is impaired in the liver from both NAFLD patients and murine models of NAFLD, as well as in lipid-overloaded human hepatocytes, and it could be due to elevated ER stress leading to apoptosis. Consequently, therapies aimed to restore the autophagic flux might attenuate or prevent the progression of NAFLD.We acknowledge the following grant support: SAF2012-33283 (MINECO, Spain), Comunidad de Madrid S2010/BMD-2423, EFSD and Amylin Paul Langerhans Grant and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM, ISCIII, Barcelona, Spain) to AMV.; SAF2010-16037, SAF2013-43713-R (MINECO) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD, ISCIII) to PMS. RD12/0042/0019 (ISCIII) and S2010/BMD-2478 (Comunidad de Madrid) to LB, PI 13/01299 and Fundación Mutua Madrileña 2012 to C G-M and AIRC IG-2012 to GMF.Peer Reviewe

Structural analysis of an agroforestry area in a portion of the xeric shrubland of northeast of Mexico

Antecedentes y Objetivos: Los estudios de comunidades vegetales permiten conocer los impactos causados por las actividades agrícolas y pecuarias, especialmente en las zonas áridas. El objetivo de este trabajo fue contrastar la diversidad, composición y estructura de los estratos arbóreo y arbustivo de tres áreas (Agroforestal, Regenerada y Referencia) del matorral xerófilo. Métodos: Se establecieron tres áreas con cuatro sitios de muestreo de 1600 m2 cada una, elegidos al azar, en donde se censaron y registraron los individuos arbóreos y arbustivos. En cada área se calcularon parámetros ecológicos, así como los índices de Shannon y Margalef. Resultados clave: Considerando las tres áreas, se registró un total de 25 especies de plantas vasculares pertenecientes a 22 géneros y 15 familias. Fabaceae fue la familia mejor representada con nueve especies, siendo el género Acacia el que tuvo un mayor número (tres). Los valores de riqueza de especies, el índice de Shannon, índice de Margalef y abundancia, entre el área Referencia y Agroforestal, fueron similares, y en ambos los resultados fueron significativamente mayores que los valores del área Regenerada. El área Agroforestal presentó menor abundancia pero mayor dominancia comparada con las otras dos áreas estudiadas y fue el área que alcanzó el mayor porcentaje de similitud con el área de Referencia. Conclusiones: La actividad Agroforestal contribuye en cierta manera con el mantenimiento de la diversidad y la composición de plantas vasculares del matorral espinoso tamaulipeco estudiado; y dicha actividad no permite cambiar en gran medida la composición y estructura de este tipo de vegetación.Background and Aims: The studies of plant communities allow to know the impacts caused by the agricultural and livestock activities, especially in arid zones. The objective of this work was to contrast the diversity, composition and structure of the arboreal and shrub strata of three areas (Agroforestry, Regenerated and Reference) of the xerophilous scrub. Methods: In each area four sampling sites of 1600 m2 each one were established randomly, where all arboreal and shrubby individuals were registered and censused. In each area, ecological parameters were calculated, as well as the Shannon and Margalef indices. Key results: In the three areas, a total of 25 species of vascular plants belonging to 22 genera and 15 families were registered. The best represented family was Fabaceae with nine species, being the genus Acacia the one that presented the largest species number (three). The observed values of species richness, the Shannon index, Margalef index and abundance between the Reference and Agroforestry area were similar, and both were significantly higher than the values of the Regenerated area. The Agroforestry area presented lower abundance but greater dominance compared with the other two areas studied, and it was the area that reached the highest percentage of similarity with the Reference area. Conclusions: The Agroforestry activity contributes in a certain way in the maintenance of the diversity and composition of vascular plants of the Tamaulipan thorn scrub studied; and this activity does not allow to change to a large extent the composition and structure of this type of vegetation.Este estudio fue apoyado parcialmente por el proyecto PROMEP/103.5/12/3585

Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro

© 2021 The Authors.Therapeutic potential of metformin in obese/diabetic patients has been associated to its ability to combat insulin resistance. However, it remains largely unknown the signaling pathways involved and whether some cell types are particularly relevant for its beneficial effects. M1-activation of macrophages by bacterial lipopolysaccharide (LPS) promotes a paracrine activation of hypoxia-inducible factor-1α (HIF1α) in brown adipocytes which reduces insulin signaling and glucose uptake, as well as β-adrenergic sensitivity. Addition of metformin to M1-polarized macrophages blunted these signs of brown adipocyte dysfunction. At the molecular level, metformin inhibits an inflammatory program executed by HIF1α in macrophages by inducing its degradation through the inhibition of mitochondrial complex I activity, thereby reducing oxygen consumption in a reactive oxygen species (ROS)-independent manner. In obese mice, metformin reduced inflammatory features in brown adipose tissue (BAT) such as macrophage infiltration, proinflammatory signaling and gene expression, and restored the response to cold exposure. In conclusion, the impact of metformin on macrophages by suppressing a HIF1α-dependent proinflammatory program is likely responsible for a secondary beneficial effect on insulin-mediated glucose uptake and β-adrenergic responses in brown adipocytes.This work was funded by grants RTI2018-094052-B-100 (MCIN/AEI/10.13039/501100011033/FEDER) , S2017/BMD-3684 (Comunidad de Madrid, Spain), Fundación Ramón Areces (Spain) and CIBERdem (ISCIII) to A.M.V., grant S2010/BMD-2423 (Comunidad de Madrid, Spain) to M.J.O. and A.M.V., PID2019-106371RB-I00 (MCIN/ AEI /10.13039/501100011033/ FEDER) to J.A and PI16/00789 (ISCIII, Spain) to M.A.F.-M. We also acknowledge all members of AMV's laboratory for helpful discussions. M.F. and B.V were supported by Inserm, CNRS, Université de Paris, and Région Ile-de-France. We also acknowledge the EFSD Albert Reynolds travel grant fellowship to V.F