105 research outputs found
Genetic polymorphism of the \u3b1s1-casein locus in five populations of goats from Mexico
With the objective of estimating allele frequencies, and testing for
population divergence for the CSN1S1 locus, genotypes of animals from
five goat populations; Saanen (n = 97), Alpine (n = 81) Toggenburg (n =
92), local goats with external appearance similar to the
Murciana-Granadina breed from Central Mexico (n = 26) and heterogeneous
local animals denominated Mosaico Lagunero (n = 30), from Northern
Mexico, were identified using PCR and Xmn1 PCR-RFLP methodology. For
Saanen, Alpine and Toggenburg, the sum of E and F alleles had the
largest frequencies (from 0.468 to 0.789), while for the groups local
Murciana-Granadina and Mosaico Lagunero the sum of the most frequent
allelic groups (A* and B*), were 0.385 and 0.533 respectively. Both
local Murciana-Granadina and Mosaico Lagunero populations showed
heterozygote excess (P < 0.08). The percentage of the total genetic
variation (FST) explained by population differences was 5.16. There was
genetic differentiation for most pair comparisons between populations
(P < 0.05), excepting for Alpine versus Toggenburg, and Toggenburg
versus Mosaico Lagunero (P > 0.05). For Saanen and Alpine the
frequencies of alleles E and F were similar to the same breeds
previously analyzed in Europe. Therefore there are opportunities of
increasing the frequency of the strong alleles for protein content Gene
Assisted Selection (GAS) in these two breeds. For Toggenburg the most
frequent allelic groups were F (0.32) and B* (0.21). Results indicate
differentiation between most populations for this locus. Moreover,
heterozygote excess in local populations indicated breed admixture
Sixteen overlooked open clusters in the fourth Galactic quadrant
Aims. This paper has two main objectives: (1) To determine the intrinsic properties of 16 faint and mostly unstudied open clusters in the poorly known sector of the Galaxy at 270\u25e6 12300\u25e6 to probe the Milky Way structure in future investigations. (2) To address previously reported systematics in Gaia DR2 parallaxes by comparing the cluster distances derived from photometry with those derived from parallaxes.
Methods. Deep UBVI photometry of 16 open clusters was carried out. Observations were reduced and analyzed in an automatic way using the ASteCA package to obtain individual distances, reddening, masses, ages, and metallicities. Photometric distances were compared to those obtained from a Bayesian analysis of Gaia DR2 parallaxes.
Results. Ten out of the sixteen clusters are true or highly probable open clusters. Two of them are quite young and follow the trace of the Carina Arm and the already detected warp. The remaining clusters are placed in the interarm zone between the Perseus and Carina Arms, as expected for older objects. We found that the cluster van den Berg-Hagen 85 is 7.5
7 109 yr old, which means that it is one of the oldest open clusters detected in our Galaxy so far. The relationship of these ten clusters with the Galaxy structure in the solar neighborhood is discussed. The comparison of distances from photometry and parallaxes data in turn reveals a variable level of disagreement.
Conclusions. Various zero-point corrections for Gaia DR2 parallax data recently reported were considered for a comparison between photometry- and parallax-based distances. The results tend to improve with some of these corrections. Photometric distance analysis suggests an average correction of 3c+0.026 mas (to be added to the parallaxes). The correction may have a more intricate dependence on distance, but addressing this level of detail will require a larger cluster sample
Revisiting the case of R Monocerotis: Is CO removed at R
Context. To our knowledge, R Mon is the only B0 star in which a gaseous Keplerian disk has been detected. However, there is some controversy about the spectral type of R Mon. Some authors propose that it could be a later B8e star, where disks are more common. Aims. Our goal is to re-evaluate the R Mon spectral type and characterize its protoplanetary disk. Methods. The spectral type of R Mon has been re-evaluated using the available continuum data and UVES emission lines. We used a power-law disk model to fit previous12CO 1 →0 and 2 →1 interferometric observations and the PACS CO data to investigate the disk structure. Interferometric detections of13CO J = 1 →0, HCO+1 →0, and CN 1 →0 lines using the IRAM Plateau de Bure Interferometer (PdBI) are presented. The HCN 1 →0 line was not detected. Results. Our analysis confirms that R Mon is a B0 star. The disk model compatible with the12CO 1 →0 and 2 →1 interferometric observations falls short of predicting the observed fluxes of the 14 < Ju< 31 PACS lines; this is consistent with the scenario in which some contribution to these lines is coming from a warm envelope and/or UV-illuminated outflow walls. More interestingly, the upper limits to the fluxes of the Ju> 31 CO lines suggest the existence of a region empty of CO at R ? 20 au in the protoplanetary disk. The intense emission of the HCO+and CN lines shows the strong influence of UV photons on gas chemistry. Conclusions. The observations gathered in this paper are consistent with the presence of a transition disk with a cavity of Rin≥ 20 au around R Mon. This size is similar to the photoevaporation radius that supports the interpretation that UV photoevaporation is main disk dispersal mechanism in massive stars
Polarizations of J/psi and psi(2S) Mesons Produced in ppbar Collisions at 1.96 TeV
We have measured the polarizations of \jpsi and \psiprime mesons as
functions of their transverse momentum \pt when they are produced promptly in
the rapidity range with \pt \geq 5 \pgev. The analysis is performed
using a data sample with an integrated luminosity of about 800 \ipb collected
by the CDF II detector. For both vector mesons, we find that the polarizations
become increasingly longitudinal as \pt increases from 5 to 30 \pgev. These
results are compared to the predictions of nonrelativistic quantum
chromodynamics and other contemporary models. The effective polarizations of
\jpsi and \psiprime mesons from -hadron decays are also reported.Comment: 8 pages, 7 figures, published in Physical Review Letter
Model-independent evidence for contributions to decays
The data sample of decays acquired with the
LHCb detector from 7 and 8~TeV collisions, corresponding to an integrated
luminosity of 3 fb, is inspected for the presence of or
contributions with minimal assumptions about
contributions. It is demonstrated at more than 9 standard deviations that
decays cannot be described with
contributions alone, and that contributions play a dominant role in
this incompatibility. These model-independent results support the previously
obtained model-dependent evidence for charmonium-pentaquark
states in the same data sample.Comment: 21 pages, 12 figures (including the supplemental section added at the
end
Quantum numbers of the state and orbital angular momentum in its decay
Angular correlations in decays, with , and , are used to measure
orbital angular momentum contributions and to determine the value of
the meson. The data correspond to an integrated luminosity of 3.0
fb of proton-proton collisions collected with the LHCb detector. This
determination, for the first time performed without assuming a value for the
orbital angular momentum, confirms the quantum numbers to be .
The is found to decay predominantly through S wave and an upper limit
of at C.L. is set on the fraction of D wave.Comment: 16 pages, 4 figure
Search for resonant ttbar production in ppbar collisions at sqrt{s}=1.96 TeV
We report on a search for narrow-width particles decaying to a top and
antitop quark pair. The data set used in the analysis corresponds to an
integrated luminosity of 680 pb^{-1} collected with the Collider Detector at
Fermilab in Run II. We present 95% confidence level upper limits on the cross
section times branching ratio. Assuming a specific topcolor-assisted
technicolor production model, the leptophobic Z' with width
\Gamma_{Z'}=0.012M_{Z'}, we exclude the mass range M_{Z'} < 725 GeV/c^2 at the
95% confidence level.Comment: 7 pages, 3 figures. submitted to Phys. Rev. Let
A Deeper Look at DES Dwarf Galaxy Candidates: Grus I and Indus II
We present deep g- and r-band Magellan/Megacam photometry of two dwarf galaxy candidates discovered in the Dark Energy Survey (DES), Grus I and Indus II (DES J2038-4609). For the case of Grus I, we resolved the main sequence turn-off (MSTO) and similar to 2 mags below it. The MSTO can be seen at g(0) similar to 24 with a photometric uncertainty of 0.03 mag. We show Grus I to be consistent with an old, metal-poor (similar to 13.3 Gyr, [Fe/H] similar to -1.9) dwarf galaxy. We derive updated distance and structural parameters for Grus I using this deep, uniform, wide-field data set. We find an azimuthally-averaged halflight radius more than two times larger (similar to 151(-31)(+21) pc; similar to 4'. 16(-0.74)(+0.54)) and an absolute V-band magnitude similar to-4.1 that is similar to 1 magnitude brighter than previous studies. We obtain updated distance, ellipticity, and centroid parameters that are in agreement with other studies within uncertainties. Although our photometry of Indus II is similar to 2-3 magnitudes deeper than the DES Y1 public release, we find no coherent stellar population at its reported location. The original detection was located in an incomplete region of sky in the DES Y2Q1 data set and was flagged due to potential blue horizontal branch member stars. The best-fit isochrone parameters are physically inconsistent with both dwarf galaxies and globular clusters. We conclude that Indus II is likely a false positive, flagged due to a chance alignment of stars along the line of sight
Geographical variation in therapy for bloodstream infections due to multidrug-resistant enterobacteriaceae: a post hoc analysis of the INCREMENT study
We aimed to describe regional differences in therapy for bloodstream infection (BSI) caused by extended-spectrum ?-lactamase-producing Enterobacteriaceae (ESBL-E) or carbapenemase-producing Enterobacteriaceae (CPE). 1,482 patients in 12 countries were included from an observational study of BSI caused by ESBL-E or CPE. Multivariate logistic regression was used to calculate adjusted odds ratios (aORs) for the influence of country of recruitment on empirical use of ?-lactam/?-lactamase inhibitors (BLBLI) or carbapenems, targeted use of BLBLI for ESBL-E and use of targeted combination therapy for CPE. The use of BLBLI for empirical therapy was least likely in sites from Israel (aOR 0.34, 95% CI 0.14-0.81), Greece (aOR 0.49, 95% CI 0.26-0.94) and Canada (aOR 0.31, 95% CI 0.11-0.88) but more likely in Italy (aOR 1.58, 95% CI 1.11-2.2) and Turkey (aOR 2.09, 95% CI 1.14-3.81), compared to Spain as a reference. Empirical carbapenems were more likely to be used in sites from Taiwan (aOR 1.73, 95% CI 1.03-2.92) and USA (aOR 1.89; 95% CI 1.05-3.39), and less likely in Italy (aOR 0.44, 95% CI 0.28-0.69) and Canada (aOR 0.10, 95% CI 0.01-0.74). Targeted BLBLI for ESBL-E was more likely in sites from Italy. Treatment at sites within Israel, Taiwan, Turkey and Brazil was associated with less combination therapy for CPE. Although this study does not provide precise data on the relative prevalence of ESBL-E or CPE, significant variation in therapy exists across countries even after adjustment for patient factors. A better understanding of what influences therapeutic choices for these infections will aid antimicrobial stewardship efforts.PH is supported by an Australian Postgraduate Award from the University of
Queensland. The study was funded by the Ministerio de Economía y Competitividad,
Instituto de Salud Carlos III - co-financed by European Development Regional Fund "A way to
achieve Europe" ERDF, Spanish Network for the Research in Infectious Diseases (REIPI
RD12/0015). BGG, JRB, APH and YC also received funds from the COMBACTE-CARE
project (grant agreement 115620), Innovative Medicines Initiative (IMI), the European
Union's Seventh Framework Programme (FP7/2007-2013) and in-kind contributions from
EFPIA companies
Clinical spectrum time course in non-Asian patients positive for anti-MDA5 antibodies
Objectives: To define the clinical spectrum time-course and prognosis of non-Asian patients positive for anti-MDA5 antibodies.
Methods: We conducted a multicentre, international, retrospective cohort study.
Results: 149 anti-MDA5 positive patients (median onset age 53 years, median disease duration 18 months), mainly females (100, 67%), were included. Dermatomyositis (64, 43%) and amyopathic dermatomyositis (47, 31%), were the main diagnosis; 15 patients (10%) were classified as interstitial pneumonia with autoimmune features (IPAF) and 7 (5%) as rheumatoid arthritis. The main clinical findings observed were myositis (84, 56%), interstitial lung disease (ILD) (108, 78%), skin lesions (111, 74%), and arthritis (76, 51%). The onset of these manifestations was not concomitant in 74 cases (50%). Of note, 32 (21.5%) patients were admitted to the intensive care unit for rapidly progressive-ILD, which occurred in median 2 months from lung involvement detection, in the majority of cases (28, 19%) despite previous immunosuppressive treatment. One-third of patients (47, 32% each) was ANA and anti-ENA antibodies negative and a similar percentage was anti-Ro52 kDa antibodies positive. Non-specific interstitial pneumonia (65, 60%), organising pneumonia (23, 21%), and usual interstitial pneumonia-like pattern (14, 13%) were the main ILD patterns observed. Twenty-six patients died (17%), 19 (13%) had a rapidly progressive-ILD.
Conclusions: The clinical spectrum of the anti-MDA5 antibodies-related disease is heterogeneous. Rapidly-progressive ILD deeply impacts the prognosis also in non-Asian patients, occurring early during the disease course. Anti-MDA5 antibody positivity should be considered even when baseline autoimmune screening is negative, anti-Ro52 kDa antibodies are positive, and radiology findings show a NSIP pattern
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