37 research outputs found
Homogeneous and heterogeneous catalysts for multicomponent reactions
[EN] Organic synthesis performed through multicomponent reactions is an attractive area of research in
organic chemistry. Multicomponent reactions involve more than two starting reagents that couple in an
exclusive ordered mode under the same reaction conditions to form a single product which contains the
essential parts of the starting materials. Multicomponent reactions are powerful tools in modern drug
discovery processes, because they are an important source of molecular diversity, allowing rapid,
automated and high throughput generation of organic compounds. This review aims to illustrate
progress in a large variety of catalyzed multicomponent reactions performed with acid, base and metal
heterogeneous and homogeneous catalysts. Within each type of multicomponent approach, relevant
products that can be obtained and their interest for industrial applications are presented.The authors wish to gratefully acknowledge the Generalitat Valenciana for the financial support in the project CONSOLIDER-INGENIO 2010 (CSD2009-00050)Climent Olmedo, MJ.; Corma CanĂłs, A.; Iborra Chornet, S. (2012). Homogeneous and heterogeneous catalysts for multicomponent reactions. RSC Advances. 2(1):16-58. https://doi.org/10.1039/c1ra00807bS16582
One-Pot Synthesis of Imidazole-4-Carboxylates by Microwave-Assisted1,5-Electrocyclization of Azavinyl Azomethine Ylides
Diversely functionalized imidazole-4-carboxylates were synthesized by microwave-assisted 1,5-eletrocyclization of 1,2-diaza-1,3-diene-derived azavinyl azomethine ylides. 1,2-Diaza-1,3-dienes were treated with primary aliphatic or aromatic amines and subjected to microwave irradiation in the presence of aldehydes. 3-Alkyl- and 3-arylimidazole-4-carboxylates were prepared in good yields through a one-pot multicomponent procedure. Modulation of the substituents at C-2, N-3 and C-5 was possible, and 2-unsubstituted imidazoles were obtained when paraformaldehyde was used