The choice of anaesthesia for glioblastoma surgery does not impact the time to recurrence

Anaesthetics used during cancer surgery may influence tumour cells and immunological response. The aim of this study was to evaluate a potential influence of the anaesthetic method (inhaled anaesthetics versus total-intravenous anaesthesia using propofol) on recurrence-free and overall survival in glioblastoma patients. We retrospectively identified patients undergoing resection of contrast enhancing glioblastoma under general anaesthesia followed by standard adjuvant treatment between January 2010 and February 2017 at two University Hospitals. Matched pairs of patients receiving either balanced with volatile anaesthetics or total intravenous anaesthesia were generated according to the known prognostic factors (extent of resection, methyl-guanine-methyl-transferase (MGMT) promoter methylation, age, Karnofsky performance score). Groups were compared using chi-square and Whitney-Man-U test. Time to recurrence was calculated using Kaplan Meier estimates. Log Rank test was used to assess the influence of the anaesthetic method. One hundred and fifty-eight (79:79) patients were included. Groups showed no significant difference in recurrence-free (volatiles: 8.0 (95% CI 6.5-9.8) vs. propofol: 8.4 (95% CI 7.9-10.1) months; p=0.54) or overall survival (propofol: 17.4 (95% CI 14.0-20.7) vs. volatiles: 16.9 (95% CI 13.9-20.1) months; p=0.85). In contrast to potential beneficial effects in some other solid tumours, the choice of anaesthetic method had no impact on survival in patients with glioblastoma in a well-defined cohort

Electrical properties and porosity of the first meter of the nucleus of 67P/Churyumov-Gerasimenko. As constrained by the Permittivity Probe SESAME-PP/Philae/Rosetta

International audienceComets are primitive objects, remnants of the volatile-rich planetesimals from which the solar system condensed. Knowing their structure and composition is thus crucial for the understanding of our origins. After the successful landing of Philae on the nucleus of 67P/Churyumov-Gerasimenko in November 2014, for the first time, the Rosetta mission provided the opportunity to measure the low frequency electrical properties of a cometary mantle with the permittivity probe SESAME-PP (Surface Electric Sounding and Acoustic Monitoring Experiment−Permittivity Probe).Aims. In this paper, we conduct an in-depth analysis of the data from active measurements collected by SESAME-PP at Abydos, which is the final landing site of Philae, to constrain the porosity and, to a lesser extent, the composition of the surface material down to a depth of about 1 m.Methods. SESAME-PP observations on the surface are then analyzed by comparison with data acquired during the descent toward the nucleus and with numerical simulations that explore different possible attitudes and environments of Philae at Abydos using a method called the Capacity-Influence Matrix Method.Results. Reasonably assuming that the two receiving electrode channels have not drifted with respect to each other during the ten-year journey of the Rosetta probe to the comet, we constrain the dielectric constant of the first meter below the surface at Abydos to be >2.45 ± 0.20, which is consistent with a porosity <50% if the dust phase is analogous to carbonaceous chondrites and <75% in the case of less primitive ordinary chondrites. This indicates that the near surface of the nucleus of 67P/Churyumov-Gerasimenko is more compacted than its interior and suggests that it could consist of a sintered dust-ice layer

SESAME: Measuring in-situ Properties of Comet 67P/Churyumov-Gerasimenko

SESAME is an instrument complex carried by the Rosetta lander Philae that will land on comet 67P/Churyumov-Gerasimenko in 2014. The main goals of this instrument suite, which was built in international co-operation, are to measure mechanical and electrical properties of the cometary surface and the shallow subsurface as well as to study particles emitted from the cometary surface. Most of the sensors are mounted within the six soles of the landing gear feet in order to provide good contact with or proximity to the cometary surface. The measuring principles, instrument designs as well as technical improvements and results from cruise phase operations are described. We conclude with comments on the consequences of the last minute change of the target comet and how to improve and to preserve the knowledge during the long-duration Rosetta mission

SESAME - An Experiment of the Rosetta Lander Philae: Objectives and General Design

SESAME is an instrument complex built in international co-operation and carried by the Rosetta lander Philae intended to land on comet 67P/Churyumov-Gerasimenko in 2014. The main goals of this instrument suite are to measure mechanical and electrical properties of the cometary surface and the shallow subsurface as well as of the particles emitted from the cometary surface. Most of the sensors are mounted within the six soles of the landing gear feet in order to provide good contact with or proximity to the cometary surface. The measuring principles, instrument designs, technical layout, operational concepts and the results from the first in-flight measurements are described. We conclude with comments on the consequences of the last minute change of the target comet and how to improve and to preserve the knowledge during the long-duration Rosetta mission