Advanced titanium scaffolds obtained by directional freeze-drying: on the influence of processing conditions

Ministry of Science and Innovation of Spain under Grant No. MAT2010-20855Junta de Andalucía (Spain) / FEDER (EU), through the project Ref. P12-TEP-140

University-enterprises: a win-win relationship, from business to research

Teaching at University is always a difficult task because it implies too much theoretical lessons while students ask for practical knowledge and Enterprises claim for good junior professionals. Finding an equilibrium among all the interests is challenging but at the same time, it is the key of success. This work shows the experience of teaching in collaboration with companies to achieve a more practical and attractive approach to day-to-day Engineering work while meeting teaching objectives. It is a win-win relationship since it motivates students because they see the direct relationship between their studies and the future job; it also helps teachers to know the knowledge required by engineering companies and, besides, enterprises will have future engineers better trained, already familiar with process and tools. Furthermore, it also increases the collaborations between University and enterprises, which is key to innovate and develop new business modelsPostprint (published version

Insulin-like growth factor I sensitization rejuvenates sleep patterns in old mice

Sleep disturbances are common during aging. Compared to young animals, old mice show altered sleep structure, with changes in both slow and fast electrocorticographic (ECoG) activity and fewer transitions between sleep and wake stages. Insulin-like growth factor I (IGF-I), which is involved in adaptive changes during aging, was previously shown to increase ECoG activity in young mice and monkeys. Furthermore, IGF-I shapes sleep architecture by modulating the activity of mouse orexin neurons in the lateral hypothalamus (LH). We now report that both ECoG activation and excitation of orexin neurons by systemic IGF-I are abrogated in old mice. Moreover, orthodromical responses of LH neurons are facilitated by either systemic or local IGF-I in young mice, but not in old ones. As orexin neurons of old mice show dysregulated IGF-I receptor (IGF-IR) expression, suggesting disturbed IGF-I sensitivity, we treated old mice with AIK3a305, a novel IGF-IR sensitizer, and observed restored responses to IGF-I and rejuvenation of sleep patterns. Thus, disturbed sleep structure in aging mice may be related to impaired IGF-I signaling onto orexin neurons, reflecting a broader loss of IGF-I activity in the aged mouse brain.This work was funded by a grant from Ciberned and is part of the project SAF2016-76462 funded by MCIN/AEI/https://doi.org/10.13039/501100011033. J.A. ZegarraValdivia acknowledges the fnancial support of the National Council of Science, Technology and Technological Innovation (CONCYTEC, Perú) through the National Fund for Scientifc and Technological Development (FONDECYT, Perú). J. Fernandes received a post-doc fellowship from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP: # 2017/14742–0; # 2019/03368–5)

Connecting the dots between root, xylem and stomata

2 páginas.- 3 referencias.- Comunicación oral presentada en el BP2021: XXIV Reunión de la Sociedad Española de Biología de Plantas y XVII Congreso Hispano-Luso de Biología de Plantas, 7 y 8 de julio de 2021. onlineStomata are present on all land plants and are key features for vascular plant water content regulation on Earth. Their primary function, i.e., stomatal closure to control water los s under soil and atmospheric drought, is Ihought to prevent cavitation in the vascular system (Brodribb et al. 2017). However, stomata are found to close much before the xylem cavitates - i.e., the leaf water potential at which stomata close by 50% (IV gs50) is much less negative than the water potential at which the xylem loses 50% of its conductivity (lV_x50) (Martin-St Paul et al. 2017). The mechanism that would allow sto mata to close promptly to a decrease in transpiration in relation to a change in leaf water potential before the decrease in hydraulic conductance is still elusive. Our hypothesis is that the loss of root-soil hydraulic conductivity, more than xylem vulnerability to embolisms, is Ihe primary constraint on transpiration during drought (RodriguezDominguez and Brodribb 2020). Thus, sto mala would close when the water potential around the roots drops more rapidly than the increase in transpiration. We investigated whether this loss of root-soil hydraulic conductivity, probably caused due to root shrinkage and the formation of air-filled gaps, aml/or damage to fine roots, appeared to be an important constraint on transpiration during drought. We conducted physiological and imaging experiments on maize plants undergoing moderate drought. We performed highresolution imaging (micro-CT) of leaves and the root-soil interface and measured in parallel the soil and plant water potentials. Transpiration, stomatal conductance, root hydraulic conductance and soil and plant water potential were also measured during soil drying in a similar set of plants. The formation of air-filled gaps along individual maize roots was visualized and quantified, finding an agreement between the soil water potential at which roots shrank and root hydraulic conductance decreased, and the soil water potential at which sto mata c1osed. These results proved the hypothesis that the loss of contact between roots and soil, and probably other root cortex modifications, triggered stomatal c10sure and transpiration reduction.Microcomputed tomography measurements were conducted at the PSYCHE beamline at SOLEIL Synchrotron (Paris, France). C.M.R-D. was supported by a "Juan de la Cierva - Incorporación" post-doctoral fellowship (Spain) and was granted a Junior Fellowship by the University of Bayreuth Centre of Intemational Excellence "Alexander von Humboldt" for conducting this specific experiment.N

Industrialized Sunspace Prototype with Solar Heat Storage. Assessment of Post-Occupational Behaviour in Adaptive Facades.

The thermal performance of two passive solar components has been investigated. An attached sunspace with horizontal heat storage and another one with vertical thermal storage were designed in order to optimize the use of solar gains and its storage and distribution in an industrialized component. These sunspaces have been tested under real conditions, comparing their thermal performance with two commonly used components in residential buildings in Spain: a window and a double window making up an attached sunspace. Different series of experimental measurements were conducted in two test-cells exposed to outdoor conditions in Pamplona (Northern Spain). As a result, nine scenarios during winter 2011 and six during summer 2012 have been carried out, comparing all of the prototypes two by two with different use modes. Results show that a sunspace with heat storage takes advantage of the solar energy and improves the indoor thermal performance of the adjacent room during winter in a better way than a window or a simple sunspace, and that it also offers better performance in summer. The best results in winter and summer were obtained when an appropriate use of the component was performed, in concordance with outdoor conditions. Several thermal control keys for the use of these components are suggested

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio

Transverse sphericity of primary charged particles in minimum bias proton-proton collisions at s=0.9\sqrt{s}=0.9, 2.76 and 7 TeV

Measurements of the sphericity of primary charged particles in minimum bias proton--proton collisions at $\sqrt{s}=0.9$, 2.76 and 7 TeV with the ALICE detector at the LHC are presented. The observable is linearized to be collinear safe and is measured in the plane perpendicular to the beam direction using primary charged tracks with $p_{\rm T}\geq0.5$ GeV/c in $|\eta|\leq0.8$. The mean sphericity as a function of the charged particle multiplicity at mid-rapidity ($N_{\rm ch}$) is reported for events with different $p_{\rm T}$ scales ("soft" and "hard") defined by the transverse momentum of the leading particle. In addition, the mean charged particle transverse momentum versus multiplicity is presented for the different event classes, and the sphericity distributions in bins of multiplicity are presented. The data are compared with calculations of standard Monte Carlo event generators. The transverse sphericity is found to grow with multiplicity at all collision energies, with a steeper rise at low $N_{\rm ch}$, whereas the event generators show the opposite tendency. The combined study of the sphericity and the mean $p_{\rm T}$ with multiplicity indicates that most of the tested event generators produce events with higher multiplicity by generating more back-to-back jets resulting in decreased sphericity (and isotropy). The PYTHIA6 generator with tune PERUGIA-2011 exhibits a noticeable improvement in describing the data, compared to the other tested generators.Comment: 21 pages, 9 captioned figures, 3 tables, authors from page 16, published version, figures from http://aliceinfo.cern.ch/ArtSubmission/node/308