The Influence Of Parent-Child Conflict And Stressful Experiences On The Health Of Youth With Asthma

Attaining a clear picture of everyday family interactions is essential for understanding how family stress and conflict adversely affects children\u27s health, especially in the context of chronic illness. Using a naturalistic observation sampling method called the Electronically Activated Recorder (EAR), we sought to investigate the effects of daily interpersonal conflicts and parental stress on pediatric asthma outcomes. We collected data from 81 children, aged 10 to 17 (M age = 12.88), and their primary caregiver as part of a larger study. Each child completed a pulmonary function test and self-report questionnaires of asthma symptoms. Asthma-related medical information was abstracted from their medical records. The Adult and Parent UCLA Life Stress Interview (LSI) assessed acute stress as the number of acutely stressful events in the past 6 months. Of these 81 participants, 45 children wore the EAR for 4 days. Trained research assistants coded the EAR files using the Everyday Child Home Observations (ECHO) Coding System for instances of interpersonal conflict (e.g., arguing, fighting, yelling) and asthma symptoms (e.g., coughing, wheezing). EAR-observed parent-child conflict (r = .36, p \u3c .05) and EAR-observed family environment conflict (r = .32, p \u3c .05) was positively associated with youth reported asthma symptoms. Further, EAR-observed wheezing coded was positively associated with EAR-observed family environment conflict (r = .34, p \u3c .05), conflict with fathers (r = .43, p \u3c .01), and general conflict in the youth\u27s life (r = .35, p \u3c .05). Additionally, we found positive associations between recently experienced stressful events in the lives of parents and multiple measures of asthma morbidity, including Emergency Department use for asthma related symptoms (r = 0.28, p \u3c 0.05), youth-BMI (r = 0.24, p \u3c 0.05), youth-reported asthma symptoms (r = 0.36, p = 0.02) and asthma severity (r = 0.27, p \u3c 0.05). We also found parental stress to negatively associated with pulmonary functioning (r = -0.29; p = 0.02) and with asthma clinic visits (r = -0.36; p \u3c 0.01). These findings show that greater conflict in everyday life within the family and broad measures of stress in parent\u27s lives are associated with multiple markers of asthma morbidity. This research has important implications for asthma interventions tailored to the individual and their family system

Self-disclosure and perceived responsiveness among youth with asthma:Links to affect and anti-inflammatory gene expression

Self-disclosure and perceived responsiveness are important building blocks of social relationships that have long-lasting consequences for health and well-being. However, the conditions under which self-disclosure and responsiveness are likely to benefit health, and how early in life these benefits arise, remain unclear. Among 141 youth (aged 10–17) with asthma, we investigated how average daily levels of self-disclosure and responsiveness are linked to positive and negative affect and the expression of the glucocorticoid receptor gene NR3C1, a marker of improved regulation of stress physiology and immune functioning. Higher levels of self-disclosure were associated with higher NR3C1 expression and positive affect only when perceptions of responsiveness were high. Furthermore, perceived responsiveness was linked to NR3C1 expression for females but not males. These results suggest that the potential benefits of self-disclosure depend on the extent to which interaction partners are perceived as responsive and that these benefits emerge prior to adulthood

Changes to the Oligosaccharide Profile of Bovine Milk at the Onset of Lactation

peer-reviewedNumerous bioactive components exist in human milk including free oligosaccharides, which represent some of the most important, and provide numerous health benefits to the neonate. Considering the demonstrated value of these compounds, much interest lies in characterising structurally similar oligosaccharides in the dairy industry. In this study, the impacts of days post-parturition and parity of the cows on the oligosaccharide and lactose profiles of their milk were evaluated. Colostrum and milk samples were obtained from 18 cows 1–5 days after parturition. Three distinct phases were identified using multivariate analysis: colostrum (day 0), transitional milk (days 1–2) and mature milk (days 3–5). LS-tetrasaccharide c, lacto-N-neotetraose, disialyllacto-N-tetraose, 3’-sial-N-acetyllactosamine, 3’-sialyllactose, lacto-N-neohexaose and disialyllactose were found to be highly affiliated with colostrum. Notably, levels of lactose were at their lowest concentration in the colostrum and substantially increased 1-day post-parturition. The cow’s parity was also shown to have a significant effect on the oligosaccharide profile, with first lactation cows containing more disialyllacto-N-tetraose, 6’-sialyllactose and LS-tetrasaccharide compared to cows in their second or third parity. Overall, this study identifies key changes in oligosaccharide and lactose content that clearly distinguish colostrum from transitional and mature milk and may facilitate the collection of specific streams with divergent biological functions

Developing Clinical and Research Priorities for Pain and Psychological Features in People With Patellofemoral Pain:An International Consensus Process With Health Care Professionals

OBJECTIVE: To decide clinical and research priorities on pain features and psychological factors in persons with patellofemoral pain. DESIGN: Consensus development process. METHODS: We undertook a 3-stage process consisting of (1) updating 2 systematic reviews on quantitative sensory testing of pain features and psychological factors in patellofemoral pain, (2) an online survey of health care professionals and persons with patellofemoral pain, and (3) a consensus meeting with expert health care professionals. Participants responded that they agreed, disagreed, or were unsure that a pain feature or psychological factor was important in clinical practice or as a research priority. Greater than 70% participant agreement was required for an item to be considered important in clinical practice or a research priority. RESULTS: Thirty-five health care professionals completed the survey, 20 of whom attended the consensus meeting. Thirty persons with patellofemoral pain also completed the survey. The review identified 5 pain features and 9 psychological factors—none reached 70% agreement in the patient survey, so all were considered at the meeting. Afte the meeting, pain catastrophizing, fear-avoidance beliefs, and pain self-efficacy were the only factors considered clinically important. All but the therma pain tests and 3 psychological factors were consid ered research priorities. CONCLUSION: Pain catastrophizing, pain self-efficacy, and fear-avoidance beliefs were factors considered important in treatment planning, clinical examination, and prognostication. Quantitative sensory tests for pain were not regarded as clinically important but were deemed to be research priorities, as were most psychological factors.</p

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Genome-wide association study identifies 74 loci associated with educational attainment

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals1. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample1,2 of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases

Religion And Spirituality In Youth With Asthma: Associations With Coping, Mood, And Diurnal Cortisol

The current work investigated the complex link between religion and health in youth with asthma. The current study points to preliminary beneficial relationships between religious behavior, positive religious coping, and positive mood, via vigor. Furthermore, the results indicate that religious coping is a unique coping strategy employed by youth that is more closely related to avoidance-oriented strategies than approach-oriented strategies. Finally, it identifies family environment as an important variable that affects the relationship between religious coping and health, including both psychological and physical health. In risky family environments, positive and negative religious coping was linked to greater negative mood; however, engaging in high amounts of positive religious coping is associated healthier HPA axis functioning. This work hints that positive religious coping strategies may not be related to better mood in the short term but associated with better biologically-based outcomes that may provide long term health benefits. Taken together, prior research highlighting the use of religious coping by youth to manage stress associated with health conditions and the current work pointing to both detrimental and favorable relationships with religious coping and health speaks to the importance of assessing for spiritual or religious struggles and how discussions of religious coping may be integrated into routine health care for those who identify it as an important factor in their daily lives