1,029 research outputs found
Structural Invariance of Sunspot Umbrae Over the Solar Cycle: 1993-2004
Measurements of maximum magnetic flux, minimum intensity, and size are
presented for 12 967 sunspot umbrae detected on the NASA/NSO
spectromagnetograms between 1993 and 2004 to study umbral structure and
strength during the solar cycle. The umbrae are selected using an automated
thresholding technique. Measured umbral intensities are first corrected for a
confirming observation of umbral limb-darkening. Log-normal fits to the
observed size distribution confirm that the size spectrum shape does not vary
with time. The intensity-magnetic flux relationship is found to be steady over
the solar cycle. The dependence of umbral size on the magnetic flux and minimum
intensity are also independent of cycle phase and give linear and quadratic
relations, respectively. While the large sample size does show a low amplitude
oscillation in the mean minimum intensity and maximum magnetic flux correlated
with the solar cycle, this can be explained in terms of variations in the mean
umbral size. These size variations, however, are small and do not substantiate
a meaningful change in the size spectrum of the umbrae generated by the Sun.
Thus, in contrast to previous reports, the observations suggest the equilibrium
structure, as testified by the invariant size-magnetic field relationship, as
well as the mean size (i.e. strength) of sunspot umbrae do not significantly
depend on solar cycle phase.Comment: 17 pages, 6 figures. Published in Solar Physic
Metal-macrofauna interactions determine microbial community structure and function in copper contaminated sediments
Peer reviewedPublisher PD
Soil organic carbon dynamics and crop yield for different crop rotations in a degraded ferruginous tropical soil in a semi-arid region: a simulation approach
In recent years, simulation models have been used as a complementary tool for research and for quantifying soil carbon sequestration under widely varying conditions. This has improved the understanding and prediction of soil organic carbon (SOC) dynamics and crop yield responses to soil and climate conditions and crop management scenarios. The goal of the present study was to estimate the changes in SOC for different cropping systems in West Africa using a simulation model. A crop rotation experiment conducted in Farakô-Ba, Burkina Faso was used to evaluate the performance of the cropping system model (CSM) of the Decision Support System for Agrotechnology Transfer (DSSAT) for simulating yield of different crops. Eight crop rotations that included cotton, sorghum, peanut, maize and fallow, and three different management scenarios, one without N (control), one with chemical fertilizer (N) and one with manure applications, were studied. The CSM was able to simulate the yield trends of various crops, with inconsistencies for a few years. The simulated SOC increased slightly across the years for the sorghum–fallow rotation with manure application. However, SOC decreased for all other rotations except for the continuous fallow (native grassland), in which the SOC remained stable. The model simulated SOC for the continuous fallow system with a high degree of accuracy normalized root mean square error (RMSE)=0·001, while for the other crop rotations the simulated SOC values were generally within the standard deviation (s.d.) range of the observed data. The crop rotations that included a supplemental N-fertilizer or manure application showed an increase in the average simulated aboveground biomass for all crops. The incorporation of this biomass into the soil after harvest reduced the loss of SOC. In the present study, the observed SOC data were used for characterization of production systems with different SOC dynamics. Following careful evaluation of the CSM with observed soil organic matter (SOM) data similar to the study presented here, there are many opportunities for the application of the CSM for carbon sequestration and resource management in Sub-Saharan Africa
Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity
Augmented T cell function leading to host damage in autoimmunity is supported by metabolic dysregulation, making targeting immunometabolism an attractive therapeutic avenue. Canagliflozin, a type 2 diabetes drug, is a sodium glucose co-transporter 2 (SGLT2) inhibitor with known off-target effects on glutamate dehydrogenase and complex I. However, the effects of SGLT2 inhibitors on human T cell function have not been extensively explored. Here, we show that canagliflozin-treated T cells are compromised in their ability to activate, proliferate, and initiate effector functions. Canagliflozin inhibits T cell receptor signaling, impacting on ERK and mTORC1 activity, concomitantly associated with reduced c-Myc. Compromised c-Myc levels were encapsulated by a failure to engage translational machinery resulting in impaired metabolic protein and solute carrier production among others. Importantly, canagliflozin-treated T cells derived from patients with autoimmune disorders impaired their effector function. Taken together, our work highlights a potential therapeutic avenue for repurposing canagliflozin as an intervention for T cell-mediated autoimmunity
Searches for very high energy gamma rays from blazars with CANGAROO-III telescope in 2005-2009
We have searched for very high energy (VHE) gamma rays from four blazars
using the CANGAROO-III imaging atmospheric Cherenkov telescope. We report the
results of the observations of H 2356-309, PKS 2155-304, PKS 0537-441, and 3C
279, performed from 2005 to 2009, applying a new analysis to suppress the
effects of the position dependence of Cherenkov images in the field of view. No
significant VHE gamma ray emission was detected from any of the four blazars.
The GeV gamma-ray spectra of these objects were obtained by analyzing Fermi/LAT
archival data. Non-simultaneous wide range (radio to VHE gamma-ray bands)
spectral energy distributions (SEDs) including CANGAROO-III upper limits, GeV
gamma-ray spectra, and archival data are discussed using a one-zone synchrotron
self-Compton (SSC) model in combination with a external Compton (EC) radiation.
The HBLs (H 2356-309 and PKS 2155-304) can be explained by a simple SSC model,
and PKS 0537-441 and 3C 279 are well modeled by a combination of SSC and EC
model. We find a consistency with the blazar sequence in terms of strength of
magnetic field and component size.Comment: 11 pages, 8 figures, Accepted for publication in Astroparticle
Physic
The Atacama Cosmology Telescope: Cosmological Parameters from the 2008 Power Spectra
We present cosmological parameters derived from the angular power spectrum of
the cosmic microwave background (CMB) radiation observed at 148 GHz and 218 GHz
over 296 deg^2 with the Atacama Cosmology Telescope (ACT) during its 2008
season. ACT measures fluctuations at scales 500<l<10000. We fit a model for the
lensed CMB, Sunyaev-Zel'dovich (SZ), and foreground contribution to the 148 GHz
and 218 GHz power spectra, including thermal and kinetic SZ, Poisson power from
radio and infrared point sources, and clustered power from infrared point
sources. The power from thermal and kinetic SZ at 148 GHz is estimated to be
B_3000 = 6.8+-2.9 uK^2, where B_l=l(l+1)C_l/2pi. We estimate primary
cosmological parameters from the 148 GHz spectrum, marginalizing over SZ and
source power. The LCDM cosmological model is a good fit to the data, and LCDM
parameters estimated from ACT+WMAP are consistent with the 7-year WMAP limits,
with scale invariant n_s = 1 excluded at 99.7% CL (3sigma). A model with no CMB
lensing is disfavored at 2.8sigma. By measuring the third to seventh acoustic
peaks, and probing the Silk damping regime, the ACT data improve limits on
cosmological parameters that affect the small-scale CMB power. The ACT data
combined with WMAP give a 6sigma detection of primordial helium, with Y_P =
0.313+-0.044, and a 4sigma detection of relativistic species, assumed to be
neutrinos, with Neff = 5.3+-1.3 (4.6+-0.8 with BAO+H0 data). From the CMB alone
the running of the spectral index is constrained to be dn/dlnk = -0.034 +-
0.018, the limit on the tensor-to-scalar ratio is r<0.25 (95% CL), and the
possible contribution of Nambu cosmic strings to the power spectrum is
constrained to string tension Gmu<1.6 \times 10^-7 (95% CL).Comment: 20 pages, 13 figures. Submitted to ApJ. This paper is a companion to
Hajian et al. (2010) and Das et al. (2010
The genomes of two key bumblebee species with primitive eusocial organization
Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation
Harnessing learning biases is essential for applying social learning in conservation
Social learning can influence how animals respond to anthropogenic changes in the environment, determining whether animals survive novel threats and exploit novel resources or produce maladaptive behaviour and contribute to human-wildlife conflict. Predicting where social learning will occur and manipulating its use are, therefore, important in conservation, but doing so is not straightforward. Learning is an inherently biased process that has been shaped by natural selection to prioritize important information and facilitate its efficient uptake. In this regard, social learning is no different from other learning processes because it too is shaped by perceptual filters, attentional biases and learning constraints that can differ between habitats, species, individuals and contexts. The biases that constrain social learning are not understood well enough to accurately predict whether or not social learning will occur in many situations, which limits the effective use of social learning in conservation practice. Nevertheless, we argue that by tapping into the biases that guide the social transmission of information, the conservation applications of social learning could be improved. We explore the conservation areas where social learning is highly relevant and link them to biases in the cues and contexts that shape social information use. The resulting synthesis highlights many promising areas for collaboration between the fields and stresses the importance of systematic reviews of the evidence surrounding social learning practices.BBSRC David Phillips Fellowship (BB/H021817/1
Kidney organ donation: developing family practice initiatives to reverse inertia
<p>Abstract</p> <p>Background</p> <p>Kidney transplantation is associated with greater long term survival rates and improved quality of life compared with dialysis. Continuous growth in the number of patients with kidney failure has not been matched by an increase in the availability of kidneys for transplantation. This leads to long waiting lists, higher treatment costs and negative health outcomes.</p> <p>Discussion</p> <p>Misunderstandings, public uncertainty and issues of trust in the medical system, that limit willingness to be registered as a potential donor, could be addressed by community dissemination of information and new family practice initiatives that respond to individuals' personal beliefs and concerns regarding organ donation and transplantation.</p> <p>Summary</p> <p>Tackling both personal and public inertia on organ donation is important for any community oriented kidney donation campaign.</p
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