Moluscos terrestres das Flores. Lista preliminar.

IV Expedição Científica do Departamento de Biologia – Flores 1989.A ilha das Flores, a mais ocidental e geologicamente uma das mais antigas do Arquipélago, regista uma das mais baixas taxas de endemismos na malacofauna terrestre Açoriana. Até ao presente, não sem alguma discórdia, apenas duas espécies, Balea nitida Mousson, 1858 e Phenacolimax (Insulivitrina) finitima (Morelet, 1860), são geralmente consideradas endémicas naquela ilha. Simroth (1889, fide Backhuys, 1975) sinonimizou com Phenacolimax (I.) pelagica (Morelet, 1860) todas as outras espécies daquele género descritas por este autor. Nobre (1924) não reconheceu a espécie descrita por Mousson, que sinonimizou com a europeia Balea perversa (L., 1758), e pôs reservas quanto às sete espécies de Phenacolimax stabile descritas por Morelet, admitindo também que um estudo mais aprofundado poderia vir a reduzir o número de espécies daquele género; Hoffmann (1929, fide Backhuys, 1975) reduziu-as a três. Riedel (1964), que fez a revisão dos Zonitidae açorianos baseado em material recolhido por P. Brinck e E. Dahl em 1957, não teve acesso a exemplares das Flores. Backhuys (1975) seleccionou as Flores como localidade tipo para Balea nitida Mousson, mencionou uma possível nova espécie de Actinella Lowe e, de modo preliminar e sem justificação descritiva, considerou P. (I.) finitima como parte daquilo que aquele autor chama 'complexo Phenacolimax (I.) brumalis (Morelet)'. O material recolhido na Expedição FLORES/89 veio revelar uma taxa de endemismos mais elevada, aparentemente mais conforme com a idade e o isolamento da ilha. Assim: (i) o subgénero Drouetia Gude, numa análise preliminar, deverá contar com duas, provavelmente três espécies novas; este subgénero, endêmico nos Açores, é objecto de estudo por um dos autores (AMFM) e terá apropriado tratamento em tempo oportuno; (ii) observação da morfologia externa do animal e da concha mostrou que poderá existir mais uma espécie de Phenacolimax para além daquela dada por Morelet para as Flores; o estudo desta espécie fará parte de um projecto de trabalho de um dos autores (CPB), a iniciar-se brevemente; (iii) aparentemente confirmam-se as suspeitas de Backhuys (1975) quanto ao género Actinella nas Flores; o material recolhido constituirá, em breve, objecto de revisão por um dos autores (RTC); (iv) finalmente, a descrição de uma nova espécie de Leptaxis Lowe foi levada a cabo por dois dos autores (AMFM e TB) e está em vias de publicação. Poderá, deste modo e em breve ser o número de endemismos das Flores aumentado significativamente, o que virá a modificar o cenário zoogeográfico do Arquipélago

Moluscos terrestres da Ilha de Santa Maria. Lista preliminar.

V Expedição Científica do Departamento de Biologia – Santa Maria e Formigas 1990.A ilha de Santa Maria tem, desde os primórdios dos estudos malacológicos do Arquipélago, chamado a atenção dos estudiosos pela originalidade da sua formação geológica e da sua malacofauna (Morelet, 1860). A pequenez dos seus 97 km2 é compensada pela sua avançada idade geológica, quando comparada com a das restantes ilhas açorianas. Se bem que a hipótese de Zbyszewski & Ferreira (1961), que apontava para o vindoboniano (ca. 12 Ma) a origem dos calcários fossilíferos existentes na ilha, tenha vindo a ser corrigida para datas muito mais recentes (ca. 3.5-4 Ma), tendo-se estimado as lavas mais antigas em cerca de 6 Ma (Feraud et al., 1984), Santa Maria continua a ser a relíquia geológica do Arquipélago. É, provavelmente, esta ancestralidade em relação às outras ilhas que justifica a elevada taxa de endemismos que a caracteriza (ca. 19% quando comparada com ca. 8% de São Miguel, numa análise preliminar de dados em preparação para publicação)

The Anabolic Androgenic Steroid Fluoxymesterone Inhibits 11β-Hydroxysteroid Dehydrogenase 2-Dependent Glucocorticoid Inactivation

Anabolic androgenic steroids (AAS) are testosterone derivatives used either clinically, in elite sports, or for body shaping with the goal to increase muscle size and strength. Clinically developed compounds and nonclinically tested designer steroids often marketed as food supplements are widely used. Despite the considerable evidence for various adverse effects of AAS use, the underlying molecular mechanisms are insufficiently understood. Here, we investigated whether some AAS, as a result of a lack of target selectivity, might inhibit 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2)-dependent inactivation of glucocorticoids. Using recombinant human 11β-HSD2, we observed inhibitory effects for several AAS. Whereas oxymetholone, oxymesterone, danazol, and testosterone showed medium inhibitory potential, fluoxymesterone was a potent inhibitor of human 11β-HSD2 (half-maximal inhibitory concentration [IC50] of 60-100nM in cell lysates; IC50 of 160nM in intact SW-620, and 530nM in MCF-7 cells). Measurements with rat kidney microsomes and lysates of cells expressing recombinant mouse 11β-HSD2 revealed much weaker inhibition by the AAS tested, indicating that the adverse effects of AAS-dependent 11β-HSD2 inhibition cannot be investigated in rats and mice. Furthermore, we provide evidence that fluoxymesterone is metabolized to 11-oxofluoxymesterone by human 11β-HSD2. Structural modeling revealed similar binding modes for fluoxymesterone and cortisol, supporting a competitive mode of inhibition of 11β-HSD2-dependent cortisol oxidation by this AAS. No direct modulation of mineralocorticoid receptor (MR) function was observed. Thus, 11β-HSD2 inhibition by fluoxymesterone may cause cortisol-induced MR activation, thereby leading to electrolyte disturbances and contributing to the development of hypertension and cardiovascular diseas

Loud calls in male crested macaques, Macaca nigra: a signal of dominance in a tolerant species

Compared to other mammals, sexual signals occur particularly often within the primate order. Nevertheless, little is known so far about the pressures under which these signals evolved. We studied loud calls in wild crested macaques to examine whether these are used as a sexual signal, particularly as a signal of dominance, in this species. Since the structure of loud calls may be influenced by the context in which they are uttered, we tested for contextual differences in call structure. Only males uttered loud calls and analysis of 194 loud calls given by 15 males showed that call structure encoded the caller's identity as well as his social status. Dominance rank was also reflected in the frequency with which males called with alpha males calling most often. The structure of loud calls, however, was not influenced by context. Our findings consolidate the assumption that, in crested macaques, loud calls serve as a signal of dominance, most probably used to prevent contests between males for mates. We herewith provide the first direct evidence for a signal of dominance in a tolerant primate species and discuss why this signal occurs in only one sex

Characterization of thermal oxide films formed on a duplex stainless steel by means of confocal-Raman microscopy and electrochemical techniques

In this work oxide films have been developed on the surface of a duplex stainless steel (UNS 1.4462) using high temperature confocal microscopy to follow their growth. The characteristics of these oxide films have been analyzed by means of weight-gain measurements, Raman microscopy and electrochemical techniques, namely potentiodynamic polarization curves and electrochemical impedance spectroscopy. The results show an increase in the amount of oxides (particularly γ-Fe2O3 and Fe3O4) with temperature. Regarding the electrochemical properties of these films, the corrosion resistance of the film tends to be lower with the heat treatment temperature, probably due to a more porous and heterogeneous scale. Mott–Schottky plots show the n-type semiconductive behavior of the films with donor densities that decrease with the enhancement of the temperature.We wish to express our gratitude to MICINN (CTQ2009-07518) (UPVO8-3E-012), to Universitat Politecnica de Valencia (CEI-01-11), to the Generalitat Valenciana for its help in the CLSM acquisition (MY08/ISIRM/S/100), and to Dr. Asuncion Jaime for her translation assistance.Sánchez Tovar, R.; Leiva García, R.; García Antón, J. (2015). Characterization of thermal oxide films formed on a duplex stainless steel by means of confocal-Raman microscopy and electrochemical techniques. Thin Solid Films. 576:1-10. https://doi.org/10.1016/j.tsf.2014.12.024S11057

The ALMA Spectroscopic Survey in the Hubble Ultra Deep Field: Evolution of the Molecular Gas in CO-selected Galaxies

We analyze the interstellar medium properties of a sample of 16 bright CO line emitting galaxies identified in the ALMA Spectroscopic Survey in the Hubble Ultra Deep Field (ASPECS) Large Program. This CO−selected galaxy sample is complemented by two additional CO line emitters in the UDF that are identified based on their MultiUnit Spectroscopic Explorer (MUSE) optical spectroscopic redshifts. The ASPECS CO−selected galaxies cover a larger range of star formation rates (SFRs) and stellar masses compared to literature CO emitting galaxies at z > 1 for which scaling relations have been established previously. Most of ASPECS CO-selected galaxies follow these established relations in terms of gas depletion timescales and gas fractions as a function of redshift, as well as the SFR–stellar mass relation (“galaxy main sequence”). However, we find that ∼30% of the galaxies (5 out of 16) are offset from the galaxy main sequence at their respective redshift, with ∼12% (2 out of 16) falling below this relationship. Some CO-rich galaxies exhibit low SFRs, and yet show substantial molecular gas reservoirs, yielding long gas depletion timescales. Capitalizing on the well-defined cosmic volume probed by our observations, we measure the contribution of galaxies above, below, and on the galaxy main sequence to the total cosmic molecular gas density at different lookback times. We conclude that main-sequence galaxies are the largest contributors to the molecular gas density at any redshift probed by our observations (z ∼ 1−3). The respective contribution by starburst galaxies above the main sequence decreases from z ∼ 2.5 to z ∼ 1, whereas we find tentative evidence for an increased contribution to the cosmic molecular gas density from the passive galaxies below the main sequenc

The ALMA Spectroscopic Survey in the HUDF: Nature and Physical Properties of Gas-mass Selected Galaxies Using MUSE Spectroscopy

We discuss the nature and physical properties of gas-mass selected galaxies in the ALMA spectroscopic survey (ASPECS) of the Hubble Ultra Deep Field (HUDF). We capitalize on the deep optical integral-field spectroscopy from the Multi Unit Spectroscopic Explorer (MUSE) HUDF Survey and multiwavelength data to uniquely associate all 16 line emitters, detected in the ALMA data without preselection, with rotational transitions of carbon monoxide (CO). We identify 10 as CO(2–1) at 1 < z < 2, 5 as CO(3–2) at 2 < z < 3, and 1 as CO(4–3) at z = 3.6. Using the MUSE data as a prior, we identify two additional CO(2–1) emitters, increasing the total sample size to 18. We infer metallicities consistent with (super-)solar for the CO-detected galaxies at z „ 1.5, motivating our choice of a Galactic conversion factor between CO luminosity and molecular gas mass for these galaxies. Using deep Chandra imaging of the HUDF, we determine an X-ray AGN fraction of 20% and 60% among the CO emitters at z ∼ 1.4 and z ∼ 2.6, respectively. Being a CO-flux-limited survey, ASPECS-LP detects molecular gas in galaxies on, above, and below the main sequence (MS) at z ∼ 1.4. For stellar masses …1010 (1010.5) M, we detect about 40% (50%) of all galaxies in the HUDF at 1 < z < 2 (2 < z < 3). The combination of ALMA and MUSE integral-field spectroscopy thus enables an unprecedented view of MS galaxies during the peak of galaxy formation

The ALMA Spectroscopic Survey in the HUDF: CO Luminosity Functions and the Molecular Gas Content of Galaxies through Cosmic History

We use the results from the ALMA large program ASPECS, the spectroscopic survey in the Hubble Ultra Deep Field (HUDF), to constrain CO luminosity functions of galaxies and the resulting redshift evolution of ρ(H2). The broad frequency range covered enables us to identify CO emission lines of different rotational transitions in the HUDF at z > 1. We find strong evidence that the CO luminosity function evolves with redshift, with the knee of the CO luminosity function decreasing in luminosity by an order of magnitude from ~2 to the local universe. Based on Schechter fits, we estimate that our observations recover the majority (up to ~90%, depending on the assumptions on the faint end) of the total cosmic CO luminosity at z = 1.0–3.1. After correcting for CO excitation, and adopting a Galactic CO-to-H2 conversion factor, we constrain the evolution of the cosmic molecular gas density ρ(H2): this cosmic gas density peaks at z ~ 1.5 and drops by a factor of ${6.5}_{-1.4}^{+1.8}$ to the value measured locally. The observed evolution in ρ(H2), therefore, closely matches the evolution of the cosmic star formation rate density ρ SFR. We verify the robustness of our result with respect to assumptions on source inclusion and/or CO excitation. As the cosmic star formation history can be expressed as the product of the star formation efficiency and the cosmic density of molecular gas, the similar evolution of ρ(H2) and ρ SFR leaves only little room for a significant evolution of the average star formation efficiency in galaxies since z ~ 3 (85% of cosmic history)

Polyphenol Content and Modulatory Activities of Some Tropical Dietary Plant Extracts on the Oxidant Activities of Neutrophils and Myeloperoxidase

Young leaves of Manihot esculenta Crantz (Euphorbiaceae), Abelmoschus esculentus (Malvaceae), Hibiscus acetosella (Malvaceae) and Pteridium aquilinum (Dennstaedtiaceae) are currently consumed as green vegetables by peoples in sub-Saharan Africa, Latin America, Asia and their migrants living in Western Europe. Sub-Saharan peoples use Manihot, Abelmoschus and Hibiscus also in the folk medicine to alleviate fever and pain, in the treatment of conjunctivitis, rheumatism, hemorrhoid, abscesses, ... The present study investigates the effects of aqueous extracts of those plants on the production of reactive oxygen species (ROS) and the release of myeloperoxidase (MPO) by equine neutrophils activated with phorbol 12-myristate 13-acetate (PMA). The ROS production was measured by lucigenin-enhanced chemiluminescence (CL), and the release of total MPO by an ELISA method. The study also investigates the effect of the extracts on the activity of MPO by studying its nitration activity on tyrosine and by using a new technique called SIEFED (Specific Immunological Extraction Followed by Enzymatic Detection) that allows studying the direct interaction of compounds with the enzyme. In all experiments, the aqueous extracts of the plants developed concentration-dependent inhibitory effects. A moderate heat treatment did not significantly modify the inhibitory capacity of the extracts in comparison to not heated ones. Total polyphenol and flavonoid contents were determined with an HPLC-UV/DAD analysis and a spectroscopic method using Folin-Ciocalteu reagent. Some polyphenols with well-known antioxidant activities (caffeic acid, chlorogenic acid, hyperoside, rosmarinic acid and rutin) were found in the extracts and may partly explain the inhibitory activities observed. The role of those dietary and medicinal plants in the treatment of ROS-dependent inflammatory diseases could have new considerations for health

The Evolution of the Baryons Associated with Galaxies Averaged over Cosmic Time and Space

We combine the recent determination of the evolution of the cosmic density of molecular gas (H2) using deep, volumetric surveys, with previous estimates of the cosmic density of stellar mass, star formation rate and atomic gas (H i), to constrain the evolution of baryons associated with galaxies averaged over cosmic time and space. The cosmic H i and H2 densities are roughly equal at z ~ 1.5. The H2 density then decreases by a factor ${6}_{-2}^{+3}$ to today's value, whereas the H i density stays approximately constant. The stellar mass density is increasing continuously with time and surpasses that of the total gas density (H i and H2) at redshift z ~ 1.5. The growth in stellar mass cannot be accounted for by the decrease in cosmic H2 density, necessitating significant accretion of additional gas onto galaxies. With the new H2 constraints, we postulate and put observational constraints on a two-step gas accretion process: (i) a net infall of ionized gas from the intergalactic/circumgalactic medium to refuel the extended H i reservoirs, and (ii) a net inflow of H i and subsequent conversion to H2 in the galaxy centers. Both the infall and inflow rate densities have decreased by almost an order of magnitude since z ~ 2. Assuming that the current trends continue, the cosmic molecular gas density will further decrease by about a factor of two over the next 5 Gyr, the stellar mass will increase by approximately 10%, and cosmic star formation activity will decline steadily toward zero, as the gas infall and accretion shut down