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Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
Adamoli L.
Addae-Boateng E.
Aderombi A.
Adeyeye A.
Adiamah A.
Adishesh M.
Agapov M.
Aggarwal A.
Aghayeva A.
Agilinko J.
Agnes A.
Agostini C.
Agoston P.
Agrawal A.
Agresta F.
Aguado H.
Aguilar Gonzalez M.
Aguzzoli L.
Ahad S.
Ahmadi N.
Ahmeidat A.
Ahn J. H.
Aiken T.
Aime A.
Ajlan A.
Akalin M.
Akaydin E.
Akeel N.
Akgor U.
Akhtar M. A.
Akhter Rahman M. M.
Akilli H.
Akin E.
Akkour K.
Akmenkalne L.
Al Abdallah M.
Al Awwad S.
Al Habes H.
Al Maadany F. S.
Al Raddadi R.
Al-Habib A.
Al-Habsi R.
Al-Ishaq Z.
Al-Khayal K.
Al-Masri M.
Al-Mohammad A.
Al-Mukhtar A.
Al-Najjar H.
Al-Omishy H.
Al-Sarireh B.
AL-Sayed M.
Al-Tamimi Y.
Alaa S.
AlAamer O.
Aladeojebi A.
Alam F.
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Alanbuki A.
Alatar A.
Alawneh F.
Alazawi D.
Albertsmeier M.
Albi Martin B.
Alburakan A.
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Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

Author: Aawsaj Y.
Abad Gurumeta A.
Abad-Motos A.
Abate E.
Abatini C.
Abbadessa F.
Abbas A. M.
Abbassi-Ghadi N.
Abbott D.
Abbott T.
Abd Elazeem H. A. S.
Abdalla M.
Abdallah M.
Abdel Al S.
Abdel Jalil R.
Abdeldayem H.
Abdelkader Salama I.
Abdelkarem M. M.
Abdelkarim M.
Abdelmajeed A.
Abdelrahman A.
Abdelrahman S.
Abdelsamed A.
Abdou M.
Abdulkareem A.
Abdulwahed E.
Abdur-Rahman L.
Abel M. K.
Abellan M.
Aboelkassem Ibrahim A.
Abosamak N. E.
Abou Chaar M. K.
Abou-Khalil J.
Abouassi A.
Aboulkassem H.
Abreu Da Silva A.
Abu J.
Abu Za'nouneh F. J.
Abu-Nayla I.
Abubakar A.
Acebes Garcia F.
Achalandabaso Boira M.
Acher A.
Acrich E.
Adamina M.
Adamoli L.
Addae-Boateng E.
Aderombi A.
Adeyeye A.
Adiamah A.
Adishesh M.
Agapov M.
Aggarwal A.
Aghayeva A.
Agilinko J.
Agnes A.
Agostini C.
Agoston P.
Agrawal A.
Agresta F.
Aguado H.
Aguilar Gonzalez M.
Aguzzoli L.
Ahad S.
Ahmadi N.
Ahmeidat A.
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Ajlan A.
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Akeel N.
Akgor U.
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Akhter Rahman M. M.
Akilli H.
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Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Displasia neuronal intestinal: análise de critérios morfológicos e comparação de métodos diagnósticos

Author: Terra Simone Antunes
Publication venue: Universidade Estadual Paulista (UNESP)
Publication date
Field of study

Introdução: A Displasia Neuronal Intestinal, tipo B (DNI-B) é uma doença neuromuscular gastrointestinal caracterizada por alterações complexas do sistema nervoso entérico. Seu diagnóstico depende da análise histopatológica de biópsias do reto, com mudanças dos critérios diagnósticos ao longo dos anos, o que dificulta a prática diagnóstica. O Consenso de Frankfurt, 1990, estabeleceu critérios histológicos qualitativos para diagnóstico de DNI-B, como hiperganglionose e hiperplasia do plexo nervoso submucoso. Meier-Ruge et al. 2004, 2006, definiu o diagnóstico de maneira quantitativa: mais de 20% de gânglios nervosos gigantes na submucosa, com mais de 8 neurônios cada, em 25 gânglios examinados, e em crianças maiores de 1 ano. Objetivos: Analisar as características morfológicas do sistema nervoso entérico em pacientes com DNI-B segundo os critérios do Consenso de Frankfurt de 1990, e testar a aplicabilidade dos critérios numéricos propostos por Meier-Ruge et al 2004. Pacientes e Métodos: Foram analisadas retrospectivamente peças cirúrgicas de cólon distal de 29 pacientes, com idade de 0 a 16 anos, com diagnóstico de DNI-B, em cortes histológicos processados para histologia convencional pela hematoxilina e eosina (H&E) e para imuno-histoquímica da calretinina. Resultados: Apenas 1 paciente contemplou estes critérios numéricos. Houve imunopositividade para calretinina nos neurônios, porém a contagem de neurônios foi menor em relação ao H&E (p=0,002). Não houve diferenças significativas entre os grupos etários de crianças menores e maiores de 1 ano em relação à hiperganglionose (p=0,789), número de neurônios (p=0,359), gânglios com sinais de imaturidade (p=0,664) e neurônios hipogênicos (p>0,999). Conclusões: Os critérios numéricos recomendados em cortes de 15µm, corados por painel histoquímico específico, apresentam aplicabilidade limitada quando transpostos à análise histopatológica convencional. Houve concordância pobre nos critérios analisados entre a H&E e a calretinina. Em relação à idade, nosso estudo mostrou que crianças maiores de 1 ano podem apresentar os mesmos aspectos histológicos de imaturidade neuronal que crianças menores de 1 ano, questionando a necessidade de um critério de idade para o diagnóstico da DNI-B.Introduction: Intestinal Neuronal Dysplasia type B (INDB) is a gastrointestinal neuromuscular disease characterized by complex changes in the enteric nervous system. The diagnosis depends on the histopathological analysis of rectal biopsies and the diagnostic criteria have changed over the years, making it difficult to diagnostic practice. The Frankfurt Consensus, 1990, established qualitative criteria for the histological diagnosis of INDB, such as gigant ganglia and hyperplasia of submucosal nerves. Meier-Ruge et al. 2004, 2006, defined quantitative criteria: over 20% of giant ganglia, with more than 8 nerve cells each, on 25 ganglia examined, and in children older than one year. Objectives: Analyze the morphological characteristics of the enteric nervous system in patients with INDB according to the Frankfurt Consensus Criteria 1990 and test the applicability of the numerical criteria proposed by Meier-Ruge et al. 2004. Patients and Methods: Surgical specimens of distal colon from 29 patients, aged 0-16 years old, diagnosed with INDB, in histological sections processed for conventional histology by hematoxylin and eosin (H&E) and for immunohistochemistry of calretinin, were retrospectively analyzed. Results: Only one patient met these numerical criteria. There was immunostaining for calretinin in neurons but the neurons count was lower in relation to H&E (p=0.002). There were no significant differences between the age groups of children younger and older than 1 year old in relation to hyperganglionosis (p=0.789), number of neurons (p=0.359), ganglion with immaturity (p=0.664) and hypogenic neurons (p>0.999). Conclusions: The numerical criteria recommended for 15μm cut, stained with specific histochemical panel, have limited applicability when transferred to conventional histopathology. There was poor agreement on the criteria analyzed between H&E and calretinin. Regarding the age, our study showed that children older one year old may present the same histological features of neuronal immaturity as children younger one year old, challenging the need for an age criterion for the diagnosis of INDB

A useful panel for the diagnosis of Hirschsprung disease in rectal biopsies: calretinin immunostaining and acetylcholinesterase histochesmistry

Author: Lourenção Pedro Luiz Toledo de Arruda
Ortolan Érika Veruska Paiva
Rodrigues Maria Aparecida Marchesan
Takegawa Bonifácio Katsunori
Terra Simone Antunes
Publication venue
Publication date
Field of study

The pathological evaluation of rectal biopsies for the diagnosis of Hirschsprung disease has been a challenging issue. We analyzed prospectively the usefulness of calretinin immunostaining and acetylcholinesterase (AChE) histochesmistry in rectal biopsies for the diagnosis of Hirschsprung disease. Frozen tissue samples from 43 patients were used for AChE histochemistry and paraffin-embedded sections for calretinin immunohistochemistry and conventional histology (hematoxylin and eosin [H&E]). Activity for AChE, was demonstrated in 13 of 43 cases, and the absence of immunoreactivity for calretinin was observed in 14 of 43 cases. Conventional histology (H&E) did not reveal ganglion cells in 24 of 43 cases. The results on calretinin were in good agreement with AChE according to the κ index (0.946; P < .001) and presented significantly higher specificity (96.7 × 63.3; P < .002) and accuracy (97.6 × 74.4; P < .003) when compared with conventional histology (H&E). The final diagnosis of Hirschsprung disease was confirmed in 13 of 43 patients who were submitted to surgical treatment. The results of the present study indicate that calretinin can be a good tool in ruling out the diagnosis of Hirschsprung disease, by showing positive staining in ganglion cells and intrinsic nerve fibers, whereas AChE is useful in confirming the diagnosis of Hirschsprung disease, by revealing activity of this enzyme in hypertrophied nerve fibers. The association between calretinin and AChE can be a useful panel for the histopathologic evaluation of rectal biopsies for the diagnosis of Hirschsprung disease. © 2013 Elsevier Inc. All rights reserved

Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Author: Aawsaj Y
Abad Gurumeta A
Abad-Motos A
Abate E
Abatini C
Abbadessa F
Abbas AM
Abbassi-Ghadi N
Abbott D
Abbott T
Abbott Tom EF
Abd Elazeem HAS
Abdalla M
Abdallah M
Abdel Al S
Abdel Jalil R
Abdeldayem H
Abdelkader Salama I
Abdelkarem MM
Abdelkarim M
Abdelmajeed A
Abdelrahman A
Abdelrahman S
Abdelsamed A
Abdou M
Abdulkareem A
Abdulwahed E
Abdur-Rahman L
Abel MK
Abellán M
Aboelkassem Ibrahim A
Abosamak NE
Abou Chaar MK
Abou Chaar Mohammad K.
Abou-Khalil J
Abouassi A
Aboulkassem H
Abreu da Silva A
Abu Za’nouneh FJ
Abu J
Abu-Nayla I
Abubakar A
Abukhalaf Sadi
Acebes García F
Achalandabaso Boira M
Acher A
Acrich E
Adamina M
Adamina Michel
Adamoli L
Addae-Boateng E
Ademuyiwa Adesoji O
Aderombi A
Adeyeye A
Adiamah A
Adishesh M
Agapov M
Agarwal Arnav
Aggarwal A
Aghayeva A
Agilinko J
Agnes A
Agostini C
Agoston P
Agrawal A
Agresta F
Aguado H
Aguilar Gonzalez M
Aguzzoli L
Ahad S
Ahmadi N
Ahmeidat A
Ahn JH
Aiken T
Aimé A
Ajlan A
Akalin M
Akaydin E
Akeel N
Akgor U
Akhtar MA
Akhter Rahman MM
Akilli H
Akin E
Akkour K
Akkulak Murat
Akmenkalne L
Al Abdallah M
Al Awwad S
Al Habes H
Al Maadany FS
Al Raddadi R
AL Sayed M
Al-Habib A
Al-Habsi R
Al-Ishaq Z
Al-Khayal K
Al-Masri M
Al-Mohammad A
Al-mukhtar A
Al-Najjar H
Al-omishy H
Al-Sarireh B
Al-Tamimi Y
Alaa S
AlAamer O
Aladeojebi A
Alakaloko Felix
Alam F
Alam N
Alam R
Alameer Ehab
Alamri A
Alamri Alex
Alanbuki A
Alatar A
Alawneh F
Alazawi D
Albertsmeier M
Albertsmeiers Markus
Albi Martin B
Alburakan A
Alcaide Matas F
Alconchel F
Aldayri Z
Aldecoa Ansorregui I
Alderson Derek
Aldokali N
Aleksić L
Alemanno G
Alexoudi V
Alfaro-Goldaracena A
Alfieri S
Alghamdi M
Alhalal H
Alhamed A
Alharthi M
Alharthi R
Alhassan B
Alhassan N
Alhefdhi A
Ali karar AA
Ali AK
Ali M
Ali S
Aliyeva Z
Aljanadi F
Aljiffry M
Alkadeeki GZ
Alkarak S
Allemand C
Allison J
Almalik O
Almasri M
Almeciga A
Almeida A
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Almeida JI
Almgla N
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Alnumani T
Alobeed O
Alomair A
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Alonso Poza A
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Alotaibi N
Alqannas M
Alresaini F
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Alsalamah R
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Alshaar Muhammad
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Alshareea E
Alsharif F
Alshaygy I
Alshryda Sattar
Alsobhi S
Althobaiti W
Altintoprak F
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Amaral MJ
Ameerally P
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Aneke IA
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Chaudhry Daoud
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De Crescenzo E
De Gea Rico A
De Graaff M
De Iaco P
De La Cruz Monroy MFI
De la Hoz Rodríguez Á
De la Rosa Abaroa MA
De Lacy FB
De Manzoni Garberini A
De Miguel Ardevines MDC
De Nardi P
De Oliveira López AL
De Pablo García-Cuenca A
De Palma G
De Pastena M
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West D
Westwood E
Whelan M
Whelan P
Whisker L
Whitehall E
Whitmore H
Wilkin R
Wilkin Richard JW
Wilkins A
Wilkins Alex
Williams G
Williams J
Williams K
Williams MA
Williams T
Williamson K
Wilson M
Wimberger P
Wimmer A
Winnand P
Winter D
Winter S
Winter Stuart C
Wolfer S
Wong MPK
Wong S
Wong WJ
Woodham A
Woodun H
Worku D
Wright G
Wright Naomi
Wullschleger M
Wustrack R
Xenaki S
Xu MJ
Xyda SE
Xynos E
Yahaya AS
Yang W
Yassin N
Ye G
Yesantharao P
Yetkin G
Yeşilyurt D
Yiallourou A
Yıldırım A
Yildiz A
Ying Y
Yip V
Yordanov S
Young R
Yousof EA
Youssef A
Youssef M
Yurttas C
Yánez C
Yüksel E
Zacharoulis D
Zafar SN
Zakai D
Zakaria AD
Zakaria R
Zakaria Z
Zambelli MF
Zambon M
Zamora L
Zamvar V
Zani S
Zanotti S
Zanus G
Zapardiel I
Zarabini AG
Zegarac M
Zelić M
Zeller N
Zengin AK
Zerbib P
Zervas K
Zese M
Zhang H
Zivanovic M
Zivkovic M
Zizzo M
Zografos C
Zonta S
Zorrilla Ortúzar J
Zourntou S
Zouzoulas D
Zubaidi A
Zullo A
Ângelo M
Älgå A
Çapoğlu R
Çelebi F
Çolak E
Öfner D
Öhlberger L
Öğücü H
Überrück L
Ćoza I
Šimko K
Šćepanović V
Žatecký J
Камалов А
Publication venue: American Society of Clinical Oncology
Publication date: 01/01/2021
Field of study

Keele Research Repository

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Author: Aawsaj Y
Abad Gurumeta A
Abad-Motos A
Abate E
Abatini C
Abbadessa F
Abbas AM
Abbassi-Ghadi N
Abbott D
Abbott T
Abbott TEF
Abd Elazeem HAS
Abdalla M
Abdallah M
Abdelaal SA
Abdeldayem H
Abdelkarem MM
Abdelkarim M
Abdelmajeed A
Abdelrahman A
Abdelrahman S
Abdelsamed A
Abdou M
Abdulkareem A
Abdulwahed E
Abdur-Rahman L
Abel MK
Abellan M
Abosamak NE
Abou Chaar MK
Abou-Khalil J
Abouassi A
Aboulkassem H
Abreu da Silva A
Abu Za'nouneh FJ
Abu J
Abu-Nayla I
Abubakar A
Abukhalaf S
Acebes Garcia F
Achalandabaso Boira M
Acher A
Acrich E
Adamina M
Adamina M
Adamoli L
Addae-Boateng E
Ademuyiwa AO
Aderombi A
Adeyeye A
Adiamah A
Adishesh M
Agapov M
Agarwal A
Aggarwal A
Aghayeva A
Agilinko J
Agnes A
Agostini C
Agoston P
Agrawal A
Agresta F
Aguado H
Aguzzoli L
Ahad S
Ahmadi N
Ahmed NR
Ahmeidat A
Ahn JH
Aiken T
Aime A
Ajlan A
Akalin M
Akaydin E
Akeel N
Akgor U
Akhtar MA
Akilli H
Akin E
Akkour K
Akkulak M
Akmenkalne L
Al Abdallah M
Al Abdel S
Al Awwad S
Al Habes H
Al Maadany FS
Al Raddadi R
AL Sayed M
Al-Habib A
Al-Habsi R
Al-Ishaq Z
Al-Khayal K
Al-Masri M
Al-Mohammad A
Al-mukhtar A
Al-Najjar H
Al-omishy H
Al-Sarireh B
Al-Tamimi Y
Alaa S
AlAamer O
Aladeojebi A
Alakaloko F
Alam F
Alam N
Alam R
Alameer E
Alamri A
Alamri A
Alanbuki A
Alatar A
Alawneh F
Alazawi D
Albertsmeier M
Albertsmeiers M
Albi Martin B
Alburakan A
Alcaide Matas F
Alconchel F
Aldayri Z
Aldecoa Ansorregui I
Alderson D
Aldokali N
Aleksic L
Alemanno G
Alexoudi V
Alfaro-Goldaracena A
Alfieri S
Alga A
Alghamdi M
Alhalal H
Alhamed A
Alharthi M
Alharthi R
Alhassan B
Alhassan N
Alhefdhi A
Ali AK
Ali M
Ali MF
Ali S
Aliyeva Z
Aljanadi F
Aljiffry M
Alkadeeki GZ
Alkarak S
Allemand C
Allison J
Almalik O
Almasri M
Almeciga A
Almeida A
Almeida AC
Almeida JI
Almgla N
Almond M
Almond M
Alnumani T
Alobeed O
Alomair A
Alonso de la Fuente N
Alonso Poza A
Alonso-Lamberti L
Alotaibi N
Alqannas M
Alresaini F
Alriyees L
Alsaif A
Alsaif F
Alsalamah R
Alsaraireh O
Alselaim N
Alser O
Alshaar M
Alshahrani M
Alshammari S
Alshareea E
Alsharif F
Alshaygy I
Alshryda S
Alsobhi S
Althobaiti W
Altintoprak F
Alurralde C
Alvarez E
Alvarez MR
Alyami M
Alzamanan M
Amaral MJ
Ameerally P
Amira G
Amonkar S
Amorim E
Ampollini L
Amrani L
Anania G
Anastasi A
Anchuelo Latorre J
Andaleeb U
Andaya V
Andrade AK
Andrade R
Andrijasevic S
Aneke IA
Ang K
Angele M
Angelo M
Angelou D
Angelou K
Annamalai S
Annessi V
Ansarin M
Anthoulakis C
Antic A
Antic S
Antonakis P
Antoniades K
Antonopoulou MI
Anula R
Anwar S
Anzak A
Aoun S
Aprile A
Aquila F
Aragon Achig EJ
Aremu I
Aremu M
Aresu G
Aribi N
Aribi S
Arican C
Arif T
Arigoni M
Arikan AE
Arkadopoulos N
Arkha Y
Armao T
Armatura G
Arminio A
Arnaud AP
Arrangoiz R
Arrowsmith L
Artigues E
Arulanantham A
Asaad P
Ascensao J
Ashcroft J
Ashmore C
Ashoush F
ASiT AS
Askari A
Asqalan A
Assaf M
Assalaarachchi H
Asti E
Astreidis I
Athanasakis E
Athanasiou A
Athayde Nemesio R
Atherton R
Athwal R
Atici DS
Atta R
Attia D
Augestad KM
Australasian T
Avci EK
Avlund T
Awad S
Ayasra F
Ayasra F
Ayasra Y
Aydin C
Ayhan A
Ayman A
Ayorinde J
Aytac E
Ayub B
Ayubi A
Azam M
Azamat IF
Azevedo C
Azevedo J
Azevedo J
Azevedo P
Azizeldine MG
Azizi A
Azzam AY
Baaij J
Babar MS
Baca B
Bachler T
Bacic G
Bacon A
Badalamenti G
Badellino E
Badra R
Baena Sanfeliu E
Baeza Pintado N
Bagraith K
Baia C
Baia M
Baiao JM
Baietti AM
Baig M
Bailon M
Bajomo O
Baker A
Baker C
Baker O
Bakmaz B
Bakolas G
Balabel M
Balakrishnan A
Balasubramaniam D
Balasubramanian I
Baldari L
Baldi C
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Balik E
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Ballal M
Ballouhey Q
Baloyiannis I
Bambina F
Ban VS
Bandara GBK
Bandiera A
Bandovas JP
Banerjee A
Bankhead-Kendall BK
Bankhead-Kendall BK
Banky B
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Baptista VH
Barabasz M
Barbier L
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Barisic G
Barker D
Barlow E
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Barmayehvar B
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Barod R
Baron R
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Barrett-Brown ZM
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Bartolini I
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Bascarevic V
Basendowah M
Bashir Y
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Bassi C
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Batistotti P
Batjer HH
Batstone M
Batstone M
Battista MJ
Bauer M
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Baxter K
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Belluco C
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Bertoli G
Bescos C
Beswick D
Bettoni J
Betz CS
Bewarder J
Beyer K
Beyrne C
Bezede C
Bhalla A
Bhangu A
Bhangu A
Bhangu AA
Bhangu AA
Bhasin S
Bhatti MI
Biala M
Bianchi MF
Bianchini M
Bianco F
Bianco F
Biasini M
Biasoni D
Bichoo R
Biel JR
Bigay K
Bilgin IA
Bille A
Bin Nasser A
Bin Traiki T
Biondi A
Bisagni P
Bisset C
Bissolotti G
Blackwell L
Blake D
Blanco-Colino R
Blanco-Colino R
Blas Laina JL
Blatt A
Blazer D
Blazquez Martin A
Boal M
Bobinski M
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Bocchialini G
Bocciolone L
Boddaert G
Boddy A
Bodla AS
Boeck MA
Boeker C
Boettcher A
Bogani G
Bogdanovic I
Bokhari A
Boland M
Bolster-van Eenennaam M
Bolt J
Bonavina G
Bonavina L
Bonci E
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Bondurri A
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Bordenave M
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Bozkurt E
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Brachini G
Bradshaw L
Bradulskis S
Bramis K
Brana I
Branquinho A
Brar A
Bratt D
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Breda D
Breen KA
Breheret R
Breik O
Bretherton C
Brewer H
Brian E
Bright T
Bristow R
Brito da Silva F
Brixton G
Brock L
Brocklehurst M
Bromage S
Brooke-Smith M
Brown B
Brown K
Brown L
Brown O
Brown S
Brown S
Brunelli A
Brunelli A
Brunocilla E
Brunt A
Bruscino A
Bruzzaniti P
Buarque IL
Budacan A
Buddingh K
Bueno Canones AD
Buerba GA
Bugra D
Bulathsinhala S
Bumbasirevic U
Burahee A
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Cagigal Ortega EP
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Camillo' A
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Candiani M
Candotti G
Canhoto C
Cano A
Cano-Valderrama O
Canonico G
Canotilho R
Cantalejo Diaz M
Cao H
Capelli P
Capezzuoli L
Capitan-Morales L
Capizzi V
Capoglu R
Capolupo GT
Carabias A
Caram EL
Carannante F
Carcoforo P
Cardoso N
Cardoso P
Caricato M
Carrano FM
Carrasco Prats M
Carroll P
Carta AG
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Castillejos-Molina RA
Catala Bauset JC
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Cervera I
Ceyhan GO
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Chai AKW
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Challacombe B
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Chiozza M
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Cozza V
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Cullinane C
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Cunha MF
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Currie A
Cvetkovic A
Cymes W
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D'Amore A
D'Andrea G
D'Angelo G
D'Ugo D
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D'Urso A
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Daiko H
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Dakpe S
Daliya P
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Davidson B
Davidson GH
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De Barros J
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De Graaff M
De Iaco P
De la Hoz Rodriguez A
De la Rosa Abaroa MA
De Lacy FB
De Miguel Ardevines MDC
De Nardi P
De Oliveira Lopez AL
De Pablo Garcia-Cuenca A
De Palma G
De Pastena M
De Simone B
De Simone V
de Solorzano Aurusa OFJ
De Sousa X
De Toma G
De Troia A
De Vincenti R
De Virgilio A
Dehal A
Del Campo Martin M
Del Valle E
Delgado Fernandez J
Deligiannidis D
Delimpalta C
Dellaportas D
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Demetriades AK
Demir H
Demirhan R
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Derkaoui Hassani F
Derksen T
Desai A
Desai A
Desai A
Desio M
Deus AC
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Devezas V
Devine M
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Di Bella A
Di Candido F
Di Chiara F
Di Franco G
Di Giuseppe M
Di Martino C
Di Martino M
Di Marzo F
Di Saverio S
Di Saverio S
Di Somma A
Di Taranto G
Diamantis A
Dias B
Diaz Del Gobbo R
Diaz Pena P
Diaz Perez D
Diaz-Feijoo B
Dickson K
Dieguez B
Diez Alonso M
Diez-Valladares L
Dijan E
Dikicier E
DiLalla G
Dincer HA
Distler M
Divya GS
Dixon J
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Dokic M
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Domingues JC
Dominguez I
Dominguez-Rosado I
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Drake TM
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Elawad A
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Elbe P
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Elena GDCR
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Esteban A
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EuroSurg
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Evoy D
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Faustino A
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Feo CV
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Publication venue: Br J Surg
Publication date: 11/11/2020
Field of study

BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas

Ezid

Crossref

AIR Universita degli studi di Milano

UCL Discovery

eScholarship - University of California

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

Apollo (Cambridge)

Bern Open Repository and Information System (BORIS)

Queen Mary Research Online

White Rose Research Online

Archivio istituzionale della ricerca - Università di Palermo