147 research outputs found
Vitamin D Binding Protein-Macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells
- Author
- A Takeda
- Bin Huang
- Bing Zhao
- CA Pettaway
- CR Dass
- Diane R. Bielenberg
- DT Connolly
- F Blasi
- GB Schneider
- Jason Wu
- Joseph Najbauer
- K Bajou
- K Bajou
- K Dass
- Kalvin J. Gregory
- KJ Livak
- L Trinh
- LK Chang
- M Fannon
- M Greco
- M Gutova
- M Kawakami
- Michael Fannon
- MR Helbert
- N Yamamoto
- N Yamamoto
- N Yamamoto
- N Yamamoto
- N Yamamoto
- N Yamamoto
- N Yamamoto
- N Yamamoto
- N Yamamoto
- NE Cooke
- O Kisker
- O Kisker
- R Besch
- S Kanda
- S Serrati
- Sami Dridi
- SB Mohamad
- Steven Pirie-Shepherd
- TW Bauer
- TW Bauer
- Weihua Jiang
- Y Koga
- Z Dong
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Background: Vitamin D binding protein-macrophage activating factor (DBP-maf) is a potent inhibitor of tumor growth. Its activity, however, has been attributed to indirect mechanisms such as boosting the immune response by activating macrophages and inhibiting the blood vessel growth necessary for the growth of tumors. Methods and Findings: In this study we show for the first time that DBP-maf exhibits a direct and potent effect on prostate tumor cells in the absence of macrophages. DBP-maf demonstrated inhibitory activity in proliferation studies of both LNCaP and PC3 prostate cancer cell lines as well as metastatic clones of these cells. Flow cytometry studies with annexin V and propidium iodide showed that this inhibitory activity is not due to apoptosis or cell death. DBP-maf also had the ability to inhibit migration of prostate cancer cells in vitro. Finally, DBP-maf was shown to cause a reduction in urokinase plasminogen activator receptor (uPAR) expression in prostate tumor cells. There is evidence that activation of this receptor correlates with tumor metastasis. Conclusions: These studies show strong inhibitory activity of DBP-maf on prostate tumor cells independent of it
Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain
- Author
- A Bonci
- A Dedeoglu
- A Drobyshevsky
- A Hammers
- A Madabhushi
- A Mechelli
- A Naressi
- A Pfefferbaum
- A Sidhu
- A Van der Linden
- A van Doorn
- AC Silva
- AJ Mcdonald
- B Giros
- Benoit Boulat
- BJ Everitt
- C Rorden
- CA Heidbreder
- CC Brun
- CE John
- CG Van Eden
- CR Gerfen
- D LeBihan
- D Ongur
- DB Carr
- DC Alexander
- DE Comings
- DL Rothman
- DW Shattuck
- E-F Lee
- EJ Nestler
- EK Miller
- EL Bearer
- EL Bearer
- Elaine L. Bearer
- F. Scott Hall
- G Paxinos
- G Paxinos
- G Sanacora
- George R. Uhl
- GF Koob
- GR Uhl
- H Ratiney
- HC Brenhouse
- HJ Groenewegen
- HP Hetherington
- HW Dong
- HW Shen
- I Aoki
- I Sora
- I Sora
- I Tkac
- I Tkáč
- IHA Franken
- IK Lyoo
- J Broman
- J Chen
- J Drago
- J Hennig
- J Kassubek
- J Mattiello
- J Tanji
- JC Lau
- JG Sled
- JM Tyszka
- JV Trinh
- JYF Wong
- K Narita
- KC Chan
- KM Hasan
- KM Hurley
- L Chen
- L Goncalves
- L Yavich
- M Cyr
- M Marjanska
- M Rudin
- M Yamashita
- MA Ariano
- MG Caron
- ML Mundorf
- N Kovacevic
- N Lepore
- N Papadakis
- ND Volkow
- Olivier Jacques Manzoni
- P Drapeau
- P Kochunov
- P Satpute-Krishnan
- PA Bottomley
- PG Morris
- PJ Basser
- PJW Pouwels
- PK Thanos
- PLA Gabbott
- PR Hof
- PW Kalivas
- R Bosse
- R Gainetdinov
- R Gruetter
- R Kalisch
- R Spanagel
- R Verma
- RG Elluru
- RG Pautler
- RJ Ralph
- RM Rodriguiz
- RP Carson
- RR Gainetdinov
- RR Gainetdinov
- RR Gainetdinov
- RR Gainetdinov
- Russell E. Jacobs
- S Canals
- S Jones
- S Kida
- S Mori
- S Spring
- SB Brian Ross
- SB Floresco
- SG Amara
- SH Snyder
- SK Song
- SN Haber
- T Watanabe
- TW Robbins
- U Wieshmann
- V Govindaraju
- WC Drevets
- Xiaowei Zhang
- XX Zhuang
- Y Ma
- Y Murayama
- Y Shinonaga
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/07/2010
- Field of study
The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asner D
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barone G
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bartsch V
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
- Beck GA
- Beck HP
- Beckingham M
- Becks KH
- Beddall A
- Beddall AJ
- Bedikian S
- Bednyakov VA
- Bee CP
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Bell PJ
- Bell WH
- Bella G
- Bella LA
- Bellagamba L
- Bellina F
- Bellomo M
- Belloni A
- Beloborodova O
- Belotskiy K
- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Beretta M
- Berge D
- Berger N
- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
- Bernat P
- Bernhard R
- Bernius C
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- Bertin A
- Bertinelli F
- Bertolucci F
- Besana MI
- Besson N
- Bethke S
- Bhimji W
- Bianchi RM
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- Biebel O
- Bieniek SP
- Bierwagen K
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Binet S
- Bingul A
- Bini C
- Biscarat C
- Bitenc U
- Black KM
- Blair RE
- Blanchard J-B
- Blanchot G
- Blazek T
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Bobbink GJ
- Bobrovnikov VB
- Bocchetta SS
- Bocci A
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeriu OEV
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Boisvert V
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- Bolnet NM
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- Bondarenko VG
- Bondioli M
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- Boorman G
- Booth CN
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- Borer C
- Borisov A
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- Borjanovic I
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- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Bourdarios C
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- Boyko IR
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- Bozovic-Jelisavcic I
- Bracinik J
- Braem A
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- Brandenburg GW
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- Buchanan J
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- Buckingham RM
- Buckley AG
- Buda SI
- Budagov IA
- Budick B
- Bueso XP
- Bugge L
- Buira-Clark D
- Bulekov O
- Bunse M
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- Castanheira MTD
- Castillo LRF
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- Cataneo F
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- Zhemchugov A
- Zheng S
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Abolins M
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- Ackers M
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- Ahlen SP
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Abolins M
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- Aleksandrov IN
- Alessandria F
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- Zaidan R
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- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
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- Zemla A
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- Zenin O
- Zenis T
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- Zenz S
- Zerwas D
- Zhan Z
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- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
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- Zhu CG
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
- Abarca-Gomez L
- Abdeen ZA
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adams RJ
- Aekplakorn W
- Afsana K
- Afzal S
- Agdeppa IA
- Aghazadeh-Attari J
- Aguilar-Salinas CA
- Agyemang C
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadizar F
- Ahmed SH
- Ahrens W
- Ajlouni K
- Al Nsour M
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Ali MM
- Alkandari A
- Alkerwi A
- Allin K
- Aly E
- Amarapurkar DN
- Amougou N
- Amouyel P
- Andersen LB
- Anderssen SA
- Anjana RM
- Ansari-Moghaddam A
- Ansong D
- Aounallah-Skhiri H
- Araujo J
- Ariansen I
- Aris T
- Arku RE
- Arlappa N
- Aryal KK
- Aspelund T
- Assah FK
- Assuncao MCF
- Auvinen J
- Avdicova M
- Azevedo A
- Azimi-Nezhad M
- Azizi F
- Azmin M
- Babu BV
- Bahijri S
- Balakrishna N
- Balanova Y
- Bamoshmoosh M
- Banach M
- Banadinovic M
- Bandosz P
- Banegas JR
- Bao KLN
- Bao TQ
- Baran J
- Barbagallo CM
- Barcelo A
- Barkat A
- Barreto M
- Barros AJD
- Barros MVG
- Bartosiewicz A
- Basit A
- Bastos JLD
- Bata I
- Batieha AM
- Batyrbek A
- Baur LA
- Beaglehole R
- Bebakar WMW
- Belavendra A
- Ben Romdhane H
- Benchekor SM
- Benet M
- Bennett JE
- Benson LS
- Berkinbayev S
- Bernabe-Ortiz A
- Bettiol H
- Bezerra J
- Bhagyalaxmi A
- Bhargava SK
- Bia D
- Biasch K
- Bikbov MM
- Bista B
- Bjerregaard P
- Bjertness E
- Bjertness MB
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- Publication venue
- 'Elsevier BV'
- Publication date
- 28/10/2022
- Field of study
Background: Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories.Methods: We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age.Findings: The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran.Interpretation: Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings.Copyright (C) 2021 World Health Organization; licensee Elsevier.</p
Rising rural body-mass index is the main driver of the global obesity epidemic in adults
- Author
- Abarca-Gomez L
- Abdeen ZA
- Abdrakhmanova S
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adams RJ
- Aekplakorn W
- Afsana K
- Agdeppa IA
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi N
- Ahmadvand A
- Ahrens W
- Ajlouni K
- Al Nsour M
- Al-Hazzaa HM
- Al-Othman AR
- Al-Raddadi R
- AlBuhairan F
- AlDhukair S
- Ali MM
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- Alkerwi A
- Alvarez-Pedrerol M
- Aly E
- Amarapurkar DN
- Amouyel P
- Amuzu A
- Anderssen SA
- Angquist LH
- Anjana RM
- Ansari-Moghaddam A
- Anselmo Olinto MT
- Aounallah-Skhiri H
- Araujo J
- Ariansen I
- Aris T
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- Aspelund T
- Assah FK
- Assuncao MCF
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- Baharudin A
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- Bandosz P
- Banegas JR
- Barbagallo CM
- Barcelo A
- Barkat A
- Barros AJD
- Barros MVG
- Bata I
- Batieha AM
- Batista RL
- Battakova Z
- Batyrbek A
- Baur LA
- Beaglehole R
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- Benedics J
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- Berkinbayev S
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- Bharadwaj S
- Bhargava SK
- Bhutta ZA
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- Biehl A
- Bikbov M
- Bista B
- Bixby H
- Bjelica DJ
- Bjerregaard P
- Bjertness E
- Bjertness MB
- Bjorkelund C
- Blokstra A
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- Bobak M
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- Boggia JG
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- Bonaccio M
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- Braeckman L
- Bragt MCE
- Brajkovich I
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- Capanzana MV
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- Carrillo-Larco RM
- Carvalho MJ
- Casanueva FF
- Casas J-P
- Caserta CA
- Celikcan E
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- Chen Z
- Cheng C-Y
- Cheng YJ
- Chetrit A
- Chikova-Iscener E
- Chinh NH
- Chiolero A
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- Costanzo S
- Cottel D
- Cowan MJ
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- Crampin AC
- Crujeiras AB
- Cruz JJ
- Cucu A
- Cui L
- D'Arrigo G
- d'Orsi E
- Dallongeville J
- Damasceno A
- Damsgaard CT
- Danaei G
- Dankner R
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- De Bacquer D
- De Curtis A
- de Gaetano G
- De Henauw S
- de Oliveira PD
- De Ridder K
- de Rooij SR
- De Smedt D
- de Wit TFR
- Deepa M
- Deev AD
- Dehghan A
- del Cristo Rodriguez-Perez M
- Delisle H
- Delpeuch F
- Dennison E
- Deschamps V
- Dhana K
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- Dobson AJ
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- Duante CA
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- Dulskiene V
- Dumith SC
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- Dziankowska-Zaborszczyk E
- Eddie R
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- Eggertsen R
- Eiben G
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- Eldemire-Shearer D
- Eliasen M
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- Engle-Stone R
- Erasmus RT
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- Eriksson JG
- Escobedo-de la Pena J
- Evans A
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- Faeh D
- Fall CH
- Farzadfar F
- Fattahi MR
- Felix-Redondo FJ
- Ferguson TS
- Fernandes RA
- Fernandez-Berges D
- Ferrante D
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- Fijalkowska A
- Fink G
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- Foeger B
- Foo LH
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- Forsner M
- Fouad HM
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- Francisco Miquel J
- Franco MDC
- Franco OH
- Frontera G
- Fuchs FD
- Fuchs SC
- Fujita Y
- Furusawa T
- Gaciong Z
- Gafencu M
- Galeone D
- Galvano F
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- Gareta D
- Garnett SP
- Gaspoz J-M
- Gasull M
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- Gazzinelli A
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- Geleijnse JM
- Ghaffar SA
- Ghanbari A
- Ghasemi E
- Ghasemian A
- Gheorghe-Fronea O-F
- Giampaoli S
- Gianfagna F
- Gill TK
- Giovannelli J
- Gironella G
- Giwercman A
- Godos J
- Gogen S
- Goldsmith RA
- Goltzman D
- Goncalves H
- Gonzalez AR
- Gonzalez-Chica DA
- Gonzalez-Gross M
- Gonzalez-Leon M
- Gonzalez-Rivas JP
- Gonzalez-Villalpando M-E
- Gottrand F
- Graca AP
- Graff-Iversen S
- Grafnetter D
- Grajda A
- Grammatikopoulou MG
- Gregg EW
- Gregor RD
- Grodzicki T
- Grontved A
- Grosso G
- Gruden G
- Gu D
- Gualdi-Russo E
- Gudmundsson EF
- Gudnason V
- Guerrero R
- Guessous I
- Guimaraes AL
- Gulliford MC
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- Gunter M
- Guo X
- Guo Y
- Gupta PC
- Gupta R
- Gureje O
- Gurzkowska B
- Gutierrez L
- Gutzwiller F
- Hadaegh F
- Hadjigeorgiou CA
- Haghshenas R
- Halkjaer J
- Hambleton IR
- Hamid ZA
- Hardy R
- Hassapidou M
- Hata J
- Haugsgjerd T
- Hayes AJ
- He J
- He Y
- Heidinger-Felso R
- Heinen M
- Hejgaard T
- Hendriks ME
- Henriques A
- Hernandez Cadena L
- Herrala S
- Herrera VM
- Herter-Aeberli I
- Heshmat R
- Hill AG
- Ho SC
- Ho SY
- Hobbs M
- Hofman A
- Hopman WM
- Horimoto ARVR
- Hormiga CM
- Horta BL
- Houti L
- Howitt C
- Htay TT
- Htet AS
- Htike MMT
- Hu Y
- Huerta JM
- Huhtaniemi IT
- Huisman M
- Husseini A
- Huybrechts I
- Hwalla N
- Hyska J
- Iacoviello L
- Ibarluzea JM
- Ibrahim MM
- Ikeda N
- Ikram MA
- Ioannidou EM
- Irazola VE
- Ishida T
- Islam M
- Ismail AA-S
- Iurilli MLC
- Ivkovic V
- Iwasaki M
- Jaaskelainen T
- Jackson RT
- Jacobs JM
- Jaddou H
- Jafar T
- James K
- Jamil KM
- Jamrozik K
- Janszky I
- Janus E
- Jarani J
- Jarvelin M-R
- Jasienska G
- Jelakovic A
- Jelakovic B
- Jennings G
- Jeong S-L
- Jerome CS
- Jiang CQ
- Jimenez RO
- Joffres M
- Johansson M
- Jokelainen JJ
- Jonas JB
- Jorgensen T
- Joshi P
- Jovic DP
- Jozwiak J
- Juolevi A
- Jurak G
- Juresa V
- Kaaks R
- Kafatos A
- Kajantie EO
- Kalter-Leibovici O
- Kamaruddin NA
- Kameli Y
- Kapantais E
- Karki KB
- Kasaeian A
- Katibeh M
- Katz J
- Katzmarzyk PT
- Kauhanen J
- Kaur P
- Kavousi M
- Kazakbaeva G
- Keil U
- Keinan-Boker L
- Keinanen-Kiukaanniemi S
- Kelishadi R
- Kelleher C
- Kemper HCG
- Kengne AP
- Kerimkulova A
- Kersting M
- Key T
- Khader YS
- Khalili D
- Khang Y-H
- Khanh LNB
- Khateeb M
- Khaw K-T
- Kheiri B
- Khosravi A
- Khouw IMSL
- Kiechl S
- Kiechl-Kohlendorfer U
- Killewo J
- Kim J
- Kim Y-Y
- Klimont J
- Klumbiene J
- Knoflach M
- Koenig J
- Koirala B
- Kolle E
- Kolsteren P
- Korpelainen R
- Korrovits P
- Korzycka M
- Koskinen S
- Kouda K
- Kovacs VA
- Kowlessur S
- Koziel S
- Kratzer W
- Kriemler S
- Kristensen PL
- Krokstad S
- Kromhout D
- Kruger HS
- Kubinova R
- Kuciene R
- Kuh D
- Kujala UM
- Kujundzic E
- Kulaga Z
- Kumar RH
- Kumar RK
- Kunesova M
- Kurjata P
- Kusuma YS
- Kuulasmaa K
- Kyobutungi C
- Laamiri FZ
- Laatikainen T
- Lachat C
- Laid Y
- Lanska V
- Lappas G
- Larijani B
- Latt TS
- Laugsand LE
- Lauria L
- Laxmaiah A
- Lazo-Porras M
- Le Port A
- Le TD
- Lee J
- Lee J
- Lee PH
- Lehtimaki T
- Lele ECB
- Lemogoum D
- Levitt NS
- Li Y
- Lilly CL
- Lim W-Y
- Lima-Costa MF
- Lin H-H
- Lin X
- Lind L
- Linneberg A
- Lissner L
- Litwin M
- Liu J
- Loit H-M
- Lopes L
- Lopez T
- Lopez-Garcia E
- Lorbeer R
- Lotufo PA
- Lozano JE
- Luksiene D
- Lundqvist A
- Lundqvist R
- Lunet N
- Lytsy P
- Ma G
- Ma J
- Machado-Coelho GLL
- Machado-Rodrigues AM
- Machi S
- Maggi S
- Magliano DJ
- Magriplis E
- Maire B
- Majer M
- Makdisse M
- Malekzadeh F
- Malekzadeh R
- Malhotra R
- Malyutina S
- Maniego LV
- Manios Y
- Mann JI
- Manzato E
- Margozzini P
- Markaki A
- Markey O
- Marques LP
- Marques-Vidal P
- Marrugat J
- Martin R
- Martin-Prevel Y
- Martorell R
- Martos E
- Marventano S
- Masoodi SR
- Mathiesen EB
- Mathur P
- Matijasevich A
- Matsha TE
- Mazur A
- Mbanya JCN
- McFarlane SR
- McGarvey ST
- Mckee M
- McLachlan S
- McLean RM
- McLean SB
- McNulty BA
- Mediene-Benchekor S
- Medzioniene J
- Mehdipour P
- Meirhaeghe A
- Meisfjord J
- Meisinger C
- Menezes AMB
- Menon GR
- Mensink GBM
- Mereke A
- Meshram II
- Metspalu A
- Meyer HE
- Mi J
- Michaelsen KF
- Michels N
- Mikkel K
- Milanovic SM
- Miller JC
- Minderico CS
- Minh HV
- Miranda JJ
- Mirkopoulou D
- Mirrakhimov E
- Misigoj-Durakovic M
- Mistretta A
- Mocanu V
- Modesti PA
- Moghaddam SS
- Mohajer B
- Mohamed MK
- Mohammad K
- Mohammadifard N
- Mohamud WNW
- Mohan V
- Mohanna S
- Mohebi F
- Moitry M
- Molbo D
- Mollehave LT
- Moller NC
- Molnar D
- Momenan A
- Mondo CK
- Monterrubio EA
- Monyeki KDK
- Moon JS
- Moreira LB
- Morejon A
- Moreno LA
- Morgan K
- Morin S
- Morovic ML
- Mortensen EL
- Moschonis G
- Mossakowska M
- Mostafa A
- Mota J
- Mota-Pinto A
- Motlagh ME
- Motta J
- Msyamboza KP
- Mu TT
- Muc M
- Mueller-Nurasyid M
- Mugosa B
- Muiesan ML
- Mukhtorova P
- Murphy N
- Mursu J
- Murtagh EM
- Musil V
- Nabipour I
- Naderimagham S
- Nagel G
- Naidu BM
- Nakamura H
- Namesna J
- Nang EEK
- Nangia VB
- Nankap M
- Narake S
- Nardone P
- Nauck M
- Navarrete-Munoz EM
- Neal WA
- Nelis K
- Nelis L
- Nenko I
- Neovius M
- Nervi F
- Nguyen CT
- Nguyen ND
- Nieto-Martinez RE
- Ning G
- Ninomiya T
- Nishtar S
- Noale M
- Noboa OA
- Norat T
- Norie S
- Noto D
- Nurk E
- Nyirenda M
- O'Neill TW
- O'Reilly D
- Obreja G
- Ochoa-Aviles AM
- Oda E
- Oh K
- Ohara K
- Ohtsuka R
- Olafsson O
- Oliveira IO
- Oltarzewski M
- Omar MA
- Onat A
- Ong SK
- Ono LM
- Ordunez P
- Ornelas R
- Ortiz AP
- Ortiz PJ
- Osler M
- Osmond C
- Ostojic SM
- Ostovar A
- Otero JA
- Overvad K
- Owusu-Dabo E
- Paccaud FM
- Paciorek CJ
- Padez C
- Pagkalos I
- Pahomova E
- Pajak A
- Palli D
- Palloni A
- Palmieri L
- Pan W-H
- Panda-Jonas S
- Pandey A
- Panza F
- Papandreou D
- Park S-W
- Parnell WR
- Parsaeian M
- Pascanu IM
- Patel ND
- Pecin I
- Pednekar MS
- Peer N
- Peixoto SV
- Peltonen M
- Pereira AC
- Perez CM
- Perez-Farinos N
- Peters A
- Petersmann A
- Petkeviciene J
- Petrauskiene A
- Petrescu CH
- Peykari N
- Pierannunzio D
- Pigeot I
- Pikhart H
- Pilav A
- Pilotto L
- Pistelli F
- Pitakaka F
- Piwonska A
- Plans-Rubio P
- Poh BK
- Pohlabeln H
- Pop RM
- Popovic SR
- Porta M
- Portegies MLP
- Posch G
- Poulimeneas D
- Pouraram H
- Pourshams A
- Poustchi H
- Pradeepa R
- Price AJ
- Price JF
- Puder JJ
- Pudule I
- Puhakka SE
- Puiu M
- Punab M
- Qasrawi RF
- Qorbani M
- Quang NL
- Quang NN
- Radhika MS
- Radic I
- Radisauskas R
- Rahim NCA
- Rahman M
- Rahman M
- Raitakari O
- Raj M
- Rajkumar H
- Rakhmatulloev S
- Ramachandran A
- Ramke J
- Ramos E
- Ramos R
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- Rampal S
- Rao KM
- Rao SR
- Rascon-Pacheco RA
- Rasmussen M
- Redon J
- Reganit PFM
- Regecova V
- Revilla L
- Ribas-Barba L
- Ribeiro R
- Riboli E
- Rigo F
- Riley LM
- Rinaldo N
- Rito A
- Ritti-Dias RM
- Rivera JA
- Robitaille C
- Rodrigues D
- Rodriguez-Artalejo F
- Rodriguez-Martinez A
- Rodriguez-Villamizar LA
- Rojas-Martinez R
- Rojroongwasinkul N
- Romaguera D
- Rosario AS
- Rosengren A
- Rouse I
- Roy JGR
- Rubinstein A
- Ruhli FJ
- Ruidavets J-B
- Ruiz Moreno E
- Russo P
- Rust P
- Rutkowski M
- Sabanayagam C
- Sachdev HS
- Safiri S
- Saidi O
- Salanave B
- Salazar-Martinez E
- Salmeron D
- Salomaa V
- Salonen JT
- Salvetti M
- Sanchez-Abanto J
- Sandjaja
- Sandra Ruiz-Betancourt B
- Sans S
- Sant'Angelo VF
- Santa-Marina L
- Santos Sanz S
- Santos Silva DA
- Santos DA
- Santos IS
- Santos O
- Santos R
- Saramies JL
- Sardinha LB
- Sarrafzadegan N
- Saum K-U
- Savin S
- Savva S
- Savy M
- Scazufca M
- Schargrodsky H
- Schienkiewitz A
- Schindler K
- Schipf S
- Schmidt CO
- Schmidt IM
- Schoettker B
- Schultsz C
- Schutte AE
- Sebert S
- Sein AA
- Selamat R
- Sember V
- Sen A
- Senbanjo IO
- Sepanlou SG
- Sequera V
- Serra-Majem L
- Servais J
- Shalnova SA
- Sharma SK
- Shaw JE
- Shengelia L
- Shibuya K
- Shimizu-Furusawa H
- Shin DW
- Shin Y
- Si-Ramlee K
- Siani A
- Siantar R
- Sibai AM
- Silva AM
- Simon M
- Simons J
- Simons LA
- Sjoberg A
- Sjostrom M
- Slowikowska-Hilczer J
- Slusarczyk P
- Smeeth L
- Snijder MB
- So H-K
- Sobngwi E
- Soderberg S
- Soekatri MYE
- Soemantri A
- Solfrizzi V
- Solomon BD
- Son TP
- Sonestedt E
- Song Y
- Sophiea MK
- Sorensen TIA
- Soric M
- Soumare A
- Spinelli A
- Spiroski I
- Staessen JA
- Stamm H
- Starc G
- Stathopoulou MG
- Staub K
- Stavreski B
- Steene-Johannessen J
- Stehle P
- Stein AD
- Stergiou GS
- Stessman J
- Stevens GA
- Stocks T
- Stoeckl D
- Stokwiszewski J
- Stratton G
- Stronks K
- Strufaldi MW
- Sturua L
- Suarez-Medina R
- Sun C-A
- Sundstrom J
- Sung Y-T
- Sunyer J
- Suriyawongpaisal P
- Swinburn BA
- Sy RG
- Sylva RC
- Szponar L
- Taddei C
- Tai ES
- Tai HL
- Tammesoo M-L
- Tamosiunas A
- Tan EJ
- Tang X
- Tanser F
- Tao Y
- Tarawneh MR
- Tarp J
- Tarqui-Mamani CB
- Taylor A
- Tchibindat F
- Tebar WR
- Tell G
- Tello T
- Theobald H
- Theodoridis X
- Thijs L
- Thuesen BH
- Ticha L
- Timmermans EJ
- Tjonneland A
- Tolonen HK
- Tolstrup JS
- Topbas M
- Topor-Madry R
- Tormo MJ
- Tornaritis MJ
- Torrent M
- Toselli S
- Traissac P
- Tran QB
- Trichopoulos D
- Trichopoulou A
- Trinh OTH
- Trivedi A
- Tsao Y-H
- Tshepo L
- Tsigga M
- Tsugane S
- Tulloch-Reid MK
- Tullu F
- Tuomainen T-P
- Tuomilehto J
- Turley ML
- Tynelius P
- Tzotzas T
- Tzourio C
- Ueda P
- Ugel EE
- Ukoli FAM
- Ulmer H
- Unal B
- Uusitalo HMT
- Vaitkeviciute J
- Valdivia G
- Vale S
- Valvi D
- van der Schouw YT
- Van Herck K
- van Rossem L
- Van Schoor NM
- van Valkengoed IGM
- Vanderschueren D
- Vanuzzo D
- Varela-Moreiras G
- Varona-Perez P
- Vatten L
- Vega T
- Veidebaum T
- Velasquez-Melendez G
- Velika B
- Veronesi G
- Verschuren WMM
- Victora CG
- Viegi G
- Viet L
- Vineis P
- Vioque J
- Virtanen JK
- Visser M
- Visvikis-Siest S
- Viswanathan B
- Vlasoff T
- Vollenweider P
- Volzke H
- Voutilainen A
- Voutilainen S
- Vrijheid M
- Vrijkotte TGM
- Vrkic TZ
- Wade AN
- Wagner A
- Waldhoer T
- Walton J
- Wanderley RS
- Wang M-D
- Wang Q
- Wang X
- Wang Y-W
- Wang YX
- Wannamethee SG
- Wareham N
- Weber A
- Weerasekera D
- Weghuber D
- Wei W
- Whincup PH
- Widhalm K
- Widyahening IS
- Wiecek A
- Wijga AH
- Wilks RJ
- Willeit J
- Willeit P
- Wilsgaard T
- Wojtyniak B
- Wong JE
- Wong NI
- Wong TY
- Wong-McClure RA
- Woo J
- Woodward M
- Wu FC
- Wu J
- Wu S
- Xu H
- Xu L
- Yamborisut U
- Yan W
- Yang L
- Yang X
- Yang Y
- Yardim N
- Yaseri M
- Ye X
- Yiallouros PK
- Yngve A
- Yoosefi M
- Yoshihara A
- You QS
- You S-L
- Younger-Coleman NO
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zaw KK
- Zdrojewski T
- Zeng Y
- Zhao D
- Zhao W
- Zheng W
- Zheng Y
- Zholdin B
- Zhou B
- Zhou M
- Zhu D
- Zhussupov B
- Zimmermann E
- Zuniga Cisneros J
- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 09/05/2019
- Field of study
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55% of the global rise in mean BMI from 1985 to 2017—and more than 80% in some low- and middle-income regions—was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing—and in some countries reversal—of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories
Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
- Author
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- Abdeen ZA
- Abu-Rmeileh NM
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- Wilks RJ
- Willeit J
- Willeit P
- Williams EA
- Wilsgaard T
- Wojtyniak B
- Wong A
- Wong NI
- Wong TY
- Wong-McClure RA
- Woo J
- Woodward M
- Woodward M
- Wu FC
- Wu S
- Wyszynska J
- Xu H
- Xu L
- Yaacob NA
- Yan W
- Yang L
- Yang X
- Yang Y
- Yasuharu T
- Ye X
- Yiallouros PK
- Yoosefi M
- Yoshihara A
- You S-L
- Younger-Coleman NO
- Yusoff AF
- Yusoff MFM
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zaw KK
- Zdrojewski T
- Zdrojewski T
- Zejglicova K
- Zeng Y
- Zhang L
- Zhang Z-Y
- Zhao D
- Zhao M-H
- Zhen S
- Zheng Y
- Zholdin B
- Zhou B
- Zhu D
- Zins M
- Zitt E
- Zocalo Y
- Zoghlami N
- Zuniga Cisneros J
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30–79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30–79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306–359) million women and 317 (292–344) million men in 1990 to 626 (584–668) million women and 652 (604–698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55–62) of women and 49% (46–52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43–51) of women and 38% (35–41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20–27) for women and 18% (16–21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. Funding WHO
Recommended from our members
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
- Author
- Aarestrup J
- Abarca-Gomez L
- Abbasi-Kangevari M
- Abdeen ZA
- Abdrakhmanova S
- Abdurrahmonova Z
- Abril GL
- Abu-Rmeileh NM
- Acosta-Cazares B
- Adam I
- Adamczyk M
- Adams RJ
- Adu-Afarwuah S
- Aekplakorn W
- Afsana K
- Afzal S
- Agbor VN
- Agdeppa IA
- Aghazadeh-Attari J
- Agren A
- Aguenaou H
- Aguilar-Salinas CA
- Aguilar-Salinas CA
- Agyemang C
- Ahmad MH
- Ahmad NA
- Ahmadi A
- Ahmadi N
- Ahmadi N
- Ahmed I
- Ahmed SH
- Ahrens W
- Aitmurzaeva G
- Ajlouni K
- Al Asfoor D
- Al Hourani HM
- Al Nsour M
- Al Qaoud NM
- Al-Hazzaa HM
- Al-Hinai H
- Al-Lahou B
- Al-Lawati JA
- Al-Raddadi R
- Alarouj M
- AlBuhairan F
- AlDhukair S
- Aldwairji MA
- Alexius S
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- Yoshihara A
- Yotov Y
- You QS
- You S-L
- Younger-Coleman NO
- Yu Y
- Yu Y-L
- Yusof SM
- Yusoff AF
- Yusoff MFM
- Zaccagni L
- Zafiropulos V
- Zainuddin AA
- Zakavi SR
- Zamani F
- Zambon S
- Zampelas A
- Zamrazilova H
- Zapata ME
- Zargar AH
- Zaw KK
- Zayed AA
- Zdrojewski T
- Zeglen M
- Zejglicova K
- Zeng Y
- Zentai A
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- Zimmet P
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- Zitt E
- Zocalo Y
- Zoghlami N
- Zuziak M
- Publication venue
- Elsevier
- Publication date
- 14/03/2024
- Field of study
Background
Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories.
Methods
We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median).
Findings
From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness.
Interpretation
The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.
Funding
UK Medical Research Council, UK Research and Innovation (Research England), UK Research and Innovation (Innovate UK), and European Union
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
- Author
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- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdesselam A
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- Abreu H
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- Acharya BS
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- Adams DL
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- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aenia T
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
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- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
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- Aleksandrov IN
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- Allbrooke BMM
- Allport PP
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- Åkesson TPA
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
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