Complete (O_7,O_8) contribution to B -> X_s gamma at order alpha_s^2

We calculate the set of O(alpha_s^2) corrections to the branching ratio and to the photon energy spectrum of the decay process B -> X_s gamma originating from the interference of diagrams involving the electromagnetic dipole operator O_7 with diagrams involving the chromomagnetic dipole operator O_8. The corrections evaluated here are one of the elements needed to complete the calculations of the B -> X_s gamma branching ratio at next-to-next-to-leading order in QCD. We conclude that this set of corrections does not change the central value of the Standard Model prediction for Br(B -> X_s gamma) by more than 1 %.Comment: 19 pages, 8 figure

Updated NNLO QCD predictions for the weak radiative B-meson decays

Weak radiative decays of the B mesons belong to the most important flavor changing processes that provide constraints on physics at the TeV scale. In the derivation of such constraints, accurate standard model predictions for the inclusive branching ratios play a crucial role. In the current Letter we present an update of these predictions, incorporating all our results for the O(alpha_s^2) and lower-order perturbative corrections that have been calculated after 2006. New estimates of nonperturbative effects are taken into account, too. For the CP- and isospin-averaged branching ratios, we find B_{s gamma} = (3.36 +_ 0.23) * 10^-4 and B_{d gamma} = 1.73^{+0.12}_{-0.22} * 10^-5, for E_gamma > 1.6GeV. Both results remain in agreement with the current experimental averages. Normalizing their sum to the inclusive semileptonic branching ratio, we obtain R_gamma = ( B_{s gamma} + B_{d gamma})/B_{c l nu} = (3.31 +_ 0.22) * 10^-3. A new bound from B_{s gamma} on the charged Higgs boson mass in the two-Higgs-doublet-model II reads M_{H^+} > 480 GeV at 95%C.L.Comment: journal version, 5 pages, no figure

Magnetic dipole operator contributions to the photon energy spectrum in anti-B -> X(s) gamma at O(alpha(s)^2)

We compute the O(\alpha_s^2) contributions to the photon energy spectrum of the inclusive decay \bar{B} -> X_s \gamma associated with the magnetic penguin operator O_7. They are an essential part of the ongoing NNLO calculation of this important decay. We use two different methods to evaluate the master integrals, one based on the differential equation approach and the other on sector decomposition, leading to identical results which in turn agree with those of a recent independent calculation by Melnikov and Mitov. We study the numerical relevance of this set of NNLO contributions in the photon energy spectrum and discuss the change of bottom quark mass scheme.Comment: 18 pages, uses axodraw.st

NNLL QCD Contribution of the Electromagnetic Dipole Operator to Gamma(anti-B -> X(s) gamma)

We present an independent calculation of that part of the O(\alpha_s^2) contribution to the decay width \Gamma(\bar B -> X_s \gamma) which arises from the self-interference term of the electromagnetic dipole operator O_7. Using a different method, we find complete agreement with a previous calculation. This NNLL contribution is an important ingredient for the complete NNLL prediction of \Gamma(\bar B -> X_s \gamma) which will resolve the charm quark mass ambiguity appearing at NLL accuracy.Comment: 15 pages, uses axodraw.st

Analysis of Neutral Higgs-Boson Contributions to the Decays B_s -> l^+l^- and B -> K l^+l^-

We report on a calculation of Higgs-boson contributions to the decays B_s -> l^+l^- and B -> K l^+l^- (l=e, mu) which are governed by the effective Hamiltonian describing b -> s l^+ l^-. Compact formulae for the Wilson coefficients are provided in the context of the type-II two-Higgs-doublet model (2HDM) and supersymmetry (SUSY) with minimal flavour violation, focusing on the case of large tan(beta). We derive, in a model-independent way, constraints on Higgs-boson-mediated interactions, using present experimental results on rare B decays including b -> s gamma, B_s -> mu^+ mu^-, and B -> K^(*) mu^+ mu^-. In particular, we assess the impact of possible scalar and pseudoscalar interactions transcending the standard model (SM) on the branching ratio of B_s -> mu^+ mu^- and the forward-backward (FB) asymmetry of mu^- in B -> K mu^+ mu^- decay. We find that the average FB asymmetry, which is unobservably small within the SM, and therefore a potentially valuable tool to search for new physics, is predicted to be no greater than 4% for a nominal branching ratio of about 6x10^{-7}. Moreover, striking effects on the decay spectrum of B -> K mu^+ mu^- are already ruled out by experimental data on the B_s -> mu^+ mu^- branching fraction. In addition, we study the constraints on the parameter space of the 2HDM and SUSY with minimal flavour violation. While the type-II 2HDM does not give any sizable contributions to the above decay modes, we find that SUSY contributions obeying the constraint on b -> s gamma can affect significantly the branching ratio of B_s -> mu^+ mu^-. We also comment on previous calculations contained in the literature.Comment: 29 pages, REVTeX, 8 figures. Minor corrections in Eqs. (5.4), (5.11) and (6.3) of the published versio

Charm quark mass dependence of the electromagnetic dipole operator contribution to anti-B -> X(s) gamma at O(alpha**2(s))

We extend existing calculations of the electromagnetic dipole operator contribution to the total decay rate and the photon energy spectrum of the decay \bar{B} -> X_s\gamma at O(\alpha_s^2) by working out the exact dependence on the charm quark mass.Comment: 10 pages, uses axodraw.sty; minor corrections, references added, matches published versio

β-Catenin Signaling Increases during Melanoma Progression and Promotes Tumor Cell Survival and Chemoresistance

Beta-catenin plays an important role in embryogenesis and carcinogenesis by controlling either cadherin-mediated cell adhesion or transcriptional activation of target gene expression. In many types of cancers nuclear translocation of beta-catenin has been observed. Our data indicate that during melanoma progression an increased dependency on the transcriptional function of beta-catenin takes place. Blockade of beta-catenin in metastatic melanoma cell lines efficiently induces apoptosis, inhibits proliferation, migration and invasion in monolayer and 3-dimensional skin reconstructs and decreases chemoresistance. In addition, subcutaneous melanoma growth in SCID mice was almost completely inhibited by an inducible beta-catenin knockdown. In contrast, the survival of benign melanocytes and primary melanoma cell lines was less affected by beta-catenin depletion. However, enhanced expression of beta-catenin in primary melanoma cell lines increased invasive capacity in vitro and tumor growth in the SCID mouse model. These data suggest that beta-catenin is an essential survival factor for metastatic melanoma cells, whereas it is dispensable for the survival of benign melanocytes and primary, non-invasive melanoma cells. Furthermore, beta-catenin increases tumorigenicity of primary melanoma cell lines. The differential requirements for beta-catenin signaling in aggressive melanoma versus benign melanocytic cells make beta-catenin a possible new target in melanoma therapy

A systematic review of high-fibre dietary therapy in diverticular disease

The exact pathogenesis of diverticular disease of the sigmoid colon is not well established. However, the hypothesis that a low-fibre diet may result in diverticulosis and a high-fibre diet will prevent symptoms or complications of diverticular disease is widely accepted. The aim of this review is to assess whether a high-fibre diet can improve symptoms and/or prevent complications of diverticular disease of the sigmoid colon and/or prevent recurrent diverticulitis after a primary episode. Clinical studies were eligible for inclusion if they assessed the treatment of diverticular disease or the prevention of recurrent diverticulitis with a high-fibre diet. The following exclusion criteria were used for study selection: studies without comparison of the patient group with a control group. No studies concerning prevention of recurrent diverticulitis with a high-fibre diet met our inclusion criteria. Three randomised controlled trials (RCT) and one case-control study were included in this systematic review. One RCT of moderate quality showed no difference in the primary endpoints. A second RCT of moderate quality and the case-control study found a significant difference in favour of a high-fibre diet in the treatment of symptomatic diverticular disease. The third RCT of moderate quality found a significant difference in favour of methylcellulose (fibre supplement). This study also showed a placebo effect. High-quality evidence for a high-fibre diet in the treatment of diverticular disease is lacking, and most recommendations are based on inconsistent level 2 and mostly level 3 evidence. Nevertheless, high-fibre diet is still recommended in several guideline

The Physics of the B Factories

This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C