14 research outputs found
Current and upcoming therapies to modulate skin scarring and fibrosis
Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. In many cases, skin remodelling may be impaired, leading to local hypertrophic scars or keloids. One should also consider that the scarring process is part of the wound healing response, which always starts with inflammation. Thus, scarring can also be induced in the dermis, in the absence of an actual wound, during chronic inflammatory processes. Considering the significant portion of the population that is subject to abnormal scarring, this review critically discusses the state-of-the-art and upcoming therapies in skin scarring and fibrosis.This work has been supported from the: Health Research Board, Health Research Awards Programme
(grant agreement number: HRA_POR/2011/84); Science Foundation Ireland, Career Development
Award Programme (grant agreement number: 15/CDA/3629); Science Foundation Ireland and the
European Regional Development Fund (grant agreement number: 13/RC/2073); EU H2020, ITN
award, Tendon Therapy Train Project (grant agreement number: 676338). The authors would like to
thank Mr M. Doczyk for designing the figures of the manuscript. D.I.Z. would like to dedicate the
manuscript to I.N.Z. who left.peer-reviewe
Current and upcoming therapies to modulate skin scarring and fibrosis
Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. In many cases, skin remodelling may be impaired, leading to local hypertrophic scars or keloids. One should also consider that the scarring process is part of the wound healing response, which always starts with inflammation. Thus, scarring can also be induced in the dermis, in the absence of an actual wound, during chronic inflammatory processes. Considering the significant portion of the population that is subject to abnormal scarring, this review critically discusses the state-of-the-art and upcoming therapies in skin scarring and fibrosis