664 research outputs found
Predicting decadal trends and transient responses of radiocarbon storage and fluxes in a temperate forest soil
Representing the response of soil carbon dynamics to global environmental change requires the incorporation of multiple tools in the development of predictive models. An important tool to construct and test models is the incorporation of bomb radiocarbon in soil organic matter during the past decades. In this manuscript, we combined radiocarbon data and a previously developed empirical model to explore decade-scale soil carbon dynamics in a temperate forest ecosystem at the Harvard Forest, Massachusetts, USA. We evaluated the contribution of different soil C fractions to both total soil CO<sub>2</sub> efflux and microbially respired C. We tested the performance of the model based on measurable soil organic matter fractions against a decade of radiocarbon measurements. The model was then challenged with radiocarbon measurements from a warming and N addition experiment to test multiple hypotheses about the different response of soil C fractions to the experimental manipulations. Our results showed that the empirical model satisfactorily predicts the trends of radiocarbon in litter, density fractions, and respired CO<sub>2</sub> observed over a decade in the soils not subjected to manipulation. However, the model, modified with prescribed relationships for temperature and decomposition rates, predicted most but not all the observations from the field experiment where soil temperatures and nitrogen levels were increased, suggesting that a larger degree of complexity and mechanistic relations need to be added to the model to predict short-term responses and transient dynamics
Minimal lepton flavor violating realizations of minimal seesaw models
We study the implications of the global U(1)R symmetry present in minimal
lepton flavor violating implementations of the seesaw mechanism for neutrino
masses. In the context of minimal type I seesaw scenarios with a slightly
broken U(1)R, we show that, depending on the R-charge assignments, two classes
of generic models can be identified. Models where the right-handed neutrino
masses and the lepton number breaking scale are decoupled, and models where the
parameters that slightly break the U(1)R induce a suppression in the light
neutrino mass matrix. We show that within the first class of models,
contributions of right-handed neutrinos to charged lepton flavor violating
processes are severely suppressed. Within the second class of models we study
the charged lepton flavor violating phenomenology in detail, focusing on mu to
e gamma, mu to 3e and mu to e conversion in nuclei. We show that sizable
contributions to these processes are naturally obtained for right-handed
neutrino masses at the TeV scale. We then discuss the interplay with the
effects of the right-handed neutrino interactions on primordial B - L
asymmetries, finding that sizable right-handed neutrino contributions to
charged lepton flavor violating processes are incompatible with the requirement
of generating (or even preserving preexisting) B - L asymmetries consistent
with the observed baryon asymmetry of the Universe.Comment: 21 pages, 4 figures; version 2: Discussion on possible generic models
extended, typos corrected, references added. Version matches publication in
JHE
Minimal Flavour Violation for Leptoquarks
Scalar leptoquarks, with baryon and lepton number conserving interactions,
could have TeV scale masses, and be produced at colliders or contribute to a
wide variety of rare decays. In pursuit of some insight as to the most
sensitive search channels, We assume that the leptoquark-lepton-quark coupling
can be constructed from the known mass matrices. We estimate the rates for
selected rare processes in three cases: leptoquarks carrying lepton and quark
flavour, leptoquarks with quark flavour only, and unflavoured leptoquarks. We
find that leptoquark decay to top quarks is an interesting search channel.Comment: 17 pages, 2 figures, minor changes and references adde
Flavoured soft leptogenesis and natural values of the B term
We revisit flavour effects in soft leptogenesis relaxing the assumption of
universality for the soft supersymmetry breaking terms. We find that with
respect to the case in which the heavy sneutrinos decay with equal rates and
equal CP asymmetries for all lepton flavours, hierarchical flavour
configurations can enhance the efficiency by more than two orders of magnitude.
This translates in more than three order of magnitude with respect to the
one-flavour approximation. We verify that lepton flavour equilibration effects
related to off-diagonal soft slepton masses are ineffective for damping these
large enhancements. We show that soft leptogenesis can be successful for
unusual values of the relevant parameters, allowing for and for values of the washout parameter up to .Comment: 23 pages, 5 figures postscript, Minor changes to match the published
version in JHE
Leptogenesis from Soft Supersymmetry Breaking (Soft Leptogenesis)
Soft leptogenesis is a scenario in which the cosmic baryon asymmetry is
produced from a lepton asymmetry generated in the decays of heavy sneutrinos
(the partners of the singlet neutrinos of the seesaw) and where the relevant
sources of CP violation are the complex phases of soft supersymmetry-breaking
terms. We explain the motivations for soft leptogenesis, and review its basic
ingredients: the different CP-violating contributions, the crucial role played
by thermal corrections, and the enhancement of the efficiency from lepton
flavour effects. We also discuss the high temperature regime GeV in
which the cosmic baryon asymmetry originates from an initial asymmetry of an
anomalous -charge, and soft leptogenesis reembodies in -genesis.Comment: References updated. Some minor corrections to match the published
versio
Measurement of the t t-bar production cross section in the dilepton channel in pp collisions at sqrt(s) = 7 TeV
The t t-bar production cross section (sigma[t t-bar]) is measured in
proton-proton collisions at sqrt(s) = 7 TeV in data collected by the CMS
experiment, corresponding to an integrated luminosity of 2.3 inverse
femtobarns. The measurement is performed in events with two leptons (electrons
or muons) in the final state, at least two jets identified as jets originating
from b quarks, and the presence of an imbalance in transverse momentum. The
measured value of sigma[t t-bar] for a top-quark mass of 172.5 GeV is 161.9 +/-
2.5 (stat.) +5.1/-5.0 (syst.) +/- 3.6(lumi.) pb, consistent with the prediction
of the standard model.Comment: Replaced with published version. Included journal reference and DO
A monovalent chimpanzee adenovirus Ebola vaccine boosted with MVA
BACKGROUND
The West African outbreak of Ebola virus disease that peaked in 2014 has caused more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for control of a future outbreak.
METHODS
In this phase 1 study, we administered a single dose of the chimpanzee adenovirus 3 (ChAd3) vaccine encoding the surface glycoprotein of Zaire ebolavirus (ZEBOV) to 60 healthy adult volunteers in Oxford, United Kingdom. The vaccine was administered in three dose levels â 1Ă1010 viral particles, 2.5Ă1010 viral particles, and 5Ă1010 viral particles â with 20 participants in each group. We then assessed the effect of adding a booster dose of a modified vaccinia Ankara (MVA) strain, encoding the same Ebola virus glyco- protein, in 30 of the 60 participants and evaluated a reduced primeâboost interval in another 16 participants. We also compared antibody responses to inactivated whole Ebola virus virions and neutralizing antibody activity with those observed in phase 1 studies of a recombinant vesicular stomatitis virusâbased vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) to determine relative potency and assess durability.
RESULTS
No safety concerns were identified at any of the dose levels studied. Four weeks after immunization with the ChAd3 vaccine, ZEBOV-specific antibody responses were similar to those induced by rVSV-ZEBOV vaccination, with a geometric mean titer of 752 and 921, respectively. ZEBOV neutralization activity was also similar with the two vaccines (geo- metric mean titer, 14.9 and 22.2, respectively). Boosting with the MVA vector increased virus-specific antibodies by a factor of 12 (geometric mean titer, 9007) and increased glycoprotein-specific CD8+ T cells by a factor of 5. Significant increases in neutralizing antibodies were seen after boosting in all 30 participants (geometric mean titer, 139; P<0.001). Virus-specific antibody responses in participants primed with ChAd3 remained positive 6 months after vaccination (geometric mean titer, 758) but were significantly higher in those who had received the MVA booster (geometric mean titer, 1750; P<0.001).
CONCLUSIONS
The ChAd3 vaccine boosted with MVA elicited B-cell and T-cell immune responses to ZEBOV that were superior to those induced by the ChAd3 vaccine alone. (Funded by the Wellcome Trust and others; ClinicalTrials.gov number, NCT02240875.
Higgs lepton flavour violation: UV completions and connection to neutrino masses
We study lepton violating Higgs (HLFV) decays, first from the effective field theory (EFT) point of view, and then analysing the different high-energy realizations of the operators of the EFT, highlighting the most promising models. We argue why two Higgs doublet models can have a BR(h â Ï ÎŒ) ⌠0.01, and why this rate is suppressed in all other realizations including vector-like leptons. We further discuss HLFV in the context of neutrino mass models: in most cases it is generated at one loop giving always BR(h â Ï ÎŒ) < 10â4 and typically much less, which is beyond experimental reach. However, both the Zee model and extended left-right symmetric models contain extra SU(2) doublets coupled to leptons and could in principle account for the observed excess, with interesting connections between HLFV and neutrino parameters
Renormalisation group improved leptogenesis in family symmetry models
We study renormalisation group (RG) corrections relevant for leptogenesis in
the case of family symmetry models such as the Altarelli-Feruglio A4 model of
tri-bimaximal lepton mixing or its extension to tri-maximal mixing. Such
corrections are particularly relevant since in large classes of family symmetry
models, to leading order, the CP violating parameters of leptogenesis would be
identically zero at the family symmetry breaking scale, due to the form
dominance property. We find that RG corrections violate form dominance and
enable such models to yield viable leptogenesis at the scale of right-handed
neutrino masses. More generally, the results of this paper show that RG
corrections to leptogenesis cannot be ignored for any family symmetry model
involving sizeable neutrino and tau Yukawa couplings.Comment: 24 pages, 6 figures and 1 tabl
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