121 research outputs found
Phase relations in K_xFe_{2-y}Se_2 and the structure of superconducting K_xFe_2Se_2 via high-resolution synchrotron diffraction
Superconductivity in iron selenides has experienced a rapid growth, but not
without major inconsistencies in the reported properties. For
alkali-intercalated iron selenides, even the structure of the superconducting
phase is a subject of debate, in part because the onset of superconductivity is
affected much more delicately by stoichiometry and preparation than in cuprate
or pnictide superconductors. If high-quality, pure, superconducting
intercalated iron selenides are ever to be made, the intertwined physics and
chemistry must be explained by systematic studies of how these materials form
and by and identifying the many coexisting phases. To that end, we prepared
pure K_2Fe_4Se_5 powder and superconductors in the K_xFe_{2-y}Se_2 system, and
examined differences in their structures by high-resolution synchrotron and
single-crystal x-ray diffraction. We found four distinct phases: semiconducting
K_2Fe_4Se_5, a metallic superconducting phase K_xFe_2Se_2 with x ranging from
0.38 to 0.58, an insulator KFe_{1.6}Se_2 with no vacancy ordering, and an
oxidized phase K_{0.51(5)}Fe_{0.70(2)}Se that forms the PbClF structure upon
exposure to moisture. We find that the vacancy-ordered phase K_2Fe_4Se_5 does
not become superconducting by doping, but the distinct iron-rich minority phase
K_xFe_2Se_2 precipitates from single crystals upon cooling from above the
vacancy ordering temperature. This coexistence of metallic and semiconducting
phases explains a broad maximum in resistivity around 100 K. Further studies to
understand the solubility of excess Fe in the K_xFe_{2-y}Se_2 structure will
shed light on the maximum fraction of superconducting K_xFe_2Se_2 that can be
obtained by solid state synthesis.Comment: 12 pages, 16 figures, supplemental materia
Anthropological Contributions to Historical Ecology: 50 Questions, Infinite Prospects
This paper presents the results of a consensus-driven process identifying 50 priority research questions for historical ecology obtained through crowdsourcing, literature reviews, and in-person workshopping. A deliberative approach was designed to maximize discussion and debate with defined outcomes. Two in-person workshops (in Sweden and Canada) over the course of two years and online discussions were peer facilitated to define specific key questions for historical ecology from anthropological and archaeological perspectives. The aim of this research is to showcase the variety of questions that reflect the broad scope for historical-ecological research trajectories across scientific disciplines. Historical ecology encompasses research concerned with decadal, centennial, and millennial human-environmental interactions, and the consequences that those relationships have in the formation of contemporary landscapes. Six interrelated themes arose from our consensus-building workshop model: (1) climate and environmental change and variability; (2) multi-scalar, multi-disciplinary; (3) biodiversity and community ecology; (4) resource and environmental management and governance; (5) methods and applications; and (6) communication and policy. The 50 questions represented by these themes highlight meaningful trends in historical ecology that distill the field down to three explicit findings. First, historical ecology is fundamentally an applied research program. Second, this program seeks to understand long-term human-environment interactions with a focus on avoiding, mitigating, and reversing adverse ecological effects. Third, historical ecology is part of convergent trends toward transdisciplinary research science, which erodes scientific boundaries between the cultural and natural
Anthropological contributions to historical ecology: 50 questions, infinite prospects.
This paper presents the results of a consensus-driven process identifying 50 priority research questions for historical ecology obtained through crowdsourcing, literature reviews, and in-person workshopping. A deliberative approach was designed to maximize discussion and debate with defined outcomes. Two in-person workshops (in Sweden and Canada) over the course of two years and online discussions were peer facilitated to define specific key questions for historical ecology from anthropological and archaeological perspectives. The aim of this research is to showcase the variety of questions that reflect the broad scope for historical-ecological research trajectories across scientific disciplines. Historical ecology encompasses research concerned with decadal, centennial, and millennial human-environmental interactions, and the consequences that those relationships have in the formation of contemporary landscapes. Six interrelated themes arose from our consensus-building workshop model: (1) climate and environmental change and variability; (2) multi-scalar, multi-disciplinary; (3) biodiversity and community ecology; (4) resource and environmental management and governance; (5) methods and applications; and (6) communication and policy. The 50 questions represented by these themes highlight meaningful trends in historical ecology that distill the field down to three explicit findings. First, historical ecology is fundamentally an applied research program. Second, this program seeks to understand long-term human-environment interactions with a focus on avoiding, mitigating, and reversing adverse ecological effects. Third, historical ecology is part of convergent trends toward transdisciplinary research science, which erodes scientific boundaries between the cultural and natural
A Cryogenic Silicon Interferometer for Gravitational-wave Detection
The detection of gravitational waves from compact binary mergers by LIGO has opened the era of gravitational wave astronomy, revealing a previously hidden side of the cosmos. To maximize the reach of the existing LIGO observatory facilities, we have designed a new instrument able to detect gravitational waves at distances 5 times further away than possible with Advanced LIGO, or at greater than 100 times the event rate. Observations with this new instrument will make possible dramatic steps toward understanding the physics of the nearby Universe, as well as observing the Universe out to cosmological distances by the detection of binary black hole coalescences. This article presents the instrument design and a quantitative analysis of the anticipated noise floor
A Cryogenic Silicon Interferometer for Gravitational-wave Detection
The detection of gravitational waves from compact binary mergers by LIGO has
opened the era of gravitational wave astronomy, revealing a previously hidden
side of the cosmos. To maximize the reach of the existing LIGO observatory
facilities, we have designed a new instrument that will have 5 times the range
of Advanced LIGO, or greater than 100 times the event rate. Observations with
this new instrument will make possible dramatic steps toward understanding the
physics of the nearby universe, as well as observing the universe out to
cosmological distances by the detection of binary black hole coalescences. This
article presents the instrument design and a quantitative analysis of the
anticipated noise floor
Waveform Modelling for the Laser Interferometer Space Antenna
LISA, the Laser Interferometer Space Antenna, will usher in a new era in
gravitational-wave astronomy. As the first anticipated space-based
gravitational-wave detector, it will expand our view to the millihertz
gravitational-wave sky, where a spectacular variety of interesting new sources
abound: from millions of ultra-compact binaries in our Galaxy, to mergers of
massive black holes at cosmological distances; from the beginnings of inspirals
that will venture into the ground-based detectors' view to the death spiral of
compact objects into massive black holes, and many sources in between. Central
to realising LISA's discovery potential are waveform models, the theoretical
and phenomenological predictions of the pattern of gravitational waves that
these sources emit. This white paper is presented on behalf of the Waveform
Working Group for the LISA Consortium. It provides a review of the current
state of waveform models for LISA sources, and describes the significant
challenges that must yet be overcome.Comment: 239 pages, 11 figures, white paper from the LISA Consortium Waveform
Working Group, invited for submission to Living Reviews in Relativity,
updated with comments from communit
Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro Imaging genetics through meta analysis (ENIGMA) Consortium
BACKGROUND: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Schizophrenia Working Group.
METHODS: The study included data from 4474 individuals with schizophrenia (mean age, 32.3 years; range, 11-78 years; 66% male) and 5098 healthy volunteers (mean age, 32.8 years; range, 10-87 years; 53% male) assessed with standardized methods at 39 centers worldwide.
RESULTS: Compared with healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen's d = -0.530/-0.516) and smaller surface area (left/right hemisphere: Cohen's d = -0.251/-0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were two to three times larger in individuals receiving antipsychotic medication relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness and positive correlations with age at onset.
CONCLUSIONS: The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N=293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease. On the electrocardiogram, the PR interval reflects conduction from the atria to ventricles and also serves as risk indicator of cardiovascular morbidity and mortality. Here, the authors perform genome-wide meta-analyses for PR interval in multiple ancestries and identify 141 previously unreported genetic loci.Peer reviewe
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