25 research outputs found
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
Gene expression studies suggest that aging of the human brain is determined by a complex interplay of molecular events, although both its region- and cell-type-specific consequences remain poorly understood. Here, we extensively characterized aging-altered gene expression changes across ten human brain regions from 480 individuals ranging in age from 16 to 106 years. We show that astrocyte- and oligodendrocyte-specific genes, but not neuron-specific genes, shift their regional expression patterns upon aging, particularly in the hippocampus and substantia nigra, while the expression of microglia- and endothelial-specific genes increase in all brain regions. In line with these changes, high-resolution immunohistochemistry demonstrated decreased numbers of oligodendrocytes and of neuronal subpopulations in the aging brain cortex. Finally, glial-specific genes predict age with greater precision than neuron-specific genes, thus highlighting the need for greater mechanistic understanding of neuron-glia interactions in aging and late-life diseases
Capsaicin modulates pulmonary antioxidant defense system during benzo(a)pyrene-induced lung cancer in swiss albino mice
Impact of Chlorella pyrenoidosa on the attenuation of hyperglycemia-mediated oxidative stress and protection of kidney tissue in streptozotocin-cadmium induced diabetic nephropathic rats
Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer
EFFECT OF CALCIUM CHANNEL BLOCKADE ON ADRENERGICALLY INDUCED RENAL VASOCONSTRICTION IN RAT MODELS OF RENAL IMPAIRMENT
WITHDRAWN: Protective effect of Emblica officinalis fruit extract on cisplatin-induced nephrotoxicity in female rats
Influence of combined hypertension and renal failure on functional α1-adrenoceptor subtypes in the rat kidney
Background and purpose: This study investigated whether the α1-adrenoceptor responsiveness of the renal vasculature was altered in the state of hypertension combined with renal failure