Unraveling the Role of Interfaces on the Spall Failure of Cu/Ta Multilayered Systems.

Molecular dynamics (MD) simulations are carried out to investigate the effects of the type and spacing of FCC/BCC interfaces on the deformation and spall behavior. The simulations are carried out using model Cu/Ta multilayers with six different types of interfaces. The results suggest that interface type can significantly affect the structure and intensity of the incoming shock wave, change the activated slip systems, alter dislocation slip and twinning behavior, affect where and how voids are nucleated during spallation and the resulting spall strength. Moreover, the above aspects are significantly affected by the interface spacing. A transition from homogeneous to heterogeneous dislocation nucleation occurs as the interface spacing is decreased to 6 nm. Depending on interface type and spacing, damage (voids) nucleation and spall failure is observed to occur not only at the Cu/Ta interfaces, but also in the weaker Cu layer interior, or even in the stronger Ta layer interior, although different mechanisms underlie each of these three distinct failure modes. These findings point to the fact that, depending on the combination of interface type and spacing, interfaces can lead to both strengthening and weakening of the Cu/Ta multilayered microstructures

Resveratrol in Management of Diabetes and Obesity: Clinical Applications, Bioavailability, and Nanotherapy

Diabetes is the most common serious metabolic disorder and one of the five leading causes of death worldwide. It is characterized by persistent hyperglycemia coincident with the induction of oxidative stress and alterations in glucose and lipid metabolism–regulating enzymes. Resveratrol has immerged as one of the leading natural ingredients to combat diabetic and its complications. Despite an abundance of laboratory and animal research, there is little clinical evidence to establish resveratrol effectiveness as a therapeutic against diabetes. Further, the poor bioavailability and stability of resveratrol in humans have been a major concern for translating basic science findings into clinical utility. In this review, we embark on large, well-controlled clinical studies to confirm the efficacy of resveratrol in the management of diabetes mellitus and gain a better insight into its biological effects in humans. Further possible methods of increasing the stability and bioavailability for such trials are also discussed

Microstructural characterization of pre-shocked and post-shocked powder

Issued as Monthly cost status reports [nos. 1-16], and Final technical report, Project E-18-X0

Mechanisms of shock-initiated intermetallic reactions

Issued as Final report, Project E-18-69