1,047 research outputs found
P/2010A2 LINEAR - I: An impact in the Asteroid Main Belt
Comet P/2010A2 LINEAR is a good candidate for membership with the Main Belt
Comet family. It was observed with several telescopes (ESO NTT, La Silla;
Gemini North, Mauna Kea; UH 2.2m, Mauna Kea) from 14 Jan. until 19 Feb. 2010 in
order to characterize and monitor it and its very unusual dust tail, which
appears almost fully detached from the nucleus; the head of the tail includes
two narrow arcs forming a cross. The immediate surroundings of the nucleus were
found dust-free, which allowed an estimate of the nucleus radius of 80-90m. A
model of the thermal evolution indicates that such a small nucleus could not
maintain any ice content for more than a few million years on its current
orbit, ruling out ice sublimation dust ejection mechanism. Rotational spin-up
and electrostatic dust levitations were also rejected, leaving an impact with a
smaller body as the favoured hypothesis, and ruling out the cometary nature of
the object.
The impact is further supported by the analysis of the tail structure.
Finston-Probstein dynamical dust modelling indicates the tail was produced by a
single burst of dust emission. More advanced models, independently indicate
that this burst populated a hollow cone with a half-opening angle alpha~40degr
and with an ejection velocity v_max ~ 0.2m/s, where the small dust grains fill
the observed tail, while the arcs are foreshortened sections of the burst cone.
The dust grains in the tail are measured to have radii between a=1-20mm, with a
differential size distribution proportional to a^(-3.44 +/- 0.08). The dust
contained in the tail is estimated to at least 8x10^8kg, which would form a
sphere of 40m radius. Analysing these results in the framework of crater
physics, we conclude that a gravity-controlled crater would have grown up to
~100m radius, i.e. comparable to the size of the body. The non-disruption of
the body suggest this was an oblique impact.Comment: 15 pages, 11 figures, in pres
Semblance analysis to assess GPR data from a five-year forensic study of simulated clandestine graves
Ground penetrating radar (GPR) surveys have proven useful for locating clandestine graves in a number of forensic searches. There has been extensive research into the geophysical monitoring of simulated clandestine graves in different burial scenarios and ground conditions. Whilst these studies have been used to suggest optimum dominant radar frequencies, the data themselves have not been quantitatively analysed to-date. This study uses a common-offset configuration of semblance analysis, both to characterise velocity trends from GPR diffraction hyperbolae and, since the magnitude of a semblance response is proportional to signal-to-noise ratio, to quantify the strength of a forensic GPR response. 2D GPR profiles were acquired over a simulated clandestine burial, with a wrapped-pig cadaver monitored at three-month intervals between 2008 and 2013 with GPR antennas of three different centre-frequencies (110, 225 and 450 MHz). The GPR response to the cadaver was a strong diffraction hyperbola. Results show, in contrast to resistivity surveys, that semblance analysis show little sensitivity to changes attributable to decomposition, and only a subtle influence of seasonality: velocity increases (0.01â0.02 m/ns) were observed in summer, associated with a decrease (5â10%) in peak semblance magnitude, SM, and potentially in the reflectivity of the cadaver. The lowest-frequency antennas consistently gave the highest signal-to-noise ratio although the grave was nonetheless detectable by all frequencies trialled. These observations suggest that forensic GPR surveys could be undertaken with little seasonal hindrance. Whilst GPR analysis cannot currently provide a quantitative diagnostic proxy for time-since-burial, the consistency of responses suggests that graves will remain detectable beyond the five years shown here
Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but cannot be fully explained by known oncogenes and tumor suppressor genes. Using a pan-cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis-defined CNA signatures are predictive of glycolytic phenotypes, including 18F-fluorodeoxy-glucose (FDG) avidity of patient tumors, and increased proliferation. The primary CNA signature is enriched for p53 mutations and is associated with glycolysis through coordinate amplification of glycolytic genes and other cancer-linked metabolic enzymes. A pan-cancer and cross-species comparison of CNAs highlighted 26 consistently altered DNA regions, containing 11 enzymes in the glycolysis pathway in addition to known cancer-driving genes. Furthermore, exogenous expression of hexokinase and enolase enzymes in an experimental immortalization system altered the subsequent copy number status of the corresponding endogenous loci, supporting the hypothesis that these metabolic genes act as drivers within the conserved CNA amplification regions. Taken together, these results demonstrate that metabolic stress acts as a selective pressure underlying the recurrent CNAs observed in human tumors, and further cast genomic instability as an enabling event in tumorigenesis and metabolic evolution
Reward processing in autism: a thematic series
This thematic series presents theoretical and empirical papers focused on understanding autism from the perspective of reward processing deficits. Although the core symptoms of autism have not traditionally been conceptualized with respect to altered reward-based processes, it is clear that brain reward circuitry plays a critical role in guiding social and nonsocial learning and behavior throughout development. Additionally, brain reward circuitry may respond to social sources of information in ways that are similar to responses to primary rewards, and recent clinical data consistently suggest abnormal behavioral and neurobiologic responses to rewards in autism. This thematic series presents empirical data and review papers that highlight the utility of considering autism from the perspective of reward processing deficits. Our hope is that this novel framework may further elucidate autism pathophysiology, with the ultimate goal of yielding novel insights with potential therapeutic implications
Stacking catalog sources in WMAP data
We stack WMAP 7-year temperature data around extragalactic point sources,
showing that the profiles are consistent with WMAP's beam models, in
disagreement with the findings of Sawangwit & Shanks (2010). These results
require that the source sample's selection is not biased by CMB fluctuations.
We compare profiles from sources in the standard WMAP catalog, the WMAP catalog
selected from a CMB-free combination of data, and the NVSS catalog, and
quantify the agreement with fits to simple parametric beam models. We estimate
the biases in source profiles due to alignments with positive CMB fluctuations,
finding them roughly consistent with those biases found with the WMAP standard
catalog. Addressing those biases, we find source spectral indices significantly
steeper than those used by WMAP, with strong evidence for spectral steepening
above 61 GHz. Such changes modify the power spectrum correction required for
unresolved point sources, and tend to weaken somewhat the evidence for
deviation from a Harrison-Zel'dovich primordial spectrum, but more analysis is
required. Finally, we discuss implications for current CMB experiments.Comment: 10 pages, 7 figures, 2 tables, submitted to MNRA
The Iowa Homemaker vol.4, no.2
Table of Contents
To the High School Girls of Iowa by Anna E. Richardson, page 3
For the College Room by Barbara Mills Dewell, page 4
The Junior-Senior Banquet by Viola Jammer and Pauline Peacock, page 4
Picnic Preparations by Louise Evans Doole, page 5
Finding Yourself by H. M. Hamlin, page 6
Stories of the Sand by Katherine Holden, page 7
Appropriate Pictures for the Home by Amanda Jacobson, page 8
The Individual Scarf by Rhea Fern Schultz, page 9
Using Your Kodak by H. P. Doole, page 10
Something Plus by Laura E. Bublitz, page 11
The Ideal Homemaker by Rosalie Larson, page 12
University Life in France by Mercie Carley, page 12
Homemaker as Citizen by Jeanette Beyer, page 13
Whoâs There and Where by Dryden Quist, page 14
Editorial, page 15
The Eternal Question, page 1
Single metallic nanoparticle imaging for protein detection in cells
We performed a visualization of membrane proteins labeled with 10-nm gold
nanoparticles in cells, using an all-optical method based on photothermal
interference contrast. The high sensitivity of the method and the stability of
the signals allows 3D imaging of individual nanoparticles without the drawbacks
of photobleaching and blinking inherent to fluorescent markers. A simple
analytical model is derived to account for the measurements of the signal
amplitude and the spatial resolution. The photothermal interference contrast
method provides an efficient, reproducible, and promising way to visualize low
amounts of proteins in cells by optical means
Long-term Geophysical Monitoring of Simulated Clandestine Graves using Electrical and Ground Penetrating Radar Methods: 4-6 Years After Burial
Geophysical and botanical monitoring of simulated graves in a tropical rainforest, Colombia, South America
In most Latin American countries there are significant numbers of missing people and forced disappearances, currently ~74,000 only in Colombia. Successful detection of shallow buried human remains by forensic search teams is currently difficult in varying terrain and climates. Within this research we built four simulated clandestine burial styles in tropical rainforests, as this is a common scenario and depositional environment encountered in Latin America, to gain knowledge of optimum forensic geophysics detection techniques. The results of geophysically monitoring these burials using ground penetrating radar, magnetic susceptibility, bulk ground conductivity and electrical resistivity are presented from one to forty three weeks post-burial. Radar survey results with both the 250 MHz and 500 MHz frequency antennae showed good detection of modern simulated burials on 2D profiles and horizontal time slices but poor detection on the other simulated graves. Magnetic susceptibility, bulk ground conductivity and electrical resistivity results were generally poor at detecting the simulated targets. Observations of botanical variations on the test site show rapid re-growth of Malvaceae and Petiveria alliacea vegetation over all burials that are common in these forests, which can make detection more difficult
Melting and differentiation of early-formed asteroids: The perspective from high precision oxygen isotope studies
A number of distinct methodologies are available for determining the oxygen isotope composition of minerals and rocks, these include laser-assisted fluorination, secondary ion mass spectrometry (SIMS)and UV laser ablation. In this review we focus on laser-assisted fluorination, which currently achieves the highest levels of precision available for oxygen isotope analysis. In particular, we examine how results using this method have furthered our understanding of early-formed differentiated meteorites. Due to its rapid reaction times and low blank levels, laser-assisted fluorination has now largely superseded the conventional externally-heated Ni âbombâ technique for bulk analysis. Unlike UV laser ablation and SIMS analysis, laser-assisted fluorination is not capable of focused spot analysis. While laser fluorination is now a mature technology, further analytical improvements are possible via refinements to the construction of sample chambers, clean-up lines and the use of ultra-high resolution mass spectrometers.
High-precision oxygen isotope analysis has proved to be a particularly powerful technique for investigating the formation and evolution of early-formed differentiated asteroids and has provided unique insights into the interrelationships between various groups of achondrites. A clear example of this is seenin samples that lie close to the terrestrial fractionation line (TFL). Based on the data from conventional oxygen isotope analysis, it was suggested that the main-group pallasites, the howardite eucrite diogenite suite (HEDs) and mesosiderites could all be derived from a single common parent body. However,high precision analysis demonstrates that main-group pallasites have a Î17O composition that is fully resolvable from that of the HEDs and mesosiderites, indicating the involvement of at least two parent bodies. The range of Î17O values exhibited by an achondrite group provides a useful means of assessing the extent to which their parent body underwent melting and isotopic homogenization. Oxygen isotope analysis can also highlight relationships between ungrouped achondrites and the more well-populated groups. A clear example of this is the proposed link between the evolved GRA 06128/9 meteorites and the brachinites.
The evidence from oxygen isotopes, in conjunction with that from other techniques, indicates that we have samples from approximately 110 asteroidal parent bodies (âŒ60 irons, âŒ35 achondrites and stony-iron, and âŒ15 chondrites) in our global meteorite collection. However, compared to the likely size of the original protoplanetary asteroid population, this is an extremely low value. In addition, almost all of the differentiated samples (achondrites, stony-iron and irons) are derived from parent bodies that were highly disrupted early in their evolution.
High-precision oxygen isotope analysis of achondrites provides some important insights into the origin of mass-independent variation in the early Solar System. In particular, the evidence from various primitive achondrite groups indicates that both the slope 1 (Y&R) and CCAM lines are of primordial significance. Î17O differences between water ice and silicate-rich solids were probably the initial source of the slope 1 anomaly. These phases most likely acquired their isotopic composition as a result of UV photo-dissociation of CO that took place either in the early solar nebula or precursor giant molecular cloud. Such small-scale isotopic heterogeneities were propagated into larger-sized bodies, such as asteroids and planets, as a result of early Solar System processes, including dehydration, aqueous alteration,melting and collisional interactions
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